Extracellular vesicle (EV) transport across the brain barriers: from mechanistic and biological insights towards strategies for delivery of therapeutics to the brain.

Base barrier cells: the key to understand compartmentalization and immune surveillance at the choroid plexus.

Deciphering the dynamic interplay between viral infections and Alzheimer’s disease pathology.

Doctoral project Arnout Bruggeman

Doctoral project Chirantan Debnath

Doctoral project Elien Clarebout

Doctoral project Joyce Foroozandeh

Doctoral project Marjana Brkic

Doctoral project Pieter Dujardin

Exploration of blood-cerebrospinal fluid barrier targeted extracellular vesicles as brain delivery strategy

Exploring the gut-brain axis, extracellular vesicles and complement in multiple sclerosis.

Extracellulaire vesikels en inflammatie: de twee boosdoeners in alfa-synucleïne propagatie?

Hijacking receptor-mediated transcytosis at the blood-cerebrospinal fluid barrier as delivery route for drugs to the brain

Identification of anti-FOLR1 VHHs as novel candidates for FOLR1-targeted (brain) tumor imaging and anti-cancer therapy.

Onderzoek naar de rol van het immuun systeem in de darm-hersenen as bij neuroinflammatoire aandoeningen.

Research on the development of new ligands for more efficient delivery of drugs into the brain.

The foes and friends among the adaptive immune system in Alzheimer’s disease

Development of New Analytical Methods for High-precision K Isotopic Analysis and the Investigation of Essential Elements Cu, Fe, Zn and K in the Context of Alzheimer's Disease <i>via </i>Multicollector Inductively Coupled Plasma-Mass Spectrometry

Doctoral project Kelly Van Looveren

Doctoral project Laure Maes

Doctoral project Lise Van Wyngene

Doctoral project Marlies Ballegeer

Doctoral project Sophie Steeland

<i>Helicobacter suis: </i>further characterization of the agent and its possible impact on the course of Parkinson’s disease

Machine learning based quantitative image analysis of correlative light and electron microscopy

Studying microglia and astrocytes in the liver-brain axis during chronic experimental hepatic encephalopathy

Studying the pathogenesis of persistent fatigue in inflammatory bowel diseases

The role of glucocorticoid resistance and TNFR1 signaling in sepsis

A profound study of gut homeostasis in Parkinson's disease.

BOF-ZAP professorship in molecular cell biology

Cell-cell communication in the neurogliovascular unit at the level of the blood-brain barrier: focus on endothelial-glial interactions, inflammation and the role of Ca2+ and connexins

Crossing the barrier: bringing the biologics revolution to the brain

Deciphering the role of extracellular vesicles (EVs) in multiple sclerosis (MS)

Fine tuning and engaging the immune system to defeat Alzheimer’s disease.

Identification of anti-FOLR1 VHHs as novel candidates for FOLR1-targeted (brain) tumor imaging and anti-cancer therapy.

Identifying novel therapeutic targets by understanding the immune landscape of the vulnerable brain during Alzheimer’s pathology

Investigating the biomarker potential and pathological role of extracellular vesicles in Parkinson’s disease.

Investigating the biomarker potential and pathological role of neuronal- and bacterial- derived extracellular vesicles in Parkinson’s disease.

OTULIN in neuroinflammation, multiple sclerosis and Alzheimer pathology

Research into the mechanisms at the blood-brain interfaces that play a role in the development and progression of neurological disorders.

Study of an innovative strategy to deliver drugs into the brain based on naturally occurring extracellular vesicles.

Study of the importance of the choroid plexus (CP) in natural aging with focus on interferon (IFN) signalling

The foes and friends among the adaptive immune system in Alzheimer’s disease

The impact of a SARS-CoV-2 infection on brain pathology and vice versa.

Unraveling the choroid plexus heterogeneity and its consequences on the biological response to inflammation.

Unraveling the heterogeneity of the choroid plexus tissue and its cell (sub)type-specific response to different inflammatory triggers.

Unravelling the interplay between the complement pathway, immune cell infiltration and extracellular vesicles within the choroid plexus in the pathology of Parkinson’s disease.

Unravelling the role of the complement pathway and extracellular vesicles at the blood-cerebrospinal fluid interface in Alzheimer’s disease.

Barriers and carriers for non-viral delivery of mRNA to induce transient protein expression in the retina: the hurdles of the inner limiting membrane and innate immunity versus the potential of mRNA self-amplification.

Design and pre-clincial evaluation of self-replicating mRNA therapeutics that produce protein drugs under control of small, non-toxic molecules

Field-flow fractionation (FFF) system for combination with high-end ICP-mass spectrometry (ICP-MS).

High-precision isotopic analysis of essential metals as a novel tool for unraveling their role in Alzheimer's disease and for diagnostic/prognostic purposes

High-precision isotopic analysis of essential metals as a novel tool for unraveling their role in Alzheimer's disease and for diagnostic/prognostic purposes

Holistic and temporal analysis of gut-brain communication during chronic gut inflammation

Matrix Metalloproteinases (MMP’s) in inflammatory diseases: therapeuytic and functional studies

Profound study of blood-brain and blood-CSF barrier disruption in systemic inflammatory disorders

Replacement and extension of basic infrastructure in the histology core facility.

SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomics

Stimulated emission depletion microscopy (STED): Nanoscopy for innovative research in the life sciences

Towards a substantial increase in therapeutic index of TNF 

BOF-ZAP professorship in molecular cell biology

Identification of novel therapeutic targets for the prevention of epithelial blood-CSF barrier disruption in systemic inflammatory diseases

Matrix metalloproteinases in inflammatory diseases: therapeutic and functional study.

High-precision Sulfur & Selenium isotopic analysis: a novel approach for studying brain redox imbalance & diagnosing/prognosing neurological disorders?