Research Explorer

Project

Fibrosis-related biomarkers and therapeutic targets for radiation-induced anorectal dysfunction
Code
365Q5611
Duration
01 October 2011 → 31 December 2016
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Medical and health sciences
    • Medical imaging and therapy
    • Medical imaging and therapy
    • Medical imaging and therapy
Keywords
radiotherapy carcinoma-associated fibroblast colon cancer fibrosis tumor environment
 
Project description
 

The molecular mechanisms underlying RT-induced anorectal functional damage are largely unexplored. One possible pathophysiological pathway is the induction of fibrosis, mediated by myofibroblast activation via Transforming Growth Factor (TGF) beta signalling. The aim of the current multicentric, multidisciplinary project is to study the role of myofibroblast activation and fibrosis in the pathogenesis of RT-induced anorectal dysfunction.