Research Explorer

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Researcher

Linos Vandekerckhove

Publications & Research Data

Awards & Distinctions

342 Results

2025

Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice

Hannah StocksJolien Van CleemputLinos VandekerckhoveAndy Wullaert

Editorial material

Assessing advances in three decades of clinical antiretroviral therapy on the HIV-1 reservoir

Irene Gonzalez-NavarroVictor UrreaCristina GalvezMaria del Carmen Garcia-GuerreroSara Moron-LopezMaria C. PuertasEulalia GrauBeatriz MotheLucia BailonCristina Miranda et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Beyond diagnosis : early antiretroviral treatment and HIV immunopathogenesis in a Belgian acute HIV infection cohort

Jozefien De ClercqLinos VandekerckhoveSarah Gerlo

Blood and tissue HIV-1 reservoirs display plasticity and lack of compartmentalization in virally suppressed people

Marion PardonsLaurens LambrechtsYtse NoppeLiesbet TermoteSofie De BraekeleerJerel VegaEllen Van GulckSarah GerloLinos Vandekerckhove

A1 Journal Article in NATURE COMMUNICATIONS

Evolution of the HIV-1 integration site landscape and inducible reservoir in early-treated people.

Tine StruyveMarion PardonsJozefien De ClercqLiesbet TermoteLaurens LambrechtsYtse NoppeMathias LichterfeldSofie RutsaertLinos Vandekerckhove

U Journal Article in PLoS pathogens

Exploring bacterial extracellular vesicles in HIV infection : building the foundations from literature to laboratory

Nele De LangheAn HendrixLinos Vandekerckhove

Integrase versus protease inhibitor therapy in advanced HIV disease (LAPTOP): a multicountry, randomised, open-label, non-inferiority trial.

Georg M N BehrensLambert AssoumouGeoffroy LiegeonAndrea AntinoriRafael MicánFrancesco G GenderiniFrank A PostJürgen K RockstrohLisa HamzahPere Domingo et al.

U Journal Article in The Lancet. Infectious diseases

Integrative assessment of total and intact HIV-1 reservoir by a 5-region multiplexed rainbow DNA digital PCR assay

Mareva DelporteLaurens LambrechtsEvy BlommeWillem van SnippenbergSofie RutsaertMaxime VerschooreEvelien De SmetYtse NoppeNele De LangheMarie-Angélique De Scheerder et al.

A1 Journal Article in CLINICAL CHEMISTRY

Investigation of human-specific innate immune signaling

Hannah StocksAndy WullaertLinos Vandekerckhove

The imperative for increased investment for an HIV cure.

Remko van LeeuwenFrançoise Barré-SinoussiMichaela Müller-TrutwinAsier Sáez-CiriónMonique NijhuisSharon R LewinThumbi Ndung'uFlorence Riako-AnamMitchell WarrenIzukanji Sikazwe et al.

U Journal Article in The lancet. HIV

Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy : an individual data-based meta-analysis of 24 prospective studies

Jesper D. GunstJesal GohilJohanthan Z. LiRonald J. BoschAndrea WhiteCatherine SeamonTae-Wook ChunBeatriz MotheKathleen GittensLauren Praiss et al.

A1 Journal Article in NATURE COMMUNICATIONS

Virulent HIV-1B : clinical challenges and proteomic insights

Kavita MehtaMareva DelporteVictoria Rios VazquezMarc J. T BlaauwLouise E. van EekerenAlbert L. GroenendijkWilhelm A VosEvy BlommeSarah GerloBram Vrancken et al.

2024

A truncated HIV Tat demonstrates potent and specific latency reversal activity (vol 67, e00417-23, 2023)

Ellen Van GulckMarion PardonsErik NijsNick VerheyenKoen DockxChristel van den EyndeEmilie BattivelliJerel VegaEric FlorenceBrigitte Autran et al.

Case series of kaposi sarcoma in HIV-negative men who have sex with men : potential therapeutic approaches

Niels HilhorstBarbara DevochtEvelien VerhaegheLore LapeireLinos VandekerckhoveSoetkin DesmetMarie-Angélique De ScheerderLieve Brochez

A2 Journal Article in JOURNAL OF DERMATOLOGY RESEARCH AND THERAPY

Development of a novel assay to characterize the HIV-1 reservoir using long-read sequencing

Laurens LambrechtsLinos VandekerckhoveWim Van Criekinge

Development of human innate immune responses in a humanized mouse model expressing four human myelopoiesis transgenes

Hannah StocksElisabeth De LeeuwBart LambrechtLinos VandekerckhoveGeert van LooAndy Wullaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort : a prospective observational cohort study

Maria SalgadoCristina GalvezMonique NijhuisMi KwonE. Fabian Cardozo-OjedaJon BadiolaMatthew J. GormanLaura E. P. HuyveneersVictor UrreaAlessandra Bandera et al.

A1 Journal Article in LANCET HIV

HIV-PULSE as a new platform to unveil HIV-1 reservoir composition : intactness, drug resistance, tropism and immune therapy predictions

Sofie De BraekeleerLiesbet TermoteSofie RutsaertLaurens LambrechtsWilhelm A. VosAlbert L. GroenendijkLouise E. van EekerenMarc BlaauwJanneke StalenhoefAnnelies Verbon et al.

Host lncRNAs and their interplay with the HIV-1 infection cycle

Willem van SnippenbergPieter MestdaghLinos VandekerckhoveWim Trypsteen

Implementation of long-acting cabotegravir and rilpivirine : primary results from the perspective of staff study participants in the Cabotegravir And Rilpivirine Implementation Study in European Locations

Cassidy A. GutnerLaurent HocquelouxCelia Jonsson-OldenbuettelLinos VandekerckhoveBerend J. van WelzenLaurence SlamaMaria Crusells-CanalesJulian Olalla SierraRebecca DeMoorJenny Scherzer et al.

A1 Journal Article in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY

In-depth analysis of the HIV reservoir confirms effectiveness and safety of dolutegravir/lamivudine in a phase 4 randomized controlled switch trial (RUMBA)

Marie-Angélique De ScheerderSophie DegrooteMareva DelporteMaja KiselinovaWim TrypsteenLara VinckeEvelien De SmetBram Van Den EeckhoutLoic SchrooyenMaxime Verschoore et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline : caution is warranted

Delphine Diana AcarWojciech WitkowskiMagdalena WejdaRuifang WeiTim DesmetBert SchepensSieglinde De CaeKoen SedeynHannah EeckhautDaria Fijalkowska et al.

A1 Journal Article in EBIOMEDICINE

Interactome of the HIV-1 proteome and human host RNA

Tinus SchynkelWillem van SnippenbergKimberly VerniersGwendolyn M. JangNevan J. KroganPieter MestdaghLinos VandekerckhoveWim Trypsteen

A1 Journal Article in EMBO REPORTS

Longitudinal analysis in early treated individuals reveals alteration in the HIV-1 integration site landscape and composition of the inducible reservoir

Tine StruyveMarion PardonsJozefien De ClercqLiesbet TermoteLaurens LambrechtsYtse NoppeM. LichterfeldSofie RutsaertLinos Vandekerckhove

Longitudinal patterns of inflammatory mediators after acute HIV infection correlate to intact and total reservoir

Jozefien De ClercqMarie-Angélique De ScheerderVirginie MortierChris VerhofstedeStefaan J. VandecasteeleSabine D. AllardCoca NecsoiStephane De WitSarah GerloLinos Vandekerckhove

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Mapping bacterial extracellular vesicle research : insights, best practices and knowledge gaps

Nele De LangheSofie Van DorpeNiké GuilbertAmélie Vander CruyssenQuentin RouxSarah DevilleSandor DedeynePhilippe TummersHannelore DenysLinos Vandekerckhove et al.

A1 Journal Article in NATURE COMMUNICATIONS

MX2 forms nucleoporin-comprising cytoplasmic biomolecular condensates that lure viral capsids

Georgios MoschonasLouis DelhayeRobin CooremanFranziska HuesersAnayat BhatZoi StylianidouElien De BousserLaure De PryckHanna GrzesikDelphine De Sutter et al.

A1 Journal Article in CELL HOST & MICROBE

Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa

Jozefien DeclercqSarah GerloSharon Van NevelNatalie De RuyckGabriële HoltappelsLiesbeth DelesieEls TobbackInés LammensNikita GerebtsovKoen Sedeyn et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

Spiroplasma infection as a cause of severe congenital keratouveitis, cataract and glaucoma

Helena Van HaeckeDimitri RoelsFanny NerinckxHeidi SchaballiePetra SchelstraeteLinos VandekerckhoveJolien Van CleemputWim Van Den BroeckLiesbeth CouckHannelore Hamerlinck et al.

A1 Journal Article in BMC OPHTHALMOLOGY

Staging of immuno-virological dynamics during acute HIV infection in a Belgian prospective cohort study

Jozefien De ClercqMarie-Angélique De ScheerderSophie VanherrewegeEls CaluweNathalie MoreelsDanny DeloozeAnnemieke DhondtMarc CoppensStefaan J. VandecasteeleSabine D. Allard et al.

A1 Journal Article in JOURNAL OF VIRUS ERADICATION

Update on human herpesvirus 7 pathogenesis and clinical aspects as a roadmap for future research

Rianne VerbeekLinos VandekerckhoveJolien Van Cleemput

A1 Journal Article in JOURNAL OF VIROLOGY

2023

A complement atlas identifies interleukin-6-dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCedric BosteelsStijn Verwaerde et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

A truncated HIV Tat demonstrates potent and specific latency reversal activity

Ellen Van GulckMarion PardonsErik NijsNick VerheyenKoen DockxChristel van den EyndeEmilie BattivelliJerel VegaEric FlorenceBrigitte Autran et al.

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bictegravir/emtricitabine/tenofovir alafenamide in older individuals with HIV : results of a 96‐week, phase 3b, open‐label, switch trial in virologically suppressed people ≥65 years of age

Franco MaggioloGiuliano RizzardiniJean‐Michel MolinaFederico PulidoStephane De WitLinos VandekerckhoveJuan BerenguerMichelle L. D'AntoniChristiana BlairSusan K. Chuck et al.

A1 Journal Article in HIV MEDICINE

Efficacy, durability, and tolerability of bictegravir/emtricitabine/tenofovir alafenamide for the treatment of HIV in a real‐world setting in Belgium

Rakan NasreddineEric FlorenceJean Cyr YombiSophie HenrardGilles DarcisJens Van PraetLinos VandekerckhoveSabine D. AllardRémy DemeesterPeter Messiaen et al.

A1 Journal Article in HIV MEDICINE

Evaluating lncRNA expression patterns during HIV-1 treatment interruption

Tinus SchynkelWillem van SnippenbergClarissa Van HeckeLinos VandekerckhoveWim Trypsteen

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploring HIV-1 protein : host RNA interactions during HIV-1 infection

Tinus SchynkelLinos VandekerckhoveWim TrypsteenPieter Mestdagh

Gut dysbiosis associates with cytokine production capacity in viral-suppressed people living with HIV

Yue ZhangSergio Andreu-SanchezNadira VadaqDaoming WangVasiliki MatzarakiWouter A. A. van der HeijdenRanko GacesaRinse K. K. WeersmaAlexandra ZhernakovaLinos Vandekerckhove et al.

A1 Journal Article in FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

HIV-PULSE : a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

Laurens LambrechtsNoah BonineRita VerstraetenMarion PardonsYtse NoppeSofie RutsaertFilip Van NieuwerburghWim Van CriekingeBasiel ColeLinos Vandekerckhove

A1 Journal Article in NUCLEIC ACIDS RESEARCH

HIV-PULSE : a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

Laurens LambrechtsNoah BonineRita VerstraetenMarion PardonsYtse NoppeSofie RutsaertFilip Van NieuwerburghWim Van CriekingeBasiel ColeLinos Vandekerckhove

In-depth assessment of the HIV-1 viral reservoir in early treated individuals

Tine StruyveMarion PardonsLiesbet TermoteJozefien De ClercqLaurens LambrechtsJerel VegaDaniel BodenMathias LichterfeldSofie RutsaertLinos Vandekerckhove

In-depth virological and immunological characterization of HIV-1 cure after CCR5 Delta 32/Delta 32 allogeneic hematopoietic stem cell transplantation

Bjoern-Erik Ole JensenElena KnopsLeon CordsNadine LuebkeMaria SalgadoKathleen Busman-SahayJacob D. D. EstesLaura E. P. HuyveneersFederico Perdomo-CelisMelanie Wittner et al.

A1 Journal Article in NATURE MEDICINE

Influence of UGT1A1 and SLC22A6 polymorphisms on the population pharmacokinetics and pharmacodynamics of raltegravir in HIV-infected adults : a NEAT001/ANRS143 sub-study

Rohan GurjarLaura DickinsonDaniel CarrWolfgang StohrStefano BonoraAndrew OwenAntonio D'AvolioAdam CursleyNathalie De CastroGerd Fatkenheuer et al.

A1 Journal Article in PHARMACOGENOMICS JOURNAL

Linking inducible HIV-1 reservoir to rebound after treatment interruption

Laurens LambrechtsYtse NoppeMarion PardonsBasiel ColeSofie RutsaertStéphane De WitGuido VanhamEric FlorenceLinos Vandekerckhove

No significant association between 25-OH vitamin D status and SARS-VoV-2 antibody response after COVID-19 vaccination in nursing home residents and staff

Eline MeyersEvelien De SmetHanne VercruysseSteven CallensElizaveta PadalkoStefan HeytensLinos VandekerckhovePiet CoolsWojciech Witkowski

A1 Journal Article in VACCINES

Optimization of a long-read sequencing assay for near full-length HIV-1 proviral genome characterization

Sofie De BraekeleerLaurens LambrechtsSofie RutsaertLinos Vandekerckhove

Optimization of a long-read sequencing assay for near full-length HIV-1 proviral genome characterization to enhance read accuracy

Sofie De BraekeleerLaurens LambrechtsSofie RutsaertLinos Vandekerckhove

Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir

Marion PardonsBasiel ColeLaurens LambrechtsWillem van SnippenbergSofie RutsaertYtse NoppeNele De LangheAnnemieke DhondtJerel VegaFilmon Eyassu et al.

A1 Journal Article in NATURE COMMUNICATIONS

Rethinking IL-1 antagonism in respiratory viral infections : a role for IL-1 signaling in the development of antiviral T cell immunity

Bram Van Den EeckhoutMarlies BallegeerJozefien De ClercqElianne BurgXavier SaelensLinos VandekerckhoveSarah Gerlo

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sniffing out safety : canine detection and identification of SARS-CoV-2 infection from armpit sweat

Chris CallewaertMaria PezavantRony VandaeleBart MeeusEllen VankrunkelsvenPhaedra Van GoethemAlain PlumackerBenoit MissetGilles DarcisSonia Piret et al.

A1 Journal Article in FRONTIERS IN MEDICINE

Targeted plasma proteomics identifies MICA and IL1R1 proteins associated with HIV-1 reservoir size

Marc J. T. BlaauwJessica Cristina dos SantosNadira VadaqWim TrypsteenWouter van der HeijdenAlbert GroenendijkZhenhua ZhangYang LiQuirijn de MastMihai G. Netea et al.

A1 Journal Article in ISCIENCE

The Rainbow 5-plex digital PCR assay improves quantification of the viral reservoir resulting in a better understanding of the HIV-1 proviral landscape

Mareva DelporteLaurens LambrechtsMarion PardonsSofie De BraekeleerEvy BlommeSofie RutsaertWim TrypsteenLinos Vandekerckhove

Unraveling ongoing inflammation after early ART by in-depth analysis of lymph nodes

Jozefien De ClercqKathleen Busman-SahayLaurens LambrechtsSofie RutsaertSol Taylor-BrillStephen BondocMarie-Angélique De ScheerderJacob EstesSarah GerloLinos Vandekerckhove

2022

A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity

Séan Mc CaffertyA. K. M. Ashiqul HaqueAster VandierendonckBrian WeidenseeMagalie PlovytMagdalena StuchlikovaNathalie FrançoisSophie ValemboisLeo HeyndrickxJohan Michiels et al.

A1 Journal Article in MOLECULAR THERAPY

A night with professor Linos : interview of approach to multidisciplinary HIV research and other applications

Tine VanhaverbekeNele De LangheEva DegraeuweEline HermansLaurens Van CampJohan Vande WalleMirko PetrovicLinos Vandekerckhove

Association of COVID-19 mortality with serum selenium, zinc and copper : six observational studies across Europe

Kamil DemircanThilo Samson ChillonTommy BrackenIlaria BulgarelliIrene CampiGijs Du LaingSamira Fafi-KremerLaura FugazzolaAlejandro Abner GarciaRaban Heller et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Benefits of antiretroviral therapy initiation during acute HIV infection

Jozefien De ClercqSofie RutsaertMarie-Angélique De ScheerderChris VerhofstedeSteven CallensLinos Vandekerckhove

A1 Journal Article in ACTA CLINICA BELGICA

Characterization of the HIV-1 viral reservoir in subtype B early treated individuals

Tine StruyveMarion PardonsLiesbet TermoteJozefien De ClercqLaurens LambrechtsJerel VegaDaniel BodenMathias LichterfeldSofie RutsaertLinos Vandekerckhove

Clonal hematopoiesis is associated with low CD4 nadir and increased residual HIV transcriptional activity in virally suppressed individuals with HIV

Wouter A. van der HeijdenRosanne C. van DeurenLisa van de WijerInge C. L. van den MunckhofMarloes SteehouwerNiels P. RiksenMihai G. NeteaQuirijn de MastLinos VandekerckhoveRicharda M. de Voer et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

COVID‐19 vaccination with BNT162b2 and ChAdOx1 vaccines has the potential to induce nasal neutralizing antibodies

Jozefien DeclercqEls TobbackStijn VanheeNatalie De RuyckSarah GerloPhilippe GevaertLinos Vandekerckhove

A1 Journal Article in ALLERGY

Diagnostic performance of the SARS-CoV-2 S1RBD IgG ELISA (immunodiagnostics) for the quantitative detection of SARS-CoV-2 antibodies on dried blood spots

Eline MeyersAnja CoenAn De SutterElizaveta PadalkoSteven CallensLinos VandekerckhoveWojciech WitkowskiStefan HeytensPiet Cools

A1 Journal Article in JOURNAL OF CLINICAL VIROLOGY

Distinct immune profiles of HIV‐infected subjects are linked to specific lipid mediator signature

Magdalena SipsSarah GerloLaura De ClercqEsteban A. GomezRomain A. ColasJesmond DalliLinos Vandekerckhove

A1 Journal Article in IMMUNITY INFLAMMATION AND DISEASE

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption

Basiel ColeLaurens LambrechtsZoe BoyerYtse NoppeMarie-Angélique De ScheerderJohn-Sebastian EdenBram VranckenTimothy E. SchlubSherry McLaughlinLisa M. Frenkel et al.

A1 Journal Article in CELL REPORTS

HCV reinfection after HCV therapy among HIV/HCV-coinfected individuals in Europe

Sarah AmeleAnastasia Karachalia SandriAlison RodgerLinos VandekerckhoveThomas BenfieldAna MilinkovicClaudine DuvivierHans-Jurgen StellbrinkHelen SambatakouNikoloz Chkhartishvili et al.

A1 Journal Article in HIV MEDICINE

Humoral and cellular responses to COVID-19 vaccination indicate the need for post-vaccination testing in frail population

Wojciech WitkowskiSarah GerloEvelien De SmetMagdalena WejdaDelphine AcarSteven CallensStefan HeytensElizaveta PadalkoHannelore VercruyssePiet Cools et al.

A1 Journal Article in VACCINES

Impact of switch towards 3TC/dolutegravir on the intact and total viral reservoir in the Rumba study

Evy BlommeWim TrypsteenMareva DelporteC. MucciniE. De SmetSophie DegrooteEls TobbackSophie VanherrewegeE. CaluweMarie-Angélique De Scheerder et al.

Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Laurens LambrechtsRita VerstraetenNoah BonineYtse NoppeSofie RutsaertMarion PardonsBasiel ColeLinos Vandekerckhove

Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Laurens LambrechtsRita VerstraetenNoah BonineYtse NoppeSofie RutsaertMarion PardonsBasiel ColeLinos Vandekerckhove

Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Laurens LambrechtsRita VerstraetenNoah BonineYtse NoppeMarion PardonsBasiel ColeLinos Vandekerckhove

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

Cedric BosteelsKarel Van DammeElisabeth De LeeuwJozefien DeclercqBastiaan MaesVictor BosteelsLevi HosteLeslie NaesensNincy DebeufJulie Deckers et al.

A1 Journal Article in CELL REPORTS MEDICINE

Monkeypox virus infection in humans across 16 countries : April-June 2022

John P. ThornhillSapha BarkatiSharon WalmsleyJuergen RockstrohAndrea AntinoriLuke B. HarrisonRomain PalichAchyuta NoriIain ReevesMaximillian S. Habibi et al.

A1 Journal Article in LANCET NEUROLOGY

Patient-reported outcomes among people living with HIV on single- versus multi-tablet regimens : data from a real-life setting

Sophie DegrooteLinos VandekerckhoveDirk VogelaersCharlotte Vanden Bulcke

A1 Journal Article in PLOS ONE

People with HIV have higher percentages of circulating CCR5+CD8+T cells and lower percentages of CCR5+regulatory T cells

Louise E. van EekerenVasiliki MatzarakiZhenhua ZhangLisa van de WijerMarc J. T. BlaauwMarien I. de JongeLinos VandekerckhoveWim TrypsteenLeo A. B. JoostenMihai G. Netea et al.

A1 Journal Article in SCIENTIFIC REPORTS

Qualitative plasma viral load determination as a tool for screening of viral reservoir size in PWH

Thessa LaeremansSigrid D'haeseJonathan AernoutKurt BarbePieter PannusSofie RutsaertEllen VancutsemGuido VanhamCoca NecsoiWard De Spiegelaere et al.

A1 Journal Article in AIDS

The 2000HIV study: Design, multi-omics methods and participant characteristics.

Wilhelm A J W VosAlbert L GroenendijkMarc J T BlaauwLouise E van EekerenAdriana NavasMaartje C P CleophasNadira VadaqVasiliki MatzarakiJéssica C Dos SantosElise M G Meeder et al.

U Journal Article in Frontiers in immunology

Triplex digital PCR assays for the quantification of intact proviral HIV-1 DNA

Willem van SnippenbergDavid GleerupSofie RutsaertLinos VandekerckhoveWard De SpiegelaereWim Trypsteen

A1 Journal Article in METHODS

Understanding changes in metabolic parameters switching to 2DR or 3DR integrase strand inhibitors (InSTIs)

Sophie DegrooteSophie VanherrewegeEls TobbackE. CaluweLara VinckeEvy BlommeLinos VandekerckhoveMarie-Angélique De Scheerder

Unraveling persistent inflammation after very early ART through in-depth analysis of lymph nodes

Jozefien De ClercqKathleen Busman-SahayLaurens LambrechtsSofie RutsaertStephen BondocSol Taylor-BrillMarie-Angélique De ScheerderJacob EstesSarah GerloLinos Vandekerckhove

2021

A rare but devastating cause of twin loss in a near-term pregnancy highlighting the features of severe SARS-CoV-2 placentitis

Sasha LibbrechtJolien Van CleemputLinos VandekerckhoveSofie ColmanElizaveta PadalkoBruno VerhasseltKoen Van de VijverAmélie DendoovenIsabelle DehaeneJo Van Dorpe

Editorial material

Bictegravir/emtricitabine/tenofovir alafenamide in virologically suppressed people with HIV aged ≥ 65 years : week 48 results of a phase 3b, open-label trial

Franco MaggioloGiuliano RizzardiniJean-Michel MolinaFederico PulidoStephane De WitLinos VandekerckhoveJuan BerenguerMichelle L. D’AntoniChristiana BlairSusan K. Chuck et al.

A1 Journal Article in INFECTIOUS DISEASES AND THERAPY

Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells

Wouter A. van der HeijdenLisa Van de WijerFarid KeramatiWim TrypsteenSofie RutsaertRob ter HorstMartin JaegerHans J.P.M. KoenenHendrik G. StunnenbergIrma Joosten et al.

A1 Journal Article in JCI INSIGHT

Clinical characteristics and outcomes of COVID‐19 in people living with HIV in Belgium : a multicenter, retrospective cohort

Rakan NasreddineEric FlorenceMichel MoutschenJean‐Cyr YombiJean‐Christophe GoffardInge DerdelinckxPatrick LacorLinos VandekerckhovePeter MessiaenStefaan Vandecasteele et al.

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

Course and survival of COVID-19 patients with comorbidities in relation to the trace element status at hospital admission

Gijs Du LaingMirko PetrovicCarl LachatMarthe De BoevreGeorg KlingenbergQian SunSarah De SaegerJozefien De ClercqLouis IdeLinos Vandekerckhove et al.

A1 Journal Article in NUTRIENTS

Cytokine and chemokine dynamics in acute HIV infection and the impact of early ART initiation

Jozefien De ClercqGrégoire ThomasSarah GerloLinos Vandekerckhove

Cytotoxic CD8+ T cells expressing CXCR5 are detectable in HIV-1 elite controllers after prolonged in vitro peptide stimulation

Philipp AdamsGilles IserentantJean-Yves ServaisLinos VandekerckhoveGuido VanhamCarole Seguin-Devaux[missing] the PhenoCure Study Group

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Development of novel assays to characterize the size and dynamics of the HIV-1 viral reservoir

Basiel ColeLinos VandekerckhoveMarion Pardons

Diagnosing COVID-19 : towards a feasible COVID-19 rule-out protocol

Jozefien De ClercqThomas MalfaitSimon MalfaitJerina BoelensLiselotte CoorevitsElizaveta PadalkoStien VandendriesscheBruno VerhasseltLieve MorbéeFre Bauters et al.

A1 Journal Article in ACTA CLINICA BELGICA

Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID) : a factorial, randomised, controlled trial

Jozefien DeclercqKarel Van DammeElisabeth De LeeuwBastiaan MaesCedric BosteelsSimon TavernierStefanie De BuyserRoos ColmanMaya HitesGil Verschelden et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

HIV cure research in the time of COVID-19 : antiretroviral therapy treatment interruption trials : a discussion paper

S. FidlerS. LewinS. DeeksO. S. SogaardLinos VandekerckhoveS. CollinsD. KellyJ. SinghM. CaskeyJ. Frater

Editorial material

Human immunotypes impose selection on viral genotypes through viral epitope specificity

Migle GabrielaiteMarc BennedbaekAdrian G. ZuccoChristina EkenbergDaniel D. MurrayVirginia L. KanGiota TouloumiLinos VandekerckhoveDan TurnerJames Neaton et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

In-depth characterization of HIV-1 reservoirs reveals links to viral rebound during treatment interruption

Basiel ColeLaurens LambrechtsZoe BoyerYtse NoppeMarie-Angélique De ScheerderJohn-Sebastian EdenBram VranckenTimothy SchlubSherry McLaughlinLisa M. Frenkel et al.

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

Basiel ColeLaurens LambrechtsPierre GantnerYtse NoppeNoah BonineWojciech WitkowskiLennie ChenSarah PalmerJames I. MullinsNicolas Chomont et al.

A1 Journal Article in NATURE COMMUNICATIONS

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of residual viremia and rebound viruses

Basiel ColeLaurens LambrechtsPierre GantnerYtse NoppeNoah BonineLennie ChenSarah PalmerJames MullinsNicolas ChomontMarion Pardons et al.

IRF7 and RNH1 are modifying factors of HIV-1 reservoirs : a genome-wide association analysis

Zhenhua ZhangWim TrypsteenMarc BlaauwXiaojing ChuSofie RutsaertLinos VandekerckhoveWouter van der HeijdenJessica Cristina Dos SantosCheng-Jian XuMorris A. Swertz et al.

A1 Journal Article in BMC MEDICINE

Launching a multidisciplinary European collaboration towards a cure for HIV : the EU2Cure Consortium

C. RokxH. A. B. PrinsLinos VandekerckhoveS. J. FidlerJ. FraterM. BracchiO. S. SogaardM. TolstropT. A. RasmussenM. Salgado et al.

Editorial material

Measuring proviral HIV-1 DNA : hurdles and improvements to an assay monitoring integration events utilising human alu repeat sequences

Eva MalatinkováJordan ThomasWard De SpiegelaereSofie RutsaertAnna Maria GerettiGeorgios PollakisWilliam A. PaxtonLinos VandekerckhoveAlessandra Ruggiero

A1 Journal Article in LIFE-BASEL

Motivations, barriers and experiences of participants in an HIV reservoir trial

Marie-Angélique De ScheerderWard P.H. van BilsenMelissa DullaersJavier Martinez-PicadoUdi DavidovichLinos Vandekerckhove

A1 Journal Article in JOURNAL OF VIRUS ERADICATION

Organ-specific genome diversity of replication-competent SARS-CoV-2

Jolien Van CleemputWillem van SnippenbergLaurens LambrechtsAmélie DendoovenValentino D'OnofrioLiesbeth CouckWim TrypsteenJan VanrusseltSebastiaan TheunsNick Vereecke et al.

A1 Journal Article in NATURE COMMUNICATIONS

PCIP-seq : simultaneous sequencing of integrated viral genomes and their insertion sites with long reads

Maria ArtesiVincent HahautBasiel ColeLaurens LambrechtsFereshteh AshrafiAmbroise MarçaisOlivier HerminePhilip GriebelNatasa ArsicFrank van der Meer et al.

A1 Journal Article in GENOME BIOLOGY

Prevalence and outcomes of pregnancies in women with HIV over a 20-year period

Justyna D. KowalskaAnnegret Pelchen-MatthewsLene RyomMarcelo H. LossoTatiana TrofimovaViktar M. MitsuraIrina KhromovaDzmitry PadutaChristoph StephanPere Domingo et al.

A1 Journal Article in AIDS

Research priorities for an HIV cure : International AIDS Society Global Scientific Strategy 2021

Steven G. DeeksNancie ArchinPaula CannonSimon CollinsR. Brad JonesMarein A. W. P. de JongOlivier LambotteRosanne LamploughThumbi Ndung'uJeremy Sugarman et al.

A1 Journal Article in NATURE MEDICINE

Robust sequential biophysical fractionation of blood plasma to study variations in the biomolecular landscape of systemically circulating extracellular vesicles across clinical conditions

Glenn VergauwenJoeri TulkensCláudio PinheiroFrancisco Avila CobosSandor DedeyneMarie-Angélique De ScheerderLinos VandekerckhoveFrancis ImpensIlkka MiinalainenGeert Braems et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Single cell epigenetic visualization assay

Sam KintWim Van CriekingeLinos VandekerckhoveWinnok H De VosKarol BomsztykDiane S KrauseOleg Denisenko

A1 Journal Article in NUCLEIC ACIDS RESEARCH

The architecture of circulating immune cells Is dysregulated in people living with HIV on long term antiretroviral treatment and relates with markers of the HIV-1 reservoir, cytomegalovirus, and microbial tanslocation

Lisa Van de WijerWouter A. van der HeijdenRob ter HorstMartin JaegerWim TrypsteenSofie RutsaertBram van CranenbroekEsther van RijssenIrma JoostenLeo Joosten et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2020

CD32+CD4+memory T cells are enriched for total HIV-1 DNA in tissues from humanized mice

P. AdamsV. FievezR. SchoberM. AmandG. IserentantSofie RutsaertG. DessillyG. VanhamF. HedinA. Cosma et al.

A1 Journal Article in ISCIENCE

Combined assays shed new light on HIV-1 proviral sequence and linked integration site

Basiel ColeLaurens LambrechtsMaria ArtesiVincent HahautWojciech WitkowskiYtse NoppeAnnemieke DhondtKeith DurkinAnne Van den BroekeLinos Vandekerckhove

Emerging PCR-based techniques to study HIV-1 reservoir persistence

Laurens LambrechtsBasiel ColeSofie RutsaertWim TrypsteenLinos Vandekerckhove

A1 Journal Article in VIRUSES-BASEL

Evaluating predictive markers for viral rebound and safety assessment in blood and lumbar fluid during HIV-1 treatment interruption

Marie-Angélique De ScheerderClarissa Van HeckeHenrik ZetterbergDietmar FuchsNele De LangheSofie RutsaertBram VranckenWim TrypsteenYtse NoppeBeatrijs Van Der Gucht et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Evolution of experimental design and research techniques in HIV-1 reservoir studies : a systematic review

Marie-Angélique De ScheerderBram DepelseneerLinos VandekerckhoveTrypsteen Wim

A1 Journal Article in AIDS REVIEWS

Exploring methods to measure DNA methylation in the context of HIV-1

Sam KintWim Van CriekingeLinos VandekerckhoveWim Trypsteen

HIV STAR : HIV-1 sequencing to identify the anatomical relevant HIV reservoir

Marie-Angélique De ScheerderLinos Vandekerckhove

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

Joeri TulkensGlenn VergauwenJan Van DeunEdward GeeurickxBert DhondtLien LippensMarie-Angélique De ScheerderIlkka MiinalainenPekka RappuBruno De Geest et al.

A1 Journal Article in GUT

Interferon-mediated long non-coding RNA response in macrophages in the context of HIV

Tinus SchynkelMatthew A. SzaniawskiAdam M. SpivakAlberto BosqueVicente PlanellesLinos VandekerckhoveWim Trypsteen

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

On the whereabouts of SARS-CoV-2 in the human body : a systematic review

Wim TrypsteenJolien Van CleemputWillem van SnippenbergSarah GerloLinos Vandekerckhove

A1 Journal Article in PLOS PATHOGENS

Population pharmacokinetics and pharmacogenetics of ritonavir-boosted darunavir in the presence of raltegravir or tenofovir disoproxil fumarate/emtricitabine in HIV-infected adults and the relationship with virological response : a sub-study of the NEAT001/ANRS143 randomized trial

Laura DickinsonRohan GurjarAndrew OwenAntonio D’AvolioGerd FäetkenheuerLinos VandekerckhoveGiovanni Di Perri

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on-going viral transcription

Pieter PannusSofie RutsaertStéphane De WitSabine D. AllardGuido VanhamBasiel ColeCoca NescoiJoeri AertsWard De SpiegelaereAchilleas Tsoumanis et al.

A1 Journal Article in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY

Tackling diagnostic challenges during the first wave of COVID-19

Jozefien De ClercqThomas MalfaitSimon MalfaitLiselotte CoorevitsElizaveta PadalkoStien VandendriesscheBruno VerhasseltLieve MorbéeFre BautersKatrien Hertegonne et al.

The elusive source of HIV-1 rebound after treatment interruption

Laurens LambrechtsBasiel ColeMarie-Angélique De ScheerderZoe BoyerYtse NoppeKatie FisherJohn-Sebastian EdenWim Van CriekingeLisa FrenkelSarah Palmer et al.

Total HIV-1 DNA as a marker of the viral reservoir

Sofie RutsaertLinos VandekerckhoveWard De Spiegelaere

Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals

Sam KintWim TrypsteenWard De SpiegelaereEva MalatinkováSabine Kinloch-de LoesTim De MeyerWim Van CriekingeLinos Vandekerckhove

A1 Journal Article in CLINICAL EPIGENETICS

Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

J. M. EberhardM. AnginC. PassaesM. SalgadoV. MonceauxE. KnopsG. KobbeB. JensenM. ChristopeitN. Kröger et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

Week 48 resistance analyses of the once-daily, single-tablet regimen darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in adults living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials

Erkki LathouwersEric Y WongKimberley BrownBryan BaughAnne GhysJohn JezorwskiEl Ghazi MohsineErika Van LanduytMagda OpsomerSandra De Meyer et al.

A1 Journal Article in AIDS RESEARCH AND HUMAN RETROVIRUSES

Week 96 results of a phase 3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naive HIV-1 patients

C OrkinJJ EronJ RockstrohD PodzamczerS EsserLinos VandekerckhoveE Van LanduytE LathouwersV HufkensJ Jezorwski et al.

A1 Journal Article in AIDS

2019

Analytical treatment interruption (ATI) in patients with very small HIV reservoir

Pieter PannusSofie RutsaertStéphane De WitGuido VanhamCoca NecsoiJoeri AertsWard De SpiegelaereAchilleas TsoumanisMarie CouttenyeNatacha Herssens et al.

Decreased NEAT1 and MALAT1 levels in HIV-1 positive individuals with high viral load

Clarissa Van HeckeSabine Kinloch-de LoesTinus SchynkelEva MalatinkováKaren VervischSofie RutsaertWim TrypsteenLinos Vandekerckhove

Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2) : week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials

Pedro CahnJuan Sierra MaderoJosé Ramón ArribasAndrea AntinoriRoberto OrtizAmanda E ClarkeChien-Ching HungJürgen K RockstrohPierre-Marie GirardJörg Sievers et al.

A1 Journal Article in LANCET

Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors

Clarissa Van HeckeWim TrypsteenEva MalatinkováWard De SpiegelaereKaren VervischSofie RutsaertSabine Kinloch-de LoesMagdalena SipsLinos Vandekerckhove

A1 Journal Article in EBIOMEDICINE

Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA

S. AmeleL. PetersM. SluzhynskaA. YakovlevA. ScherrerP. DomingoJ. GerstoftJ. P. ViardM. GisingerR. Flisiak et al.

A1 Journal Article in HIV MEDICINE

Evaluation of HIV-1 reservoir levels as possible markers for virological failure during boosted darunavir monotherapy

Sofie RutsaertWard De SpiegelaereLaura De ClercqLinos Vandekerckhove

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Gold nanoparticle-mediated photoporation enables delivery of macromolecules over a wide range of molecular weights in human CD4+ T cells

Laurens RaesClarissa Van HeckeJulie MichielsStephan StremerschJuan FraireToon BransRanhua XiongStefaan De SmedtLinos VandekerckhoveKoen Raemdonck et al.

A1 Journal Article in CRYSTALS

HIV rebound is predominantly fueled by genetically identical viral expansions from diverse reservoirs

Marie-Angélique De ScheerderBram VranckenSimon DellicourTimothy SchlubEunok LeeWei ShaoSofie RutsaertChris VerhofstedeTessa KerreThomas Malfait et al.

A1 Journal Article in CELL HOST & MICROBE

Immediate versus deferred switching from a boosted protease inhibitor-based regimen to a dolutegravir-based regimen in virologically suppressed patients with high cardiovascular risk or age ≥50 years : final 96-week results of the NEAT022 study

JM GatellL AssoumouG MoyleL WatersM JohnsonP DomingoJ FoxE MartinezHJ StellbrinkG Guaraldi et al.

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

In-vitro viral suppressive capacity correlates with immune checkpoint marker expression on peripheral CD8+ T cells in treated HIV-positive patients

Pieter PannusPhilipp AdamsElisabeth WillemsLeo HeyndrickxEric FlorenceSofie RutsaertWard De SpiegelaereLinos VandekerckhoveCarole Seguin-DevauxGuido Vanham

A1 Journal Article in AIDS

Increased numbers of intact HIV sequences in a4b7 T cells during acute seroconversion

Sofie RutsaertPilar Garcia BroncanoMarie-Angélique De ScheerderBasiel ColeMathias LichterfeldLinos Vandekerckhove

Interferon-mediated long non-coding RNA response to HIV infection in macrophages

Tinus SchynkelClarissa Van HeckeVicente PlanellesLinos VandekerckhoveWim Trypsteen

Long non-coding RNAs and latent HIV : a search for novel targets for latency reversal

Wim TrypsteenCory H WhiteAmey MukimCelsa A SpinaWard De SpiegelaereSteve LefeverChristopher H WoelkAlberto BosqueLinos VandekerckhoveNadejda Beliakova-Bethell

Long non-coding RNAs and latent HIV : a search for novel targets for latency reversal

Wim TrypsteenCory H WhiteAmey MukimCelsa A SpinaWard De SpiegelaereSteve LefeverVicente PlanellesAlberto BosqueChristopher H WoelkLinos Vandekerckhove et al.

A1 Journal Article in PLOS ONE

Long-term treatment with atazanavir (ATV) in real life in Belgium: a retrospective observational cohort of 2264 HIV patients.

Stéphane De WitEric FlorenceLinos VandekerkhoveJean-Christophe GoffardBernard VandercamEric Van WijngaerdenMichel MoutschenRémy DemeesterPatrick LacorMarc Delforge et al.

U Journal Article in Acta clinica Belgica

Mapping acute HIV-1-infection : designing a webtool to capture multicentric & multidiscipinary data

Jozefien De ClercqCedric TitsDamien BertrandSophie VanherrewegeSofie RutsaertLaura DeclercqMarie-Angélique De ScheerderLinos Vandekerckhove

Predictors of virological failure in HIV-1-infected patients switching to dolutegravir maintenance monotherapy

Ingeborg E.A. WijtingSofie RutsaertCasper RokxDavid M. BurgerAnnelies VerbonJeroen J. A. van KampenCharles A. B. BoucherBart J. A. RijndersLinos Vandekerckhove

A1 Journal Article in HIV MEDICINE

Relationship between HIV-1 env sequences from rebound plasma virus and viral outgrowth

Basiel ColeMarie-Angélique De ScheerderPieter PannusSofie RutsaertYtse NoppeStéphane De WitSabine AllardGuido VanhamEric FlorenceLinos Vandekerckhove

Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER) : final results of a multicentre, prospective, observational study

Alison J RodgerValentina CambianoTina BruunPietro VernazzaSimon CollinsOlaf DegenGiulio Maria CorbelliVicente EstradaAnna Maria GerettiApostolos Beloukas et al.

A1 Journal Article in LANCET

Safety, tolerability and impact on viral reservoirs of the addition to antiretroviral therapy of ABX464, an investigational antiviral drug, in individuals living with HIV-1 : a Phase IIa randomised controlled study

Sofie RutsaertJean-Marc SteensPaul GinesteBasiel ColeSam KintP Noel BarrettJamal TaziDidier ScherrerHartmut J EhrlichLinos Vandekerckhove

A1 Journal Article in JOURNAL OF VIRUS ERADICATION

Switching from a protease inhibitor-based regimen to a dolutegravir-based regimen : a randomized clinical trial to determine the effect on peripheral blood and ileum biopsies from antiretroviral therapy-suppressed human immunodeficiency virus-infected individuals

Sara Morón-LópezJordi NavarroMontse JimenezSofie RutsaertVíctor UrreaMaria C PuertasAriadna TorrellaLaura De ClercqBibiana Planas RibasCristina Gálvez et al.

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

Switching to doravirine/lamivudine/tenofovir disoproxil fumarate (DOR/3TC/TDF) maintains HIV-1 virologic suppression through 48 weeks : results of the DRIVE-SHIFT trial

Margaret JohnsonPrincy KumarJean-Michel MolinaGiuliano RizzardiniPedro CahnMarkus BickelJosep MallolasYan ZhouCristiana MoraisSushma Kumar et al.

A1 Journal Article in JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Transcriptomic correlates of HIV reservoir size during antiretroviral therapy

Wim TrypsteenMohamed Abdel-MohsenXutao DengChristopher D PilcherSteven G DeeksLinos VandekerckhoveSatish K Pillai

Uptake and effectiveness of two-drug compared with three-drug antiretroviral regimens among HIV-positive individuals in Europe

B. NeesgaardA. Pelchen-MatthewsL. RyomE. FlorenceL. PetersA. RoenV. SvedhemA. ClarkeT. BenfieldV. Mitsura et al.

A1 Journal Article in AIDS

Week 96 efficacy and safety results of the phase 3, randomized EMERALD trial to evaluate switching from boosted-protease inhibitors plus emtricitabine/tenofovir disoproxil fumarate regimens to the once daily, single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in treatment-experienced, virologically-suppressed adults living with HIV-1

Joseph J EronChloe OrkinDouglas CunninghamFederico PulidoFrank A PostStéphane De WitErkki LathouwersVeerle HufkensJohn JezorwskiRomana Petrovic et al.

A1 Journal Article in ANTIVIRAL RESEARCH

2018

Abacavir usage patterns and hypersensitivity reactions in the EuroSIDA cohort

A RoenK LautA Pelchen-MatthewsE BorodulinaL CaldeiraA ClarkeB ClotetA d'Arminio MonforteG FätkenheuerJM Gatell Artigas et al.

A1 Journal Article in HIV MEDICINE

Beneficial impact of early treatment on restriction factor expression profile

Clarissa Van HeckeWim TrypsteenEva MalatinkováWard De SpiegelaereKaren VervischMargaret JohnsonSabine Kinloch-de LoesMagdalena SipsLinos Vandekerckhove

Beneficial impact of early treatment on restriction factor expression profile

Clarissa Van HeckeMagdalena SipsEva MalatinkováWard De SpiegelaereKaren VervischMargaret JohnsonSabine Kinloch-de LoesWim TrypsteenLinos Vandekerckhove

Contribution of lncRNAs in establishment of HIV latency in central memory CD4 T cells

Wim TrypsteenCory WhiteAlberto BosquePieter MestdaghSteve LefeverCelsa A SpinaLinos VandekerckhoveNadejd Beliakova-Bethell

Contribution of lncRNAs in the establishment of HIV latency in CD4+ T cell models

Wim TrypsteenClarissa Van HeckeTinus SchynkelCory H WhiteChristopher WoelkAlberto BosqueCelsa SpinaSteve LefeverPieter MestdaghLinos Vandekerckhove et al.

Digital PCR as a tool to measure HIV persistence

Sofie RutsaertKobus BosmanWim TrypsteenMonique NijhuisLinos Vandekerckhove

A1 Journal Article in RETROVIROLOGY

Evaluation of bisulfite kits for DNA methylation profiling in terms of DNA fragmentation and DNA recovery using digital PCR

Sam KintWard De SpiegelaereJonas De KeselLinos VandekerckhoveWim Van Criekinge

A1 Journal Article in PLOS ONE

Evaluation of recommendations provided by a multidisciplinary infectious diseases team as part of an antimicrobial stewardship program

Andreas CapiauSofie CraeyeJulie De KeulenaerSabine DeryckereKaren VermisSteven CallensDiana Huis in 't VeldSarah TemmermanLinos VandekerckhoveDirk Vogelaers et al.

Evaluation of recommendations provided by a multidisciplinary infectious diseases team as part of an antimicrobial stewardship program

Andreas CapiauSofie CraeyeJulie De KeulenaerSabine DeryckereKaren VermisSteven CallensDiana Huis in 't VeldSarah TemmermanLinos VandekerckhoveDirk Vogelaers et al.

Gender differences in the use of cardiovascular interventions in HIV-positive persons; the D:A:D Study

Camilla I HatlebergLene RyomWafaa El-SadrAmanda MocroftPeter ReissStephane De WitFrancois DabisChristian PradierAntonella d'Arminio MonforteHelen Kovari et al.

A1 Journal Article in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY

Highlights from the HIV Cure and Reservoir Symposium, 11-12 September 2017, Ghent, Belgium

Sam KintClarissa Van HeckeBasiel ColeLinos VandekerckhoveMagdalena Sips

Editorial material

Impact of an antimicrobial stewardship programme on the quality of care indicators for Staphylococcus aureus bacteraemia

Franky BuyleSteven CallensJerina BoelensLinos VandekerckhoveDiana Huis in 't VeldGeert ClaeysKaren VermisSabine DeryckereJulie De KeulenaerIsabel Leroux-Roels et al.

Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance

Axel FunThomas LeitnerLinos VandekerckhoveMartin DäumerAlexander ThielenBernd BuchholzAndy IM HoepelmanElizabeth H GisolfPauline J SchipperAnnemarie MJ Wensing et al.

A1 Journal Article in RETROVIROLOGY

In-depth validation of total HIV-1 DNA assays for quantification of various HIV-1 subtypes

Sofie RutsaertWard De SpiegelaereClarissa Van HeckeMarie-Angélique De ScheerderMaja KiselinovaKaren VervischWim TrypsteenLinos Vandekerckhove

A1 Journal Article in SCIENTIFIC REPORTS

Incidence of cancer and overall risk of mortality in individuals treated with raltegravir-based and non-raltegravir-based combination antiretroviral therapy regimens

A Cozzi-LepriR ZangerleL MachalaK ZilmerM RistolaC PradierO KirkH SambatakouG FaetkenheuerI Yust et al.

A1 Journal Article in HIV MEDICINE

Long-term use of darunavir/ritonavir-containing regimens in daily practice in Belgium : retrospective observational cohort data of 1701 HIV-patients

Stéphane De WitEric FlorenceLinos VandekerckhoveBernard VandercamJean-Christophe GoffardEric Van WijngaerdenMichel MoutschenRemy DemeesterPushpike ThilakarathneHilde Piryns

A1 Journal Article in ACTA CLINICA BELGICA

Patient-reported outcomes in first-line antiretroviral therapy : results from NEAT001/ANRS143 trial comparing darunavir/ritonavir in combination with tenofovir/emtricitabine or raltegravir

Elizabeth C. GeorgeRaffaella BucciardiniLaura RichertNikos DedesVincenzo FragolaPythia NieuwkerkBruno SpireAlain Volny-AnneBrian WestJean-Michel Molina et al.

A1 Journal Article in JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Standardizing digital PCR diagnostics and pioneering long non-coding RNA discovery in the context of HIV cure research

Wim TrypsteenLinos VandekerckhoveWard De Spiegelaere

Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?

Amanda MocroftKamilla LautPeter ReissJose GatellVidar OrmaasenMatthias CavassiniVesna HadziosmanovicKamal MansinhoChristian PradierMarta Vasylyev et al.

A1 Journal Article in AIDS

Which HIV-infected adults with high CD4 T-cell counts benefit most from immediate initiation of antiretroviral therapy? : a post-hoc subgroup analysis of the START trial

Jean-Michel MolinaBirgit GrundFred GordinIan WilliamsMauro SchechterMarcello LossoMatthew LawErnest EkongNoluthando MwelaseAthanasios Skoutelis et al.

A1 Journal Article in LANCET HIV

2017

Aggressive extensive cardiac mass in an HIV-1-infected patient : should we go for comfort therapy?

DELPHINE VERVLOETMichel De PauwLAURENT DEMULIERJan VercammenWim TerrynEVA STEELLinos Vandekerckhove

A1 Journal Article in ACTA CLINICA BELGICA

Beneficial impact of early treatment on restriction factor expression profile

Clarissa Van HeckeMagdalena SipsEva MalatinkováWard De SpiegelaereKaren VervischMargaret JohnsonSabine Kinloch-de LoesWim TrypsteenLinos Vandekerckhove

Challenges of in vitro HIV latency models

Pawel BonczkowskiLinos VandekerckhoveWard De Spiegelaere

Contribution of lncRNAs in establishment of HIV latency in central memory CD4 T cells

Wim TrypsteenCory WhiteAlberto BosqueCelsa SpinaSteve LefeverPieter MestdaghLinos VandekerckhoveNadejd Beliakova-Bethell

Contribution of lncRNAs in the establishment of HIV latency in central memory CD4 T cells

Wim TrypsteenCory WhiteAlberto BosqueSteve LefeverPieter MestdaghLinos VandekerckhoveChristopher Woelk

Cross-validation of HIV DNA assays to quantify different HIV-1 subtypes

Sofie RutsaertWard De SpiegelaereClarissa Van HeckeMarie-Angélique De ScheerderMaja KiselinovaKaren VervischWim TrypsteenLinos Vandekerckhove

Defining a Total HIV DNA threshold as guidance for therapy simplification strategies

Sofie RutsaertIngeborg WijtingWard De SpiegelaereLaura De ClercqBart RijndersLinos Vandekerckhove

Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay (vol 6, 36111, 2016)

Wim TrypsteenPejman MohammadiClarissa Van HeckePieter MestdaghSteve LefeverYvan SaeysPieter De BleserJo VandesompeleAngela CiuffiLinos Vandekerckhove et al.

Fight fire with fire : gene therapy strategies to cure HIV

Jon HuygheMagdalena SipsLinos Vandekerckhove

A1 Journal Article in EXPERT REVIEW OF ANTI-INFECTIVE THERAPY

Highlights from the 24th conference on retroviruses and opportunistic infections, 13-16 February 2017, Seattle, Washington, USA

Trevor A CrowellHermione LyallEva MalatinkováSanjay BhaganiDenise HsuDonn J ColbyChristina PolyakChristina PsomasAndrew HillEsther N Gathogo et al.

A1 Journal Article in JOURNAL OF VIRUS ERADICATION

HIV DNA as a predictive marker for virological failure of darunavir/r monotherapy : a substudy of the PROTEA trial to define a cut-off for succes

Sofie RutsaertWard De SpiegelaereLaura De ClercqLinos Vandekerckhove

HIV integration sites in latently infected cell lines : evidence of ongoing replication

Jori SymonsAbha ChopraEva MalatinkováWard De SpiegelaereShay LearyDon CooperChike O AbanaAjantha RhodesSimin D RezaeiLinos Vandekerckhove et al.

A1 Journal Article in RETROVIROLOGY

HIV reservoir characterization symposium 19 September 2016, Ghent, Belgium

Eva MalatinkováWard De SpiegelaereLinos VandekerckhoveMagdalena Sips

A1 Journal Article in JOURNAL OF VIRUS ERADICATION

lncRNA discovery in the HIV replication cycle adds new layer in HIV-host interplay

Wim TrypsteenMohammadi PejmanClarissa Van HeckePieter MestdaghSteve LefeverPieter De BleserJo VandesompeleAngela CiuffiWard De SpiegelaereLinos Vandekerckhove

Raltegravir 1200 mg once daily versus raltegravir 400 mg twice daily, with tenofovir disoproxil fumarate and emtricitabine, for previously untreated HIV-1 infection : a randomised, double-blind, parallel-group, phase 3, non-inferiority trial

Pedro CahnRichard KaplanPaul E SaxKathleen SquiresJean-Michel MolinaAnchalee AvihingsanonWinai RatanasuwanEvelyn RojasMohammed RassoolMark Bloch et al.

A1 Journal Article in LANCET HIV

Short-course Toll-like receptor 9 agonist treatment impacts innate immunity and plasma viremia in individuals with human immunodeficiency virus infection

Line VibholmMariane H SchleimannJesper F HøjenThomas BenfieldRasmus OffersenKatrine RasmussenRikke OlesenAnders DigeJørgen AgnholtJudith Grau et al.

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

The expression profile of host restriction factors in different cohorts of HIV-1 infected patients

Clarissa Van HeckeEva MalatinkováMargaret JohnsonSabine Kinloch-de LoesWim TrypsteenLinos Vandekerckhove

Utility of integrated HIV-1 DNA quantification in cure studies

Alessandra RuggieroEva MalatinkováSofie RutsaertWilliam A PaxtonLinos VandekerckhoveWard De Spiegelaere

A1 Journal Article in FUTURE VIROLOGY

2016

Antiretroviral resistance at virological failure in the NEAT 001/ANRS 143 trial : raltegravir plus darunavir/ritonavir or tenofovir/emtricitabine plus darunavir/ritonavir as first-line ART

S Lambert-NiclotEC GeorgeA PozniakE WhiteC SchwimmerH JessenM JohnsonD DunnCF PernoB Clotet et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cumulative and current exposure to potentially nephrotoxic antiretrovirals and development of chronic kidney disease in HIV-positive individuals with a normal baseline estimated glomerular filtration rate : a prospective international cohort study

Amanda MocroftJens D LundgrenMichael RossChristoph A FuxPeter ReissOlivier MorannePhilippe MorlatAntonella d'Arminio MonforteOle KirkLene Ryom et al.

A1 Journal Article in LANCET HIV

Diagnostic utility of droplet digital PCR for HIV reservoir quantification

Wim TrypsteenMaja KiselinovaLinos VandekerckhoveWard De Spiegelaere

A2 Journal Article in JOURNAL OF VIRUS ERADICATION

Differential expression of lncRNAs during the HIV replication cycle : an underestimated layer in the HIV-host interplay

Wim TrypsteenPejman MohammadiClarissa Van HeckePieter MestdaghSteve LefeverYvan SaeysPieter De BleserJo VandesompeleAngela CiuffiLinos Vandekerckhove et al.

A1 Journal Article in SCIENTIFIC REPORTS

Disparities in HIV clinic care across Europe : findings from the EuroSIDA clinic survey

Jeffrey V LazarusKamilla Grønborg LautKelly Safreed-HarmonLars PetersMargaret JohnsonGerd FätkenheuerIrina KhromovaLinos VandekerckhoveKatarzyna MaciejewskaRoxana Radoi et al.

A1 Journal Article in BMC INFECTIOUS DISEASES

Highlights from the conference on retroviruses and opportunistic infections 2016 : 22-25 February 2016, Boston, Massachusetts, USA

S FidlerJ AnanworanichLinos VandekerckhoveMaja KiselinovaA SchuetzJH VeraE DwyerJ Alagaratnam

Editorial material

HIV-1 Vpr N-terminal tagging affects alternative splicing of the viral genome

Ann BaeyensEvelien NaessensAnouk Van NuffelKarin WeeningAnne-Marie ReillyEva ClaeysWim TrypsteenLinos VandekerckhoveSven EyckermanKris Gevaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy

A WinstonW StöhrA AntinoriA Arenas-PintoJM LibreH AmievaA CabieI WilliamsG Di PerriMJ Tellez et al.

A1 Journal Article in HIV MEDICINE

In search of predictive biomarkers of the replication-competent HIV-1 reservoir

Maja KiselinovaLinos VandekerckhoveWard De Spiegelaere

Infection-related and -unrelated malignancies, HIV and the aging population

L ShepherdA BorgesB LedergerberP DomingoA CastagnaJ RockstrohB KnyszJ TomazicI KarpovO Kirk et al.

A1 Journal Article in HIV MEDICINE

Integrated and total HIV-1 DNA predict ex vivo viral outgrowth

Maja KiselinovaWard De SpiegelaereMaria Jose BuzonEva MalatinkováMathias LichterfeldLinos Vandekerckhove

A1 Journal Article in PLOS PATHOGENS

Late presentation to HIV testing is overestimated when based on the consensus definition

A SasseE FlorenceA PharrisS De WitP LacorD Van BeckhovenJ DeblondeM-L DelforgeK FransenJ-C Goffard et al.

A1 Journal Article in HIV MEDICINE

Minimal requirements for primary HIV latency models based on a systematic review

Pawel BonczkowskiMarie-Angélique De ScheerderWard De SpiegelaereLinos Vandekerckhove

A1 Journal Article in AIDS REVIEWS

Modeling HIV-1 latency in primary T cells using a replication-competent virus

Laura MartinsPawel BonczkowskiAdam M SpivakWard De SpiegelaereCamille L NovisAna Beatriz DePaula-SilvaEva MalatinkováWim TrypsteenAlberto BosqueLinos Vandekerckhove et al.

A1 Journal Article in AIDS RESEARCH AND HUMAN RETROVIRUSES

Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models

Pawel BonczkowskiMarie-Angélique De ScheerderEva MalatinkováAlexandra BorchZora MelkovaRenate KoenigWard De SpiegelaereLinos Vandekerckhove

A1 Journal Article in SCIENTIFIC REPORTS

Sexual activity without condoms and risk of HIV transmission in serodifferent couples when the HIV-positive partner is using suppressive antiretroviral therapy

AJ RodgerV CambianoT BruunP VernazzaS CollinsJ van LunzenGM CorbelliV EstradaAM GerettiA Beloukas et al.

A1 Journal Article in JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The future of digital polymerase chain reaction in virology

Matthijs VynckWim TrypsteenOlivier ThasLinos VandekerckhoveWard De Spiegelaere

A1 Journal Article in MOLECULAR DIAGNOSIS & THERAPY

The long lasting impact of early treatment initiation on the size and dynamics of HIV-1 reservoirs

Eva MalatinkováLinos VandekerckhoveWard De Spiegelaere

The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure

Maja KiselinovaWard De SpiegelaereLinos Vandekerckhove

A2 Journal Article in JOURNAL OF VIRUS ERADICATION

Transmission of HIV drug resistance and the predicted effect on current first-line regimens in Europe

L Marije HofstraNicolas SauvageotJan AlbertIvailo AlexievFederico GarciaDaniel StruckDavid AMC Van de VijverBirgitta ÅsjöDanail BeshkovSuzie Coughlan et al.

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

2015

Accurate quantification of episomal HIV-1 two-long terminal repeat circles by use of optimized DNA isolation and droplet digital PCR

Eva MalatinkováMaja KiselinovaPawel BonczkowskiWim TrypsteenPeter MessiaenJOLIEN VERMEIREBruno VerhasseltKAREN VERVISCHLinos VandekerckhoveWard De Spiegelaere

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

Aviremia 10 years postdiscontinuation of antiretroviral therapy initiated during primary human immunodeficiency virus-1 infection and association with gag-specific T-cell responses

Sabine Kinloch-de LoesLucy DorellHongbing YangGareth AD HardySabine YerlyCristina CelleraiLinos VandekerckhoveWard De SpiegelaereEva MalatinkováWillie Wee Lee Koh et al.

A1 Journal Article in OPEN FORUM INFECTIOUS DISEASES

Aviremia 10-year post-ART discontinuation initiated at seroconversion

Sabine KinlochLucy DorrelHongbing YangLinos VandekerckhoveWard De SpiegelaereEva MalatinkovaSabine YerlyDaniel WebsterMargaret Johnson

Changing utilization of Stavudine (d4T) in HIV-positive people in 2006-2013 in the EuroSIDA study

D PodlekarevaD GrintI KarpovA RakmanovaK MansinhoN ChentsovaI ZeltinaM LossoM ParczewskiJD Lundgren et al.

A1 Journal Article in HIV MEDICINE

Comparison of digital PCR platforms and semi-nested qPCR as a tool to determine the size of the HIV reservoir

Kobus J BosmanMonique NijhuisPetra M Van HamAnnemarie MJ WensingKAREN VERVISCHLinos VandekerckhoveWard De Spiegelaere

A1 Journal Article in SCIENTIFIC REPORTS

Comparison of methods for in-house screening of HLA*B57:01 to prevent abacavir hypersensitivity in HIV-1 care

Ward De SpiegelaereJan PhilippéKAREN VERVISCHChris VerhofstedeEva MalatinkováMaja KiselinovaWim TrypsteenPawel BonczkowskiDirk VogelaersSteven Callens et al.

A1 Journal Article in PLOS ONE

Comprehensive longitudinal characterization of HIV-1 reservoir markers in patients on stable antiretroviral treatment

Maja KiselinovaWard De SpiegelaereMaria Jose BuzonEva MalatinkováMathias LichterfeldLinos Vandekerckhove

ddcRquant: threshold determination for single channel droplet digital PCR experiments

Wim TrypsteenMatthijs VynckJan De NevePawel BonczkowskiMaja KiselinovaEva MalatinkováKAREN VERVISCHOlivier ThasLinos VandekerckhoveWard De Spiegelaere

ddpcRquant: threshold determination for single channel droplet digital PCR experiments

Wim TrypsteenMatthijs VynckJan De NevePawel BonczkowskiMaja KiselinovaEva MalatinkováKAREN VERVISCHOlivier ThasLinos VandekerckhoveWard De Spiegelaere

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Drug resistance is rarely the cause or consequence of long-term persistent low-level viraemia in HIV-1-infected patients on ART

Leen VancoillieVirginie MortierEls DemecheleerMarlies SchauvliegeLinos VandekerckhoveDirk VogelaersChris Verhofstede

A1 Journal Article in ANTIVIRAL THERAPY

During stably suppressive antiretroviral therapy integrated HIV-1 DNA load in peripheral blood is associated with the frequency of CD8 cells expressing HLA-DR/DP/DQ

Alessandra RuggieroWard De SpiegelaereAlessandro Cozzi-LepriMaja KiselinovaGeorgios PollakisApostolos BeloukasLinos VandekerckhoveMatthew StrainDouglas RichmanAndrew Phillips et al.

A1 Journal Article in EBIOMEDICINE

Efficacy of tenofovir and efavirenz in combination with lamivudine or emtricitabine in antiretroviral-naive patients in Europe

JE SwartzLinos VandekerckhoveH AmmerlaanAC de VriesJ BegovacWFW BiermanCAB BoucherME van der EndeZ GrossmanR Kaiser et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Extreme value theory for threshold determination in droplet digital PCR experiments

Matthijs VynckWim TrypsteenJan De NevePawel BonczkowskiMaja KiselinovaEva MalatinkováKAREN VERVISCHOlivier ThasLinos VandekerckhoveWard De Spiegelaere

Fluoxetine suppresses calcium signaling in human T lymphocytes through depletion of intracellular calcium stores

Veerle GobinMarijke De BockBart BroeckxMaja KiselinovaWard De SpiegelaereLinos VandekerckhoveKatleen Van SteendamLuc LeybaertDieter Deforce

A1 Journal Article in CELL CALCIUM

HIV resistance testing and detected drug resistance in Europe

Anna SchultzeAndrew N PhillipsRoger ParedesManuel BattegayJürgen K RockstrohLadislav MachalaJanez TomazicPierre M GirardInga JanuskevicaKamilla Gronborg-Laut et al.

A1 Journal Article in AIDS

HIV-1 RNA and HIV-1 DNA persistence during suppressive ART with PI-based or nevirapine-based regimens

Maja KiselinovaAnna Maria GerettiEva MalatinkováKAREN VERVISCHApostolos BeloukasPeter MessiaenPawel BonczkowskiWim TrypsteenSteven CallensChris Verhofstede et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and mucosal reservoirs

Eva MalatinkováWard De SpiegelaerePawel BonczkowskiMaja KiselinovaWim TrypsteenMargaret JohnsonChris VerhofstedeDanny De LoozeCharles MurraySabine Kinloch-de Loes et al.

A1 Journal Article in ELIFE

Impact of a decade of successful antiretroviral therapy started during HIV-1 seroconversion on blood and gut reservoirs

Sabine Kinloch-de LoesEva MalatinkováWard De SpiegelaerePawel BonczkowskiMaja KiselinovaKAREN VERVISCHWim TrypsteenMargaret JohnsonDanny De LoozeLinos Vandekerckhove

Integration site analysis of latently infected cell lines: evidence of ongoing replication

Jory SymonsSharon LewinAbha ChopraEva MalatinkováWard De SpiegelaereShay LearyDavid CooperLinos VandekerckhoveSimon MallalPaul Cameron

Long-term early antiretroviral therapy limits the HIV-1 reservoir size as compared to later treatment initiation but not to levels found in long-term non-progressors

Eva MalatinkováWard De SpiegelaerePawel BonczkowskiMaja KiselinovaKAREN VERVISCHWim TrypsteenMargaret JohnsonChris VerhofstedeDanny De LoozeCharles Murray et al.

Primary resistance to integrase strand-transfer inhibitors in Europe

M CasadellàPM van HamM Noguera-JulianA van KesselC PouLM HofstraJR SantosF GarciaD StruckI Alexiev et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Reference gene validation for RT-qPCR, a note on different available software packages

Ward De SpiegelaereJutta Dern-WielochRoswitha WeigelValérie SchumacherHubert SchorleDaniel NettersheimMartin BergmannRalph BrehmSabine KlieschLinos Vandekerckhove et al.

A1 Journal Article in PLOS ONE

Robust regression methods for real-time PCR

Wim TrypsteenJan De NeveKobus BosmanMonique NijhuisOlivier ThasLinos VandekerckhoveWard De Spiegelaere

Robust regression methods for real-time polymerase chain reaction

Wim TrypsteenJan De NeveKobus BosmanMonique NijhuisOlivier ThasLinos VandekerckhoveWard De Spiegelaere

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Th1/17 polarization of CD4 T cells supports HIV-1 persistence during antiretroviral therapy

Hong SunDhohyung KimXiaodong LiMaja KiselinovaZhengyu OuyangLinos VandekerckhoveHong ShangEric S RosenbergXu G YuMathias Lichterfeld

A1 Journal Article in JOURNAL OF VIROLOGY

Threshold determination in droplet digital PCR experiments using extreme value theory

Matthijs VynckWim TrypsteenJan De NevePawel BonczkowskiMaja KiselinovaEva MalatinkováKAREN VERVISCHOlivier ThasLinos VandekerckhoveWard De Spiegelaere

2014

A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe

A MocroftP ReissA RakhmanovaD BanhegyiAN PhillipsS De WitM RistolaJD LundgrenJ GrarupO Kirk et al.

A1 Journal Article in INFECTION

Accurate episomal HIV 2-LTR circles quantification using optimized DNA isolation and droplet digital PCR

Eva MalatinkováMaja KiselinovaPawel BonczkowskiWim TrypsteenPeter MessiaenJOLIEN VERMEIREBruno VerhasseltKaren VervischLinos VandekerckhoveWard De Spiegelaere

Antiretrovirals for HIV prevention: when should they be recommended?

Maja KiselinovaWard De SpiegelaereChris VerhofstedeSteven CallensLinos Vandekerckhove

A1 Journal Article in EXPERT REVIEW OF ANTI-INFECTIVE THERAPY

Characterization of serotonin transporter expression in human T lymphocytes

Veerle GobinKatleen Van SteendamMaja KiselinovaWard De SpiegelaereLinos VandekerckhoveDieter Deforce

Comparative performances of HIV-1 RNA load assays at low viral load levels: results of an international collaboration

Luke C SwensonBryan CobbAnna Maria GerettiP Richard HarriganMario PoljakCarole Seguin-DevauxChris VerhofstedeMarc WirdenAlessandra AmendolaJurg Boni et al.

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

Comparison of droplet digital PCR and seminested real-time PCR for quantification of cell-associated HIV-1 RNA

Maja KiselinovaAlexander O PasternakWard De SpiegelaereDirk VogelaersBen BerkhoutLinos Vandekerckhove

A1 Journal Article in PLOS ONE

Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient

Jori SymonsLinos VandekerckhoveGero HutterAnnemarie MJ WensingPetra M van HamSteven G DeeksMonique Nijhuis

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

Deteriorating renal function and clinical outcomes in HIV-positive persons

Amanda MocroftLene RyomJosip BegovacAntonella D'Arminio MonforteAnne VassilenkoJose GatellEric FlorenceVidar OrmaasenOle KirkJens D Lundgren et al.

A1 Journal Article in AIDS

Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study

David A KamaraLene RyomMichael RossOle KirkPeter ReissPhilippe MorlatOlivier MoranneChristoph A FuxAmanda MocroftCaroline Sabin et al.

A1 Journal Article in BMC NEPHROLOGY

Disseminated infection with Mycobacterium tilburgii in a male immunocompromised patient

SARAH TEMMERMANLinos VandekerckhoveERICA SERMIJNDirk VogelaersGeert ClaeysMario VaneechouttePiet CoolsSteven Callens

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

Factors associated with the continuum of care of HIV infected patients in Belgium

Dominique Van BeckhovenPatrick LacorMichel MoutschenDenis PiérardAndré SasseDolorès VairaSigi Van den WijngaertBernard VandercamMarc Van RanstEric Van Wijngaerden et al.

Immuno-virological discordance and the risk of non-AIDS and AIDS events in a large observational cohort of HIV-patients in Europe

Alexander ZoufalyAlessandro Cozzi-LepriJoanne ReekieOle KirkJens LundgrenPeter ReissDjordje JevtovicLadislav MachalaRobert ZangerleAmanda Mocroft et al.

A1 Journal Article in PLOS ONE

Implementation of a multidisciplinary infectious diseases team in a tertiary hospital within an Antimicrobial Stewardship Program

Franky BuyleMATTHIAS WALLAERTNATHALIE BECKJerina BoelensSteven CallensGeert ClaeysSABINE DERYCKEREEVELIEN HAEGEMANIsabel Leroux-RoelsERICA SERMIJN et al.

A1 Journal Article in ACTA CLINICA BELGICA

Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe

Dineke FrentzDavid AMC Van de VijverAna B AbecasisJan AlbertOsamah HamoudaLouise B JørgensenClaudia KüchererDaniel StruckJean-Claude SchmitJurgen Vercauteren et al.

A1 Journal Article in BMC INFECTIOUS DISEASES

Increased incidence of antiretroviral drug discontinuation among patients with viremic hepatitis C virus coinfection and high hyaluronic acid, a marker of liver fibrosis

Daniel GrintLars PetersJuergen K RockstrohStephane De WitVictor M MitsuraBrygida KnyszCourt PedersenOle KirkJens D LundgrenAmanda Mocroft et al.

A1 Journal Article in AIDS

Increased risk of cardiovascular disease (CVD) with age in HIV-positive men: a comparison of the D:A:D CVD risk equation and general population CVD risk equations

K PetoumenosP ReissL RyomM RickenbachCA SabinW El-SadrAD MonforteAN PhillipsS De WitO Kirk et al.

A1 Journal Article in HIV MEDICINE

Markers associated with persisting low-level viraemia under antiretroviral therapy in HIV-1 infection

Leen VancoillieEls DemecheleerSteven CallensDirk VogelaersLinos VandekerckhoveVirginie MortierChris Verhofstede

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Patterns of transmitted HIV drug resistance in Europe vary by risk group

Dineke FrentzDavid van de VijverAna AbecasisJan AlbertOsamah HamoudaLouise JørgensenClaudia KüchererDaniel StruckJean-Claude SchmitJurgen Vercauteren et al.

A1 Journal Article in PLOS ONE

Processing of blood samples influences PBMC viability and outcome of cell-mediated immune responses in antiretroviral therapy-naïve HIV-1-infected patients

Patricia BourguignonFrédéric ClementFrédéric RenaudVivien Le BrasMarguerite KoutsoukosWivine BurnyPhilippe MorisClarisse LorinAlix CollardGeert Leroux-Roels et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons

Leah ShepherdJean-Claude SouberbielleJean-Philippe BastardSoraya FellahiJaqueline CapeauJoanne ReekiePeter ReissAnders BlaxhultMarkus BickelClifford Leen et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Quantification of integrated HIV DNA by repetitive-sampling Alu-HIV PCR on the basis of Poisson statistics

Ward De SpiegelaereEva MalatinkováLindsay LynchFilip Van NieuwerburghPeter MessiaenUna O'DohertyLinos Vandekerckhove

A1 Journal Article in CLINICAL CHEMISTRY

Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs

Pawel BonczkowskiWard De SpiegelaereAlberto BosqueCory H WhiteAnouk Van NuffelEva MalatinkováMaja KiselinovaWim TrypsteenWojciech WitkowskiJOLIEN VERMEIRE et al.

A1 Journal Article in RETROVIROLOGY

Ritonavir-boosted darunavir combined with raltegravir or tenofovir-emtricitabine in antiretroviral-naive adults infected with HIV-1: 96 week results from the NEAT001/ANRS143 randomised non-inferiority trial

François RaffiAbdel G BabikerLaura RichertJean-Michel MolinaElizabeth C GeorgeAndrea AntinoriJose R ArribasJesper GrarupFleur HudsonChristine Schwimmer et al.

A1 Journal Article in LANCET

The impact of nevirapine- versus protease inhibitor-based regimens on virological markers of HIV-1 persistence during seemingly suppressive ART

Maja KiselinovaMaria AnnaEva MalatinkováKAREN VERVISCHApostolos BeloukasPeter MessiaenPawel BonczkowskiWim TrypsteenSteven CallensChris Verhofstede et al.

Thrombocytopenia is associated with an increased risk of cancer during treated HIV disease

Álvaro H BorgesJens D LundgrenAnnalisa RidolfoChristine KatlamaFrancisco AntunesAnna GrzeszczukAnders BlaxhultViktar M MitsuraManuela DoroanaManuel Battegay et al.

A1 Journal Article in AIDS

Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D) : a multicohort collaboration

CJ SmithL RyomR WeberP MorlatC PradierP ReissJD KowalskaS de WitM LawW el Sadr et al.

A1 Journal Article in LANCET

2013

A translational approach to new diagnostic tools and therapies for HIV care

Peter MessiaenLinos VandekerckhoveDirk Vogelaers

Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: the D:A:D study

Lene RyomAmanda MocroftOle KirkSigne W WormDavid A KamaraPeter ReissMichael RossChristoph A FuxPhilippe MorlatOlivier Moranne et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Associations between immune depression and cardiovascular events in HIV infection

Caroline A SabinLene RyomStephane De WitAmanda MocroftAndrew N PhillipsSigne W WormRainer WeberAntonella D'Arminio MonfortePeter ReissDavid Kamara et al.

A1 Journal Article in AIDS

Boosted protease inhibitor monotherapy in HIV-infected adults: outputs from a pan-European expert panel meeting

José R ArribasManuela DoroanaDan TurnerLinos VandekerckhoveAdrian Streinu-Cercel

A1 Journal Article in AIDS RESEARCH AND THERAPY

Calciphylaxis: a rare complication in alcoholic liver disease

ERICA SERMIJNTINE STROBBELinos VandekerckhoveLouis LibbrechtIsabelle ColleR SchoonjansDirk Vogelaers

A1 Journal Article in ACTA CLINICA BELGICA

CD4 cell count and viral load-specific rates of AIDS, non-AIDS and deaths according to current antiretroviral use

Amanda MocroftAndrew N PhillipsJose GatellAndrej HorbanBruno LedergerberKai ZilmerDjordje JevtovicFernando MaltezDaria PodlekarevaJens D Lundgren et al.

A1 Journal Article in AIDS

Clinical use of HIV integrase inhibitors : a systematic review and meta-analysis

Peter MessiaenAnnemarie MJ WensingAxel FunMonique NijhuisNele BrusselaersLinos Vandekerckhove

A1 Journal Article in PLOS ONE

Cutaneous metastatic tuberculous abcess in a patient with cervico-mediastinal lymphatic tuberculosis

SVEN DEKEYZERF MoermanSteven CallensLinos Vandekerckhove

A1 Journal Article in ACTA CLINICA BELGICA

Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infection

Sharon L WalmsleyAntonio AntelaNathan ClumeckDan DuiculescuAndrea EberhardFelix GutiérrezLaurent HocquelouxFranco MaggioloUriel SandkovskyCatherine Granier et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Droplet digital PCR, the new tool in HIV reservoir quantification?

Ward De SpiegelaereMaja KiselinovaEva MalatinkováAlexander PasternakBen BerkhoutLinos Vandekerckhove

Frequency and predictors of HIV-1 co-receptor switch in treatment naive patients

Virginie MortierKenny DauweLeen VancoillieDelfien StaelensFilip Van WanzeeleDirk VogelaersLinos VandekerckhoveKristen ChalmetChris Verhofstede

A1 Journal Article in PLOS ONE

Limited cross-border infections in patients newly diagnosed with HIV in Europe

Dineke FrentzAnnemarie MJ WensingJan AlbertDimitrios ParaskevisAna B AbecasisOsamah HamoudaLouise B JørgensenClaudia KüchererDaniel StruckJean-Claude Schmit et al.

A1 Journal Article in RETROVIROLOGY

Non-AIDS defining cancers in the D:A:D Study : time trends and predictors of survival: a cohort study

Signe W WormMark BowerPeter ReissFabrice BonnetMatthew LawGerd FätkenheuerAntonella d'Arminio MonforteDonald I AbramsAndrew GrulichEric Fontas et al.

A1 Journal Article in BMC INFECTIOUS DISEASES

Polyfunctional CD4⁺ T cell responses in HIV-1 infected viral controllers compared with those in healthy recipients of an adjuvanted polyprotein HIV-1 vaccine

Eva Van BraeckelIsabelle DesombereFrédéric ClementLinos VandekerckhoveChris VerhofstedeDirk VogelaersGeert Leroux-Roels

A1 Journal Article in VACCINE

Quantification of integrated HIV DNA by repetitive sampling Alu-HIV PCR and Poisson statistics

Ward De SpiegelaereEva MalatinkováFilip Van NieuwerburghUna O'DohertyLinos Vandekerckhove

Stability of hepatitis C virus (HCV) RNA levels among interferon-naïve HIV/HCV-coinfected individuals treated with combination antiretroviral therapy

D GrintL PetersJ ReekieV SorianoO KirkB KnyszO SuetnovA LazzarinB LedergerberJK Rockstroh et al.

A1 Journal Article in HIV MEDICINE

Temporal changes and regional differences in treatment uptake of hepatitis C therapy in EuroSIDA

D GrintL PetersC Schwarze-ZanderM BeniowskiC PradierM BattegayD JevtovicV SorianoJD LundgrenJK Rockstroh et al.

A1 Journal Article in HIV MEDICINE

Touchdown digital PCR for quantification of difficult amplicons in the HIV genome

Ward De SpiegelaereEva MalatinkováMaja KiselinovaPawel BonczkowskiChris VerhofstedeDirk VogelaersLinos Vandekerckhove

Touchdown digital polymerase chain reaction for quantification of highly conserved sequences in the HIV-1 genome

Ward De SpiegelaereEva MalatinkováMaja KiselinovaPawel BonczkowskiChris VerhofstedeDirk VogelaersLinos Vandekerckhove

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

2012

A national cohort of HIV-infected patients in Belgium: design and main characteristics

D Van BeckhovenA BuvéJ RuelleL SeylerA Sassethe Belgian HIV cohort study groupDirk VogelaersLinos Vandekerckhove

A1 Journal Article in ACTA CLINICA BELGICA

Characterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression

Peter MessiaenWard De SpiegelaereJose AlcamiKaren VervischPetra Van AckerBruno VerhasseltPieter MeuwissenEsther CalongeNuria GonzalezFelix Gutierrez-Rodero et al.

A1 Journal Article in PLOS ONE

Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial

Edwin DeJesusJürgen K RockstrohKeith HenryJean-Michel MolinaJoseph GatheSrinivasan RamanathanXuelian WeiKitty YaleJavier SwarcbergKirsten White et al.

A1 Journal Article in LANCET

Comprehensive characterization of LEDGF/p75 in a HIV-1 infected patient cohort

Peter MessiaenWard De SpiegelaereJose AlcamiPaul CouckePetra Van AckerKaren VervischBruno VerhasseltPieter MeeuwissenBruce PoppeDirk Vogelaers et al.

Correlation of coreceptor usage and disease progression

Chris VerhofstedeMonique NijhuisLinos Vandekerckhove

A1 Journal Article in CURRENT OPINION IN HIV AND AIDS

Hepatitis C virus viremia increases the incidence of chronic kidney disease in HIV-infected patients

Lars PetersDaniel GrintJens D LundgrenJürgen K RockstrohVincent SorianoPeter ReissAnna GrzeszczukHelen SambatakouAmanda MocroftOle Kirk et al.

A1 Journal Article in AIDS

Heterogeneity in outcomes of treated HIV-positive patients in Europe and North America: relation with patient and cohort characteristics

Margaret T MayRobert S HoggAmy C JusticeBryan E ShepherdDominique CostagliolaBruno LedergerberRodolphe ThiébautM John GillOle KirkArd van Sighem et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Impact of triplicate testing on HIV genotypic tropism prediction in routine clinical practice

J SymonsLinos VandekerckhoveR ParedesChris VerhofstedeR BellidoEls DemecheleerPM van HamSFL van LelyveldAJ StamD van Versendaal et al.

A1 Journal Article in CLINICAL MICROBIOLOGY AND INFECTION

Predicting the short-term risk of diabetes in HIV-positive patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study

Kathy PetoumenosSigne W WormEric FontasRainer WeberStephane De WitMathias BruyandPeter ReissWafaa El-SadrAntonella D'Arminio MonforteNina Friss-Moller et al.

A1 Journal Article in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY

Presence of CXCR4-using HIV-1 in patients with recently diagnosed infection: correlates and evidence for transmission

Kristen ChalmetKenny DauweLander FoquetFranky BaatzCarole Seguin-DevauxBeatrijs Van Der GuchtDirk VogelaersLinos VandekerckhoveJean PlumChris Verhofstede

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Regional differences in AIDS and non-AIDS related mortality in HIV-positive individuals across Europe and Argentina : the EuroSIDA study

Joanne ReekieJustyna D KowalskaIgor KarpovJurgen RockstrohAnders KarlssonAza RakhmanovaAndrzej HorbanOle KirkJens D LundgrenAmanda Mocroft et al.

A1 Journal Article in PLOS ONE

The clinical benefits of antiretroviral therapy in severely immunocompromised HIV-1-infected patients with and without complete viral suppression

Amanda MocroftWendy P BannisterOle KirkJystyna D KowalskaPeter ReissAntonella D'Arminio-MonforteJose GatellMartin FisherHanna TrochaAza Rakhmanova et al.

A1 Journal Article in ANTIVIRAL THERAPY

The cure of the 'Berlin patient': why did pre-existing X4-variants not emergence after allogeneic CCR5-Delta 32 SCT?

J SymonsS DeeksG HutterA WensingJ MartinP van HamLinos VandekerckhoveM Nijhuis

Ultra-deep sequencing of HIV-1 reverse transcriptase before start of an NNRTI-based regimen in treatment-naive patients

Peter MessiaenChris VerhofstedeIna VandenbrouckeSylvie DinakisVeerle Van EygenKim ThysBart WintersJeroen AerssensDirk VogelaersLieven J Stuyver et al.

A1 Journal Article in VIROLOGY

2011

A comparison of the long-term durability of nevirapine, efavirenz and lopinavir in routine clinical practice in Europe: a EuroSIDA study

J ReekieP ReissB LedergerberD SedlacekM ParczewskiJ GatellC KatlamaG FätkenheuerJD LundgrenA Mocroft et al.

A1 Journal Article in HIV MEDICINE

A standardized algorithm for determining the underlying cause of death in HIV infection as AIDS or non-AIDS related: results from the EuroSIDA study

Justyna D KowalskaAmanda MocroftBruno DergerberEric FlorenceMatti RistolaJosip BegovacHelen SambatakouCourt PedersenJens D LundgrenOle Kirk et al.

A1 Journal Article in HIV CLINICAL TRIALS

A376S in the connection subdomain of HIV-1 reverse transcriptase confers increased risk of virological failure to nevirapine therapy

Roger ParedesMaria Carmen PuertasWendy BannisterMónica KisicAlessandro Cozzi-lepriChristian PouRocío BellidoGilberto BetancorJohannes BognerPanagiotis Gargalianos et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Comparison of phenotypic and genotypic tropism determination in triple-class-experienced HIV patients eligible for maraviroc treatment

Linos VandekerckhoveChris VerhofstedeEls DemecheleerStephane De WitEric FlorenceKatrien FransenMichel MoutschenWendy MostmansKabamba KabeyaNicola Mackie et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Comprehensive characterization of LEDGF/p75 in a HIV-1-infected patient cohort

Peter MessiaenWard De SpiegelaereChris VerhofstedePaul CouckePetra Van AckerPhilip VlummensKAREN VERVISCHDirk VogelaersBruce PoppeJose Alcami et al.

Concordance between HIV-1 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA

Chris VerhofstedeD BrudneyJacqueline ReynaertsD VairaK FransenA De BelC Seguin-DevauxS De WitLinos VandekerckhoveA-M Geretti

A1 Journal Article in HIV MEDICINE

Estimating prevalence of accumulated HIV-1 drug resistance in a cohort of patients on antiretroviral therapy

Wendy P BannisterAlessandro Cozzi-LepriJesper KjærClotet BonaventuraAdriano LazzarinJean-Paul ViardGitte KronbergDan DuiculescuMarek BeniowskLadislav Machala et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

European guidelines on the clinical management of HIV-1 tropism testing

Linos VandekerckhoveAMJ WensingR KaiserF Brun-VézinetB ClotetA De LucaS DresslerF GarciaAM GerettiT Klimkait et al.

A1 Journal Article in LANCET INFECTIOUS DISEASES

Fatal and nonfatal AIDS and non-AIDS events in HIV-1-positive individuals with high CD4 cell counts according to viral load strata

Joanne ReekieJose M GatellIsrael YustElzbieta BakowskaAza RakhmanovaMarcelo LossoMaksym KrasnovPatrick FrancioliJustyna D KowalskaAmanda Mocroft et al.

A1 Journal Article in AIDS

Selection of the raltegravir resistance pathway is affected by the HIV-1 population size

A FunLinos VandekerckhoveM DäumerA ThielenB BuchholzLJ Maarschalk-EllerbroekPJ SchipperAMJ WensingM Nijhuis

Tuberculosis among HIV-positive patients across Europe: changes over time and risk factors

Alexey KrukWendy BannisterDaria N PodlekarevaNelly P ChentsovaAza G RakhmanovaAndrzej HorbanPerre DomingoAmanda MocroftJens D LundgrenOle Kirk et al.

A1 Journal Article in AIDS

Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study

Jean-Paul ViardJean-Claude SouberbielleOle KirkJoanne ReekieBrygida KnyszMarcelo LossoJose GatellCourt PedersenJohannes R BognerJens D Lundgren et al.

A1 Journal Article in AIDS

2010

An adjuvanted protein HIV vaccine induces polyfunctional CD4 T-cell responses in healthy volunteers similar to those in HIV-infected viral controllers

Eva Van BraeckelFrédéric ClementLinos VandekerckhoveDirk VogelaersGeert Leroux-Roels

An adjuvanted protein HIV vaccine induces polyfunctional CD4(+) T-cell responses in healthy volunteers similar to those in HIV-infected viral controllers

Eva Van BraeckelFrédéric ClementLinos VandekerckhoveDirk VogelaersGeert Leroux-Roels

Dialysis and renal transplantation in HIV-infected patients: a European survey

Joan Carles TrullasAmanda MocroftFederico CofanJérome TourretAsunción MorenoCorinne Isnard BagnisChristoph Andreas FuxChristine KatlamaPeter ReissJens Lundgren et al.

A1 Journal Article in JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Effect of triplicate testing on genotypic tropism prediction in routine clinical practice

J SymonsLinos VandekerckhoveR ParedesChris VerhofstedeR BellidoEls DemecheleerPaulyn Van HammeSFL van LelyveldAL StamD van Versendaal et al.

Epidemiological study of phylogenetic transmission clusters in a local HIV-1 epidemic reveals distinct differences between subtype B and non-B infections

Kristen ChalmetDelfien StaelensStijn BlotSylvie DinakisJolanda PelgromJean PlumDirk VogelaersLinos VandekerckhoveChris Verhofstede

A1 Journal Article in BMC INFECTIOUS DISEASES

Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients

Amanda MocroftOle KirkPeter ReissStephane De WitDalibor SedlacekMarek BeniowskiJose GatellAndrew N PhillipsBruno LedergerberJens D Lundgren et al.

A1 Journal Article in AIDS

GSK-1349572, a novel integrase inhibitor for the treatment of HIV infection

Linos Vandekerckhove

A1 Journal Article in CURRENT OPINION IN INVESTIGATIONAL DRUGS

High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates

Jens VerheyenChris VerhofstedeElena KnopsLinos VandekerckhoveAxel FunDiede BrunenKenny DauweAnnemarie MJ WensingHerbert PfisterRolf Kaiser et al.

A1 Journal Article in AIDS

High prevalence of the metabolic syndrome in HIV-infected patients: impact of different definitions of the metabolic syndrome

Signe W WormNina Friss-MøllerMathias BruyandAntonella D'Arminio MonforteMartin RickenbachPeter ReissWafaa El-SadrAndrew PhilipsJens LundgrenCaroline Sabin et al.

A1 Journal Article in AIDS

History of viral suppression on combination antiretroviral therapy as a predictor of virological failure after a treatment change

J ReekieA MocroftB LedergerberM BeniowskiB ClotetJ Van LunzenA ChiesiC PradierL MachaleJD Lundgren et al.

A1 Journal Article in HIV MEDICINE

HIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays

Ina VandenbrouckeHerwig Van MarckWendy MostmansVeerle Van EygenEvelien RondelezKim ThysKurt Van BaelenKatrien FransenDolores VairaKabamba Kabeya et al.

A1 Journal Article in AIDS RESEARCH AND THERAPY

Impaired hemoglobin scavenging during an acute HIV-1 retroviral syndrome

Joris DelangheJan PhilippéFILIP MOERMANMarc De BuyzereLiesbeth L VynckierAlain VerstraeteDirk VogelaersLinos Vandekerckhove

A1 Journal Article in CLINICA CHIMICA ACTA

Invasive infection with Rhodococcus equi : two case reports and review of literature

VINCIANE GUYSSENSLinos VandekerckhoveIsabelle ColleP De RudderStijn BlotDirk Vogelaers

A1 Journal Article in ACTA CLINICA BELGICA

Morbidity and mortality of bloodstream infections in patients with severe burn injury

Nele BrusselaersStan MonstreyThomas SnoeijDominique VandijckChristelle LizyEric HosteSTEFAAN LAUWAERTKirsten ColpaertLinos VandekerckhoveDirk Vogelaers et al.

A1 Journal Article in AMERICAN JOURNAL OF CRITICAL CARE

O121. Consensus statement of the European guidelines on clinical management of HIV-1 tropism testing

Linos VandekerckhoveAMJ WensingR KaiserF Brun-VezinetB ClotetA De LucaS DresslerF GarciaAM GerettiT Klimkait et al.

Predicting the risk of cardiovascular disease in HIV-infected patients: the Data collection on Adverse Effects of Anti-HIV Drugs Study

Nina Friis-MøllerRodolphe ThiébautPeter ReissRainer WeberAntonella D'Arminio MonforteStephane De WitWafaa El-SadrEric FontasSigne WormOle Kirk et al.

A1 Journal Article in EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

Predictors of hepatitis B virus genotype and viraemia in HIV-infected patients with chronic hepatitis B in Europe

Victor SorianoAmanda MocroftLars PetersJürgen RockstrohFrancisco AntunesNikolai KirkbyStephane De WitAntonella d'Arminio MonforteRobert FlisiakJens Lundgren et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Serious fatal and nonfatal non-AIDS-defining illnesses in Europe

Amanda MocroftPeter ReissJacek GasiorowskiBruno LedergerberJustyna KowalskaAntonio ChiesiJose GatellAza RakhmanovaMargaret JohnsonOle Kirk et al.

A1 Journal Article in JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Severe drug-induced liver injury associated with prolonged use of Linezolid

Liesbet De BusPieter DepuydtLouis LibbrechtLinos VandekerckhoveJOKE NOLLETDominique BenoitDirk VogelaersHans Van Vlierberghe

A2 Journal Article in JOURNAL OF MEDICAL TOXICOLOGY

2009

Comparison of population and 454 genotyping and Trofile phenotyping for tropism determination in patients selected for maraviroc initiation

Linos VandekerckhoveChris VerhofstedeI VandenbrouckeC BoothH Van MarckAM GerettiL Stuyver

CXCR4-using HIV type 1 variants are more commonly found in peripheral blood mononuclear cell DNA than in plasma RNA

Chris VerhofstedeLinos VandekerckhoveVeerle Van EygenEls DemecheleerIna VandenbrouckeBart WintersJean PlumDirk VogelaersLieven Stuyver

A1 Journal Article in JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Evaluation of antibiotic dosages in patients with reduced kidney function

Franky BuyleTine VerdonckDirk VogelaersJohan DecruyenaereLinos VandekerckhoveTOM FIERSAnnemieke DhondtHugo Robays

High prevalence of bevirimat resistance mutations in non-B subtypes and in PI-resistant HIV isolates

J VerheyenChris VerhofstedeE KnopsLinos VandekerckhoveA FunD BrunenKenny DauweA WensingH PfisterR Kaiser et al.

Maraviroc: perspectives for use in antiretroviral-naive HIV-1-infected patients

Linos VandekerckhoveChris VerhofstedeDirk Vogelaers

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Outcome and resources use of severe burn injury patients with nosocomial bloodstream infection : results of a matched cohort study

Nele BrusselaersStan MonstreyEric HosteChristelle LizyDominique VandijckLinos VandekerckhoveLieven AnnemansDirk VogelaersStijn Blot

Population and clonal tropism phenotyping of clinical isolates and comparison with next generation sequencing and prediction tools

K Van BaelenE RondelezL Van WesenbeeckW MostmansH Van MarckV Van EygenChris VerhofstedeLinos VandekerckhoveI VandenbrouckeL Stuyver

Risk factors for treatment-limiting toxicities in patients starting nevirapine-containing antiretroviral therapy

Anouk M KesselringFerndinand W WitCaroline A SabinJens D LundgrenM John GillJose M GatellAndri RauchJulio S MontanerFrank De WolfPeter Reiss et al.

A1 Journal Article in AIDS

2008

Abacavir hypersensitivity

Linos VandekerckhoveStijn BlotDirk Vogelaers

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Fluconazole exposure and selection for Candida non-albicans

Dominique VandijckStijn BlotLinos VandekerckhoveDirk Vogelaers

A1 Journal Article in ANESTHESIA AND ANALGESIA

Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability - A study of 4 individuals infected with closely related HIV-1 strains

Kristen ChalmetFilip Van WanzeeleEls DemecheleerKenny DauweJolanda PelgromBeatrijs Van Der GuchtDirk VogelaersJean PlumLieven StuyverLinos Vandekerckhove et al.

A1 Journal Article in Virology

Maraviroc: integration of a new antiretroviral drug class into clinical practice

Linos VandekerckhoveChris VerhofstedeDirk Vogelaers

A1 Journal Article in Journal of Antimicrobial Chemotherapy

Resistance pathway analysis of diketo acid-based integrase inhibitors allows mapping and prediction of chemical properties of integrase inhibitors

A VoetF ChristM De MaeyerZ DebyserLinos Vandekerckhove

2007

Detection of drug resistance mutations as a predictor of subsequent virological failure in patients with HIV-1 viral rebounds of less than 1,000 RNA copies/ml

Chris VerhofstedeFilip Van WanzeeleBeatrijs Van Der GuchtJolanda PelgromLinos VandekerckhoveJean PlumDirk Vogelaers

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

Lentiviral nuclear import: a complex interplay between virus and host

Jan De rijckLinos VandekerckhoveFrauke ChristZeger Debyser

A1 Journal Article in BIOESSAYS

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV

Anneleen HombrouckJan De RijckJelle HendrixLinos VandekerckhoveArnout VoetMarc De MaeyerMyriam WitvrouwYves EngelborghsFrauke ChristRik Gijsbers et al.

A1 Journal Article in PLOS PATHOGENS

2006

Cellular co-factors of HIV-1 integration

Bénédicte Van MaeleKatrien BusschotsLinos VandekerckhoveFrauke ChristZeger Debyser

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

Jan De RijckLinos VandekerckhoveRik GijsbersAnneleen HombrouckJelle HendrixJo VercammenYves EngelborghsFrauke ChristZeger Debyser

A1 Journal Article in JOURNAL OF VIROLOGY

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

Linos VandekerckhoveFrauke ChristBénédicte Van MaeleJan De RijckRik GijsbersChris Van den HauteMyriam WitvrouwZeger Debyser

A1 Journal Article in JOURNAL OF VIROLOGY

2005

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

Stéphane EmilianiAurélie MousnierKatrien BusschotsMarlène MarounBénédicte Van MaeleDenis TempeLinos VandekerckhoveFanny MoisantLilia Ben-SlamaMyriam Witvrouw et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY