Research Explorer

Project

The molecular and structural basis of GM-CSF and IL-2 by viral GIF to achieve immunomodulation.

Code
3G097413
Duration
01 January 2013 → 31 December 2018
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Medicinal and biomolecular chemistry
    • Biochemistry and metabolism
    • Microbiology
    • Molecular and cell biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Biophysics
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Microbiology
    • Molecular and cell biology
    • Biophysics
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Molecular and cell biology
    • Biophysics
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Microbiology
    • Molecular and cell biology
Keywords
protein-protein interactions host-pathogen interactions structural biology immune system subversion immunology
 
Project description

This project aims to elucidate the structure-function landscape of the interaction between viral GIF with GM-CSF and IL-2, thereby setting the stage to understand immune system subversion. Our research initiative builds upon recent exciting developments in our research group and unites structural studies (X-ray crystallography, SAXS, and EM) with interaction studies and cellular assays.