Project

Structural, thermodynamic, and kinetic characterization of CSF-1/CSF-1R cytokine/receptor interaction

Duration
01 October 2007 → 30 September 2011
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Condensed matter physics and nanophysics
    • Medicinal and biomolecular chemistry
    • Molecular and cell biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Biophysics
    • Molecular and cell biology
    • Biophysics
    • Molecular and cell biology
    • Biophysics
    • Molecular and cell biology
Keywords
structural biology microcalorimetry cytokine-receptor interactions thermodynamics hematopoiesis binding studies
 
Project description

Hematopoiesis, the making of blood cells, is initiated via the binding of hematopoietic cytokines to specific receptors on the surface of hematopoietic stem cells. We will dissect the interactions of Flt3L and SCF, two essential cytokines, with their respective receptors using structural biology (x-ray crystallography) and bindingstudies (microcalorimetry and SPR). We hope to generate insights leading to the design of agonists with improved binding properties.