Research Explorer

Project

Structural and biophysical characterisation of XcpP and XcpQ of the bacterial type 2 secretion system from Pseudomonas aeruginosa.
Code
3F015509
Duration
01 October 2009 → 30 September 2013
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
XcpQ XcpP T2SS
 
Project description

This interdisciplinary research project focuses on the bacterial type 2 secretion system of Pseudomonas aeruginosa, an opportunistic gram-negative pathogen. This secretion system (the "Xcp-machinery") has two key components: XcpP and XcpQ, which interact with each other. With this research we aim to perform structural, biochemical and biofysical studies to elucidate the architecture and interactions of XcpP and XcpQ.