Project

Use of bispecific AcTakines to boost innate and adaptive immune responses after acute HIV-1 infection

Duration
15 November 2019 → Ongoing
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Virology
  • Medical and health sciences
    • Applied immunology
    • Compound screening
Keywords
Acute HIV-infection Broadly neutralizing antibodies Cytokines HIV-1
 
Project description

The potential of AcTakines (immunocytokines with reduced binding affinity to decrease systemic side-effects) will be explored as a strategy towards HIV-1 cure. Bispecific IFN-I and IL-1β AcTakines will be constructed, targeting both HIV-infected cells and immune effector cell. They will be tested in vitro on primary cells from early treated HIV+ individuals and in vivo in a humanized mouse model.