Code
01GB1317
Duration
01 January 2017 → 31 October 2022
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Cellular interactions and extracellular matrix
-
Medical and health sciences
- Innate immunity
- Virology
Keywords
innate immunity
herpes simplex virus type 1 & 2
animal alphaherpesviruses (pseudorabies virus
bovine herpesvirus 1)
pseudorabies virus
respiratory tract
Project description
Alphaherpesvirus infections cause respiratory and genital problems in humans and animals. In the present project proposal, it will be examined how alphaherpesviruses cross different barriers of the respiratory and genital mucosa (mucus, defensins, basement membrane) and how they escape local innate immunity (interferon, ILC/NK cells). The research results will contribute to the development of new/better drugs and vaccines.