Close the gates! Alphaherpesvirus-induced closure of gap junctions and its consequences for the antiviral response

Alphaherpesvirus-induced downregulation of ligands for the activating NK cell receptor NKG2D

Doctoral project Alexander Tishchenko Khoruzh

Doctoral project Maria Setas Lopes Pontes

Doctoral project Nina Van Opdenbosch

Doctoral project Robert Jansens

Doctoral project Ruth Verhamme

Doctoral project Thary Jacob

Functions of porcine gamma-delta T lymphocytes

HIDING AND RESIDING – Pseudorabies virus-induced downregulation of ligands for the activating NK cell receptor NKG2D and comparison of porcine blood with liver NK cells

Identification of alphaherpesvirus mechanisms that suppress the activity of plasmacytoid dendritic cells

Pseudorabies virus interaction with innate antiviral interferons in porcine epithelial cells

Pseudorabies virus interaction with the NF-êB signaling pathway in epithelial cells

Pseudorabies virus-mediated activation and inhibition of the porcine inflammasome

Uncovering the mechanism underlying and consequences of alphaherpesvirus-induced formation of tunneling nanotubes (TNTs)

Who is pulling the strings – Unraveling the interactions between pseudorabies virus and plasmacytoid dendritic cells

Doctoral project Jun Xiang

Doctoral project Katrien Poelaert

Early pathogenesis of African swine fever

Japanese encephalitis virus infection in its natural amplification and reservoir host, the pig -Immune responses in an asymptomatic host

SETTING THE STAGE : Impact of beta-glucans and the liver environment on porcine natural killer cells

Study of flavivirus interactions with indigenous mosquitoes and natural amplification hosts

Alphaherpesviruses and the innate antiviral defence in the respiratory and genital tract: a fight for supremacy

Alphaherpesvirus-induced downregulation of ligands for the activating NK cell receptor NKG2D

Alphaherpesvirus-induced downregulation of ligands for the activating NK cell receptor NKG2D

Alphaherpesvirus-mediated modulation of plasmacytoid dendritic cells

Alphaherpesvirus-mediated modulation of plasmacytoid dendritic cells

Antigen presentation and memory-like responses by porcine natural killer cells and their potential for alphaherpesvirus vaccine design.

BOF-ZAP professorship in veterinary immunology

Characterization of the effects of the US3 protein of alphaherpesviruses on the cytoskeleton and viral spread in order to identify new antiviral strategies

Herpesvirus interactions with cellular signaling pathways, and their consequences for virus immune evasion and spread.

Hijacking of antigen-presenting cells by viruses to facilitate spread and subvert the immune response

Identification of alphaherpesvirus mechanisms that suppress the activity of plasmacytoid dendritic cells

Impact of peripheral virus infection on the central nervous system

Inhibition and activation of Natural Killer (NK) cells by alphaherpesviruses

Interaction of alphaherpesviruses with the type III interferon system in the upper respiratory tract

Interaction of alphaherpesvirus glycoproteins with natural killer cells and dendritic cells

In vitro model of alphaherpesvirus latency and reactivation

Live cell analysis equipment for the study of biosafety level BSL3 pathogens

Modulation of NK cells by alpha herpes viruses with the aim of optimizing vaccines and virotherapy

Natural killer (NK) cell memory in the pig

Optimization of an in vitro model for the induction of a latent herpesvirus infection for alpha

Optimized activation of plasmacytoid dendritic cells to increase Th1 responses in the pig

Recent data predict an increased risk for virus transmission upon Japanese encephalitis virus (JEV) introduction in pigs: Study of JEV induced immune responses and evaluation of diagnostic tests

Recognition of alfaherpesvirus envelope glycoproteins by dendritic cells and natural killer cells

Semi-confocal microscopy system for the study of virus-cell interactions and cell migration

The herpesvirus toolkit to elucidate the molecular biology of tunneling nanotubes (TNTs) and TNT-like cell projections

The mechanism of alphaherpesvirus US3-mediated activation of p21-activated kinases (PAKs) and its consequences on nuclear egress and viral spread.

Tunneling nanotubes induced by the US3 protein of alphaherpesviruses

Uncovering the mechanism underlying and consequences of alphaherpesvirus-induced formation of tunneling nanotubes (TNTs)

Uncovering the mechanism underlying and consequences of alphaherpesvirus-induced formation of tunneling nanotubes (TNTs)

Vector-free transmission of Japanese encehalitis virus (JEV) in pigs - increased risk associated with a potential emergence: Study of JEV pathogenesis in pigs upon infection via different inoculation route

Viral control of the epitranscriptome: alphaherpesvirus-induced m6A mRNA demethylation

Viral glycoprotein gB-dependent NFκB activation as a potential target for antivirals/vaccine design against alphaherpesvirus infections.

Virus-cell interactions of alphaherpesviruses that affect the innate immune response

A thorough study on the tumor suppressor genes BRCA1 and SYK during mammary tumorogenesis in dogs

Equipement for a new L3 laboratory enabling in vitro experiments with high risk pathogens

Fluorescene activated cell sorter

Identification of pathogen receptors and signal transduction pathways

Replacement of confocal fluorescence microscope for visualisation of biological processes in humans and animals

Robust, user-friendly and state-of-the-art fluorescence activated cell sorter (FACS)

Stimulated emission depletion microscopy (STED): Nanoscopy for innovative research in the life sciences

The putative effect of cortical and neuropeptides of the CRF-family on the interaction between visceral afferents, mast cells and dendritic cells during intestinal inflammation

Ultracentrifuge for virological and cell biological applications.

BOF-ZAP professorship in veterinary immunology