Research Explorer

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Researcher

Olivier De Wever

Publications & Research Data

Awards & Distinctions

412 Results

2026

Exploration of patient-derived models as a tool to support therapeutic decision making in sarcoma patients

Stefanie GijselsGabriëlle van RamshorstOlivier De WeverGwen Sys

From pitfalls to progress in quantitative single-cell elemental analysis by time-of-flight ICP-mass spectrometry

Rinus DejongheAna Lores PadínEduardo Bolea FernandezThibaut Van AckerOlivier De WeverFrank Vanhaecke

A1 Journal Article in SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY

Low-dose chronic exposure to hemin and kynurenine enhances metabolic adaptation in a colorectal cancer cell model

Elien AlderweireldtCharlotte GrootaertStijn LucaFilip Van NieuwerburghAndreja RajkovicJohn Van CampOlivier De Wever

A1 Journal Article in SCIENTIFIC REPORTS

Novel rectal cancer spheroid models reveal metabolic and transcriptional adaptations driving radiotherapy response

Diogo Miguel Monteiro EstêvãoMiguel da Cruz RibeiroAna Canha-BorgesCatarina Macedo-SilvaFlávia Raquel Teixeira De CastroJoana LencartTom BoterbergOlga SousaCarmen JerónimoIola F. Duarte et al.

A1 Journal Article in RADIOTHERAPY AND ONCOLOGY

2025

A living sarcoma biobank for translational research purposes

Stefanie GijselsMerlijn VekemanSuzanne FischerDavid CreytensAlexander AckermanAnaïs OngenaetLaurens BoiEline SegersJens De TemmermanFrancesca Casteur et al.

Blood collection tube and RNA purification method recommendations for extracellular RNA transcriptome profiling

The exRNAQC ConsortiumJasper AnckaertFrancisco Avila CobosAnneleen DecockPhilippe DecruyenaereJill DeleuKatleen De PreterOlivier De WeverJilke De WildeBert Dhondt et al.

A1 Journal Article in NATURE COMMUNICATIONS

Breaking barriers in cancer research : the promise of a non-taxoid microtubule stabilizer and three-dimensional spheroid models

Stephanie VermeulenOlivier De WeverHerman Depypere

CDX2 loss in colorectal cancer cells is associated with invasive properties and tumor budding

Nils BodmerKristin UthRina MehmetiCansaran Saygili DemirDeborah StrokaNassim Ghaffari-Tabrizi-WizsyAlessandro LugliOlivier De WeverInti ZlobecMario P. Tschan

A1 Journal Article in SCIENTIFIC REPORTS

Chitosan/γ-PGA nanoparticles and IFN-γ immunotherapy : a dual approach for triple-negative breast cancer treatment

Flávia Raquel Teixeira De CastroMarta Laranjeiro PintoCatarina Leite PereiraKarine SerreÂngela Margarida CostaBruno CavadasMário Adolfo BarbosaKarim VermaelenSergio LeónDiego Serrano et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Engineered dendritic cells-derived extracellular vesicles for cancer immunotherapy

Margarida Oliveira CoelhoSofia Torres QuintasBruno SarmentoOlivier De WeverFlávia Raquel Teixeira De Castro

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Fibroblast activation protein on human natural killer cells : insights from natural killer cell activation and crosstalk with cancer-associated fibroblasts

Yentl Van RymenantAnke de GrootLaura DirkxEmile VerhulstJoni De LooseIsabel PintelonTias VerhezenJorrit De WaeleSofie ThysOlivier De Wever et al.

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Identifying novel treatments for sarcoma through relevant surgical mouse models

Stefanie GijselsSuzanne FischerLotte LegiestGabriëlle van RamshorstGwen SysOlivier De Wever

Immune checkpoint inhibitors in gynecologic cancer : getting to prime T(I)ME?

Emiel De JaeghereHannelore DenysOlivier De WeverFrédéric Amant

Launching SMART 3D cancer models

Sam ErnstOlivier De Wever

Editorial material

Online microdroplet calibration for accurate elemental analysis via single-cell ICP-TOF-MS

Ana Lores PadínRinus DejongheOlivier De WeverFrank Vanhaecke

Preserving potential : surgeons as key partners in establishing a living sarcoma biobank for translational research purposes

Stefanie GijselsMerlijn VekemanSuzanne FischerDavid CreytensAlexander AckermanAnaïs OngenaetLaurens BoiEline SegersJens De TemmermanFrancesca Casteur et al.

A1 Journal Article in SURGICAL ONCOLOGY-OXFORD

Repurposing itraconazole and pyrimethamine with temozolomide as a combinatorial treatment for glioblastoma

Thibault LootensJelle VandersteeneHarry PinsonSam ErnstTom BoterbergVanessa VermeirssenOlivier De WeverFrederik De SmetRobrecht Raedt

Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids

Eva BlondeelSam ErnstFelix De VuystÁkos DiósdiCláudio PinheiroDiogo EstêvãoPekka RappuRobin BoiySandor DedeyneLigia Craciun et al.

A1 Journal Article in NATURE PROTOCOLS

Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids (Apr, 10.1038/s41596-025-01150-y, 2025)

Eva BlondeelSam ErnstFelix De VuystÁkos DiósdiCláudio PinheiroDiogo Miguel Monteiro EstêvãoPekka RappuRobin BoiySandor DedeyneLigia Craciun et al.

Single-cell ICP-MS analysis of large human cells : addressing transport efficiency and size-dependent bias

Mina NikolićAna Lores PadínThibaut Van AckerOlivier De WeverEduardo Bolea FernandezFrank Vanhaecke

Spheroid-based tools as stepping stones towards rigorous and mechanistically insightful research.

Eva BlondeelOlivier De WeverHannelore DenysAn Hendrix

The placticity of cancer-associated fibroblasts

Zihan XiaOlivier De WeverAn Hendrix

The Spheroid Light Microscopy Image Atlas for morphometrical analysis of three-dimensional cell cultures

Eva BlondeelArne PeirsmanStephanie VermeulenFilippo PiccininiFelix De VuystDiogo Miguel Monteiro EstêvãoSayida Al-JameiMartina BedeschiGastone CastellaniTânia Cruz et al.

A1 Journal Article in SCIENTIFIC DATA

Trash or treasure : biogenesis and func.On of extracellular vesicle subsets in hormone-positive breast cancer

Robin BoiyAn HendrixOlivier De Wever

2024

An evaluation of the analytical and biological robustness of a method for quantifying iron in individual red blood cells via single-cell tandem ICP-mass spectrometry

Rinus DejongheEduardo Bolea FernandezAna Lores PadínThibaut Van AckerAna Maria Rua IbarzOlivier De WeverFrank Vanhaecke

A1 Journal Article in MICROCHEMICAL JOURNAL

Associations of the gut microbiome with outcomes in cervical and endometrial cancer patients treated with pembrolizumab : insights from the phase II PRIMMO trial

Emiel De JaeghereHannelore HamerlinckSandra TuyaertsLien LippensAn M.T. Van NuffelRegina Baiden-AmissahPeter VuylstekeStéphanie HenryXuan Bich TrinhPeter A. van Dam et al.

A1 Journal Article in GYNECOLOGIC ONCOLOGY

Cancer‐associated fibroblasts mediate resistance to neoadjuvant therapy in breast cancer

Zihan XiaStephanie VermeulenUjjwal SuwalPekka RappuJyrki HeinoFelix De VuystSandor DedeyneAn HendrixHannelore DenysOlivier De Wever

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

Clinical consequences of the increasing complexity of intratumour heterogeneity in soft-tissue sarcoma

Stefanie GijselsSuzanne FischerDavid CreytensMerlijn VekemanAlexander AckermanLaurens BoiEline SegersRuben Van BoxstaelGwen SysGabriëlle van Ramshorst et al.

DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas

Gamze BildikJoshua P. GrayWeiqun MaoHailing YangRumeysa OzyurtVivian R. OrellanaOlivier De WeverMark S. CareyRobert C. BastZhen Lu

A1 Journal Article in AUTOPHAGY

Dual-ligand PROTACS mediate superior target protein degradation in vitro and therapeutic efficacy in vivo

Yong ChenZihan XiaUjjwal SuwalPekka RappuJyrki HeinoOlivier De WeverBruno De Geest

A1 Journal Article in CHEMICAL SCIENCE

Generation of post-surgical minimal residual disease models to investigate metastasis in soft tissue sarcoma patient-derived orthotopic xenografts

Suzanne FischerDavid CreytensStefanie GijselsBenedicte DescampsLore LapeireAn HendrixGwen SysOlivier De Wever

A2 Journal Article in STAR PROTOCOLS

Glioblastoma-associated mesenchymal stem/stromal cells and cancer-associated fibroblasts : partners in crime?

Thibault LootensBart RomanChristian StevensOlivier De WeverRobrecht Raedt

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification and validation of extracellular vesicle reference genes for the normalization of RT‐qPCR data

Cláudio PinheiroNiké GuilbertLien LippensQuentin RouxRobin BoiySuzanne FischerSofie Van DorpeBram De CraeneGeert BerxTom Boterberg et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Mapping bacterial extracellular vesicle research : insights, best practices and knowledge gaps

Nele De LangheSofie Van DorpeNiké GuilbertAmélie Vander CruyssenQuentin RouxSarah DevilleSandor DedeynePhilippe TummersHannelore DenysLinos Vandekerckhove et al.

A1 Journal Article in NATURE COMMUNICATIONS

Minimal information for studies of extracellular vesicles (MISEV2023) : from basic to advanced approaches

Joshua A. WelshDeborah C. I. GoberdhanLorraine O'DriscollEdit I. BuzasCherie BlenkironBenedetta BussolatiHoujian CaiDolores Di VizioTom A. P. DriedonksUta Erdbrügger et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Navigating the complexity of intratumor heterogeneity in precision medicine

Stefanie GijselsSuzanne FischerDavid CreytensLaurens BoiEline SegersGwen SysGabriëlle van RamshorstOlivier De Wever

PDXGhent : patient derived tumor xenografting mouse Core Facility Ghent

Liselot MusSteven GoossensTim LammensLindsey DevisscherPanagiotis NtziachristosOlivier De WeverFrédéric Clement

PDXGhent : patient derived tumor xenografting mouse core facility Ghent

Liselot MusSteven GoossensTim LammensLindsey DevisscherPanagiotis NtziachristosOlivier De WeverFrédéric Clement

Pelophen B is a non-taxoid binding microtubule-stabilizing agent with promising preclinical anticancer properties

Stephanie VermeulenSam ErnstEva BlondeelZihan XiaPekka RappuJyrki HeinoSandor DedeyneHannelore DenysGwen SysStefanie Gijsels et al.

A1 Journal Article in SCIENTIFIC REPORTS

Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma : results of the phase II PRIMMO study (vol 72, pg 475, 2022)

Emiel De JaeghereSandra TuyaertsAn M. T. Van NufelAnn BelmansKris BogaertsRegina Baiden-AmissahLien LippensPeter VuylstekeStéphanie HenryXuan Bich Trinh et al.

Quantitative determination and subcellular mapping of Pt-based drugs in single breast tumour cells via laser ablation-ICP-mass spectrometry

Legna Colina VegasThibaut Van AckerWilmer VillarrealOlivier De WeverAlzir Azevedo BatistaJoaquim Araújo NóbregaFrank Vanhaecke

A1 Journal Article in DALTON TRANSACTIONS

Repurposing itraconazole and pyrimethamine with temozolomide as a combinatorial treatment for glioblastoma

Thibault LootensJelle VandersteeneHarry PinsonTom BoterbergVanessa VermeirssenOlivier De WeverFrederik De SmetRobrecht Raedt

Single tumour, many faces - unraveling intratumour complexity in soft-tissue sarcoma

Stefanie GijselsSuzanne FischerDavid CreytensMerlijn VekemanAlexander AckermanLaurens BoiEline SegersRuben Van BoxstaelGwen SysOlivier De Wever et al.

Single tumour, many faces : unraveling intratumour complexity of soft tissue sarcoma

Stefanie GijselsSuzanne FischerDavid CreytensMerlijn VekemanAlexander AckermanLaurens BoiEline SegersRuben Van BoxstaelGabriëlle van RamshorstGwen Sys et al.

Single tumour, many faces : unraveling intratumour complexity of soft-tissue sarcoma

Stefanie GijselsSuzanne FischerDavid CreytensMerlijn VekemanGabriëlle van RamshorstGwen SysOlivier De Wever

Zebrafish avatars : toward functional precision medicine in low-grade serous ovarian cancer

Charlotte FieuwsJan Willem BekBram PartonElyne De NeefOlivier De WeverMilena HoorneMarta F. EstradaJo Van DorpeHannelore DenysKoen Van de Vijver et al.

A1 Journal Article in CANCERS

2023

A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment

Elly De VlieghereKoen Van de VijverEva BlondeelNathan CarpentierRouba GhobeiraJarne PauwelsSebastian RiemannManon MinsartCharlotte FieuwsJohanna Mestach et al.

A1 Journal Article in BIOMATERIALS RESEARCH

Analyzing extracellular vesicles in liquid biopsies : the road towards clinical application

Bert DhondtNicolaas LumenAn HendrixOlivier De Wever

Benchmarking blood collection tubes and processing intervals for extracellular vesicle performance metrics

Bert DhondtCláudio PinheiroEdward GeeurickxJoeri TulkensGlenn VergauwenEdwin Van Der PolRienk NieuwlandAnneleen DecockIlkka MiinalainenPekka Rappu et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Benchmarking blood collection tubes and processing intervals for extracellular vesicle performance metrics

Bert DhondtCláudio PinheiroEdward GeeurickxJoeri TulkensGlenn VergauwenEdwin Van Der PolRienk NieuwlandAnneleen DecockIlkka MiinalainenPekka Rappu et al.

Chronic exposure to dietary compounds shifts bioenergetics in colorectal cancer

Elien AlderweireldtCharlotte GrootaertAndreja RajkovicFilip Van NieuwerburghJohn Van CampOlivier De Wever

Deep learning-based tool for morphotypic analysis of 3D multicellular spheroids

Filippo PiccininiArne PeirsmanMariachiara StellatoJae-chul PyunMaria M. TumedeiMarcella TazzariOlivier De WeverAnna TeseiGiovanni MartinelliGastone Castellani

A1 Journal Article in JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY

Depletion of soluble cytokines unlocks the immunomodulatory bioactivity of extracellular vesicles

Quentin RouxRobin BoiyFelix De VuystMercedes TkachCláudio PinheiroSofie De GeyterIlkka MiinalainenClotilde TheryOlivier De WeverAn Hendrix

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Development of a live tissue sarcoma biobank to support the creation of patient-derived translational models

Merlijn VekemanAlexander AckermanAnaïs OngenaetSuzanne FischerStefanie GijselsOlivier De WeverAn HendrixDavid CreytensGwen Sys

Direct lysis of 3D cell cultures for RT-qPCR gene expression quantification

Fien GysensLisa OstynEllen GoeteynEva BlondeelJustine NuytensOlivier De WeverEric de Bony de LavergneAurélie CrabbéPieter Mestdagh

A1 Journal Article in SCIENTIFIC REPORTS

Dramatic impact of blood collection tube and RNA purification method on extracellular RNA transcriptomes

Jasper AnckaertFrancisco Avila CobosAnneleen DecockPhilippe DecruyenaereJill DeleuKatleen De PreterOlivier De WeverJilke De WildeBert DhondtThibaut D'huyvetter et al.

Effect on colorectal cancer bioenergetics by chronic exposure to red meat metabolites

Elien AlderweireldtCharlotte GrootaertSophie Van WeldenDebby LaukensAndreja RajkovicJohn Van CampOlivier De Wever

Effect on colorectal cancer bioenergetics by chronic exposure to red meat metabolites

Elien AlderweireldtCharlotte GrootaertAndreja RajkovicFilip Van NieuwerburghStijn LucaJohn Van CampOlivier De Wever

Endoglin, a novel biomarker and therapeutical target to prevent malignant peripheral nerve sheath tumor growth and metastasis

Teresa González-MuñozAngela Di GiannataleSusana García-SilvaVanesa SantosSara Sánchez-RedondoClaudia SaviniOsvaldo Graña-CastroCarmen Blanco-AparicioSuzanne FischerOlivier De Wever et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Ex vivo sarcoma cell cultures from paired primary, local relapse and metastatic sites reveals phenotypic heterogeneity

Stefanie GijselsSuzanne FischerLaurens BoiEline SegersGwen SysGabriëlle van RamshorstOlivier De Wever

Expanding the toolbox : development of tools to aid rigor and standardization in extracellular vesicle research

Cláudio PinheiroAn HendrixOlivier De Wever

Exploring spheroids in the light of adipose tissue engineering

Arne PeirsmanPhillip BlondeelOlivier De Wever

Histologic tumor type as a determinant of survival in hormone receptor-positive, HER2-negative, pT1-3 invasive ductal and lobular breast cancer

Menekse GOKERHannelore DenysAn HendrixOlivier De WeverKoen Van de VijverGeert Braems

A1 Journal Article in BREAST CANCER RESEARCH

Integrating automated liquid handling in the separation workflow of extracellular vesicles enhances specificity and reproducibility

Sofie Van DorpeLien LippensRobin BoiyCláudio PinheiroGlenn VergauwenPekka RappuIlkka MiinalainenPhilippe TummersHannelore DenysOlivier De Wever et al.

A1 Journal Article in JOURNAL OF NANOBIOTECHNOLOGY

Orthotopic xenografts of paired sarcoma primary tumour, local relapse and metastatic sites reveals phenotypic heterogeneity in a minimal residual disease model

Stefanie GijselsSuzanne FischerDavid CreytensMerlijn VekemanAlexander AckermanGwen SysGabriëlle van RamshorstOlivier De Wever

Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma : results of the phase II PRIMMO study

Emiel De JaeghereSandra TuyaertsAn M. T. Van NuffelAnn BelmansKris BogaertsRegina Baiden-AmissahLien LippensPeter VuylstekeStéphanie HenryXuan Bich Trinh et al.

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts

Suzanne FischerDavid CreytensSofie De GeyterElly De VliegherePiet PattynSarah-Lee BekaertKaat DurinckNadine Van RoyAn HendrixLore Lapeire et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer

Cristina MunteanEva BlondeelLaure HarinckKunal PednekarJai PrakashOlivier De WeverJeanne Leblond ChainStefaan De SmedtKatrien RemautKoen Raemdonck

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Rigor and standardization in extracellular vesicle research to enable clinical translation

Quentin RouxAn HendrixOlivier De Wever

Selective modulation of cancer-associated fibroblasts in the tumor microenvironment by the small molecule inhibitor C16

Christophe MangodtChristian StevensOlivier De WeverBart Roman

The impact of red meat metabolites on the metabolic flexibility of colon cancer cells

Elien AlderweireldtJohn Van CampOlivier De Wever

Vascularized adipose tissue engineering : moving towards soft tissue reconstruction

Arne PeirsmanHuu Tuan NguyenMichiel Van WaeyenbergeCarlos CeballosJohana BolivarSatoru KawakitaFlorian VanlauweZuzana TirpakovaSofie Van DorpeLana Van Damme et al.

A1 Journal Article in BIOFABRICATION

2022

2022-RA-638-ESGO Pembrolizumab with multimodal immunomodulation in chemotherapy-pretreated cervical, endometrial, and uterine cancer : the PRIMMO phase II trial

Emiel De JaeghereSandra TuyaertsAnn M.T. van NuffelAnn BelmansKris BogaertsRegina Baiden-AmissahPeter VuylstekeStéphanie HenryXuan Bich TrinhPeter A. van Dam et al.

A two-front nutritional environment fuels colorectal cancer : perspectives for dietary intervention

Elien AlderweireldtCharlotte GrootaertOlivier De WeverJohn Van Camp

A1 Journal Article in TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effect of chronic exposure of dietary compounds on colorectal cancer bioenergetics

Elien AlderweireldtCharlotte GrootaertAndreja RajkovicJohn Van CampOlivier De Wever

Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR‐200 levels in extracellular vesicles

Rahul BhomeMuhammad EmaduddinVictoria JamesLouise M. HouseStephen M. ThirdboroughMassimiliano MelloneJoeri TulkensJohn N. PrimroseGareth J. ThomasOlivier De Wever et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Heterogeneity of CAFfeinated tumors : sweet targeting perspectives

Olivier De Wever

Editorial material

Hybrid scaffolds as long-term in vitro co-culture model for targeted treatment of ovarian cancer

Elly De VlieghereEva BlondeelNathan CarpentierKoen Van de VijverSandra Van VlierbergheOlivier De Wever

Hybrid scaffolds to create long-term in vitro co-culture model for targeted treatment of ovarian cancer

Elly De VlieghereEva BlondeelNathan CarpentierKoen Van de VijverSandra Van VlierbergheOlivier De Wever

Metastasized orthotopic patient-derived xenografts as preclinical model to guide therapeutic decision making in soft tissue sarcoma patients

Suzanne FischerElly De VlieghereDavid CreytensOlivier De WeverAn HendrixLore LapeireGwen Sys

One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer

Jonas SteenbruggeJulie BellemansNiels Vander ElstKristel DemeyereJosephine De VliegherTimothy PereraOlivier De WeverWim Van Den BroeckWard De SpiegelaereNiek Sanders et al.

A1 Journal Article in ONCOIMMUNOLOGY

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Jasper AnckaertFrancisco Avila CobosAnneleen DecockPhilippe DecruyenaereJill DeleuKatleen De PreterOlivier De WeverJilke De WildeBert DhondtThibaut D'huyvetter et al.

Preclinical platform for long-term evaluation of drug efficacy using three-dimensional tumor-stroma spheroids embedded in stiffness-tunable scaffolds

Elly De VlieghereEva BlondeelNathan CarpentierManon MinsartKoen Van de VijverSandra Van VlierbergheOlivier De Wever

Single-event ICP-mass spectrometry analysis : faster data acquisition speed opens the way to novel applications

Eduardo Bolea FernandezAna Maria Rua IbarzLieve BalcaenThibaut Van AckerTong LiuFrank VanhaeckeChristophe MangodtOlivier De WeverGlen WoodsDiego Leite et al.

Systemically circulating bacterial extracellular vesicles : origin, fate, and function

An HendrixOlivier De Wever

Editorial material

The first mitochondrial metastasis suppressor : NME4 loss-of-function impairs organelle structure and function

Uwe SchlattnerMarie-Lise LacombeFrédéric LamarcheCécile Cottet-RousselleMalgorzata Tokarska-SchlattnerEric FontaineOlivier De WeverTeresita Padilla-BenavidesPatricia SteegBéatrice Nawrocki-Raby et al.

The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice : a new factor in the host-microbiome interaction

Evelien WynendaeleNathan DebunneYorick JanssensAnton De SpiegeleerFrederick VerbekeLiesa TackSophie Van WeldenEvy GoossensDaniel KnappeRalf Hoffmann et al.

A1 Journal Article in BMC BIOLOGY

2021

A systematic review on extracellular vesicles-enriched fat grafting : a shifting paradigm

Mohammad GhiaslooLaura De WildeKashika SinghPatrick TonnardAlexis VerpaeleOlivier De WeverPhillip Blondeel

A1 Journal Article in AESTHETIC SURGERY JOURNAL

Automated liquid handling for highly specific and reproducible density‐based separation of extracellular vesicles from human body fluids

Sofie Van DorpeLien LippensRobin BoiyHannelore DenysOlivier De WeverAn Hendrix

Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells

Aranit HarizajBenedicte DescampsChristophe MangodtStephan StremerschArianna StoppaLieve BalcaenToon BransHilde De RoosterNausikaa DevriendtJuan Fraire et al.

A1 Journal Article in BIOMATERIALS SCIENCE

Delivery routes matter : safety and efficacy of intratumoral immunotherapy

Emily De LombaerdeOlivier De WeverBruno De Geest

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

In vitro and in situ activity-based labeling of fibroblast activation protein with UAMC1110-derived probes

Yentl Van RymenantMuhammet TancRoos Van ElzenAn BrackeOlivier De WeverKoen AugustynsAnne-Marie LambeirMark KockxIngrid De MeesterPieter Van Der Veken

A1 Journal Article in FRONTIERS IN CHEMISTRY

Marine seagrass extract of Thalassia testudinum suppresses colorectal tumor growth, motility and angiogenesis by autophagic stress and immunogenic cell death pathways

Ivones Hernández-BalmasedaIdania Rodeiro GuerraKen DeclerckJosé Alfredo Herrera IsidrónClaudina Pérez-NovoGuy Van CampOlivier De WeverKethia GonzálezMayrel LabradaAdriana Carr et al.

A1 Journal Article in MARINE DRUGS

Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance

Catalina LodillinskyLaetitia FuhrmannMarie IrondelleOlena PylypenkoXiao-Yan LiHélène Bonsang-KitzisFabien ReyalSophie VacherClaire CalmelOlivier De Wever et al.

A1 Journal Article in ONCOGENE

MISpheroID : a knowledgebase and transparency tool for minimum information in spheroid identity

Arne PeirsmanEva BlondeelTasdiq AhmedJasper AnckaertDominique AudenaertTom BoterbergKrisztina BuzasNeil CarragherGastone CastellaniFlávia Castro et al.

A1 Journal Article in NATURE METHODS

OMO-1 reduces progression and enhances cisplatin efficacy in a 4T1-based non-c-MET addicted intraductal mouse model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckEric CiamporceroTimothy PereraEvelyne Meyer

A1 Journal Article in NPJ BREAST CANCER

Patient-derived cell lines and xenografts from sarcoma patients as models for therapeutic decision making

Suzanne FischerDavid CreytensGwen SysLore LapeireAn HendrixOlivier De Wever

Recombinant extracellular vesicles as biological reference material for method development, data normalization and assessment of (pre-)analytical variables

Edward GeeurickxLien LippensPekka RappuBruno De GeestOlivier De WeverAn Hendrix

A1 Journal Article in NATURE PROTOCOLS

Robust sequential biophysical fractionation of blood plasma to study variations in the biomolecular landscape of systemically circulating extracellular vesicles across clinical conditions

Glenn VergauwenJoeri TulkensCláudio PinheiroFrancisco Avila CobosSandor DedeyneMarie-Angélique De ScheerderLinos VandekerckhoveFrancis ImpensIlkka MiinalainenGeert Braems et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Ana Rita Pombo AntunesIsabelle ScheyltjensFrancesca LodiJulie MessiaenAsier AntoranzJohnny DuerinckDaliya KanchevaLiesbet MartensKaren De VlaminckHannah Van Hove et al.

A1 Journal Article in NATURE NEUROSCIENCE

Single-event tandem ICP-mass spectrometry for the quantification of chemotherapeutic drug-derived Pt and endogenous elements in individual human cells

Tong LiuEduardo Bolea FernandezChristophe MangodtOlivier De WeverFrank Vanhaecke

A1 Journal Article in ANALYTICA CHIMICA ACTA

Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Targeting USP13 ‐mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non‐small cell lung cancer

Philippe GironCarolien EggermontAmir NoeparastHugo VandenplasErik TeugelsRamses ForsythOlivier De WeverPedro Aza‐BlancGustavo J. GutierrezJacques De Grève

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor

Marie-Lise LacombeFrederic LamarcheOlivier De WeverTeresita Padilla-BenavidesAlyssa CarlsonImran KhanAnda HunaSophie VacherClaire CalmelCéline Desbourdes et al.

A1 Journal Article in BMC BIOLOGY

Tissue engineered hybrid scaffold with relevant stiffness and extracellular matrix (ECM) as long-term in vitro model for low-grade serous ovarian carcinoma (LGSOC)

Elly De VlieghereEva BlondeelNathan CarpentierSebastian RiemannWim CeelenSandra Van VlierbergheOlivier De Wever

Unexpected effects of a selective and potent c-MET inhibitor in an immunocompetent intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckAnnegret Van der AaEric CiamporceroTimothy PereraEvelyne Meyer

2020

Analyzing bacterial extracellular vesicles in human body fluids by orthogonal biophysical separation and biochemical characterization

Joeri TulkensOlivier De WeverAn Hendrix

A1 Journal Article in NATURE PROTOCOLS

Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma

René Delgado-HernándezIvones Hernández-BalmasedaIdania Rodeiro-GuerraJulio Cesar Rodriguez GonzalezOlivier De WeverEmilie LogieKen DeclerckClaudina Pérez-NovoWim Vanden Berghe

A1 Journal Article in MELANOMA RESEARCH

Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer

Flávia CastroMarta L. PintoCatarina L. PereiraKarine SerreMário A. BarbosaKarim VermaelenFátima GärtnerRaquel M. GonçalvesOlivier De WeverMaria J. Oliveira

A1 Journal Article in BIOMATERIALS

Development and application of a biological reference material for extracellular vesicle research

Edward GeeurickxOlivier De WeverAn HendrixSven Eycerman

Effect of (processed) meat related compounds on intestinal organoids

Elien AlderweireldtCharlotte GrootaertOlivier De WeverJohn Van Camp

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma

Elien De ThayeKoen Van de VijverJoni Van der MeulenJoachim TaminauGlenn WagemansHannelore DenysJo Van DorpeGeert BerxWim CeelenJan Van Bocxlaer et al.

A1 Journal Article in SCIENTIFIC REPORTS

Feasibility of mechanical extrusion to coat nanoparticles with extracellular vesicle membranes

Jan Van DeunQuentin RouxSarah DevilleThibaut Van AckerPekka RappuIlkka MiinalainenJyrki HeinoFrank VanhaeckeBruno De GeestOlivier De Wever et al.

A1 Journal Article in CELLS

Fructosamine-3-kinase as a potential treatment option for age-related macular degeneration

Sander De BruyneCaroline Van den BroeckeHenk VrielinckSamira KhelifiOlivier De WeverKen BrackeManon HuizingNezahat BostonJonas HimpeMarijn Speeckaert et al.

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

In vivo selection of the MDA-MB-231br/eGFP cancer cell line to obtain a clinically relevant rat model for triple negative breast cancer brain metastasis

Valerie De MeulenaereBenedicte DescampsOlivier De WeverChristian VanhoveKarel Deblaere

A1 Journal Article in PLOS ONE

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

Joeri TulkensGlenn VergauwenJan Van DeunEdward GeeurickxBert DhondtLien LippensMarie-Angélique De ScheerderIlkka MiinalainenPekka RappuBruno De Geest et al.

A1 Journal Article in GUT

Localization and expression of nuclear factor of activated T-cells 5 in myoblasts exposed to pro-inflammatory cytokines or hyperosmolar stress and in biopsies from myositis patients

Sandrine HerbeletElly De VlieghereAmanda GonçalvesBoel De PaepeKarsten SchmidtEline NysLaurens WeynantsJoachim WeisGert Van PeerJo Vandesompele et al.

Bookchapter in Myokines, adipokines, cytokines in muscle pathophysiology

MIFlowCyt-EV : a framework for standardized reporting of extracellular vesicle flow cytometry experiments

Joshua A. WelshEdwin Van Der PolGer J.A. ArkesteijnMichel BremerAlain BrissonFrank CoumansFrançoise Dignat-GeorgeErika DugganIonita GhiranBernd Giebel et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

mTor inhibitor GDC-0349 improves ASO induced SAMMSON knock down resulting in enhanced anti-tumor efficacy in uveal melanoma

Shanna DewaeleBoel De PaepeLouis DelhayeEric de Bony de LavergneJilke De WildeKatrien VanderheydenJasper AnckaertNurten YigitEveline Vanden EyndeFariba Nemati et al.

Preparation of multi-omics grade extracellular vesicles by density-based fractionation of urine

Bert DhondtNicolaas LumenOlivier De WeverAn Hendrix

A2 Journal Article in STAR PROTOCOLS

Splenic 18F-FDG uptake on baseline PET/CT is associated with oncological outcomes and tumor immune state in uterine cervical cancer

Emiel De JaeghereFrederiek LalooLien LippensMieke Van BockstalKathia De ManEline NaertJo Van DorpeKoen Van de VijverPhilippe TummersAmin Makar et al.

A1 Journal Article in GYNECOLOGIC ONCOLOGY

Splenic hematopoietic and stromal cells in cancer progression

Jonas SteenbruggeEmiel De JaeghereEvelyne MeyerHannelore DenysOlivier De Wever

A1 Journal Article in CANCER RESEARCH

Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control study-important considerations for liquid biopsies

Anneleen DecockJasper AnckaertCeline EveraertJustine NuytensScott KuerstenAn HendrixJo VandesompelePieter MestdaghBert DhondtRuben Van Paemel et al.

Targeting the tumor microenvironment in colorectal peritoneal metastases

Wim CeelenRobert G. RamsayVignesh NarasimhanAlexander G. HeriotOlivier De Wever

A1 Journal Article in TRENDS IN CANCER

The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness

Liselot MusIrina LambertzShana ClaeysCandy KumpsWouter Van LoockeChristophe Van NesteGanesh UmapathyMarica VaapilChristoph BartenhagenGenevieve Laureys et al.

A1 Journal Article in SCIENTIFIC REPORTS

Tumor engineered model for low-grade serous ovarian carcinoma (LGSOC) : mimicking the tumor environment on a cellular and biophysical level

Elly De VlieghereEva BlondeelWim CeelenBruno De GeestGeert BerxSandra Van VlierbergheOlivier De Wever

Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine

Bert DhondtEdward GeeurickxJoeri TulkensJan Van DeunGlenn VergauwenLien LippensIlkka MiinalainenPekka RappuJyrki HeinoPiet Ost et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

2019

A 3D CFD model of the interstitial fluid pressure and drug distribution in heterogeneous tumor nodules during intraperitoneal chemotherapy

Margo SteuperaertCharlotte DebbautCharlotte CarlierOlivier De WeverBenedicte DescampsChristian VanhoveWim CeelenPatrick Segers

A1 Journal Article in DRUG DELIVERY

A supporting ecosystem to mature extracellular vesicles into clinical application

Olivier De WeverAn Hendrix

A1 Journal Article in EMBO JOURNAL

Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma : a preclinical F98 glioblastoma rat model study

Valerie De MeulenaereEllen BonteJeroen VerhoevenJean-Pierre Kalala OkitoLeen PietersAnne VralOlivier De WeverLuc LeybaertIngeborg GoethalsChristian Vanhove et al.

A1 Journal Article in PLOS ONE

ALK positively regulates MYCN activity through repression of HBP1 expression

Shana ClaeysGeertrui DeneckerKaat DurinckBieke DecaestekerLiselot MusSiebe LoontiensSuzanne VanhauwaertKristina AlthoffCaroline WigerupDaniel Bexell et al.

A1 Journal Article in ONCOGENE

Cell line derived xenograft mouse models are a suitable in vivo model for studying tumor budding in colorectal cancer

Laurent M. C. GeorgesOlivier De WeverJosé A. GalvánHeather DawsonAlessandro LugliPieter DemetterInti Zlobec

A1 Journal Article in FRONTIERS IN MEDICINE

Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

Annemiek UvynRuben De CoenOlivier De WeverKim DeswarteBart LambrechtBruno De Geest

A1 Journal Article in CHEMICAL COMMUNICATIONS

Cellular and sub-cellular Cu isotope fractionation in the human neuroblastoma SH-SY5Y cell line : proliferating versus neuron-like cells

Marta Costas RodriguezLegna Colina VegasNikolay SolovyevOlivier De WeverFrank Vanhaecke

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Comparative immune profiling of an aggressive 4T1-based versus a non-aggressive Py230-based intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereOlivier De WeverSteven Van LaereEvelyne Meyer

Comparative profiling of metastatic 4T1- vs. non-metastatic Py230-based mammary tumors in an intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckLuc DirixSteven Van LaereEvelyne Meyer

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Dramatic differences in RNA purification kit performance in the extracellular RNA quality control study : important considerations for liquid biopsies

Annelien MorlionJasper AnckaertFrancisco Avila CobosAnneleen DecockOlivier De WeverBert DhondtCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

Dramatic differences in RNA purification kit performance in the extracellular RNA quality control study : important considerations for liquid biopsies

Annelien MorlionJasper AnckaertFrancisco Avila CobosAnneleen DecockOlivier De WeverBert DhondtCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

Effect of processed meat related compounds on colon cells

Elien AlderweireldtCharlotte GrootaertStefaan De SmetAndreja RajkovicOlivier De WeverJohn Van Camp

Effect of processed meat related compounds on colon cells

Elien AlderweireldtCharlotte GrootaertStefaan De SmetAndreja RajkovicOlivier De WeverJohn Van Camp

Evaluating the impact of RNA purification kit and blood collection tube in the extracellular RNA quality control study : important considerations for liquid biopsies

Annelien MorlionJasper AnckaertFrancisco Avila CobosAnneleen DecockJill DeleuOlivier De WeverBert DhondtCeline EveraertCarolina FierroHetty Helsmoortel et al.

Exploration of the urinary proteome in the search for new biomarkers for prostate cancer : a promising role for extracellular vesicles

Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxLien LippensJoeri Tulkenslkka MiinalainenPekka RappuJyrki Heino Oulu, FinlandPiet Ost et al.

Fibroblasts fuel immune escape in the tumor microenvironment

Emiel De JaeghereHannelore DenysOlivier De Wever

A1 Journal Article in TRENDS IN CANCER

Laser ablation-tandem ICP-mass spectrometry (LA-ICP-MS/MS) imaging of iron oxide nanoparticles in Ca-rich gelatin microspheres

Thibaut Van AckerEduardo Bolea FernandezElly De VlieghereJingxian GaoOlivier De WeverFrank Vanhaecke

A1 Journal Article in JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Preclinical evaluation of local prolonged release of paclitaxel from gelatin microspheres for the prevention of recurrence of peritoneal carcinomatosis in advanced ovarian cancer

Kaat De ClercqFeifan XieOlivier De WeverBenedicte DescampsAnne HoorensAn VermeulenWim CeelenChris Vervaet

A1 Journal Article in SCIENTIFIC REPORTS

Quantitative determination of Cu via LA-ICP-MS in single triple-negative breast tumor cells after treatment with a new Cu phosphine complex

Legna Colina-VegasThibaut Van AckerWilmer VillarrealAlzir Azevedo BatistaOlivier De WeverJoaquim Araujo NobregaFrank Vanhaecke

Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models

Yves DepetterSilke GeursRob De VreeseSophie GoethalsElien VandoornAlien LaevensJonas SteenbruggeEvelyne MeyerPascal de TullioMarc Bracke et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Sonoprinting liposomes on tumor spheroids by microbubbles and ultrasound

Silke RooversJoke DeprezD PriwitaningrumG LajoinieN RivronHeidi DeclercqOlivier De WeverE StrideS Le GacM Versluis et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Splenic metabolic activity as biomarker in cervical cancer

Emiel De JaeghereFrederiek LalooLien LippensKathia De ManMieke Van BockstalKoen Van de VijverPhilippe TummersAmin MakarPieter De VisschereOlivier De Wever et al.

Stromal integrin α11 regulates PDGFRβ signaling and promotes breast cancer progression

Irina PrimacErik MaquoiSilvia BlacherRitva HeljasvaaraJan Van DeunHilde YH SmelandAnnalisa CanaleThomas LouisLinda StuhrNor Eddine Sounni et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors

Yves DepetterSilke GeursJorick FranceusDamijan KnezTom DesmetKarolien De BosscherOlivier De WeverStanislav GobecMatthias D'hooghe

A1 Journal Article in CHEMISTRYSELECT

Synthesis of selective HDAC6 inhibitors and their evaluation in cancer models

Yves DepetterMatthias D'hoogheOlivier De Wever

The effect of processed meat related compounds on colon cells : relevance of long term approach

Elien AlderweireldtCharlotte GrootaertStefaan De SmetOlivier De WeverJohn Van Camp

The generation and use of recombinant extracellular vesicles as biological reference material

Edward GeeurickxJoeri TulkensBert DhondtJan Van DeunLien LippensGlenn VergauwenElisa HeyrmanDelphine De SutterKris GevaertFrancis Impens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Tumor engineered model for peritoneal metastasis with controllable stiffness

Elly De VlieghereWim CeelenBruno De GeestHeidi DeclercqSandra Van VlierbergheOlivier De Wever

Tumor engineered scaffolds recapitulate a human peritoneal tumor environment at the cellular and biophysical level

Elly De VlieghereWim CeelenBruno De GeestHeidi DeclercqSandra Van VlierbergheOlivier De Wever

Tumor engineering a clinical relevant model that recapitulates the tumor environment of peritoneal metastases in vitro and in vivo

Elly De VlieghereEmiel De JaeghereGlenn WagemansThibaut Van AckerChristian VanhoveSarah NeytsGeert BerxFrank VanhaeckeWim CeelenBruno De Geest et al.

2018

A new Ru(II) complex : DNA/HSA-binding, anti-migration and biological properties in a human breast tumor cell line

Legna Colina-VegasThibaut Van AckerOlivier De WeverAlzir Azevedo BatistaJoaquim Araujo NobregaFrank Vanhaecke

Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer

Jonas SteenbruggeKoen BreyneKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckCecile ColpaertPeter VermeulenSteven Van LaereEvelyne Meyer

A1 Journal Article in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Applications of laser ablation-inductively coupled plasma-mass spectrometry imaging in experimental peritoneal metastatic cancer research regarding tissue engineered biomaterials

Thibaut Van AckerElly De VlieghereEduardo Bolea FernandezOlivier De WeverFrank Vanhaecke

Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition

Yves DepetterSilke GeursFlore Vanden BusscheRob De VreeseJorick FranceusTom DesmetOlivier De WeverMatthias D'hooghe

A1 Journal Article in MEDCHEMCOMM

Bursting the bubble : introducing rigor in extracellular vesicle research to track and target cancer

Jan Van DeunOlivier De WeverAn Hendrix

Children’s screen time alters the expression of saliva extracellular miR-222 and miR-146a

Annette VriensEline B ProvostNelly D SaenenPatrick De BoeverKaren VrijensOlivier De WeverMichelle PlusquinTim S Nawrot

A1 Journal Article in SCIENTIFIC REPORTS

Glucocorticoids indirectly decrease colon cancer cell proliferation and invasion via effects on cancer-associated fibroblasts

Zuzanna DrebertElly De VlieghereJolien BridelanceOlivier De WeverKarolien De BosscherMarc BrackeIlse Beck

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo

Olivier De WeverEmiel De JaeghereElly De Vlieghere

Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo

Emiel De JaeghereElly De VlieghereJasper Van HoorickSandra Van VlierbergheGlenn WagemansLeen PietersElodie MelsensMarleen PraetJo Van DorpeMatthieu Boone et al.

A1 Journal Article in BIOMATERIALS

Hypoxia imaging with 18F-FAZA PET/CT predicts radiotherapy response in esophageal adenocarcinoma xenografts

Elodie MelsensElly De VlieghereBenedicte DescampsChristian VanhoveKen KersemansFilip De VosIngeborg GoethalsBoudewijn BransOlivier De WeverWim Ceelen et al.

A1 Journal Article in RADIATION ONCOLOGY

Impact of the microenvironment on tumour budding in colorectal cancer

Laurent MC GeorgesLaurine VersetInti ZlobecPieter DemetterOlivier De Wever

A1 Journal Article in Advances in Experimental Medicine and Biology

Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro

Silvio HolznerStefan BrennerAtanas Georgiev AtanasovDaniel SenfterSerena StadlerChi Huu NguyenAdryan FristiohadyDaniela MilovanovicNicole HuttarySigurd Krieger et al.

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Is there a role for quorum sensing peptides in cancer?

Evelien WynendaeleYorick JanssensNathan DebunneOlivier De WeverBart De Spiegeleer

Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma

Elmina Mammadova-BachTristan RuppCaroline SpenléIvo JivkovPattabhiraman ShankaranarayananAnnick KleinLaura PisarskyAgnès Méchine-NeuvilleGérard CremelMichèle Kedinger et al.

A1 Journal Article in BIOLOGY OF THE CELL

Localization and expression of nuclear factor of activated T-cells 5 in myoblasts exposed to pro-inflammatory cytokines or hyperosmolar stress and in biopsies from myositis patients

Sandrine HerbeletElly De VlieghereAmanda GonçalvesBoel De PaepeKarsten SchmidtEline NysLaurens WeynantsJoachim WeisGert Van PeerJo Vandesompele et al.

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde ThéryKenneth W WitwerElena AikawaMaria Jose AlcarazJohnathon D AndersonRamaroson AndriantsitohainaAnna AntoniouTanina ArabFabienne ArcherGeorgia K Atkin-Smith et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF1R activation

Joke TommeleinElly De VlieghereLaurine VersetElodie MelsensJustine LeendersBenedicte DescampsAnnelies DebucquoyChristian VanhovePatrick PauwelsChristian P Gespach et al.

A1 Journal Article in CANCER RESEARCH

Recombinant extracellular vesicles : biological reference material to standardize extracellular vesicle research

Edward GeeurickxElisa HeyrmanJan Van DeunLien LippensJoeri TulkensBert DhondtGlenn VergauwenKris GevaertFrancis ImpensIlkka Miinalainen et al.

Recombinant extracellular vesicles : biological reference material to standardize extracellular vesicle research

Edward GeeurickxElisa HeyrmanJan Van DeunLien LippensJoeri TulkensBert DhondtGlenn VergauwenKris GevaertFrancis ImpensIlkka Miinalainen et al.

Repeatable, high-purity isolation of urinary extracellular vesicles for uro-oncological biomarker studies

Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxJoeri TulkensLien LippensIlkka MiinalainenPekka RappuJyrki HeinoNicolaas Lumen et al.

Reproduceerbare isolatie van hoog-zuivere urinaire extracellulaire vesikels voor uro-oncologische biomerkerstudies

Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxJoeri TulkensLien LippensSarah BuelensElise De BleserFilip PoelaertTom Claeys et al.

Reproducible high-purity isolation of urinary extracellular vesicles for uro-oncological biomarker studies

Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxJoeri TulkensLien LippensSarah BuelensElise De BleserIlkka MiinalainenPekka Rappu et al.

Reproducible isolation of high-purity urinary extracellular vesicles for uro-oncological biomarker studies

Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxJoeri TulkensLien LippensSarah BuelensElise De BleserFilip PoelaertTom Claeys et al.

Some diffuse large B cell lymphomas (DLBCLs) present with clone-dependent TTF-1 positivity

Mieke Van BockstalAlessandra CamboniElly De VlieghereFrederic De RyckAnn-Sophie CandaeleSOFIE GEENENLies VandemaeleOlivier De WeverLouis LibbrechtSofie Verbeke et al.

A1 Journal Article in HISTOPATHOLOGY

Species-dependent extracranial manifestations of a brain seeking breast cancer cell line

Valerie De MeulenaereSara NeytBert VandeghinstePieter MolletOlivier De WeverElke DecrockLuc LeybaertIngeborg GoethalsChristian VanhoveBenedicte Descamps et al.

A1 Journal Article in PLOS ONE

Synthesis of C-ring-modified blebbistatin derivatives and evaluation of their myosin II ATPase inhibitory potency

Bart RomanSigrid VerhasseltChristophe MangodtOlivier De WeverChristian Stevens

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer

Alfiah NoorIjeoma Adaku UmeloPeter KronenbergerPhilipe GironElly De VlieghereOlivier De WeverErik TeugelsJacques De Grève

A2 Journal Article in ONCOTARGET

The extracellular RNA quality control (exRNAQC) study : controlling pre-analytical variables of RNA sequencing in blood-based precision medicine

Francisco Avila CobosAnneleen DecockKatleen De PreterBert DhondtOlivier De WeverBram De WildeCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

The extracellular RNA quality control (exRNAQC) study : controlling pre-analytical variables of RNA sequencing in blood-based precision medicine

Francisco Avila CobosAnneleen DecockKatleen De PreterOlivier De WeverBram De WildeBert DhondtCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

The small GTPase Rab27B stimulates secretion of a subpopulation of ARRDC1-positive small extracellular vesicles (SEV)

Lien LippensRobin BoiyBert DhondtBruno De GeestKatrien VandecasteeleHannelore DenysOlivier De WeverAn Hendrix

Transparent reporting of experimental parameters in assays measuring phenotypic steps in metastasis

Robin BoiyJonas SteenbruggeJan Van DeunAn HendrixEvelyne MeyerOlivier De Wever

A1 Journal Article in CLINICAL & EXPERIMENTAL METASTASIS

Tumor immune profiling and host NF-kappaB activity assessment in a novel Py230-based intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereNiek SandersOlivier De WeverSteven Van LaereEvelyne Meyer

Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation

Julie JacobsVanessa DeschoolmeesterKaren ZwaenepoelTal FlieswasserChristophe DebenJolien Van den BosscheChristophe HermansChristian RolfoMarc PeetersOlivier De Wever et al.

A1 Journal Article in ONCOIMMUNOLOGY

Urinary extracellular vesicle biomarkers in urological cancers : from discovery towards clinical implementation

Bert DhondtJan Van DeunSilke VermaerkeArio de MarcoNicolaas LumenOlivier De WeverAn Hendrix

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

2017

A JAK3/STAT3 passenger activation in a lapatinib-acquired resistance model of HER2-amplified breast cancer

Mieke Van BockstalNadine Van RoyGlenn VergauwenKathleen LambeinVeronique CocquytLouis LibbrechtHannelore DenysMarc BrackeOlivier De Wever

ADAM-17/FHL2 colocalisation suggests interaction and role of these proteins in colorectal cancer

Laurine VersetJoke TommeleinChristine DecaesteckerElly De VlieghereMarc BrackeIsabelle SalmonOlivier De WeverPieter Demetter

A1 Journal Article in TUMOR BIOLOGY

Cancer cell lysate entrapment in CaCO3 engineered with polymeric TLR-agonists : immune-modulating microparticles in view of personalized antitumor vaccination

Lien LybaertKeun Ah RyuLutz NuhnRiet De RyckeOlivier De WeverAlfred C ChonAaron P Esser-KahnBruno De Geest

A1 Journal Article in CHEMISTRY OF MATERIALS

Circulating extracellular vesicles in cancer : a strategy to unlock hidden secrets

Glenn VergauwenRudy Van den BroeckeOlivier De WeverAn Hendrix

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling

Serena StadlerChi Huu NguyenHelga SchachnerDaniela MilovanovicSilvio HolznerStefan BrennerJulia EichsteiningerMira StadlerDaniel SenfterLiselotte Krenn et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Confounding factors in extracellular vesicle ultrafiltration and protein analysis

Glenn VergauwenBert DhondtJan Van DeunEvy TimmermanKris GevaertGeert BraemsRudy Van den BroeckeVeronique CocquytHannelore DenysOlivier De Wever et al.

Confounding factors of ultrafiltration and protein analysis in extracellular vesicle research

Glenn VergauwenBert DhondtJan Van DeunEva De SmedtGeert BerxEvy TimmermanKris GevaertIlkka MiinalainenVeronique CocquytGeert Braems et al.

A1 Journal Article in SCIENTIFIC REPORTS

Developments and future clinical outlook of taxane nanomedicines

Benoit LouageOlivier De WeverWim E HenninkBruno De Geest

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties

Sigrid VerhasseltBart RomanOlivier De WeverKristof Van HeckeRik Van DeunMarc BrackeChristian Stevens

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

EV-TRACK : transparent reporting and centralizing knowledge in extracellular vesicle research

Jan Van DeunPieter MestdaghPatrizia AgostinisÖzden AkaySushma AnandJasper AnckaertZoraida Andreu MartinezTine BaetensEls BegheinLaurence Bertier et al.

A1 Journal Article in NATURE METHODS

Exosomal microRNAs derived from colorectal cancer-associated fibroblasts : role in driving cancer progression

Rahul BhomeRebecca W GohMarc D BullockNir PillarStephen M ThirdboroughMassimiliano MelloneReza MirnezamiDieter GaleaKirill VeselkovQuan Gu et al.

A1 Journal Article in AGING-US

Heterocellular 3D scaffolds as biomimetic of peritoneal metastases

Elly De VlieghereEmiel De JaeghereJasper Van HoorickGlenn WagemansLeen PietersElodie MelsensSara NeytBruno De GeestPeter DubruelWim Ceelen et al.

Heterocellular 3D scaffolds as biomimetic of peritoneal metastasis in vitro and in vivo

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Elodie MelsensElly De VlieghereBenedicte DescampsChristian VanhoveOlivier De WeverWim CeelenPiet Pattyn

A1 Journal Article in ONCOLOGY REPORTS

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Emiel De JaeghereElly De VlieghereSara NeytBert VandeghinsteJasper Van HoorickGlenn WagemansLeen PietersElodie MelsensGeert BerxSandra Van Vlierberghe et al.

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Margo SteuperaertGiuseppe Falvo D'Urso LabateCharlotte DebbautOlivier De WeverChristian VanhoveWim CeelenPatrick Segers

A1 Journal Article in DRUG DELIVERY

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Frank AW CoumansAlain R BrissonEdit I BuzasFrançoise Dignat-GeorgeEsther EE DreesSamir El-AndaloussiCostanza EmanueliAleksandra GaseckaAn HendrixAndrew F Hill et al.

A1 Journal Article in CIRCULATION RESEARCH

mRNA capture sequencing enabled liquid biopsy screening

Anneleen DecockOlivier De WeverBert DhondtCarolina FierroAn HendrixHetty HelsmoortelScott KuerstenPieter MestdaghNele NijsPiet Ost et al.

Multimodal imaging in an experimental rat model for brain metastasis

Valerie De MeulenaereChristian VanhoveSara NeytBert VandeghinsteElke DecrockOlivier De WeverBenedicte DescampsKarel Deblaere

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Lien LybaertKeun Ah RyuRiet De RyckeAlfred C ChonOlivier De WeverKarim VermaelenAaron Esser-KahnBruno De Geest

A1 Journal Article in ADVANCED SCIENCE

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Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxTom ClaeysFilip PoelaertSarah BuelensNicolaas LumenAn HendrixOlivier De Wever

Purification of urinary extracellular vesicles for uro-oncological biomarker studies using an iodixanol (Optiprep™) density gradient

Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxTom ClaeysFilip PoelaertSarah BuelensAn HendrixOlivier De WeverNicolaas Lumen

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Lore LapeireAn HendrixEvelyne LecoutereMieke Van BockstalJo VandesompeleDawn MaynardGeert BraemsRudy Van den BroeckeCathérine MüllerMarc Bracke et al.

A1 Journal Article in ONCOTARGET

Stromal reaction and paracrine consequences of radiotherapy in colorectal cancer

Joke TommeleinOlivier De WeverMarc Bracke

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

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Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The extracellular RNA quality control (exRNAQC) study : testing and controlling pre-analytical variables of RNA sequencing on liquid biopsies

Anneleen DecockOlivier De WeverBert DhondtThibaut D'huyvetterHetty HelsmoortelAn HendrixAnnouck PhilippronKimberly VerniersPieter MestdaghJo Vandesompele

The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome

Lotte PyfferoenElisabeth BrabantsCeline EveraertNancy De CabooterKelly HeynsKim DeswarteManon VanheerswynghelsSofie De PrijckGlenn WaegemansMelissa Dullaers et al.

A1 Journal Article in ONCOIMMUNOLOGY

Tumour tissue transport after intraperitoneal anticancer drug delivery

Charlotte CarlierAda MathysEmiel De JaeghereMargo SteuperaertOlivier De WeverWim Ceelen

A1 Journal Article in INTERNATIONAL JOURNAL OF HYPERTHERMIA

When neighbors talk : colon cancer cell invasion and tumor microenvironment myofibroblasts

Jolien BridelanceZuzanna DrebertOlivier De WeverMarc BrackeIlse Beck

A1 Journal Article in CURRENT DRUG TARGETS

2016

Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts

Joke TommeleinFélix GremonprezLaurine VersetElly De VlieghereGlenn WagemansChristian GespachTom BoterbergPieter DemetterWim CeelenMarc Bracke et al.

A1 Journal Article in ONCOTARGET

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Brandon LeonardGabriel J StarrettMatthew J MaurerAnn L ObergMieke Van BockstalJo Van DorpeOlivier De WeverJozien HellemanAnieta M SieuwertsEls MJJ Berns et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Chitinase 3-like 1 as breast cancer metastasis biomarker for differential tumor progression in the intraductal versus the fat pad preclinical model

Jonas SteenbruggeKoen BreyneSofie DeniesMelissa DekimpeKristel DemeyereOlivier De WeverNiek SandersEvelyne Meyer

Comparison of the adipose and luminal mammary gland compartment as orthotopic inoculation sites in a 4T1-based immunocompetent preclinical model for triple-negative breast cancer

Jonas SteenbruggeKoen BreyneSofie DeniesMelissa DekimpeKristel DemeyereOlivier De WeverPeter VermeulenSteven Van LaereNiek SandersEvelyne Meyer

A1 Journal Article in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Dissemination and adhesion of peritoneal cancer cells to the peritoneal wall

Elly De VlieghereMarc BrackeLaurine VersetPieter DemetterOlivier De Wever

Bookchapter in Intraperitoneal cancer therapy : principles and practice

ETV5 functionally connect ALK and CXCR4 signaling in neuroblastoma

Irina LambertzShana ClaeysCandy KumpsLiselot MusEls JanssensNadine Van RoyBram De WildeGenevieve LaureysJan CoolsOlivier De Wever et al.

ETV5 functionally connects ALK and CXCR4 signaling in neuroblastoma

Irina LambertzLiselot MusCandy KumpsShana ClaeysNadine Van RoyBram De WildeGenevieve LaureysJohannes ShulteOlivier De WeverKatleen De Preter et al.

EV-TRAQ: tracking transparent reporting and quality to boost standardized extracellular vesicle research

Jan Van DeunPieter MestdaghJasper AnckaertJo VandesompeleOlivier De WeverAn Hendrix

FHL2 : a scaffold protein of carcinogenesis, tumour-stroma interactions and treatment response

Laurine VersetLynn FeysAnne-Laure TrepantOlivier De WeverPieter Demetter

A1 Journal Article in HISTOLOGY AND HISTOPATHOLOGY

Function of extracellular vesicle-associated miRNAs in metastasis

Bert DhondtQuentin RousseauOlivier De WeverAn Hendrix

A1 Journal Article in CELL AND TISSUE RESEARCH

Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions : in vitro and in vivo characterization

Kaat De ClercqCharlotte SchelfhoutMarc BrackeOlivier De WeverMieke Van BockstalWim CeelenJean Paul RemonChris Vervaet

A1 Journal Article in BIOMATERIALS

Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity

María Díaz-NúñezAlejandro Díez-TorreOlivier De WeverRicardo AndradeJon ArluzeaMargarita SilióJuan Aréchaga

A1 Journal Article in BMC CANCER

Isolation of extracellular vesicles from urine samples

Bert DhondtNicolaas LumenAn HendrixOlivier De Wever

Isolation of urinary extracellular vesicles for uro-oncological biomarker studies is complicated by Tamm-Horsfall protein

Bert DhondtDelphine DavelooseGlenn VergauwenJan Van DeunEdward GeeurickxTom ClaeysFilip PoelaertAn HendrixOlivier De WeverNicolaas Lumen

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Jan Van DeunPieter MestdaghJo VandesompeleOlivier De WeverAn Hendrix

Nanoscopic tumor tissue distribution of platinum after intraperitoneal administration in a xenograft model of ovarian cancer

Charlotte CarlierBrecht LaforceStijn Van MalderenFélix GremonprezRemi TucoulouJulie VillanovaOlivier De WeverFrank VanhaeckeWim CeelenLaszlo Vincze

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

NewTumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells

Elly De VlieghereMarc BrackePieter DemetterWim CeelenChristian VanhoveBruno De GeestOlivier De Wever

NFAT5 in Duchenne muscular dystrophy cultured myoblasts after exposure to hyperosmolar salt conditions

Sandrine HerbeletAmanda GonçalvesElly De VlieghereGert Van PeerBoel De PaepeChris GuerinJo VandesompeleOlivier De WeverJan De Bleecker

NFAT5 in inflammatory myopathies and Duchenne muscular dystrophy

Sandrine HerbeletAmanda GonçalvesElly De VlieghereBoel De PaepeChris GuerinOlivier De WeverJan De Bleecker

Quantitative and functional requirements for bioluminescent cancer models

Lynn FeysBenedicte DescampsChristian VanhoveStefan VermeulenJo VandesompeleKatrien VanderheydenKathy Messensmarc brackeOlivier De Wever

A1 Journal Article in IN VIVO

Quantitative evaluation of single cell spread on collagen matrices

Elly De VlieghereGlenn WagemansS De BackerZuzanna DrebertJoke TommeleinQuentin RousseauB WeynMarleen Van TroysMarc BrackeOlivier De Wever

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

Radiation-induced collateral damage : impact on metastasis

Lynn FeysOlivier De WeverMarc Bracke

Radiation-induced collateral damage : impact on metastasis

Lynn FeysMarc BrackeOlivier De Wever

Recent exposure to ultrafine particles in school children alters miR-222 expression in the extracellular fraction of saliva

Annette VriensTim S NawrotNelly D SaenenEline B ProvostMichal KicinskiWouter LefebvreCharlotte VanpouckeJan Van DeunOlivier De WeverKaren Vrijens et al.

A1 Journal Article in ENVIRONMENTAL HEALTH

Sensing mutant ALK: Capicua and ETV5 as executors of aberrant ALK-driven MAPK signaling

Irina LambertzLiselot MusCandy KumpsShana ClaeysWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van RoyBram De Wilde et al.

SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis

Elham Al KubaisyKholoud ArafatOlivier De WeverAhmed H HassanSamir Attoub

A1 Journal Article in EXPERT OPINION ON THERAPEUTIC TARGETS

The core protein to myogenesis NFAT5 forms aggresomes in normal and Duchenne muscular dystrophy myotubes exposed to cell stressors

Sandrine HerbeletElly De VlieghereAmanda GonçalvesBoel De PaepeChris GuerinOlivier De WeverJan De Bleecker

The core protein to myogenesis NFAT5 forms aggresomes in normal and Duchenne muscular dystrophy myotubes exposed to cell stressors

Sandrine HerbeletElly De VlieghereGert Van PeerBoel De PaepeEline NysLaurens WeynantsJo VandesompeleOlivier De WeverJens SchmidtJan De Bleecker

The effects of quorum sensing peptides on colon cancer cells: implications for the role of the gut microbiome

Yorick JanssensEvelien WynendaeleFrederick VerbekeAn HendrixOlivier De WeverMarc BrackeBart De Spiegeleer

Transiently responsive block copolymer micelles based on N-(2-hydroxypropyl)methacrylamide engineered with hydrolyzable ethylcarbonate side chains

Sabah KasmiBenoit LouageLutz NuhnAlexandra Van DriesscheJan Van DeunIzet KaralicMartijn RisseeuwSerge Van CalenberghRichard HoogenboomRiet De Rycke et al.

A1 Journal Article in BIOMACROMOLECULES

2015

Addition of NaCl upregulates NFAT5 expression in Duchenne muscular dystrophy cultured myotubes

Laurens WeynantsEline NysSandrine HerbeletBoel De PaepeElly De VlieghereLiselot MusLynn FeysOlivier De WeverJan De Bleecker

An open data ecosystem for cell migration research

Paola MasuzzoLennart Martensthe 2014 Cell Migration workshop participantsChristophe AmpeOlivier De WeverMarleen Van Troys

Editorial material

Biological properties of extracellular vesicles and their physiological functions

María Yáñez-MóPia R-M SiljanderZoraida AndreuApolonija Bedina ZavecFrancesc E BorràsEdit I BuzasKrisztina BuzasEnriqueta CasalFrancesco CappelloJoana Carvalho et al.

A2 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics

Elly De VlieghereLaurine VersetPieter DemetterMarc BrackeOlivier De Wever

A1 Journal Article in VIRCHOWS ARCHIV

Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer

Joke TommeleinLaurine VersetTom BoterbergPieter DemetterMarc BrackeOlivier De Wever

A1 Journal Article in FRONTIERS IN ONCOLOGY

Chick heart invasion assay for testing the invasiveness of cancer cells and the activity of potentially anti-invasive compounds

Marc BrackeBart RomanChristian StevensLiselot MusVirinder ParmarOlivier De WeverMarcus Mareel

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Combined inhibition of rho-associated protein kinase and EGFR suppresses the invasive phenotype in EGFR-dependent lung cancer cells

Ijeoma Adaku UmeloOlivier De WeverPeter KronenbergerAlfiah NoorErik TeugelsGang ChenMarc BrackeJacques De Grève

A1 Journal Article in LUNG CANCER

Combined targeting of EGFR/HER promotes anti-tumor efficacy in subsets of KRAS mutant lung cancer resistant to single EGFR blockade

Ijeoma Adaku UmeloOlivier De WeverPeter KronenbergerJan Van DeunAlfiah NoorKshitiz SinghErik TeugelsGang ChenMarc BrackeJacques De Grève

A1 Journal Article in ONCOTARGET

Communication of quorum sensing peptides with breast cancer cells

Frederick VerbekeEvelien WynendaeleMarianne LauwersAn HendrixChristian Paul G. BurvenichOlivier De Wevermarc brackeBart De Spiegeleer

Crosstalk between the microbiome and cancer cells by quorum sensing peptides

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

A1 Journal Article in PEPTIDES

Data on in vivo selection of SK-OV-3 Luc ovarian cancer cells and intraperitoneal tumor formation with low inoculation numbers

Elly De VlieghereCharlotte CarlierWim CeelenMarc BrackeOlivier De Wever

A2 Journal Article in DATA IN BRIEF

Effect of Cx-mimetic peptide administration on breast cancer brain metastasis development: a preclinical serial MRI study

Valerie De MeulenaereElke DecrockSara NeytOlivier De WeverFilip De VosChristian VanhoveHannelore DenysBenedicte DescampsKarel Deblaere

Effect of GAP27 on breast cancer brain metastasis development: initial results

Valerie De MeulenaereElke DecrockSara NeytOlivier De WeverFilip De VosChristian VanhoveHannelore DenysBenedicte DescampsKarel Deblaere

ETV5 functionally connect ALK and RET signaling in neuroblastoma

Irina LambertzShana ClaeysCandy KumpsLiselot MusAnneleen BeckersEls JanssensNadine Van RoyGenevieve LaureysJohannes SchulteOlivier De Wever et al.

Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations

MM KoczorowskaS TholenF BucherL LutzJN KizhakkedathuOlivier De WeverUF WellnerML BiniossekA StahlS Lassmann et al.

A1 Journal Article in MOLECULAR ONCOLOGY

Fibroblast-induced matrix remodeling paves the path for invasion

Mieke Van BockstalLouis LibbrechtOlivier De Wever

A1 Journal Article in CELL CYCLE

Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer

Ijeoma UmeloAmir NoeparestGang ChenMarleen RenardCaroline GeersJohan Van SteenkistePhilippe GironOlivier De WeverErik TeugelsJacques De Grève

A1 Journal Article in ONCOTARGET

Impact of neoadjuvant therapy on cancer-associated fibroblasts in rectal cancer

Laurine VersetJoke TommeleinXavier Moles LopezChristine DecaesteckerTom BoterbergElly De VlieghereIsabelle SalmonMarcus MareelMarc BrackeOlivier De Wever et al.

A1 Journal Article in RADIOTHERAPY AND ONCOLOGY

Inflammatory- and NaCl-induced expression of NFAT5 in muscle cells point to common stress response mechanisms

Sandrine HerbeletKarsten SchmidtJana ZschüntzschEline NysLaurens WeynantsBoel De PaepeOlivier De WeverJan De BleeckerJens Schmidt

Is intraductal inoculation of tumour cells a more relevant in vivo model for immune-competent breast cancer metastasis than the classical fat pad model?

Koen BreyneSofie DeniesJonas SteenbruggeMelissa DekimpeKristel DemeyereOlivier De WeverNiek SandersEvelyne Meyer

Modulation of exosome release by cancer cells: a screening of potential inhibitors

Gertjan RasschaertAn HendrixOlivier De Wever

Multi-modality imaging in a pre-clinical model of developing rat brain metastases: initial results

Valerie De MeulenaereBenedicte DescampsSara NeytElke DecrockOlivier De WeverFilip De VosChristian VanhoveKarel Deblaere

Multi-modality imaging in a pre-clinical model of developing rat brain metastases: initial results

Valerie De MeulenaereBenedicte DescampsSara NeytOlivier De WeverElke DecrockFilip De VosChristian VanhoveKarel Deblaere

Multi-modality imaging in a pre-clinical model of developing rat brain metastases: initial results

Valerie De MeulenaereBenedicte DescampsSara NeytOlivier De WeverElke DecrockFilip De VosChristian VanhoveKarel Deblaere

NFAT5 forms aggregates in normal and Duchenne muscular dystrophy cultured myotubes after exposure to cell stressors

Sandrine HerbeletIlse BeckZuzanna DrebertOlivier De WeverJan De Bleecker

Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumor growth in a mouse colorectal carcinomatosis model

Félix GremonprezBenedicte DescampsAndrei IzmerChristian VanhoveFrank VanhaeckeOlivier De WeverWim Ceelen

A1 Journal Article in ONCOTARGET

Pro-inflammatory cell stress in muscle cells is directed by NFAT5

Sandrine HerbeletJens SchmidtOlivier De WeverEline NysLaurens WeynantsDorien ClarisseGlenn VergauwenBoel De PaepeJan De Bleecker

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling

Lynn FeysBenedicte DescampsChristian VanhoveAnne VralLiv VeldemanStefan VermeulenCarlos De WagterMarc BrackeOlivier De Wever

A1 Journal Article in ONCOTARGET

Stromal protein expression in breast cancer is differentially regulated by TGF-β1

Mieke Van BockstalKathleen LambeinMireille Van GeleElly De VlieghereRidha LimameGeert Braemsmarc brackeHannelore DenysLouis LibbrechtOlivier De Wever

The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro

Bart De SpiegeleerFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeEvelien Wynendaele

A1 Journal Article in PLOS ONE

The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia

Julia D KnopfStefan TholenMaria M KoczorowskaOlivier De WeverMartin L BiniossekOliver Schilling

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells

Elly De VlieghereFélix GremonprezLaurine VersetLore MariënChristopher JonesBram De CraeneGeert BerxBenedicte DescampsChristian VanhoveJean Paul Remon et al.

A1 Journal Article in BIOMATERIALS

When fat becomes an ally of the enemy : adipose tissue as collaborator in human breast cancer

Lore LapeireHannelore DenysVeronique CocquytOlivier De Wever

A2 Journal Article in HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION

When the fat (lady) starts to sing : the role of adipose tissue secreted factors in breast cancer progression

Lore LapeireVeronique CocquytOlivier De Wever

2014

Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice

Sandra DupouyVan Kien DoanZherui WuNajat MourraJin LiuOlivier De WeverFrédérique Penault LlorcaAnne CayreAmal KouchkarAnne Gompel et al.

A1 Journal Article in ONCOTARGET

Bio-hybrid tumor cell-templated capsules: a generic formulation strategy for tumor associated antigens in view of immune therapy

Lien LybaertElly De VlieghereRiet De RyckeNane VanparijsOlivier De WeverStefaan De KokerBruno De Geest

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells

Jinheng WangAn HendrixSophie HernotMiguel LemaireElke De BruyneEls Van ValckenborghTony LahoutteOlivier De WeverKarin VanderkerkenEline Menu

A1 Journal Article in BLOOD

Cancer-associated adipose tissue promotes breast cancer progression by paracrine Oncostatin M and Jak/STAT3 signaling

Lore LapeireAn HendrixKathleen LambeinMieke Van BockstalGeert BraemsRudy Van den BroeckeRIDHA LIMAMEPieter MestdaghJo VandesompeleChristian Vanhove et al.

A1 Journal Article in CANCER RESEARCH

Cancer-associated adipose tissue promotes breast cancer progression by paracrine Oncostatin M and JAK3/STAT3 signaling

Lore LapeireAn HendrixKathleen LambeinMieke Van BockstalGeert BraemsRudy Van den BroeckeRidha LimamePieter MestdaghJo VandesompeleChristian Vanhove et al.

Carcinoma-associated fibroblasts provide operational flexibility in metastasis

Olivier De WeverMieke Van BockstalMarcus MareelAn HendrixMarc Bracke

A1 Journal Article in SEMINARS IN CANCER BIOLOGY

Crosstalk between mammalian cells and the microbiome through quorum sensing peptides, influencing cancer metastasis

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

Differential regulation of extracellular matrix protein expression in carcinoma-associated fibroblasts by TGF-β1 regulates cancer cell spreading but not adhesion

Mieke Van BockstalKathleen LambeinMireille Van GeleElly De VlieghereRIDHA LIMAMEGeert BraemsRudy Van den BroeckeVeronique CocquytHannelore Denysmarc bracke et al.

A2 Journal Article in ONCOSCIENCE

Expression profiling of migrated and invaded breast cancer cells predicts early metastatic relapse and reveals Krüppel-like factor 9 as a potential suppressor of invasive growth in breast cancer

RIDHA LIMAMEKen Op de BeeckSteven Van LaereLieselot CroesAnnemieke De WildeLuc DirixGuy Van CampMarc PeetersOlivier De WeverFilip Lardon et al.

A2 Journal Article in ONCOSCIENCE

Histopathological characterization of ductal carcinoma in situ (DCIS) of the breast according to HER2 amplification status and molecular subtype

Mieke Van BockstalKathleen LambeinHannelore DenysGeert BraemsANN NUYTSRudy Van den BroeckeVeronique CocquytOlivier De WeverLouis Libbrecht

A1 Journal Article in VIRCHOWS ARCHIV

How does the human microbiome affect cancer outcome?

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma

A BouchekiouaL ScourzicOlivier De WeverY ZhangP CerveraA Aline-FardinT MercherP GaulardR NygaD Jeziorowska et al.

A1 Journal Article in LEUKEMIA

Krüppel-like factors in cancer progression: three fingers on the steering wheel

RIDHA LIMAMEKen Op de BeeckFilip LardonOlivier De WeverPatrick Pauwels

A1 Journal Article in ONCOTARGET

Mesenchymal stem cell secreted platelet derived growth factor exerts a pro-migratory effect on resident Cardiac Atrial appendage Stem Cells

Severina WindmoldersAstrid De BoeckRemco KoninckxAnnick DaniëlsOlivier De WeverMarc BrackeMarc HendrikxKaren HensenJean-Luc Rummens

A1 Journal Article in JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Micro-particle encapsulated carcinoma-associated fibroblast (CAF) deceive and redirect disseminated cancer cells

Elly De VlieghereLaurine VersetChristian VanhoveLore MariënJean Paul RemonPieter DemetterMarc BrackeBruno De GeestOlivier De Wever

Modifications of cell signalling and redox balance by targeting protein acetylation using natural and engineered molecules: implications in cancer therapy

Kavya VenkateswaranAmit VermaAnant N BhattPaban K AgrawalaHanumantharao G RajShashwat MalhotraAshok K PrasadOlivier De WeverMarc BrackeLuciano Saso et al.

A1 Journal Article in CURRENT TOPICS IN MEDICINAL CHEMISTRY

Molecular MRI in preclinical research

Benedicte DescampsSara NeytFilip De VosValerie De MeulenaereElke DecrockJulie BolcaenIngeborg GoethalsOlivier De WeverTom BoterbergKarel Deblaere et al.

Molecular MRI in preclinical research

Benedicte DescampsSara NeytFilip De VosValerie De MeulenaereElke DecrockJulie BolcaenIngeborg GoethalsOlivier De WeverTom BoterbergKarel Deblaere et al.

Quorum sensing peptides: missing link between microbiome and health?

Evelien WynendaeleFrederick VerbekeMatthias D'HondtAn HendrixChristophe Van De WieleChristian Paul G. BurvenichKathelijne PeremansOlivier De Wevermarc brackeBart De Spiegeleer

Screening of inhibitors for modulation of exosome release by cancer cells

Gertjan RasschaertAn HendrixOlivier De Wever

Single cell and spheroid collagen type I invasion assay

Olivier De WeverAn HendrixAstrid De BoeckFrank EertmansWendy WestbroekGeert BraemsMarc Bracke

Bookchapter in Metastasis research protocols

Six-weeks follow-up of developing metastases in the rat brain: preliminary results of a multi-modal imaging approach

Valerie De MeulenaereBenedicte DescampsSara NeytOlivier De WeverFilip De VosChristian VanhoveKarel Deblaere

Stromal characteristics are potential prognostic markers for ipsilateral locoregional recurrence in ductal carcinoma in situ (DCIS)

Mieke Van BockstalKathleen LambeinOlivier De WeverMarleen PraetVeronique CocquytRudy Van den BroeckeGeert BraemsHannelore DenysLouis Libbrecht

The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling

Jan Van DeunPieter MestdaghRaija SormunenLotte PyfferoenKarim VermaelenVeronique CocquytJo VandesompeleMarc BrackeOlivier De WeverAn Hendrix

The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling

Jan Van DeunPieter MestdaghRaija SormunenVeronique CocquytKarim VermaelenJo VandesompeleMarc BrackeOlivier De WeverAn Hendrix

A2 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

2013

A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis

Katrien Van ImpeJonas BethuyneSteven CoolFrancis ImpensDavid Ruano-GallegoOlivier De WeverBerlinda VanlooMarleen Van TroysKathleen LambeinCiska Boucherie et al.

A1 Journal Article in BREAST CANCER RESEARCH

Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling

Astrid De BoeckPatrick PauwelsKaren HensenJean-Luc RummensWendy WestbroekAn HendrixDawn MaynardHannelore DenysKathleen LambeinGeert Braems et al.

A1 Journal Article in GUT

CAF-encapsulated mico-particels capture free cancer cells from the peritoneal fluid

Elly De VlieghereLaurine VersetChristian VanhoveLore MariënJean Paul RemonPieter DemetterMarc BrackeBruno De GeestOlivier De Wever

Development of a new highly specific targeting probe for non-invasive in vivo visualization of Ncadherin expression in prostate cancer

Christian VanhoveCaroline DumolynPiet OstOlivier De WeverFilip De Vos

Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression

Astrid De BoeckAn HendrixDawn MaynardMieke Van BockstalAnnick DaniëlsPatrick PauwelsChristian GespachMarc BrackeOlivier De Wever

A1 Journal Article in PROTEOMICS

Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer

L VersetJoke TommeleinX Moles LopezCarolien DecaesteckerMarcus MareelMarc BrackeIlse SalmonOlivier De WeverP Demetter

A1 Journal Article in BRITISH JOURNAL OF CANCER

miR-145 overexpression suppresses the migration and invasion of metastatic melanoma cells

Peter DynoodtReinhart SpeeckaertOlivier De WeverINES CHEVOLETLieve BrochezJo LambertMireille Van Gele

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

Protein secretome analysis of evolving and responding tumor ecosystems

Olivier De WeverAstrid De BoeckDawn MaynardMarc BrackeAn Hendrix

A1 Journal Article in CURRENT PROTEOMICS

Rab27 GTPases distribute extracellular nanomaps for invasive growth and metastasis: implications for prognosis and treatment

An HendrixOlivier De Wever

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rab27B-mediated metabolic reprogramming induces secretome acidification and chemoresistance in breast cancer cells

An HendrixCarla CicconeChristian GespachMarc BrackeOlivier De WeverWendy Westbroek

A2 Journal Article in EXOSOMES AND MICROVESICLES

Radiation-induced myosin IIA expression stimulates collagen type I matrix reorganization

Stéphanie BlockhuysBart Van RompayeRiet De RyckeKathleen LambeinKathleen ClaesMarc BrackeCarlos De WagterOlivier De Wever

A1 Journal Article in RADIOTHERAPY AND ONCOLOGY

Stromal architecture and periductal decorin are potential prognostic markers for ipsilateral locoregional recurrence in ductal carcinoma in situ of the breast

Mieke Van BockstalKathleen LambeinOlivier GevaertOlivier De WeverMarleen PraetVeronique CocquytRudy Van den BroeckeGeert BraemsHannelore DenysLouis Libbrecht

A1 Journal Article in HISTOPATHOLOGY

Targeted liposome-loaded microbubbles for cell-specific ultrasound-triggered drug delivery

Bart GeersOlivier De WeverJo DemeesterMarc BrackeStefaan De SmedtIne Lentacker

A1 Journal Article in SMALL

Tenascin-C downregulates Wnt inhibitor Dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model

Falk SaupeAnja SchwenzerYundan JiaIsabelle GasserCaroline SpenléBenoit LangloisMartial KammererOlivier LefebvreRuslan HlushchukTristan Rupp et al.

A1 Journal Article in CELL REPORTS

The in ovo CAM-assay as a xenograft model for sarcoma

Gwen SysLore LapeireNikita StevensHerman FavoreelRamses ForsythMarc BrackeOlivier De Wever

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Tunable self-assembled nanogels composed of well-defined thermoresponsive hyaluronic acid-polymer conjugates

Jing JingDavid AlaimoElly De VlieghereChristine JérômeOlivier De WeverBruno De GeestRachel Auzély-Velty

A1 Journal Article in JOURNAL OF MATERIALS CHEMISTRY B

Vacuolar H+ ATPase expression and activity is required for Rab27B dependent invasive growth and metastasis of breast cancer

An HendrixRaija SormunenWendy WestbroekKathleen LambeinHannelore DenysGwen SysGeert BraemsRudy Van den BroeckeVeronique CocquytChristian Gespach et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

2012

An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue

An HendrixKathleen LambeinWendy WestbroeckMiguel C SeabraVeronique CocquytPatrick PauwelsMarc BrackeChristian GespachOlivier De Wever

A1 Journal Article in INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Bone marrow-derived mesenchymal stem cells in colorectal cancer: NRG at the invasion front

Astrid De BoeckMarc BrackeOlivier De Wever

Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time technology and classic endpoint assays

Ridha LimameAn WoutersBea PauwelsErik FransenMarc PeetersFilip LardonOlivier De WeverPatrick Pauwels

A1 Journal Article in PLOS ONE

Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1

Liesbeth De CockOlivier De WeverSandra Van VlierbergheEls VanderleydenPeter DubruelFilip De VosChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in SOFT MATTER

Engineered 3D microporous gelatin scaffolds to study cell migration

Liesbeth De CockOlivier De WeverHamida HammadBart LambrechtEls VanderleydenPeter DubruelFilip De VosChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in CHEMICAL COMMUNICATIONS

Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchyinal transition

Radia Ouelaa-BenslamaOlivier De WeverAn HendrixMichèle SabbahKathleen LambeinDavid LandGrégoire PrévostMarc BrackeMien-Chie HungAnnette K Larsen et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

Multi-targeting the ERBB receptors may overcome EGFR-T790M-mediated resistance to tyrosine kinase inhibitors

IA UmeloOlivier De WeverE TeugelsG Chenmarc brackeJ de Greve

Rab27B, an ex(o)citing driver of breast cancer growth, invasion and metastasis

An HendrixWendy WestbroekMarc BrackeOlivier De Wever

Recent developments in myofibroblast biology paradigms for connective tissue remodeling

Boris HinzSem H PhanVictor J ThannickalMarco PrunottoAlexis DesmouliereJohn VargaOlivier De WeverMarcus MareelGiulio Gabbian

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Tumor grafts derived from sarcoma patients retain tumor morphology, viability, and invasion potential and indicate disease outcomes in the chick chorioallantoic membrane model

Gwen SysMieke Van BockstalRamses ForsythMaurice BalkeBart PoffynDirk UyttendaeleMarc BrackeOlivier De Wever

A1 Journal Article in CANCER LETTERS

2011

Adipose tissue in breast cancer : not an idle bystander but an active participant in breast cancer progression

Lore LapeireAn HendrixKathleen LambeinGeert BraemsP ValetRudy Van den BroeckeMarc BrackeVeronique CocquytHannelore DenysOlivier De Wever

CCN5, a novel transcriptional repressor of the transforming growth factor beta signaling pathway

Michèle SabbahCéline PrunierNathalie FerrandVirginie MegalophonosKathleen LambeinOlivier De WeverNicolas NazaretJoël LachuerSylvie DumontGérard Redeuilh

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

Developmental and cancer research on the mammary gland nowadays: preface

Marc BrackeOlivier De Wever

Editorial material

Experimental procedures to assay invasion-associated activities of primary cultured fibroblasts

An HendrixKoen JacobsAstrid De BoeckWendy WestbroeckMarc BrackeOlivier De Wever

Bookchapter in Mouse as a model organism : from animal to cells

Invasie en metastasering

Marc BrackeOlivier De WeverLuc Vakaet

Bookchapter in Kanker biomedisch bekeken

Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts

Olivier De WeverJoëlle Sobczak-ThépotAnne-Sophie Vercoutter-EdouartJean-Claude MichalskiRadia Ouelaa-BenslamaDwayne G StupackMarc BrackeJean YJ Wangchristian GespachShahin Emami

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

Rab27B, een biomarker voor ER-positieve borsttumoren met slechte prognose?

An HendrixMarc BrackeOlivier De Wever

A2 Journal Article in ONCO (NEDERLANDSE ED.)

Rab27B, een biomarker voor ER-positieve borsttumoren met slechte prognose?

An HendrixMarc BrackeOlivier De Wever

A4 Journal Article in GUNAÏKEIA (NEDERLANDSE EDITIE)

Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis

Soraya SinFlorian BoninValérie PetitDidier MeseureFrançois LallemandIvan BiècheAkeila BellahcèneVincent CastronovoOlivier De WeverChristian Gespach et al.

A1 Journal Article in JOURNAL OF THE NATIONAL CANCER INSTITUTE

Signaling networks in cancer: an interview with Christian Gespach

Olivier De Wever

Editorial material

The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells

Lara DeryckeChristophe StoveAnne-Sophie Vercoutter-EdouartOlivier De WeverLaurent DolléNathalie ColpaertHerman DepypereJean-Claude MichalskiMarc Bracke

A1 Journal Article in INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The tumor ecosystem regulates the roads for invasion and metastasis

An HendrixChristian GespachMarc BrackeOlivier De Wever

A1 Journal Article in CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY

Use of tamoxifen before and during pregnancy

Geert BraemsHannelore DenysOlivier De WeverVeronique CocquytRudy Van den Broecke

A1 Journal Article in ONCOLOGIST

2010

An ex(o)citing machinery for invasive tumor growth

An HendrixWendy WestbroekMarc BrackeOlivier De Wever

A1 Journal Article in CANCER RESEARCH

Cellular and molecular mechanisms of cancer cell invasion

Olivier De WeverLore LapeireAstrid De BoeckAn Hendrix

A4 Journal Article in VERHANDELINGEN VAN DE KONINKLIJKE ACADEMIE VOOR GENEESKUNDE VAN BELGIË

Direct Effects of Delta Opioid Receptor Agonists on Invasion-associated Activities of HCT-8/E11 Colon Cancer Cells

Delphine DebruyneA LeroyOlivier De WeverLuc VakaetMarcus MareelMarc Bracke

A1 Journal Article in ANTICANCER RESEARCH

Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis

An HendrixDawn MaynardPatrick PauwelsGeert BraemsHannelore DenysRudy Van den BroeckeJo LambertSimon Van BelleVeronique CocquytChristian Gespach et al.

A1 Journal Article in JOURNAL OF THE NATIONAL CANCER INSTITUTE

Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells

Mathieu BoissanOlivier De WeverFloria LizarragaDominique WendumRenaud PoinclouxNicolas ChignardChristele Desbois-MouthonSylvie DufourBeatrice Nawrocki-RabyPhilippe Birembaut et al.

A1 Journal Article in CANCER RESEARCH

Modeling and quantification of cancer cell invasion through collagen type I matrices

Olivier De WeverAn HendrixAstrid De BoeckWendy WestbroekGeert BraemsShahin EmamiMichèle SabbahChristian GespachMarc Bracke

A1 Journal Article in INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

P-cadherin counteracts myosin II-B function : implications in melanoma progression

Koen JacobsMireille Van GeleRamses ForsythLieve BrochezBarbara VanhoeckeOlivier De WeverMarc Bracke

A1 Journal Article in MOLECULAR CANCER

Resident and bone marrow-derived mesenchymal stem cells in head and neck squamous cell carcinoma

Astrid De BoeckKishan NarineWilfried De NeveMarcus MareelMarc BrackeOlivier De Wever

A1 Journal Article in ORAL ONCOLOGY

The NF-κB inhibitor IκBα negates colon cancer cell migration, invasion, proliferation and tumor growth

Samir AttoubRabah IratniSuhail Al-SalamKhouloud ArafatMAH Al SultanNadia Al MarzouqiEric BruyneelMarc BrackeOlivier De WeverChristian Gespach

A2 Journal Article in JOURNAL OF MEDICAL SCIENCES (BENTHAM)

The role of myofibroblasts in communicating tumor ecosystems

Olivier De WeverAstrid De BoeckPieter DemetterMarcus MareelMarc Bracke

Bookchapter in Tumor-associated fibroblasts and their matrix

The secretory GTPase RAB27b drives poor prognosis in ER alpha-positive breast cancer

An HendrixHannelore DenysGeert BraemsPatrick PauwelsRudy Van den BroeckeVeronique CocquytWendy Westbroekmarc brackeOlivier De Wever

The secretory small GTPase Rab27B as a marker for breast cancer progression

An HendrixGeert BraemsMarc BrackeMiguel C SeabraWilliam A GahlOlivier De WeverWendy Westbroek

A1 Journal Article in ONCOTARGET

2009

Inhibition of Heterotrimeric G Protein Signaling by a Small Molecule Acting on G alpha Subunit

MA AyoubM DamianC GespachE FerrandisO LavergneOlivier De WeverJL BaneresJP PinGP Prevost

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment

Hannelore DenysGeert BraemsKathleen LambeinPatrick PauwelsAn HendrixAstrid De BoeckVeronique MathieuMarc BrackeOlivier De Wever

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

The myofibroblast, electron microscopy and cancer research: reply

Olivier De Wever

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

The secretory small GTPase Rab27B regulates invasive tumor growth and metastasis through extracellular heat shock protein 90 alpha

An HendrixD MaynardP PauwelsG BraemsHannelore DenysRudy Van den BroeckeSimon Van BelleVeronique Cocquytmarc brackeM Seabra et al.

2008

A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome

Wendy WestbroekM TUCHMANB TINLOYOlivier De WeverT VILBOUXJM HERTZH HASLEC HEILMANNA HELIP-WOOLEYR KLETA et al.

A1 Journal Article in MOLECULAR GENETICS AND METABOLISM

Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells

V GOUYERD FONTAINEPieter DumontOlivier De WeverH FONTAYNE-DEVAUDE LETEURTRES TRUANTD DELACOURH DROBECQJP KERCKAERT et al.

A1 Journal Article in ONCOGENE

Differential impact of TGF-β and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion

Hannelore DenysLara DeryckeAn HendrixWendy WestbroekAlexander GheldofKishan NarinePatrick PauwelsChristian GespachMarc BrackeOlivier De Wever

A1 Journal Article in CANCER LETTERS

Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front

Olivier De WeverPatrick PauwelsBram De CraeneM SABBAHS EMAMIG REDEUILHC GESPACHmarc brackeGeert Berx

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers

Michele SabbahShahin EmamiGerard RedeuilhSylvia JulienGregoire PrevostAmazia ZimberRadia OuelaaMarc BrackeOlivier De WeverChristian Gespach

A1 Journal Article in DRUG RESISTANCE UPDATES

Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73 alpha tumor suppressor

Jean-Pierre RoperchKarima El QuadraniAn HendrixShabin EmamiOlivier De WeverGerry MelinaChristian Gespach

A1 Journal Article in Cancer Research

Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells

A FRITAHC SAUCIEROlivier De Wevermarc brackeI BIECHER LIDEREAUC GESPACHS DROUOTG REDEUILHM SABBAH

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

Stromal myofibroblasts are drivers of invasive cancer growth

Olivier De WeverPieter DemetterMarcus MareelMarc Bracke

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

The Transforming Functions of PI3-kinase-gamma Are Linked to Disruption of Intercellular Adhesion and Promotion of Cancer Cell Invasion

Samir AttoubOlivier De WeverEric BruyneelMarcus MareelChristian Gespach

A1 Journal Article in ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

2007

Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha 1-integrins during colon cancer cell invasion

SABINE VAN SLAMBROUCKC GRIJELMOOlivier De WeverErik BruyneelS EMAMIC GESPACHWim Steelant

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

Akt1 & 2 depletion by RNA interference reduced tumor growth and invasion in human colon cancer cells

A GABONOlivier De WeverErik Bruyneelmarc brackeC GESPACHS ATTOUB

Cell motility and breast cancer metastasis.

Marc BrackeDaan De MaeseneerVeerle Van MarckLara DeryckeBarbara VanhoeckeOlivier De WeverHerman Depypere

Bookchapter in Metastasis of Breast Cancer.

Estrogen receptor alpha (ER alpha) and insulin-like growth factor I receptor (IGF-IR) cross-talk in the gonadotropic alpha T3-1 cell line

F EertmansWillem DhoogeOlivier De Wevermarc brackeFrank ComhaireJean Kaufman

A1 Journal Article in JOURNAL OF CELLULAR PHYSIOLOGY

Estrogen receptor signaling is an unstable feature of the gonadotropic LβT2 cell line

F EertmansWillem DhoogeOlivier De WeverWim Vanden BergheVeerle BogaertMarc BrackeGuy HaegemanFrank ComhaireJean Kaufman

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasis

S RODRIGUESOlivier De WeverErik BruyneelRJ ROONEYC GESPACH

A1 Journal Article in ONCOGENE

Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac JNK-dependent signaling pathways in colon cancer cells

C GRIJELMOC RODRIGUEM SVRCEKErik BruyneelAn HendrixOlivier De WeverC GESPACH

A1 Journal Article in CELLULAR SIGNALLING

Soluble cadherins as cancer biomarkers

Olivier De WeverLara DeryckeAn HendrixGert De MeerleerF GODEAUHerman Depyperemarc bracke

A1 Journal Article in CLINICAL & EXPERIMENTAL METASTASIS

The tandem PDZ domains of syntenin promote cell invasion

Kris MeerschaertErik BruyneelOlivier De WeverBerlinda VanlooCiska Boucheriemarc brackeJoël VandekerckhoveJan Gettemans

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

2006

Growth factor modulation of fibroblast proliferation, differentiation, and invasion: Implications for tissue valve engineering

K NARINEOlivier De WeverDillis Van ValckenborghKatrien Francoismarc brackeStefaan De SmetMarcus MareelGuido Van Nooten

A1 Journal Article in TISSUE ENGINEERING

Pro-invasive molecular cross-signaling between cancer cells and myofibroblasts

Olivier De WeverMarcus Mareel

Bookchapter in Tissue repair, contraction and the myofibroblast

Role of adipocyte-derived resistin in breast cancer

Dillis Van ValckenborghOlivier De WeverAn HendrixM BRACKER VANDENBROECKESimon Van BelleP PAUWELSVeronique CocquytHANNELORE DENYS

Soluble N-cadherin fragment promotes angiogenesis

Lara DeryckeL MORBIDELLIM ZICHEOlivier De Wevermarc brackeElisabeth Van Aken

A1 Journal Article in CLINICAL & EXPERIMENTAL METASTASIS

Soluble N-cadherin in human biological fluids

Lara DeryckeOlivier De WeverVeronique StoveBarbara VanhoeckeJoris DelangheHerman Depyperemarc bracke

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

2005

Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment

QD NGUYENOlivier De WeverErik BruyneelAn HendrixWZ XIEA LOMBETM LEIBLMarcus MareelF GIESELERmarc bracke et al.

A1 Journal Article in ONCOGENE

2004

A road map for cancer invasion : implication of myofibroblasts and other factors

Olivier De WeverMarc BrackeMarcus Mareel

Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-beta or wounding

Olivier De WeverWendy WestbroekA VERLOESN BLOEMENmarc brackeC GESPACHErik BruyneelMarcus Mareel

A1 Journal Article in JOURNAL OF CELL SCIENCE

Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes

C RIVATOlivier De WeverErik BruyneelMarcus MareelC GESPACHS ATTOUB

A1 Journal Article in ONCOGENE

Germinal tumor invasion and the role of the testicular stroma

A DIEZ-TORREU SILVANOlivier De WeverErik BruyneelMarcus MareelJ ARECHAGA

A1 Journal Article in INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Invasion and MMP expression profile in desmoid tumours

H DENYSOlivier De WeverB NUSGENSY KONGR SCIOTAT LEK VAN DAMA JADIDIZADEHS TEJPARMarcus Mareel et al.

A1 Journal Article in BRITISH JOURNAL OF CANCER

Mutated E-cadherin: Genomic and functional characterization in thyroid cells from the KAT family

AS ROCHAOlivier De WeverS MOREIRAMJ COSTAJoël VandekerckhoveMarcus MareelP SOARES

A1 Journal Article in THYROID

Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent proinvasive signals to human colon cancer cells through RhoA and Rac

Olivier De WeverQD NGUYENLeen Van Hoordemarc brackeErik BruyneelC GESPACHMarcus Mareel

A1 Journal Article in FASEB JOURNAL

The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3β and c-Jun/AP-1 signaling

Nathalie Le FlochChristine RivatOlivier De WeverErik BruyneelMarcus MareelTrevor DaleChristian Gespach

A1 Journal Article in FASEB JOURNAL

2003

Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands

G SURIANOC OLIVEIRAP FERREIRAJC MACHADOMC BORDINOlivier De WeverErik BruyneelN MOGUILEVSKYN GREHANTR PORTER et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Invasion of retinal pigment epithelial cells: N-cadherin, hepatocyte growth factor, and focal adhesion kinase

Elisabeth Van AkenOlivier De WeverLeen Van HoordeErik BruyneelJean DelaeyMarcus Mareel

A1 Journal Article in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Requirement of both mucins and proteoglycans in cell-cell dissociation and invasiveness of colon carcinoma HT-29 cells

S TRUANTErik BruyneelV GOUYEROlivier De WeverFR PRUVOTMarcus MareelG HUET

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Role of tissue stroma in cancer cell invasion

Olivier De WeverMarcus Mareel

A1 Journal Article in JOURNAL OF PATHOLOGY

The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion

G SURIANOD MULHOLLANDOlivier De WeverP FERREIRAAR MATEUSErik BruyneelCC NELSONMarcus MareelJ YOKOTAD HUNTSMAN et al.

A1 Journal Article in ONCOGENE

2002

Role of myofibroblasts at the invasion front.

Olivier De WeverMarcus Mareel

A1 Journal Article in BIOLOGICAL CHEMISTRY

2001

Defective E-cadherin/catenin complexes in human cancer

Elisabeth Van AkenOlivier De WeverASC DA ROCHAMarcus Mareel

A1 Journal Article in VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY