Generation of a dynamic spatial map of the cellular landscape of HIV-infected gut and its application in unraveling the role of tissue-resident T cells in HIV

Strategies against persistent HIV-1 reservoirs

Analysis of intact HIV proviral sequences using primer based assays

A novel CRISPR/Cas9-based nanomedicine strategy targeting CD4+ cells to cure HIV

Beyond Diagnosis: Early Antiretroviral Treatment and HIV Immunopathogenesis in a Belgian Acute HIV Infection Cohort

Development of a novel assay to characterize the HIV-1 reservoir using long-read sequencing.

Development of nanobody based stratigies for an HIV cure

Doctoral project Pieter Pannus

Doctoral project Zoi Stylianidou

HIV-1 DNA based enrichment of intact proviruses: finding a helix in a haystack

Impact of HIV-1 tropism and subtype on the HIV reservoir

Implementation of nanopore based HIV sequencing in the Human Functional Genome Project

Next generation CAR T-cells for HIV cure

Generation of HIV Env-targeting nanobodies for application in innovative immunotherapy strategies

ABSL3 mice housing system to develop new therapies against virulent pathogens

A living weapon: Can CAR T cells eliminate the latent HIV reservoir?

Analysis of the viral reservoir in acute seroconverters

A novel CRISPR/Cas9-based nanomedicine strategy targeting CD4+ cells to cure HIV

A novel CRISPR/Cas9-based nanomedicine strategy targeting CD4+ cells to cure HIV

Apoptosis associated lncRNAs in HIV-1 infection: new targets to selectively kill latent viral reservoirs.

ASP-L, An antisense HIV RNA transcript that acts in HIV latency

Automatic bench-top cell sorter with biosafety hood for use in a level 3 class biosafety laboratory

Cofunding core facility - The digital PCR Core

Collen-Francqui Research professor Linos Vandekerckhove

COVID-Trace: from tracking virus-host interactions at the single-cell level to tracing cellular markers for clinical patient stratification.

Covid-Track: applying quantitative virology and single-cell genomics to unravel the virus-host interactions leading to severe immunopathologies in COVID-19 patients

Defining HIV reservoirs that rebound following suspension of Art

Defining molecular pathways triggered by IL-10 and TGFb that drive HIV integrationand persistence in Tfh cells in lymph nodes

Development of a novel assay to characterize the HIV-1 reservoir using long-read sequencing

Development of novel assays to characterize the size and dynamics of the HIV-1 viral reservoir.

Direct quantification of virus-cell interactions in a biosafety level 3 laboratory

Dissection of the HIV reservoir in acutely infected patients treated immediately

Eranet to Unravel new Roads to Eradiction and a Cure for Aids

Evaluation of new tools to study the HIV latent reservoir in vitro and in vivo

Exploring the spontaneously active HIV-1 reservoir: molecular drivers and contriubtion to viral rebound

Feasibility evaluation of anti-HIV Antibody-secreting Chimeric Antigen Receptor T cells as a potential cure in acute seroconverters

Fonds A.B.: Blood and genome analyzes in the context of the Covid19-pandemic

Functional analysis of T cells infiltrating the lungs of severely ill COVID-19 patients

HIV-1 DNA based enrichment of intact proviruses: finding a helix in a haystack

HIV-1 integration as a driver of clonal expansion and HIV-1 transcription during antiretroviral therapy

HIV-1 postintegration latency: from molecular mechnisms to potential therapeutic strategies

HIV Nanoheroes: novel CRISPR/Cas9-based CD4+ cell-specific HHV-7 vectors to cure HIV

How do ILCs go wrong: unravelling the mechanisms of ILC depletion and functions in HIV infection

Hybrid CAR – improving cellular therapies for infectious diseases

Hybrid CARs on the road to HIV cure

Identification and evaluation of potential biomarkers for cells that are latently infected with HIV

Long non-coding RNAs functioning in HIV infection and latency development

Long non-coding RNAs in HIV latency: a new approach for improved latency reversal in shock-and-kill cure strategies.

Multi-OMICS identification and validation of mechanisms triggered by Immune interventions aimed at reducing the size of the replication competent Reservoir- Bioinfo

Multi-OMICS identification and validation of mechanisms triggered by Immune interventions aimed at reducing the size of the replication competent Reservoir- Project 1

Optimization of Hybrid CAR T cells to cure HIV

Paving the way for a multidimensional therapeutic cure approach in patients treated during acute HIV seroconversion

Persistent non-HIV pathogens: important drivers of HIV-1 persistence?

Reversing Immune Dysfunction for HIV-1 Eradication

Selection and Evolution of HIV-1 reservoir cells in blood and tissues - YEAR 3

Selection and Evolution of HIV-1 reservoir cells in blood and tissues - YEAR 3

Selection and Evolution of HIV-1 reservoir cells in blood and tissues - YEAR 4

Selection and evolution of HIV reservoir in blood and tissues

Size estimation of the viral reservoir of HIV infected patients undergoing HAART: a promising approach to guide therapy towards a functional cure

TENACITY: T cell-targeting nanomaterials deliver CRISPR-based individualized gene therapy to cure HIV

The role of neutrophils in immune-protection and immunepathology of HIV disease

Towards the clinical application of total HIV DNA: a valuable marker for the diagnosis of HIV-infected infants and treatment follow-up in HIV adults.

Transferred Immunity by Gene Editing of Antigen Receptors (TIGEAR)

Use of bispecific AcTakines to boost innate and adaptive immune responses after acute HIV-1 infection

Automated system for high-pure extraction of RNA and DNA from samples of limited quantity.

Democratizing High-Throughput Next Generation Sequencing across different Life Science Fields: the AVITI Next Generation Sequencer.

Development and application of digital PCR

FullPicture: Combining Spectral Flow Cytometry with High-Speed Cell Imaging to enable comprehensive profiling of plant and animal cells and their components in real time.

Generation of HIV Env-targeting nanobodies for application in innovative immunotherapy strategies.

Studying human inflammasome signaling in an in vivo context using humanized mice

Unraveling host and viral factors underlying HIV latency in the gut

Clinical validation of new targets for the inhibition of HIV replication.