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Researcher
Roosmarijn Vandenbroucke
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
188
Results
2026
Base barrier cells provide compartmentalization of choroid plexus, brain and CSF
Daan Verhaege
Clint De Nolf
Lore Van Acker
Wouter Claeys
Jonas Castelein
Elien Van Wonterghem
Griet Van Imschoot
Pieter Dujardin
Ward De Spiegelaere
Esther Hoste
et al.
A1
Journal Article
in
NATURE NEUROSCIENCE
2026
Decoding brain border immunity to enable future therapeutic avenues
Lien Van Hoecke
Lore Van Acker
Roosmarijn Vandenbroucke
A1
Journal Article
in
TRENDS IN IMMUNOLOGY
2026
Ferroptosis-armed dendritic cell vaccines for glioma immunotherapy
Mariia Saviuk
Victoria D. Turubanova
Sara De Brée
Sandra Van Lint
Teresa Mendes Maia
Simon Devos
Iuliia Efimova
Julie Braet
Lore Van Oudenhove
Gitta Boons
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2026
RNA-based CLEM (RCLEM) bridging RNA localisation and ultrastructural mapping in 3D
Daan Verhaege
Lore Van Acker
Camille Wagner
Yentl van den Berghe
Jérémy Verbeke
Martin Guilliams
Anna Kremer
Lien Van Hoecke
Roosmarijn Vandenbroucke
A1
Journal Article
in
JOURNAL OF MICROSCOPY
2026
Systemic inflammation modulates clearance and drives extra-hepatic distribution of extracellular vesicles
Svetlana Pavlova
Doste R. Mamand
Andre Gorgens
Antje M. Zickler
Wenyi Zheng
Xiuming Liang
Oscar P. B. Wiklander
Manuchehr Abedi-Valugerdi
Elien Van Wonterghem
Junhua Xie
et al.
A1
Journal Article
in
JOURNAL OF EXTRACELLULAR VESICLES
2026
2025
Characterisation of a human multi-organ-on-chip model to unravel gut-blood-brain communication
Laure Maes
Sophie Van Welden
Roosmarijn Vandenbroucke
Debby Laukens
C3
Conference
2025
Complement C3 in neuroinflammation and Alzheimer's disease
Pieter Dujardin
Roosmarijn Vandenbroucke
Charysse Vandendriessche
Dissertation
2025
Digital light processing of photo-crosslinkable gelatin to create biomimetic 3D constructs serving small intestinal tissue regeneration
Laure Maes
Anna Szabó
Jens Van Haevermaete
Indi Geurs
Koen Dewettinck
Roosmarijn Vandenbroucke
Sandra Van Vlierberghe
Debby Laukens
A1
Journal Article
in
BIOMATERIALS ADVANCES
2025
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Xiuming Liang
Dhanu Gupta
Junhua Xie
Elien Van Wonterghem
Lien Van Hoecke
Justin Hean
Zheyu Niu
Marziyeh Ghaeidamini
Oscar P. B. Wiklander
Wenyi Zheng
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2025
Exploring novel in vitro tools to unravel gut-blood-brain communication
Laure Maes
Debby Laukens
Roosmarijn Vandenbroucke
Dissertation
2025
Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis
Junhua Xie
Marlies Burgelman
Pieter Dujardin
Jonas Castelein
Griet Van Imschoot
Elien Van Wonterghem
Hannah Lernout
Sjoerd Schetters
Charysse Vandendriessche
Lien Van Hoecke
et al.
A1
Journal Article
in
FLUIDS AND BARRIERS OF THE CNS
2025
Mesenchymal stromal cell extracellular vesicles as immune modulators and drug carriers in neurodegenerative disorders
Lien Van Hoecke
Cristiano Lucci
Roosmarijn Vandenbroucke
A1
Journal Article
in
TRENDS IN NEUROSCIENCES
2025
Pre-formation loading of extracellular vesicles with exogenous molecules using photoporation
Jana Ramon
Cláudio Pinheiro
Charysse Vandendriessche
Estefanía Lozano-Andrés
Herlinde De Keersmaecker
Deep Punj
Juan Fraire
Edward Geeurickx
Marca H. M. Wauben
Pieter Vader
et al.
A1
Journal Article
in
JOURNAL OF NANOBIOTECHNOLOGY
2025
Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease : lessons from animal studies
Wouter Claeys
Anja Geerts
Lien Van Hoecke
Christophe Van Steenkiste
Roosmarijn Vandenbroucke
A1
Journal Article
in
NEURAL REGENERATION RESEARCH
2025
The gut-brain axis in Alzheimer's disease is shaped by commensal gut microbiota derived extracellular vesicles
Junhua Xie
Lien Van Hoecke
Elien Van Wonterghem
Griet Van Imschoot
Vanessa Andries
Lars Vereecke
Roosmarijn Vandenbroucke
A1
Journal Article
in
GUT MICROBES
2025
2024
An immunological puzzle : the adaptive immune system fuels Alzheimer’s disease pathology
Lien Van Hoecke
Jonas Castelein
Junhua Xie
Lore Van Acker
Griet Van Imschoot
Elien Van Wonterghem
Ine Vlaeminck
Daan Verhaege
Wouter Claeys
Keimpe Wierda
et al.
A1
Journal Article
in
BRAIN BEHAVIOR AND IMMUNITY
2024
Beyond genetics: including the environmental dimension in amyloidosis mouse models for Alzheimer's disease
Lien Van Hoecke
Roosmarijn Vandenbroucke
A1
Journal Article
in
ACTA NEUROPATHOLOGICA COMMUNICATIONS
2024
Challenging the conventional wisdom : re-evaluating smpd3's role in extracellular vesicle biogenesis
Marlies Burgelman
Pieter Dujardin
Anthony Willems
Tino Hochepied
Griet Van Imschoot
Elien Van Wonterghem
Lien Van Hoecke
Charysse Vandendriessche
Roosmarijn Vandenbroucke
A2
Journal Article
in
JOURNAL OF EXTRACELLULAR BIOLOGY
2024
Development of new analytical methods for high-precision K isotopic analysis and the investigation of essential elements Cu, Fe, Zn and K in the context of alzheimer's disease via multicollector inductively coupled plasma-mass spectrometry
Kasper Hobin
Frank Vanhaecke
Roosmarijn Vandenbroucke
Patrick Santens
Dissertation
2024
High-precision K isotopic analysis of cerebrospinal fluid and blood serum microsamples via multicollector inductively coupled plasma-mass spectrometry equipped with 1013 Ω faraday cup amplifier resistors
Kasper Hobin
Marta Costas Rodriguez
Elien Van Wonterghem
Roosmarijn Vandenbroucke
Frank Vanhaecke
A1
Journal Article
in
ANALYTICA CHIMICA ACTA
2024
Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease
Sahana Srinivasan
Daliya Kancheva
Sofie De Ren
Takashi Saito
Maude Jans
Fleur Boone
Charysse Vandendriessche
Ine Paesmans
Herve Maurin
Roosmarijn Vandenbroucke
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2024
Involvement of the choroid plexus in Alzheimer's disease pathophysiology : findings from mouse and human proteomic studies
Aurore Delvenne
Charysse Vandendriessche
Johan Gobom
Marlies Burgelman
Pieter Dujardin
Clint De Nolf
Betty M. Tijms
Charlotte E. Teunissen
Suzanne E. Schindler
Frans Verhey
et al.
A1
Journal Article
in
FLUIDS AND BARRIERS OF THE CNS
2024
Microfluidic interfaces for chronic bidirectional access to the brain
Simone Marcigaglia
Robin De Plus
Charysse Vandendriessche
Eleonore Schiltz
Marie-Lynn Cuypers
Jordi Cools
Luis D Hoffman
Roosmarijn Vandenbroucke
Maarten Dewilde
Sebastian Haesler
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2024
Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson's disease (GUT-PARFECT) : a double-blind, placebo-controlled, randomised, phase 2 trial
Arnout Bruggeman
Charysse Vandendriessche
Hannelore Hamerlinck
Danny De Looze
David J. Tate
Marnik Vuylsteke
Lindsey De Commer
Lindsay Devolder
Jeroen Raes
Bruno Verhasselt
et al.
A1
Journal Article
in
ECLINICALMEDICINE
2024
The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis
Femke Van Gaever
Fleur Mingneau
Sam Vanherle
Yasmine Driege
Mira Haegman
Elien Van Wonterghem
Junhua Xie
Roosmarijn Vandenbroucke
Jerome J. A. Hendriks
Rudi Beyaert
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2024
The spreading and effects of human recombinant α-synuclein preformed fibrils in the cerebrospinal fluid of mice
Charysse Vandendriessche
Arnout Bruggeman
Joyce Foroozandeh
Lien Van Hoecke
Pieter Dujardin
Junhua Xie
Griet Van Imschoot
Elien Van Wonterghem
Jonas Castelein
Cristiano Lucci
et al.
A1
Journal Article
in
ENEURO
2024
2023
Alzheimer's disease and age-related changes in the Cu isotopic composition of blood plasma and brain tissues of the APP^(NL-G-F) murine model revealed by multi-collector ICP-mass spectrometry
Kasper Hobin
Marta Costas Rodriguez
Elien Van Wonterghem
Roosmarijn Vandenbroucke
Frank Vanhaecke
A1
Journal Article
in
BIOLOGY-BASEL
2023
Bacterial extracellular vesicles : an emerging avenue to tackle diseases
Junhua Xie
Freddy Haesebrouck
Lien Van Hoecke
Roosmarijn Vandenbroucke
A1
Journal Article
in
TRENDS IN MICROBIOLOGY
2023
Choroid plexus base barrier cells : the key to understand compartmentalization and immune surveillance at the blood-CFS barrier
Daan Verhaege
Roosmarijn Vandenbroucke
Lien Van Hoecke
Dissertation
2023
Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes
Wouter Claeys
Lien Van Hoecke
Hannah Lernout
Clint De Nolf
Griet Van Imschoot
Elien Van Wonterghem
Daan Verhaege
Jonas Castelein
Anja Geerts
Christophe Van Steenkiste
et al.
A1
Journal Article
in
JOURNAL OF NEUROINFLAMMATION
2023
Exploring the gut-brain axis, extracellular vesicles and complement in multiple sclerosis
Marlies Burgelman
Roosmarijn Vandenbroucke
Charysse Vandendriessche
Dissertation
2023
Free complement and complement containing extracellular vesicles as potential biomarkers for neuroinflammatory and neurodegenerative disorders
Marlies Burgelman
Pieter Dujardin
Charysse Vandendriessche
Roosmarijn Vandenbroucke
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2023
Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology
Junhua Xie
Arnout Bruggeman
Clint De Nolf
Charysse Vandendriessche
Griet Van Imschoot
Elien Van Wonterghem
Lars Vereecke
Roosmarijn Vandenbroucke
A1
Journal Article
in
EMBO JOURNAL
2023
Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling
Junhua Xie
Lien Cools
Griet Van Imschoot
Elien Van Wonterghem
Marie Pauwels
Ine Vlaeminck
Chloë De Witte
Samir EL Andaloussi
Keimpe Wierda
Lies De Groef
et al.
A1
Journal Article
in
JOURNAL OF EXTRACELLULAR VESICLES
2023
Limitations of PLX3397 as a microglial investigational tool : peripheral and off-target effects dictate the response to inflammation
Wouter Claeys
Daan Verhaege
Griet Van Imschoot
Elien Van Wonterghem
Lore Van Acker
Laura Amelinck
Federico Francesco De Ponti
Charlotte Scott
Anja Geerts
Christophe Van Steenkiste
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2023
Proteomic comparison between non-purified cerebrospinal fluid and cerebrospinal fluid-derived extracellular vesicles from patients with Alzheimer's, Parkinson's and Lewy body dementia
Yael Hirschberg
Natalia Valle-Tamayo
Oriol Dols-Icardo
Sebastiaan Engelborghs
Bart Buelens
Roosmarijn Vandenbroucke
Yannick Vermeiren
Kurt Boonen
Inge Mertens
A1
Journal Article
in
JOURNAL OF EXTRACELLULAR VESICLES
2023
Studying microglia and astrocytes in the liver-brain axis during chronic experimental hepatic encephalopathy
Wouter Claeys
Roosmarijn Vandenbroucke
Christophe Van Steenkiste
Anja Geerts
Dissertation
2023
Studying the pathogenesis of persistent fatigue in inflammatory bowel diseases
Marie Truyens
Debby Laukens
Triana Lobatón Ortega
Roosmarijn Vandenbroucke
Dissertation
2023
2022
A mouse model of hepatic encephalopathy : bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.
Wouter Claeys
Lien Van Hoecke
Anja Geerts
Hans Van Vlierberghe
Sander Lefere
Griet Van Imschoot
Elien Van Wonterghem
Bart Ghesquière
Roosmarijn Vandenbroucke
Christophe Van Steenkiste
A1
Journal Article
in
SCIENTIFIC REPORTS
2022
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation
Lidia Yshii
Emanuela Pasciuto
Pascal Bielefeld
Loriana Mascali
Pierre Lemaitre
Marika Marino
James Dooley
Lubna Kouser
Stijn Verschoren
Vasiliki Lagou
et al.
A1
Journal Article
in
NATURE IMMUNOLOGY
2022
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer's disease
Charysse Vandendriessche
Dimitrios Kapogiannis
Roosmarijn Vandenbroucke
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2022
Characterising extracellular vesicles from individual low volume cerebrospinal fluid samples, isolated by SmartSEC
Yael Hirschberg
Kurt Boonen
Karin Schildermans
Annemieke van Dam
Isabel Pintelon
Charysse Vandendriessche
Milica Velimirovic Fanfani
An Jacobs
Roosmarijn Vandenbroucke
Inge Nelissen
et al.
A2
Journal Article
in
JOURNAL OF EXTRACELLULAR BIOLOGY
2022
Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics
Marie Pauwels
Junhua Xie
Adam Ceroi
Sriram Balusu
Jonas Castelein
Elien Van Wonterghem
Griet Van Imschoot
Andrew Ward
Trevelyan R. Menheniott
Oskar Gustafsson
et al.
A1
Journal Article
in
BIOMATERIALS
2022
Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation
Karen De Vlaminck
Hannah Van Hove
Daliya Kancheva
Isabelle Scheyltjens
Ana Rita Pombo Antunes
Jonathan Bastos
Monica Vara-Perez
Leen Ali
Myrthe Mampay
Lauren Deneyer
et al.
A1
Journal Article
in
IMMUNITY
2022
Exploration of blood-cerebrospinal fluid barrier targeted extracellular vesicles as brain delivery strategy
Marie Pauwels
Roosmarijn Vandenbroucke
Lien Van Hoecke
Dissertation
2022
Fighting fire with fire : the immune system might be key in our fight against Alzheimer’s disease
Pieter Dujardin
Roosmarijn Vandenbroucke
Lien Van Hoecke
A1
Journal Article
in
DRUG DISCOVERY TODAY
2022
High-precision isotopic analysis of Cu and Fe via multi-collector inductively coupled plasma-mass spectrometry reveals lipopolysaccharide-induced inflammatory effects in blood plasma and brain tissues
Kasper Hobin
Marta Costas Rodriguez
Elien Van Wonterghem
Roosmarijn Vandenbroucke
Frank Vanhaecke
A1
Journal Article
in
FRONTIERS IN CHEMISTRY
2022
Hijacking receptor-mediated transcytosis at the blood-cerebrospinal fluid barrier as delivery route for drugs to the brain
Nele Plehiers
Roosmarijn Vandenbroucke
Dissertation
2022
Microdissection and whole mount scanning electron microscopy visualization of mouse choroid plexus
Elien Van Wonterghem
Lien Van Hoecke
Griet Van Imschoot
Daan Verhaege
Marlies Burgelman
Roosmarijn Vandenbroucke
A1
Journal Article
in
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
2022
Neurometabolic and gliovascular changes in murine hepatic encephalopathy
Wouter Claeys
Lien Van Hoecke
Anja Geerts
Hans Van Vlierberghe
Xavier Verhelst
Sander Lefere
Helena Degroote
Griet Van Imschoot
Elien Van Wonterghem
Roosmarijn Vandenbroucke
et al.
C3
Conference
2022
Recent insights into viral infections as a trigger and accelerator in Alzheimer's disease
Lize De Vlieger
Roosmarijn Vandenbroucke
Lien Van Hoecke
A1
Journal Article
in
DRUG DISCOVERY TODAY
2022
Studying the impact of the gastrointestinal bacteria on the brain, focusing on the blood-cerebrospinal fluid barrier and Alzheimer's disease
Junhua Xie
Roosmarijn Vandenbroucke
Freddy Haesebrouck
Lien Van Hoecke
Dissertation
2022
Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis
Marijke De Bock
Maarten De Smet
Stijn Verwaerde
Hanane Tahiri
Steffi Schumacher
Valérie Van Haver
Katja Witschas
Christian Steinhäuser
Nathalie Rouach
Roosmarijn Vandenbroucke
et al.
A1
Journal Article
in
JCI INSIGHT
2022
The impact of systemic inflammation on Alzheimer's disease pathology
Junhua Xie
Lien Van Hoecke
Roosmarijn Vandenbroucke
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2022
The tremendous biomedical potential of bacterial extracellular vesicles
Junhua Xie
Qiqiong Li
Freddy Haesebrouck
Lien Van Hoecke
Roosmarijn Vandenbroucke
A1
Journal Article
in
TRENDS IN BIOTECHNOLOGY
2022
2021
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles
Dhanu Gupta
Oscar P. B. Wiklander
Andre Goergens
Mariana Conceicao
Giulia Corso
Xiuming Liang
Yiqi Seow
Sriram Balusu
Ulrika Feldin
Beklem Bostancioglu
et al.
A1
Journal Article
in
NATURE BIOMEDICAL ENGINEERING
2021
Anti-inflammatory mesenchymal stromal cell-derived extracellular vesicles improve pathology in Niemann-Pick type C disease
Lien Van Hoecke
Caroline Van Cauwenberghe
Verena Boerger
Arnout Bruggeman
Jonas Castelein
Griet Van Imschoot
Elien Van Wonterghem
Robin Dittrich
Wouter Claeys
Junhua Xie
et al.
A1
Journal Article
in
BIOMEDICINES
2021
Effect of endotoxemia induced by intraperitoneal injection of lipopolysaccharide on the Mg isotopic composition of biofluids and tissues in mice
Rosa Grigoryan
Marta Costas Rodriguez
Elien Van Wonterghem
Roosmarijn Vandenbroucke
Frank Vanhaecke
A1
Journal Article
in
FRONTIERS IN MEDICINE
2021
Extracellular vesicles : a double-edged sword in sepsis
Marlies Burgelman
Charysse Vandendriessche
Roosmarijn Vandenbroucke
A1
Journal Article
in
PHARMACEUTICALS
2021
Gastric Helicobacter suis infection partially protects against neurotoxicity in A 6-OHDA Parkinson’s disease mouse model
Helena Berlamont
Arnout Bruggeman
Eva Bauwens
Charysse Vandendriessche
Elien Clarebout
Junhua Xie
Sofie De Bruyckere
Griet Van Imschoot
Elien Van Wonterghem
Richard Ducatelle
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2021
Helicobacter and the potential role in neurological disorders : there is more than Helicobacter pylori
Nina Gorlé
Eva Bauwens
Freddy Haesebrouck
Annemieke Smet
Roosmarijn Vandenbroucke
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2021
Helicobacter suis : further characterization of the agent and its possible impact on the course of Parkinson's disease
Helena Berlamont
Freddy Haesebrouck
Annemieke Smet
Roosmarijn Vandenbroucke
Dissertation
2021
Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease
Charysse Vandendriessche
Sriram Balusu
Caroline Van Cauwenberghe
Marjana Brkić
Marie Pauwels
Nele Plehiers
Arnout Bruggeman
Pieter Dujardin
Griet Van Imschoot
Elien Van Wonterghem
et al.
A1
Journal Article
in
ACTA NEUROPATHOLOGICA COMMUNICATIONS
2021
Involvement of the choroid plexus in the pathogenesis of Niemann-Pick disease type C
Lien Van Hoecke
Caroline Van Cauwenberghe
Kristina Dominko
Griet Van Imschoot
Elien Van Wonterghem
Jonas Castelein
Junhua Xie
Wouter Claeys
Charysse Vandendriessche
Anna Kremer
et al.
A1
Journal Article
in
FRONTIERS IN CELLULAR NEUROSCIENCE
2021
Low-grade peripheral inflammation affects brain pathology in the App(NL-G-F)mouse model of Alzheimer's disease
Junhua Xie
Nina Gorlé
Charysse Vandendriessche
Griet Van Imschoot
Elien Van Wonterghem
Caroline Van Cauwenberghe
Eef Parthoens
Evelien Van Hamme
Saskia Lippens
Lien Van Hoecke
et al.
A1
Journal Article
in
ACTA NEUROPATHOLOGICA COMMUNICATIONS
2021
Profiling of extracellular small RNAs highlights a strong bias towards non-vesicular secretion
Helena Sork
Mariana Conceicao
Giulia Corso
Joel Nordin
Yi Xin Fiona Lee
Kaarel Krjutskov
Jakub Orzechowski Westholm
Pieter Vader
Marie Pauwels
Roosmarijn Vandenbroucke
et al.
A1
Journal Article
in
CELLS
2021
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
Ana Rita Pombo Antunes
Isabelle Scheyltjens
Francesca Lodi
Julie Messiaen
Asier Antoranz
Johnny Duerinck
Daliya Kancheva
Liesbet Martens
Karen De Vlaminck
Hannah Van Hove
et al.
A1
Journal Article
in
NATURE NEUROSCIENCE
2021
Special delEVery : extracellular vesicles as promising delivery platform to the brain
Marie Pauwels
Charysse Vandendriessche
Roosmarijn Vandenbroucke
A1
Journal Article
in
BIOMEDICINES
2021
The neurogliovascular unit in hepatic encephalopathy
Wouter Claeys
Lien Van Hoecke
Sander Lefere
Anja Geerts
Xavier Verhelst
Hans Van Vlierberghe
Helena Degroote
Lindsey Devisscher
Roosmarijn Vandenbroucke
Christophe Van Steenkiste
A1
Journal Article
in
JHEP REPORTS
2021
The power of imaging to understand extracellular vesicle biology in vivo
Frederik J. Verweij
Leonora Balaj
Chantal M. Boulanger
David R. F. Carter
Ewoud B. Compeer
Gisela D’Angelo
Samir El Andaloussi
Jacky G. Goetz
Julia Christina Gross
Vincent Hyenne
et al.
A1
Journal Article
in
NATURE METHODS
2021
2020
A murine model of hepatic encephalopathy : validation and neurobehavioral testing
Wouter Claeys
Anja Geerts
Sander Lefere
Hans Van Vlierberghe
Griet Van Imschoot
Elien Van Wonterghem
Roosmarijn Vandenbroucke
Christophe Van Steenkiste
C3
Conference
2020
Exploring the role of extracellular vesicles in Alzheimer's and Parkinson's disease
Charysse Vandendriessche
Roosmarijn Vandenbroucke
Caroline Van Cauwenberghe
Dissertation
2020
Extracellular vesicles in Alzheimer's and Parkinson's disease : small entities with large consequences
Charysse Vandendriessche
Arnout Bruggeman
Caroline Van Cauwenberghe
Roosmarijn Vandenbroucke
A1
Journal Article
in
CELLS
2020
High-precision isotopic analysis of Mg and Ca in biological samples using multi-collector ICP-mass spectrometry after their sequential chromatographic isolation : application to the characterization of the body distribution of Mg and Ca isotopes in mice
Rosa Grigoryan
Marta Costas Rodriguez
Roosmarijn Vandenbroucke
Frank Vanhaecke
A1
Journal Article
in
ANALYTICA CHIMICA ACTA
2020
Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model
Lynn van Olst
Daan Verhaege
Marc Franssen
Alwin Kamermans
Bart Roucourt
Sofie Carmans
Ellen Ytebrouck
Susanne M.A. van der Pol
Dennis Wever
Marko Popovic
et al.
A1
Journal Article
in
NEUROBIOLOGY OF AGING
2020
Study of the importance of the choroid plexus in peripheral and brain inflammation
Nina Gorlé
Roosmarijn Vandenbroucke
Freddy Haesebrouck
Dissertation
2020
Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury
Evy Lefevere
Manuel Salinas-Navarro
Lien Andries
Lut Noterdaeme
Isabelle Etienne
Elien Van Wonterghem
Stefan Vinckier
Benjamin M. Davis
Tine Van Bergen
Inge Van Hove
et al.
A1
Journal Article
in
GLIA
2020
2019
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
Hannah Van Hove
Liesbet Martens
Isabelle Scheyltjens
Karen De Vlaminck
Ana Rita Pombo Antunes
Sofie De Prijck
Niels Vandamme
Sebastiaan De Schepper
Gert Van Isterdael
Charlotte Scott
et al.
A1
Journal Article
in
NATURE NEUROSCIENCE
2019
A study of cecal ligation and puncture-induced sepsis in tissue-specific tumor necrosis factor receptor 1-deficient mice
Jolien Vandewalle
Sophie Steeland
Sara Van Ryckeghem
Melanie Eggermont
Elien Van Wonterghem
Roosmarijn Vandenbroucke
Claude Libert
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2019
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer : an ISEV position paper arising from the ISEV membranes and EVs workshop
Ashley E Russell
Alexandra Sneider
Kenneth W Witwer
Paolo Bergese
Suvendra N Bhattacharyya
Alexander Cocks
Emanuele Cocucci
Uta Erdbrugger
Juan M Falcon-Perez
David W Freeman
et al.
A1
Journal Article
in
JOURNAL OF EXTRACELLULAR VESICLES
2019
Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock
Tinneke Delvaeye
Maarten De Smet
Stijn Verwaerde
Elke Decrock
Aleksandra Czekaj
Roosmarijn Vandenbroucke
Kelly Lemeire
Amanda Gonçalves
Wim Declercq
Peter Vandenabeele
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
Choroid plexus tumor necrosis factor receptor 1 : a new neuroinflammatory piece of the complex Alzheimer's disease puzzle
Sophie Steeland
Roosmarijn Vandenbroucke
A1
Journal Article
in
NEURAL REGENERATION RESEARCH
2019
Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain
Tjasa Lepko
Melanie Pusch
Tamara Mueller
Dorothea Schulte
Janina Ehses
Michael Kiebler
Julia Hasler
Hagen B. Huttner
Roosmarijn Vandenbroucke
Charysse Vandendriessche
et al.
A1
Journal Article
in
EMBO JOURNAL
2019
Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine
Zifu Zhong
João Paulo Portela Catani
Séan Mc Cafferty
Liesbeth Couck
Wim Van Den Broeck
Nina Gorlé
Roosmarijn Vandenbroucke
Bert Devriendt
Sebastian Ulbert
Lieselotte Cnops
et al.
A1
Journal Article
in
VACCINES
2019
Impact of gastric Helicobacter infections on the stomach-brain axis
Eva Bauwens
Freddy Haesebrouck
Annemieke Smet
Roosmarijn Vandenbroucke
Dissertation
2019
Interferons : a molecular switch between damage and repair in ageing and Alzheimer's disease
Nina Gorlé
Roosmarijn Vandenbroucke
A1
Journal Article
in
MECHANISMS OF AGEING AND DEVELOPMENT
2019
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Peter Brown
Aik-Choon Tan
Mohamed A. El-Esawi
Thomas Liehr
Oliver Blanck
Douglas P. Gladue
Gabriel M. F. Almeida
Tomislav Cernava
Carlos O. Sorzano
Andy W. K. Yeung
et al.
A1
Journal Article
in
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
2019
Overexpression of Gilz protects mice against lethal septic peritonitis
Marlies Ballegeer
Jolien Vandewalle
Melanie Eggermont
Gert Van Isterdael
Lien Dejager
Liesbet De Bus
Johan Decruyenaere
Roosmarijn Vandenbroucke
Claude Libert
A1
Journal Article
in
SHOCK
2019
Studies on structural and functional changes of mouse choroid plexus in the initiation of neuroinflammation
Marjana Brkić
Roosmarijn Vandenbroucke
Selma Kanazir
Claude Libert
Dissertation
2019
The N‐terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond
Sarah Naessens
Julie De Zaeytijd
Delfien Syx
Roosmarijn Vandenbroucke
Frédéric Smeets
Caroline Van Cauwenbergh
Bart Leroy
Frank Peelman
Frauke Coppieters
A1
Journal Article
in
HUMAN MUTATION
2019
2018
A new venue of TNF targeting
Sophie Steeland
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2018
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
Sofie Voet
Conor Mc Guire
Nora Hagemeyer
Arne Martens
Anna Schroeder
Peter Wieghofer
Carmen Daems
Ori Staszewski
Lieselotte Vande Walle
Marta Joana Costa Jordao
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2018
Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease
Sophie Steeland
Nina Gorlé
Charysse Vandendriessche
Sriram Balusu
Marjana Brkić
Caroline Van Cauwenberghe
Griet Van Imschoot
Elien Van Wonterghem
Riet De Rycke
Anna Kremer
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2018
Functional characterization of N-terminal TIMP3 mutation underlying Sorsby fundus dystrophy in Belgian and French pedigrees
Sarah Naessens
Delfien Syx
Frank Peelman
Roosmarijn Vandenbroucke
Sarah De Jaegere
Frédéric Smeets
Julie De Zaeytijd
Bart Leroy
Elfride De Baere
Frauke Coppieters
C3
Conference
2018
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice
Marlies Ballegeer
Kelly Van Looveren
Steven Timmermans
Melanie Eggermont
Sofie Vandevyver
Fabien Henri Thery
Karen Dendoncker
Jolien Souffriau
Jolien Vandewalle
Lise Van Wyngene
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2018
Quantifying the average number of nucleic acid therapeutics per nanocarrier by single particle tracking microscopy
Elisa Zagato
Lotte Vermeulen
Heleen Dewitte
Griet Van Imschoot
Roosmarijn Vandenbroucke
Jo Demeester
Stefaan De Smedt
Kristiaan Neyts
Katrien Remaut
Kevin Braeckmans
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2018
Simultaneous inhibition of tumor necrosis factor receptor 1 and matrix metalloproteinase 8 completely protects against acute inflammation and sepsis
Sophie Steeland
Sara Van Ryckeghem
Jolien Vandewalle
Marlies Ballegeer
Elien Van Wonterghem
Melanie Eggermont
Johan Decruyenaere
Liesbet De Bus
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
CRITICAL CARE MEDICINE
2018
The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection
Nina Gorlé
Caroline Blaecher
Eva Bauwens
Charysse Vandendriessche
Sriram Balusu
Jolien Vandewalle
Caroline Van Cauwenberghe
Elien Van Wonterghem
Griet Van Imschoot
Cheng Liu
et al.
A1
Journal Article
in
BRAIN BEHAVIOR AND IMMUNITY
2018
2017
Current research into brain barriers and the delivery of therapeutics for neurological diseases : a report on CNS barrier congress London, UK, 2017
John Greenwood
Margareta Hammarlund-Udenaes
Hazel C Jones
Alan W Stitt
Roosmarijn Vandenbroucke
Ignacio A Romero
Matthew Campbell
Gert Fricker
Birger Brodin
Heiko Manninga
et al.
A1
Journal Article
in
FLUIDS AND BARRIERS OF THE CNS
2017
Effect of a gastral infection with zoonotic Helicobacter species on brain barrier integrity
Eva Bauwens
Caroline Blaecher
Helena Berlamont
Nina Gorlé
Richard Ducatelle
Claude Libert
Roosmarijn Vandenbroucke
Annemieke Smet
Freddy Haesebrouck
C3
Conference
2017
Novel insights into the choroid plexus' response to systemic inflammation and Alzheimer's disease
Sriram Balusu
Roosmarijn Vandenbroucke
Claude Libert
Kris Gevaert
Dissertation
2017
Therapeutic targeting of inflammatory mediators in sepsis and neurodegenerative diseases
Sophie Steeland
Claude Libert
Roosmarijn Vandenbroucke
Dissertation
2017
TNFR1 inhibition with a nanobody protects against EAE development in mice
Sophie Steeland
Sara Van Ryckeghem
Griet Van Imschoot
Riet De Rycke
Wendy Toussaint
Leen Vanhoutte
Christian Vanhove
Filip De Vos
Roosmarijn Vandenbroucke
Claude Libert
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor
Tom Holvoet
Sarah Devriese
Karolien Castermans
Sandro Boland
Dirk Leysen
Yves-Paul Vandewynckel
Lindsey Devisscher
Lien Van den Bossche
Sophie Van Welden
Melissa Dullaers
et al.
A1
Journal Article
in
GASTROENTEROLOGY
2017
2016
A hidden epithelial barrier in the brain with a central role in regulating brain homeostasis implications for aging
Roosmarijn Vandenbroucke
A1
Journal Article
in
ANNALS OF THE AMERICAN THORACIC SOCIETY
2016
A study of inflammatory mechanisms involved in systemic inflammation and brain trauma
Delphine Demeestere
Roosmarijn Vandenbroucke
Claude Libert
Dissertation
2016
Caloric restriction: beneficial effects on brain aging and Alzheimer's disease
Caroline Van Cauwenberghe
Charysse Vandendriessche
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
MAMMALIAN GENOME
2016
Comment on 'Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice'
Lynda Grine
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
BRITISH JOURNAL OF DERMATOLOGY
2016
Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs
Stephan Stremersch
Roosmarijn Vandenbroucke
Elien Van Wonterghem
An Hendrix
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2016
Development and validation of a small single-domain antibody that effectively inhibits matrix metalloproteinase 8
Delphine Demeestere
Eline Dejonckheere
Sophie Steeland
Paco Hulpiau
Jurgen Haustraete
Nick Devoogdt
Rielana Wichert
Christoph Becker-Pauly
Elien Van Wonterghem
Sylviane Dewaele
et al.
A1
Journal Article
in
MOLECULAR THERAPY
2016
Efficient analysis of mouse genome sequences reveal many nonsense variants
Sophie Steeland
Steven Timmermans
Sara Van Ryckeghem
Paco Hulpiau
Yvan Saeys
Marc Van Montagu
Roosmarijn Vandenbroucke
Claude Libert
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2016
Elucidation of the molecular cause underlying Sorsby fundus dystrophy in a large Belgian pedigree : functional characterization of N-terminal TIMP3 mutation
Sarah Naessens
Delfien Syx
Roosmarijn Vandenbroucke
Brecht Guillemyn
Sarah De Jaegere
Bart Leroy
Elfride De Baere
Frauke Coppieters
C3
Conference
2016
Elucidation of the molecular cause underlying Sorsby fundus dystrophy in a large Belgian pedigree : N-terminal TIMP3 mutation 15 years later
Sarah Naessens
Delfien Syx
Roosmarijn Vandenbroucke
Brecht Guillemyn
Sarah De Jaegere
Bart Leroy
Elfride De Baere
Frauke Coppieters
C3
Conference
2016
Elucidation of the molecular cause underlying Sorsby fundus dystrophy in a large Belgian pedigree : N-terminal TIMP3 mutation 15 years later
Sarah Naessens
Delfien Syx
Roosmarijn Vandenbroucke
Brecht Guillemyn
Sarah De Jaegere
Bart Leroy
Elfride De Baere
Frauke Coppieters
C3
Conference
2016
Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier
Steffen E Storck
Sabrina Meister
Julius Nahrath
Julius N Meissner
Nils Schubert
Alessandro Di Spiezio
Sandra Baches
Roosmarijn Vandenbroucke
Yvonne Bouter
Ingrid Prikulis
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2016
Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles
Sriram Balusu
Elien Van Wonterghem
Riet De Rycke
Koen Raemdonck
Stephan Stremersch
Kris Gevaert
Marjana Brkić
Delphine Demeestere
Valerie Vanhooren
An Hendrix
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2016
Into rather unexplored terrain : transcellular transport across the blood-brain barrier
Marijke De Bock
Valérie Van Haver
Roosmarijn Vandenbroucke
Elke Decrock
Nan Wang
Luc Leybaert
A1
Journal Article
in
GLIA
2016
MMP-3 deficiency alleviates endotoxin-induced acute inflammation in the posterior eye segment
Inge Van Hove
Evy Lefevere
Lies De Groef
Jurgen Sergeys
Manuel Salinas-Navarro
Claude Libert
Roosmarijn Vandenbroucke
Lieve Moons
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2016
Mouse models of ageing and their relevance to disease
Sulev Kõks
Soner Dogan
Bilge Guvenc Tuna
Herminia González-Navarro
Paul Potter
Roosmarijn Vandenbroucke
A1
Journal Article
in
MECHANISMS OF AGEING AND DEVELOPMENT
2016
Nanobodies as therapeutics: big opportunities for small antibodies
Sophie Steeland
Roosmarijn Vandenbroucke
Claude Libert
A1
Journal Article
in
DRUG DISCOVERY TODAY
2016
Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability
Ranhua Xiong
Roosmarijn Vandenbroucke
Katleen Broos
Toon Brans
Elien Van Wonterghem
Claude Libert
Jo Demeester
Stefaan De Smedt
Kevin Braeckmans
A1
Journal Article
in
NATURE COMMUNICATIONS
2016
Study of the role and regulation of glucocorticoid induced leucine zipper (GILZ) and GR dimers in acute inflammation
Marlies Ballegeer
Claude Libert
Roosmarijn Vandenbroucke
Dissertation
2016
The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease : more than just a barrier
Sriram Balusu
Marjana Brkić
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
NEURAL REGENERATION RESEARCH
2016
The effect of aging on brain barriers and the consequences for Alzheimer's disease development
Nina Gorlé
Caroline Van Cauwenberghe
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
MAMMALIAN GENOME
2016
Topical imiquimod yields systemic effects due to unintended oral uptake
Lynda Grine
Sophie Steeland
Sara Van Ryckeghem
Marlies Ballegeer
Stefan Lienenklaus
Siegfried Weiss
Niek Sanders
Roosmarijn Vandenbroucke
Claude Libert
A1
Journal Article
in
SCIENTIFIC REPORTS
2016
Transient hepatic overexpression of insulin-like growth factor 2 induces free cholesterol and lipid droplet formation
Sonja M Kessler
Stephan Laggai
Elien Van Wonterghem
Katja Gemperlein
Rolf Müller
Johannes Haybaeck
Roosmarijn Vandenbroucke
Manfred Ogris
Claude Libert
Alexandra K Kiemer
A1
Journal Article
in
FRONTIERS IN PHYSIOLOGY
2016
With mouse age comes wisdom : a review and suggestions of relevant mouse models for age-related conditions
Susanne Drechsler
Marina A Lynch
Susana Novella
Herminia González-Navarro
Silva Hecimovic
Erica Barini
Valter Tucci
Rui E Castro
Roosmarijn Vandenbroucke
Marcin Osuchowski
et al.
A1
Journal Article
in
MECHANISMS OF AGEING AND DEVELOPMENT
2016
2015
Amyloid β oligomers disrupt blood-CSF barrier integrity by activating matrix metalloproteinases
Marjana Brkić
Sriram Balusu
Elien Van Wonterghem
Nina Gorlé
Iryna Benilova
Anna Kremer
Inge Van Hove
Lieve Moons
Bart De Strooper
Selma Kanazir
et al.
A1
Journal Article
in
JOURNAL OF NEUROSCIENCE
2015
An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17
Lynda Grine
Lien Dejager
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
CYTOKINE & GROWTH FACTOR REVIEWS
2015
Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders
Delphine Demeestere
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
DRUG DISCOVERY TODAY
2015
Decreased TNF levels and improved retinal ganglion cell survival in MMP-2 Null mice suggest a role for MMP-2 as TNF sheddase
Lies De Groef
Manuel Salinas-Navarro
Griet Van Imschoot
Claude Libert
Roosmarijn Vandenbroucke
Lieve Moons
A1
Journal Article
in
MEDIATORS OF INFLAMMATION
2015
Determining differentially expressed miRNAs and validating miRNA-target relationships using the SPRET/Ei mouse strain
Steven Timmermans
Filip Van Hauwermeiren
Leen Puimège
Lien Dejager
Elien Van Wonterghem
Valerie Vanhooren
Pieter Mestdagh
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
MAMMALIAN GENOME
2015
Dual inhibition of TNFR1 and IFNAR1 in imiquimod-induced psoriasiform skin inflammation in mice
Lynda Grine
Lien Dejager
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2015
Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases
Marjana Brkić
Sriram Balusu
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
MEDIATORS OF INFLAMMATION
2015
Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1
Sophie Steeland
Leen Puimège
Roosmarijn Vandenbroucke
Filip Van Hauwermeiren
Jurgen Haustraete
Nick Devoogdt
Paco Hulpiau
Geert Leroux-Roels
Debby Laukens
Philip Meuleman
et al.
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2015
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1
Leen Puimège
Filip Van Hauwermeiren
Sophie Steeland
Sara Van Ryckeghem
Jolien Vandewalle
Sofie Lodens
Lien Dejager
Sofie Vandevyver
Jan Staelens
Steven Timmermans
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2015
Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice
Tatyana Sklyarova
Jolanda van Hengel
Elien Van Wonterghem
Claude Libert
Frans Van Roy
Roosmarijn Vandenbroucke
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
2015
Passenger mutations confound interpretation of all genetically modified congenic mice
Tom Vanden Berghe
Paco Hulpiau
Liesbet Martens
Roosmarijn Vandenbroucke
Elien Van Wonterghem
Seth W Perry
Inge Bruggeman
Tatyana Divert
Sze Men Choi
Marnik Vuylsteke
et al.
A1
Journal Article
in
IMMUNITY
2015
Synthesis and validation of a hydroxypyrone-based, potent, and specific matrix metalloproteinase-12 inhibitor with anti-inflammatory activity in vitro and in vivo
J Aerts
Roosmarijn Vandenbroucke
R Dera
Sriram Balusu
Elien Van Wonterghem
L Moons
Claude Libert
W Dehaen
L Arckens
A1
Journal Article
in
MEDIATORS OF INFLAMMATION
2015
Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders
Delphine Demeestere
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
BRAIN BEHAVIOR AND IMMUNITY
2015
TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction
Filip Van Hauwermeiren
Roosmarijn Vandenbroucke
Lynda Grine
Sofie Lodens
Elien Van Wonterghem
Riet De Rycke
N De Geest
B Hassan
Claude Libert
A1
Journal Article
in
MUCOSAL IMMUNOLOGY
2015
2014
A new angle on blood–CNS interfaces: a role for connexins?
Marijke De Bock
Roosmarijn Vandenbroucke
Elke Decrock
Maxime Culot
Romeo Cecchelli
Luc Leybaert
A1
Journal Article
in
FEBS LETTERS
2014
An acute phase protein ready to go therapeutic for sepsis
Sofie Vandevyver
Lien Dejager
Roosmarijn Vandenbroucke
Claude Libert
Editorial material
2014
Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models
Filip Van Hauwermeiren
Roosmarijn Vandenbroucke
Lynda Grine
Leen Puimège
Elien Van Wonterghem
Hong Zhang
Claude Libert
A1
Journal Article
in
INTERNATIONAL JOURNAL OF CANCER
2014
Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro
Heleen Dewitte
Rein Verbeke
Karine Breckpot
Roosmarijn Vandenbroucke
Claude Libert
Stefaan De Smedt
Ine Lentacker
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2014
Is there new hope for therapeutic matrix metalloproteinase inhibition?
Roosmarijn Vandenbroucke
Claude Libert
A1
Journal Article
in
NATURE REVIEWS DRUG DISCOVERY
2014
Magnetic layer-by-layer coated particles for efficient MRI of dendritic cells and mesenchymal stem cells
Marie-Luce De Temmerman
Stefaan Soenen
Nathalie Symens
Bart Lucas
Roosmarijn Vandenbroucke
Claude Libert
Jo Demeester
Stefaan De Smedt
Uwe Himmelreich
Joanna Rejman
A1
Journal Article
in
NANOMEDICINE
2014
Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation
Roosmarijn Vandenbroucke
Ineke Vanlaere
Filip Van Hauwermeiren
Elien Van Wonterghem
C Wilson
Claude Libert
A1
Journal Article
in
MUCOSAL IMMUNOLOGY
2014
Study of the role of type I interferons in TNF-mediated inflammation
Lynda Grine
Claude Libert
Roosmarijn Vandenbroucke
Dissertation
2014
Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death
Debby Laukens
Lindsey Devisscher
Lien Van den Bossche
Pieter Hindryckx
Roosmarijn Vandenbroucke
Yves-Paul Vandewynckel
Claude Cuvelier
Brigitta Brinkman
Claude Libert
Peter Vandenabeele
et al.
A1
Journal Article
in
LABORATORY INVESTIGATION
2014
2013
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF
Roosmarijn Vandenbroucke
Eline Dejonckheere
Filip Van Hauwermeiren
Sofie Lodens
Riet De Rycke
Elien Van Wonterghem
An Staes
Kris Gevaert
Carlos López-Otin
Claude Libert
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2013
Mice overexpressing β-1,4-galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis
Valerie Vanhooren
Roosmarijn Vandenbroucke
Sylviane Dewaele
Evelien Van Hamme
Jody Haigh
Tino Hochepied
Claude Libert
A1
Journal Article
in
PLOS ONE
2013
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium
Filip Van Hauwermeiren
Marietta Armaka
Niki Karagianni
Ksanthi Kranidioti
Roosmarijn Vandenbroucke
Sonja Loges
Maarten Van Royen
Jan Staelens
Leen Puimège
Ajay Palagani
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2013
2012
Intracellular drug delivery in Leishmania-infected macrophages: evaluation of saponin-loaded PLGA nanoparticles
H Van De Ven
M Vermeersch
Roosmarijn Vandenbroucke
A Matheeussen
S Apers
W Weyenberg
Stefaan De Smedt
P Cos
L Maes
A Ludwig
A1
Journal Article
in
JOURNAL OF DRUG TARGETING
2012
Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases
Roosmarijn Vandenbroucke
Eline Dejonckheere
Philippe Van Lint
Delphine Demeestere
Elien Van Wonterghem
Ineke Vanlaere
Leen Puimège
Filip Van Hauwermeiren
Riet De Rycke
Conor Mc Guire
et al.
A1
Journal Article
in
JOURNAL OF NEUROSCIENCE
2012
Modulation of dendritic cells by lipid grafted polyelectrolyte microcapsules
Marie-Luce De Temmerman
Joanna Rejman
Bart Lucas
Roosmarijn Vandenbroucke
Claude Libert
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2012
Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen
Marie-Luce De Temmerman
Joanna Rejman
Roosmarijn Vandenbroucke
Stefaan De Koker
Claude Libert
Johan Grooten
Jo Demeester
Bruno Gander
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2012
2011
A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?
Roosmarijn Vandenbroucke
Eline Dejonckheere
Claude Libert
A1
Journal Article
in
EUROPEAN RESPIRATORY JOURNAL
2011
Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression
Eline Dejonckheere
Roosmarijn Vandenbroucke
Claude Libert
A1
Journal Article
in
CYTOKINE & GROWTH FACTOR REVIEWS
2011
Matrix metalloproteinases as drug targets in ischemia/reperfusion injury
Eline Dejonckheere
Roosmarijn Vandenbroucke
Claude Libert
A1
Journal Article
in
DRUG DISCOVERY TODAY
2011
mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells
Marie-Luce De Temmerman
Heleen Dewitte
Roosmarijn Vandenbroucke
Bart Lucas
Claude Libert
Jo Demeester
Stefaan De Smedt
Ine Lentacker
Joanna Rejman
A1
Journal Article
in
BIOMATERIALS
2011
The first MMP in sepsis
Roosmarijn Vandenbroucke
Lien Dejager
Claude Libert
Editorial material
2011
Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1
Filip Van Hauwermeiren
Roosmarijn Vandenbroucke
Claude Libert
A1
Journal Article
in
CYTOKINE & GROWTH FACTOR REVIEWS
2011
2010
Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death
Mathieu Vinken
Elke Decrock
Elke De Vuyst
Marijke De Bock
Roosmarijn Vandenbroucke
Bruno De Geest
Jo Demeester
Niek Sanders
Tamara Vanhaecke
Luc Leybaert
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2010
The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls
Dries Vercauteren
Roosmarijn Vandenbroucke
Arwyn T Jones
Joanna Rejman
Jo Demeester
Stefaan De Smedt
Niek Sanders
Kevin Braeckmans
A1
Journal Article
in
MOLECULAR THERAPY
2010
2009
Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery
Koen Raemdonck
Broes Naeye
Kevin Buyens
Roosmarijn Vandenbroucke
A Hogset
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
Advanced Functional Materials
2009
Monitoring ALS1 and ALS3 Gene Expression During In Vitro Candida albicans Biofilm Formation Under Continuous Flow Conditions
Heleen Nailis
Roosmarijn Vandenbroucke
Kelly Tilleman
Dieter Deforce
Hans Nelis
Tom Coenye
A1
Journal Article
in
MYCOPATHOLOGIA
2009
Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes
Ine Lentacker
Nan Wang
Roosmarijn Vandenbroucke
Jo Demeester
Stefaan De Smedt
Niek Sanders
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2009
2008
Can ultrasound solve the transport barrier of the neural retina?
Liesbeth Peeters
Ine Lentacker
Roosmarijn Vandenbroucke
Bart Lucas
Jo Demeester
Niek Sanders
Stefaan De Smedt
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2008
Dextran microgels for time-controlled delivery of siRNA
Koen Raemdonck
Tinneke Van Thienen
Roosmarijn Vandenbroucke
Niek Sanders
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2008
Evaluation of Digitally Encoded Layer-by-layer Coated Microparticles as Cell Carriers
Farzaneh Fayazpour
Bart Lucas
Roosmarijn Vandenbroucke
Stefaan Derveaux
Jan Tavernier
Sam Lievens
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2008
Loading of PEGylated siRNA lipoplexes on microbubbles restores their siRNA delivery capacity in the presence of ultrasound
Roosmarijn Vandenbroucke
Ine Lentacker
Jo Demeester
Stefaan De Smedt
Niek Sanders
C1
Conference
2008
Maintaining the silence: reflections on long-term RNAi
Koen Raemdonck
Roosmarijn Vandenbroucke
Jo Demeester
Niek Sanders
Stefaan De Smedt
A1
Journal Article
in
DRUG DISCOVERY TODAY
2008
New strategies for nucleic acid delivery to conquer cellular and nuclear membranes
Ine Lentacker
Roosmarijn Vandenbroucke
Bart Lucas
Jo Demeester
Stefaan De Smedt
Niek Sanders
A1
Journal Article
in
Journal of Controlled Release
2008
Non-viral delivery strategies to guide therapeutic nucleic acids through cellular barriers
Roosmarijn Vandenbroucke
Niek Sanders
Jo Demeester
Stefaan De Smedt
Dissertation
2008
Opportunities for digitally encoded microcarriers in pharmacy and cell-based assays
Farzaneh Fayazpour
Bart Lucas
N HUYGEBAERT
Kevin Braeckmans
Stefaan Derveaux
Roosmarijn Vandenbroucke
Jean Paul Remon
Jo Demeester
Chris Vervaet
Stefaan De Smedt
C1
Conference
2008
Prolonged gene silencing in hepatoma cells and primary hepatocytes after siRNA delivery with biodegradable poly(beta-amino esters)
Roosmarijn Vandenbroucke
Bruno De Geest
Jo Demeester
Stefaan De Smedt
Niek Sanders
C1
Conference
2008
Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters)
Roosmarijn Vandenbroucke
Bruno De Geest
Stefan Bonné
M VINKEN
T VAN HAECKE
H HEIMBERG
E WAGNER
V ROGIERS
Stefaan De Smedt
Jo Demeester
et al.
A1
Journal Article
in
JOURNAL OF GENE MEDICINE
2008
Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles
Roosmarijn Vandenbroucke
Ine Lentacker
Jo Demeester
Stefaan De Smedt
Niek Sanders
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2008
2007
Cellular entry pathway and gene transfer capacity of TAT-modified lipoplexes
Roosmarijn Vandenbroucke
Stefaan De Smedt
Jo Demeester
Niek Sanders
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
2007
Line FRAP with the confocal laser scanning microscope for diffusion measurements in small regions of 3-D samples
Kevin Braeckmans
Katrien Remaut
Roosmarijn Vandenbroucke
Bart Lucas
Stefaan De Smedt
Jo Demeester
A1
Journal Article
in
BIOPHYSICAL JOURNAL
2007
Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore
Roosmarijn Vandenbroucke
Bart Lucas
Jo Demeester
Stefaan De Smedt
Niek Sanders
C1
Conference
2007
Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore
Roosmarijn Vandenbroucke
Bart Lucas
Jo Demeester
Stefaan De Smedt
Niek Sanders
A1
Journal Article
in
NUCLEIC ACIDS RESEARCH
2007
2006
E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion
Kristin Strumane
Arnaud Bonnomet
Christophe Stove
Roosmarijn Vandenbroucke
Beatrice Nawrocki-Raby
Erik Bruyneel
Marcus Mareel
Philippe Birembaut
Geert Berx
Frans Van Roy
A1
Journal Article
in
CANCER RESEARCH
2006
Intracellularly degradable polyelectrolyte microcapsules
Bruno De Geest
Roosmarijn Vandenbroucke
AM GUENTHER
GB SUKHORUKOV
WE HENNINK
Niek Sanders
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
ADVANCED MATERIALS
2006
The internalization route resulting in successful gene expression depends on polyethylenimine both cell line and polyplex type
K VON GERSDORFF
Niek Sanders
Roosmarijn Vandenbroucke
Stefaan De Smedt
E WAGNER
M OGRIS
A1
Journal Article
in
MOLECULAR THERAPY
2006
Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA
Ine Lentacker
Bruno De Geest
Roosmarijn Vandenbroucke
Liesbeth Peeters
Jo Demeester
Stefaan De Smedt
Niek Sanders
A1
Journal Article
in
LANGMUIR
2006
2004
Enhancement of nuclear uptake of therapeutic genes and macromolecules by using NLS and PTD containing viral peptides
Roosmarijn Vandenbroucke
Els Vanderleyden
Stefaan De Smedt
Niek Sanders
Jo Demeester
C1
Conference
2004