Project

Design and development of new selective HDAC6 inhibitors with applications in cancer therapy

Duration
01 October 2014 → 14 October 2018
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
Keywords
HDAC6 cancer biology
 
Project description

This project will embark on the current interest in HDAC6 as a therapeutic target, aiming at the development and assessment of new HDAC6 inhibitors as potential novel clinical candidates for anticancer therapy. The research will include activities related to the design, synthesis and biological evaluation of new chemical entities as selective HDAC6 inhibitors on the one hand, and activities related to the assessment of the functional inhibition on tumor cell activities by the new HDAC6 inhibitors on the other hand.