Cofunding Core Facility - Clinical Tissue and Cell Culture core

Decoding novel therapeutic targets against rectal cancer iron metabolism and immune microenvironment

Doctoral project Eva Blondeel

Doctoral project Quentin Rousseau

Doctoral project Zihan Xia

Heterogeneity of cancer-associated fibroblast organization in the tumour environment: therapeutic applications and consequences of ex vivo adaptations

Biosensor tools for imaging-assisted biofabrication

Doctoral project An Gelaude

Doctoral project Astrid De Boeck

Doctoral project Glenn Vergauwen

Doctoral project Lore Lapeire

Doctoral project Oriane Gillon

Doctoral project Parisa Shali

Doctoral project Rinus Dejonghe

Doctoral project Sam Ernst

Evaluation of multidrug adjunctive cancer treatment (MDACT) in glioblastoma

Exploring bacterial extracellular vesicles in liquid biopsies from cancer patients

Exploring bacterial extracellular vesicles in liquid biopsies from cancer patients

Exploring bacterial extracellular vesicles in liquid biopsies from cancer patients

Impact of cancer-associated fibroblasts and their secretome on immune cross-talk upon irradiation

Patient-derived mouse models of metastasized soft tissue sarcomas as guide for therapeutic decisions in metastasized sarcoma patients

Rigor and standardization in extracellular vesicle research to enable clinical translation

Selective modulation of cancer-associated fibroblasts in the tumor microenvironment by the small molecule inhibitor C16

The role of bacterial extracellular vesicles in cancer

The study of bacterial extracellular vesicles in anti-tumour responses

Trash or Treasure Biogenesis and Function of Extracellular Vesicle subsets in Hormone-Positive Breast Cancer

beurs EVDS Arne Peirsman: Design of a 3D printed and perfused breast cancer metastasis model (3D PAP Be CAME model)

Beurs Joke Tommelein: Radiotherapy-induced damage to cancer-associated fibroblasts promotes colorectal cancer progression through IGF-1/AKT signaling

BOF-ZAP professorship in cancer research

Cancer Associated Fibroblasts (CAF) Function in Tumor Expansion and Invasion

Can the Rnome, encapsulated in extracellular vesicles, assist in directing therapy in patients with metastatic Castration Resistant Prostate Cancer

Cofunding Core Facility - Patient-derived xenograft models

Design and evaluation of a traceable reference material for extracellular vesicles

Evaluation of cellular dynamics using automated widefield imaging

Exosomal miRNAs as a biomarker for early targeted therapy response in advanced triple negative breast cancer

Exosomes: customized messengers tumor ecosystems.

Extracellullar vesicle signatures as biomarker of therapeutic efficiency in metastatic breast cancer

Fibrosis-related biomarkers and therapeutic targets for radiation-induced anorectal dysfunction

Identification of Low-Grade Serous Ovarian Carcinoma (LGSOC) therapeutics using clinical relevant spheroid and tumor-engineered models for peritoneal metastasis.

Identification of recombinant nanobodies for exosome immunecapture in breast cancer diagnosis

Impact of MEK targeted therapy on cancer-associated fibroblast state and consequential effects for cancer progression

INnovative Flemish IN vivo Imaging TechnologY (INFINITY)

IVIS Lumina III LT In Vivo imaging system.

Longitudinal imaging of cellular dynamics with a biostation IM-Q (microscope with sensitive CCD camera and integrated incubator)

METAstasis in the Lab: quantification and validation of a new approach method to test therapeutics targeting metastasis

Microparticle-encapsulated tumor-environment interactions to capture disseminated mesothelioma cells

Models to study cancer metastasis

Myosin II as a central regulator of exosome-related communications in the tumor environment

Plasma-activated liquids: an innovative method to treat cancer

primary vs secondary resistance to EGFR-targeted therapy in colorectal cancer: biological and predictive significance of stromal-derived neuregulin-1

Pro-invasive response of tumor-associated myofibroblasts to radiation therapy

Rab27B-mediated pre-metastatic niche formation: possible therapeutic opportunities

Targeting cancer-associated fibroblasts to overcome immunosuppressive mechanisms in mismatch repair-deficient tumors

Targeting of early metastic lesions by exosome-mimetic nanoparticles

Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases

Targeting tumor microenvironment to counteract cancer progression

The metastic niche: preparation, function and translational evidence of a permissieve micro environment for cancer dissemination

Therapeutic targeting of early metastasis by exosome-mimetic gold nanoparticles

The tumor-ecosystem: a source of therapeutic targets and prognostic biomarkers

Tissue and cell culture core facility

Traceable reference standard for extracellular vesicles

Tumor engineering a clinical relevant in vivo model for peritoneal metastasis

Use of the small GTPase Rab27b to diagnose and treat poor prognosis estrogen-receptor-positive (ER+) breast cancer

Analyzing the immunobiological function of circulating bacterial extracellular vesicles in cancer patients

A patient derived xenograft (PDX) platform for in vivo evaluation of novel anticancer therapies

Cancer invasion and metastasis: development of a new spheroid confrontation assay and preclinical characterisation of a novel inhibitory mechanism

Design and development of new selective HDAC6 inhibitors with applications in cancer therapy

Development and implementation of analytical methods based on laser ablation – and single-event ICP-mass spectrometry for examining metal(loid) signatures in cancer

Evaluating the potential of Multidrug Adjunctive Cancer Treatment (MDACT) in glioblastoma

Exosome staging to predict axillary lymph node metastasis in early breast cancer.

Exploring the biology of bacterial extracellular vesicles in human biofluids.

Field-flow fractionation (FFF) system for combination with high-end ICP-mass spectrometry (ICP-MS).

Function and biogenesis of extracellular vesicle subsets in cancer

Identification of anti-FOLR1 VHHs as novel candidates for FOLR1-targeted (brain) tumor imaging and anti-cancer therapy.

IVIS Lumina II Bioluminescence camera for laboratory animal research

Photolithographic DNA printer for massively parallel synthesis of DNA oligonucleotides for spatial - omics and hybrid capture target enrichment applications

Single-cell ICP-mass spectrometry in the biological sciences: on the way to real-world use

Stimulated emission depletion microscopy (STED): Nanoscopy for innovative research in the life sciences

Study of fibroblast stromagenesis in a 3-dimensional tissue context

Temporally and spatially resolved multi-element information at the micro- and nano-scale: development of new analytical methods and their application to metallomics and nanotechnology

The formation of metastases is the main cause of cancer-related mortality

Ultrafast-scanning tandem ICP-mass spectrometer for interference-free and highly-sensitive transient signal monitoring

Upgrade of confocal FLIM microscope with two-photon excitation and detection modules

White light laser-based confocal fluorescence lifetime imaging microscope for multi-parameter 3D live imaging

BOF-ZAP professorship in cancer research

Resistance to EGFR-targeted therapy in colorectal cancer: biological significance of stromal-derived neuregulin-1

Role of tumor based cancer cell