Research Explorer

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Researcher

Roosmarijn Vandenbroucke

154 Results

2023

Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes

Wouter ClaeysLien Van HoeckeHannah LernoutClint De NolfGriet Van ImschootElien Van WonterghemDaan VerhaegeJonas CasteleinAnja GeertsChristophe Van Steenkiste et al.

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

Free complement and complement containing extracellular vesicles as potential biomarkers for neuroinflammatory and neurodegenerative disorders

Marlies BurgelmanPieter DujardinCharysse VandendriesscheRoosmarijn Vandenbroucke

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling

Junhua XieLien CoolsGriet Van ImschootElien Van WonterghemMarie PauwelsIne VlaeminckChloë De WitteSamir EL AndaloussiKeimpe WierdaLies De Groef et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Studying the pathogenesis of persistent fatigue in inflammatory bowel diseases

Marie TruyensDebby LaukensTriana Lobatón OrtegaRoosmarijn Vandenbroucke

2022

A mouse model of hepatic encephalopathy : bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheSander LefereGriet Van ImschootElien Van WonterghemBart GhesquièreRoosmarijn VandenbrouckeChristophe Van Steenkiste

A1 Journal Article in SCIENTIFIC REPORTS

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Lidia YshiiEmanuela PasciutoPascal BielefeldLoriana MascaliPierre LemaitreMarika MarinoJames DooleyLubna KouserStijn VerschorenVasiliki Lagou et al.

A1 Journal Article in NATURE IMMUNOLOGY

Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer's disease

Charysse VandendriesscheDimitrios KapogiannisRoosmarijn Vandenbroucke

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Characterising extracellular vesicles from individual low volume cerebrospinal fluid samples, isolated by SmartSEC

Yael HirschbergKurt BoonenKarin SchildermansAnnemieke van DamIsabel PintelonCharysse VandendriesscheMilica Velimirovic FanfaniAn JacobsRoosmarijn VandenbrouckeInge Nelissen et al.

A2 Journal Article in JOURNAL OF EXTRACELLULAR BIOLOGY

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

Marie PauwelsJunhua XieAdam CeroiSriram BalusuJonas CasteleinElien Van WonterghemGriet Van ImschootAndrew WardTrevelyan R. MenheniottOskar Gustafsson et al.

A1 Journal Article in BIOMATERIALS

Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation

Karen De VlaminckHannah Van HoveDaliya KanchevaIsabelle ScheyltjensAna Rita Pombo AntunesJonathan BastosMonica Vara-PerezLeen AliMyrthe MampayLauren Deneyer et al.

A1 Journal Article in IMMUNITY

Exploration of blood-cerebrospinal fluid barrier targeted extracellular vesicles as brain delivery strategy

Marie PauwelsRoosmarijn VandenbrouckeLien Van Hoecke

Fighting fire with fire : the immune system might be key in our fight against Alzheimer’s disease

Pieter DujardinRoosmarijn VandenbrouckeLien Van Hoecke

A1 Journal Article in DRUG DISCOVERY TODAY

High-precision isotopic analysis of Cu and Fe via multi-collector inductively coupled plasma-mass spectrometry reveals lipopolysaccharide-induced inflammatory effects in blood plasma and brain tissues

Kasper HobinMarta Costas RodriguezElien Van WonterghemRoosmarijn VandenbrouckeFrank Vanhaecke

A1 Journal Article in FRONTIERS IN CHEMISTRY

Hijacking receptor-mediated transcytosis at the blood-cerebrospinal fluid barrier as delivery route for drugs to the brain

Nele PlehiersRoosmarijn Vandenbroucke

Microdissection and whole mount scanning electron microscopy visualization of mouse choroid plexus

Elien Van WonterghemLien Van HoeckeGriet Van ImschootDaan VerhaegeMarlies BurgelmanRoosmarijn Vandenbroucke

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Neurometabolic and gliovascular changes in murine hepatic encephalopathy

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheXavier VerhelstSander LefereHelena DegrooteGriet Van ImschootElien Van WonterghemRoosmarijn Vandenbroucke et al.

Recent insights into viral infections as a trigger and accelerator in Alzheimer's disease

Lize De VliegerRoosmarijn VandenbrouckeLien Van Hoecke

A1 Journal Article in DRUG DISCOVERY TODAY

Studying the impact of the gastrointestinal bacteria on the brain, focusing on the blood-cerebrospinal fluid barrier and Alzheimer's disease

Junhua XieRoosmarijn VandenbrouckeFreddy HaesebrouckLien Van Hoecke

Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis

Marijke De BockMaarten De SmetStijn VerwaerdeHanane TahiriSteffi SchumacherValérie Van HaverKatja WitschasChristian SteinhäuserNathalie RouachRoosmarijn Vandenbroucke et al.

A1 Journal Article in JCI INSIGHT

The impact of systemic inflammation on Alzheimer's disease pathology

Junhua XieLien Van HoeckeRoosmarijn Vandenbroucke

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The tremendous biomedical potential of bacterial extracellular vesicles

Junhua XieQiqiong LiFreddy HaesebrouckLien Van HoeckeRoosmarijn Vandenbroucke

A1 Journal Article in TRENDS IN BIOTECHNOLOGY

2021

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles

Dhanu GuptaOscar P. B. WiklanderAndre GoergensMariana ConceicaoGiulia CorsoXiuming LiangYiqi SeowSriram BalusuUlrika FeldinBeklem Bostancioglu et al.

A1 Journal Article in NATURE BIOMEDICAL ENGINEERING

Anti-inflammatory mesenchymal stromal cell-derived extracellular vesicles improve pathology in Niemann-Pick type C disease

Lien Van HoeckeCaroline Van CauwenbergheVerena BoergerArnout BruggemanJonas CasteleinGriet Van ImschootElien Van WonterghemRobin DittrichWouter ClaeysJunhua Xie et al.

A1 Journal Article in BIOMEDICINES

Effect of endotoxemia induced by intraperitoneal injection of lipopolysaccharide on the Mg isotopic composition of biofluids and tissues in mice

Rosa GrigoryanMarta Costas RodriguezElien Van WonterghemRoosmarijn VandenbrouckeFrank Vanhaecke

A1 Journal Article in FRONTIERS IN MEDICINE

Extracellular vesicles : a double-edged sword in sepsis

Marlies BurgelmanCharysse VandendriesscheRoosmarijn Vandenbroucke

A1 Journal Article in PHARMACEUTICALS

Gastric Helicobacter suis infection partially protects against neurotoxicity in A 6-OHDA Parkinson’s disease mouse model

Helena BerlamontArnout BruggemanEva BauwensCharysse VandendriesscheElien ClareboutJunhua XieSofie De BruyckereGriet Van ImschootElien Van WonterghemRichard Ducatelle et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Helicobacter and the potential role in neurological disorders : there is more than Helicobacter pylori

Nina GorléEva BauwensFreddy HaesebrouckAnnemieke SmetRoosmarijn Vandenbroucke

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Helicobacter suis : further characterization of the agent and its possible impact on the course of Parkinson's disease

Helena BerlamontFreddy HaesebrouckAnnemieke SmetRoosmarijn Vandenbroucke

Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease

Charysse VandendriesscheSriram BalusuCaroline Van CauwenbergheMarjana BrkicMarie PauwelsNele PlehiersArnout BruggemanPieter DujardinGriet Van ImschootElien Van Wonterghem et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

Involvement of the choroid plexus in the pathogenesis of Niemann-Pick disease type C

Lien Van HoeckeCaroline Van CauwenbergheKristina DominkoGriet Van ImschootElien Van WonterghemJonas CasteleinJunhua XieWouter ClaeysCharysse VandendriesscheAnna Kremer et al.

A1 Journal Article in FRONTIERS IN CELLULAR NEUROSCIENCE

Low-grade peripheral inflammation affects brain pathology in the App(NL-G-F)mouse model of Alzheimer's disease

Junhua XieNina GorléCharysse VandendriesscheGriet Van ImschootElien Van WonterghemCaroline Van CauwenbergheEef ParthoensEvelien Van HammeSaskia LippensLien Van Hoecke et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

Profiling of extracellular small RNAs highlights a strong bias towards non-vesicular secretion

Helena SorkMariana ConceicaoGiulia CorsoJoel NordinYi Xin Fiona LeeKaarel KrjutskovJakub Orzechowski WestholmPieter VaderMarie PauwelsRoosmarijn Vandenbroucke et al.

A1 Journal Article in CELLS

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Ana Rita Pombo AntunesIsabelle ScheyltjensFrancesca LodiJulie MessiaenAsier AntoranzJohnny DuerinckDaliya KanchevaLiesbet MartensKaren De VlaminckHannah Van Hove et al.

A1 Journal Article in NATURE NEUROSCIENCE

Special delEVery : extracellular vesicles as promising delivery platform to the brain

Marie PauwelsCharysse VandendriesscheRoosmarijn Vandenbroucke

A1 Journal Article in BIOMEDICINES

The neurogliovascular unit in hepatic encephalopathy

Wouter ClaeysLien Van HoeckeSander LefereAnja GeertsXavier VerhelstHans Van VlierbergheHelena DegrooteLindsey DevisscherRoosmarijn VandenbrouckeChristophe Van Steenkiste

A1 Journal Article in JHEP REPORTS

The power of imaging to understand extracellular vesicle biology in vivo

Frederik J. VerweijLeonora BalajChantal M. BoulangerDavid R. F. CarterEwoud B. CompeerGisela D’AngeloSamir El AndaloussiJacky G. GoetzJulia Christina GrossVincent Hyenne et al.

A1 Journal Article in NATURE METHODS

2020

A murine model of hepatic encephalopathy : validation and neurobehavioral testing

Wouter ClaeysAnja GeertsSander LefereHans Van VlierbergheGriet Van ImschootElien Van WonterghemRoosmarijn VandenbrouckeChristophe Van Steenkiste

Exploring the role of extracellular vesicles in Alzheimer's and Parkinson's disease

Charysse VandendriesscheRoosmarijn VandenbrouckeCaroline Van Cauwenberghe

Extracellular vesicles in Alzheimer's and Parkinson's disease : small entities with large consequences

Charysse VandendriesscheArnout BruggemanCaroline Van CauwenbergheRoosmarijn Vandenbroucke

A1 Journal Article in CELLS

High-precision isotopic analysis of Mg and Ca in biological samples using multi-collector ICP-mass spectrometry after their sequential chromatographic isolation : application to the characterization of the body distribution of Mg and Ca isotopes in mice

Rosa GrigoryanMarta Costas RodriguezRoosmarijn VandenbrouckeFrank Vanhaecke

A1 Journal Article in ANALYTICA CHIMICA ACTA

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model

Lynn van OlstDaan VerhaegeMarc FranssenAlwin KamermansBart RoucourtSofie CarmansEllen YtebrouckSusanne M.A. van der PolDennis WeverMarko Popovic et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

Study of the importance of the choroid plexus in peripheral and brain inflammation

Nina GorléRoosmarijn VandenbrouckeFreddy Haesebrouck

Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury

Evy LefevereManuel Salinas-NavarroLien AndriesLut NoterdaemeIsabelle EtienneElien Van WonterghemStefan VinckierBenjamin M. DavisTine Van BergenInge Van Hove et al.

A1 Journal Article in GLIA

2019

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Hannah Van HoveLiesbet MartensIsabelle ScheyltjensKaren De VlaminckAna Rita Pombo AntunesSofie De PrijckNiels VandammeSebastiaan De SchepperGert Van IsterdaelCharlotte Scott et al.

A1 Journal Article in NATURE NEUROSCIENCE

A study of cecal ligation and puncture-induced sepsis in tissue-specific tumor necrosis factor receptor 1-deficient mice

Jolien VandewalleSophie SteelandSara Van RyckeghemMelanie EggermontElien Van WonterghemRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer : an ISEV position paper arising from the ISEV membranes and EVs workshop

Ashley E RussellAlexandra SneiderKenneth W WitwerPaolo BergeseSuvendra N BhattacharyyaAlexander CocksEmanuele CocucciUta ErdbruggerJuan M Falcon-PerezDavid W Freeman et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

Tinneke DelvaeyeMaarten De SmetStijn VerwaerdeElke DecrockAleksandra CzekajRoosmarijn VandenbrouckeKelly LemeireAmanda GonçalvesWim DeclercqPeter Vandenabeele et al.

A1 Journal Article in SCIENTIFIC REPORTS

Choroid plexus tumor necrosis factor receptor 1 : a new neuroinflammatory piece of the complex Alzheimer's disease puzzle

Sophie SteelandRoosmarijn Vandenbroucke

A1 Journal Article in NEURAL REGENERATION RESEARCH

Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain

Tjasa LepkoMelanie PuschTamara MuellerDorothea SchulteJanina EhsesMichael KieblerJulia HaslerHagen B. HuttnerRoosmarijn VandenbrouckeCharysse Vandendriessche et al.

A1 Journal Article in EMBO JOURNAL

Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine

Zifu ZhongJoão Paulo Portela CataniSéan Mc CaffertyLiesbeth CouckWim Van Den BroeckNina GorléRoosmarijn VandenbrouckeBert DevriendtSebastian UlbertLieselotte Cnops et al.

A1 Journal Article in VACCINES

Impact of gastric Helicobacter infections on the stomach-brain axis

Eva BauwensFreddy HaesebrouckAnnemieke SmetRoosmarijn Vandenbroucke

Interferons : a molecular switch between damage and repair in ageing and Alzheimer's disease

Nina GorléRoosmarijn Vandenbroucke

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Peter BrownAik-Choon TanMohamed A. El-EsawiThomas LiehrOliver BlanckDouglas P. GladueGabriel M. F. AlmeidaTomislav CernavaCarlos O. SorzanoAndy W. K. Yeung et al.

A1 Journal Article in DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION

Overexpression of Gilz protects mice against lethal septic peritonitis

Marlies BallegeerJolien VandewalleMelanie EggermontGert Van IsterdaelLien DejagerLiesbet De BusJohan DecruyenaereRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in SHOCK

Studies on structural and functional changes of mouse choroid plexus in the initiation of neuroinflammation

Marjana BrkicRoosmarijn VandenbrouckeSelma KanazirClaude Libert

The N‐terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond

Sarah NaessensJulie De ZaeytijdDelfien SyxRoosmarijn VandenbrouckeFrédéric SmeetsCaroline Van CauwenberghBart LeroyFrank PeelmanFrauke Coppieters

A1 Journal Article in HUMAN MUTATION

2018

A new venue of TNF targeting

Sophie SteelandClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa Jordao et al.

A1 Journal Article in NATURE COMMUNICATIONS

Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease

Sophie SteelandNina GorléCharysse VandendriesscheSriram BalusuMarjana BrkicCaroline Van CauwenbergheGriet Van ImschootElien Van WonterghemRiet De RyckeAnna Kremer et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Functional characterization of N-terminal TIMP3 mutation underlying Sorsby fundus dystrophy in Belgian and French pedigrees

Sarah NaessensDelfien SyxFrank PeelmanRoosmarijn VandenbrouckeSarah De JaegereFrédéric SmeetsJulie De ZaeytijdBart LeroyElfride De BaereFrauke Coppieters

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

Marlies BallegeerKelly Van LooverenSteven TimmermansMelanie EggermontSofie VandevyverFabien Henri TheryKaren DendonckerJolien SouffriauJolien VandewalleLise Van Wyngene et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Quantifying the average number of nucleic acid therapeutics per nanocarrier by single particle tracking microscopy

Elisa ZagatoLotte VermeulenHeleen DewitteGriet Van ImschootRoosmarijn VandenbrouckeJo DemeesterStefaan De SmedtKristiaan NeytsKatrien RemautKevin Braeckmans

A1 Journal Article in MOLECULAR PHARMACEUTICS

Simultaneous inhibition of tumor necrosis factor receptor 1 and matrix metalloproteinase 8 completely protects against acute inflammation and sepsis

Sophie SteelandSara Van RyckeghemJolien VandewalleMarlies BallegeerElien Van WonterghemMelanie EggermontJohan DecruyenaereLiesbet De BusClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in CRITICAL CARE MEDICINE

The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection

Nina GorléCaroline BlaecherEva BauwensCharysse VandendriesscheSriram BalusuJolien VandewalleCaroline Van CauwenbergheElien Van WonterghemGriet Van ImschootCheng Liu et al.

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

2017

Current research into brain barriers and the delivery of therapeutics for neurological diseases : a report on CNS barrier congress London, UK, 2017

John GreenwoodMargareta Hammarlund-UdenaesHazel C JonesAlan W StittRoosmarijn VandenbrouckeIgnacio A RomeroMatthew CampbellGert FrickerBirger BrodinHeiko Manninga et al.

A1 Journal Article in FLUIDS AND BARRIERS OF THE CNS

Effect of a gastral infection with zoonotic Helicobacter species on brain barrier integrity

Eva BauwensCaroline BlaecherHelena BerlamontNina GorléRichard DucatelleClaude LibertRoosmarijn VandenbrouckeAnnemieke SmetFreddy Haesebrouck

Novel insights into the choroid plexus' response to systemic inflammation and Alzheimer's disease

Sriram BalusuRoosmarijn VandenbrouckeClaude LibertKris Gevaert

TNFR1 inhibition with a nanobody protects against EAE development in mice

Sophie SteelandSara Van RyckeghemGriet Van ImschootRiet De RyckeWendy ToussaintLeen VanhoutteChristian VanhoveFilip De VosRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in SCIENTIFIC REPORTS

Therapeutic targeting of inflammatory mediators in sepsis and neurodegenerative diseases

Sophie SteelandClaude LibertRoosmarijn Vandenbroucke

Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor

Tom HolvoetSarah DevrieseKarolien CastermansSandro BolandDirk LeysenYves-Paul VandewynckelLindsey DevisscherLien Van den BosscheSophie Van WeldenMelissa Dullaers et al.

A1 Journal Article in GASTROENTEROLOGY

2016

A hidden epithelial barrier in the brain with a central role in regulating brain homeostasis implications for aging

Roosmarijn Vandenbroucke

A1 Journal Article in ANNALS OF THE AMERICAN THORACIC SOCIETY

A study of inflammatory mechanisms involved in systemic inflammation and brain trauma

Delphine DemeestereRoosmarijn VandenbrouckeClaude Libert

Caloric restriction: beneficial effects on brain aging and Alzheimer's disease

Caroline Van CauwenbergheCharysse VandendriesscheClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in MAMMALIAN GENOME

Comment on 'Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice'

Lynda GrineClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in BRITISH JOURNAL OF DERMATOLOGY

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

Stephan StremerschRoosmarijn VandenbrouckeElien Van WonterghemAn HendrixStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Development and validation of a small single-domain antibody that effectively inhibits matrix metalloproteinase 8

Delphine DemeestereEline DejonckheereSophie SteelandPaco HulpiauJurgen HaustraeteNick DevoogdtRielana WichertChristoph Becker-PaulyElien Van WonterghemSylviane Dewaele et al.

A1 Journal Article in MOLECULAR THERAPY

Efficient analysis of mouse genome sequences reveal many nonsense variants

Sophie SteelandSteven TimmermansSara Van RyckeghemPaco HulpiauYvan SaeysMarc Van MontaguRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidation of the molecular cause underlying Sorsby fundus dystrophy in a large Belgian pedigree : N-terminal TIMP3 mutation 15 years later

Sarah NaessensDelfien SyxRoosmarijn VandenbrouckeBrecht GuillemynSarah De JaegereBart LeroyElfride De BaereFrauke Coppieters

Elucidation of the molecular cause underlying Sorsby fundus dystrophy in a large Belgian pedigree : N-terminal TIMP3 mutation 15 years later

Sarah NaessensDelfien SyxRoosmarijn VandenbrouckeBrecht GuillemynSarah De JaegereBart LeroyElfride De BaereFrauke Coppieters

Elucidation of the molecular cause underlying Sorsby fundus dystrophy in a large Belgian pedigree : functional characterization of N-terminal TIMP3 mutation

Sarah NaessensDelfien SyxRoosmarijn VandenbrouckeBrecht GuillemynSarah De JaegereBart LeroyElfride De BaereFrauke Coppieters

Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier

Steffen E StorckSabrina MeisterJulius NahrathJulius N MeissnerNils SchubertAlessandro Di SpiezioSandra BachesRoosmarijn VandenbrouckeYvonne BouterIngrid Prikulis et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles

Sriram BalusuElien Van WonterghemRiet De RyckeKoen RaemdonckStephan StremerschKris GevaertMarjana BrkicDelphine DemeestereValerie VanhoorenAn Hendrix et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Into rather unexplored terrain : transcellular transport across the blood-brain barrier

Marijke De BockValérie Van HaverRoosmarijn VandenbrouckeElke DecrockNan WangLuc Leybaert

A1 Journal Article in GLIA

MMP-3 deficiency alleviates endotoxin-induced acute inflammation in the posterior eye segment

Inge Van HoveEvy LefevereLies De GroefJurgen SergeysManuel Salinas-NavarroClaude LibertRoosmarijn VandenbrouckeLieve Moons

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mouse models of ageing and their relevance to disease

Sulev KõksSoner DoganBilge Guvenc TunaHerminia González-NavarroPaul PotterRoosmarijn Vandenbroucke

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

Nanobodies as therapeutics: big opportunities for small antibodies

Sophie SteelandRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in DRUG DISCOVERY TODAY

Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability

Ranhua XiongRoosmarijn VandenbrouckeKatleen BroosToon BransElien Van WonterghemClaude LibertJo DemeesterStefaan De SmedtKevin Braeckmans

A1 Journal Article in NATURE COMMUNICATIONS

Study of the role and regulation of glucocorticoid induced leucine zipper (GILZ) and GR dimers in acute inflammation

Marlies BallegeerClaude LibertRoosmarijn Vandenbroucke

The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease : more than just a barrier

Sriram BalusuMarjana BrkicClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in NEURAL REGENERATION RESEARCH

The effect of aging on brain barriers and the consequences for Alzheimer's disease development

Nina GorléCaroline Van CauwenbergheClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in MAMMALIAN GENOME

Topical imiquimod yields systemic effects due to unintended oral uptake

Lynda GrineSophie SteelandSara Van RyckeghemMarlies BallegeerStefan LienenklausSiegfried WeissNiek SandersRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in SCIENTIFIC REPORTS

Transient hepatic overexpression of insulin-like growth factor 2 induces free cholesterol and lipid droplet formation

Sonja M KesslerStephan LaggaiElien Van WonterghemKatja GemperleinRolf MüllerJohannes HaybaeckRoosmarijn VandenbrouckeManfred OgrisClaude LibertAlexandra K Kiemer

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

With mouse age comes wisdom : a review and suggestions of relevant mouse models for age-related conditions

Susanne DrechslerMarina A LynchSusana NovellaHerminia González-NavarroSilva HecimovicErica BariniValter TucciRui E CastroRoosmarijn VandenbrouckeMarcin Osuchowski et al.

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

2015

Amyloid β oligomers disrupt blood-CSF barrier integrity by activating matrix metalloproteinases

Marjana BrkicSriram BalusuElien Van WonterghemNina GorléIryna BenilovaAnna KremerInge Van HoveLieve MoonsBart De StrooperSelma Kanazir et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17

Lynda GrineLien DejagerClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders

Delphine DemeestereClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in DRUG DISCOVERY TODAY

Decreased TNF levels and improved retinal ganglion cell survival in MMP-2 Null mice suggest a role for MMP-2 as TNF sheddase

Lies De GroefManuel Salinas-NavarroGriet Van ImschootClaude LibertRoosmarijn VandenbrouckeLieve Moons

A1 Journal Article in MEDIATORS OF INFLAMMATION

Determining differentially expressed miRNAs and validating miRNA-target relationships using the SPRET/Ei mouse strain

Steven TimmermansFilip Van HauwermeirenLeen PuimègeLien DejagerElien Van WonterghemValerie VanhoorenPieter MestdaghClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in MAMMALIAN GENOME

Dual inhibition of TNFR1 and IFNAR1 in imiquimod-induced psoriasiform skin inflammation in mice

Lynda GrineLien DejagerClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases

Marjana BrkicSriram BalusuClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in MEDIATORS OF INFLAMMATION

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1

Sophie SteelandLeen PuimègeRoosmarijn VandenbrouckeFilip Van HauwermeirenJurgen HaustraeteNick DevoogdtPaco HulpiauGeert Leroux-RoelsDebby LaukensPhilip Meuleman et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1

Leen PuimègeFilip Van HauwermeirenSophie SteelandSara Van RyckeghemJolien VandewalleSofie LodensLien DejagerSofie VandevyverJan StaelensSteven Timmermans et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice

Tatyana SklyarovaJolanda van HengelElien Van WonterghemClaude LibertFrans Van RoyRoosmarijn Vandenbroucke

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Passenger mutations confound interpretation of all genetically modified congenic mice

Tom Vanden BerghePaco HulpiauLiesbet MartensRoosmarijn VandenbrouckeElien Van WonterghemSeth W PerryInge BruggemanTatyana DivertSze Men ChoiMarnik Vuylsteke et al.

A1 Journal Article in IMMUNITY

Synthesis and validation of a hydroxypyrone-based, potent, and specific matrix metalloproteinase-12 inhibitor with anti-inflammatory activity in vitro and in vivo

J AertsRoosmarijn VandenbrouckeR DeraSriram BalusuElien Van WonterghemL MoonsClaude LibertW DehaenL Arckens

A1 Journal Article in MEDIATORS OF INFLAMMATION

TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction

Filip Van HauwermeirenRoosmarijn VandenbrouckeLynda GrineSofie LodensElien Van WonterghemRiet De RyckeN De GeestB HassanClaude Libert

A1 Journal Article in MUCOSAL IMMUNOLOGY

Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders

Delphine DemeestereClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

2014

A new angle on blood–CNS interfaces: a role for connexins?

Marijke De BockRoosmarijn VandenbrouckeElke DecrockMaxime CulotRomeo CecchelliLuc Leybaert

A1 Journal Article in FEBS LETTERS

An acute phase protein ready to go therapeutic for sepsis

Sofie VandevyverLien DejagerRoosmarijn VandenbrouckeClaude Libert

Editorial material

Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models

Filip Van HauwermeirenRoosmarijn VandenbrouckeLynda GrineLeen PuimègeElien Van WonterghemHong ZhangClaude Libert

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro

Heleen DewitteRein VerbekeKarine BreckpotRoosmarijn VandenbrouckeClaude LibertStefaan De SmedtIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Is there new hope for therapeutic matrix metalloproteinase inhibition?

Roosmarijn VandenbrouckeClaude Libert

A1 Journal Article in NATURE REVIEWS DRUG DISCOVERY

Magnetic layer-by-layer coated particles for efficient MRI of dendritic cells and mesenchymal stem cells

Marie-Luce De TemmermanStefaan SoenenNathalie SymensBart LucasRoosmarijn VandenbrouckeClaude LibertJo DemeesterStefaan De SmedtUwe HimmelreichJoanna Rejman

A1 Journal Article in NANOMEDICINE

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation

Roosmarijn VandenbrouckeIneke VanlaereFilip Van HauwermeirenElien Van WonterghemC WilsonClaude Libert

A1 Journal Article in MUCOSAL IMMUNOLOGY

Study of the role of type I interferons in TNF-mediated inflammation

Lynda GrineClaude LibertRoosmarijn Vandenbroucke

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

Debby LaukensLindsey DevisscherLien Van den BosschePieter HindryckxRoosmarijn VandenbrouckeYves-Paul VandewynckelClaude CuvelierBrigitta BrinkmanClaude LibertPeter Vandenabeele et al.

A1 Journal Article in LABORATORY INVESTIGATION

2013

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

Roosmarijn VandenbrouckeEline DejonckheereFilip Van HauwermeirenSofie LodensRiet De RyckeElien Van WonterghemAn StaesKris GevaertCarlos López-OtinClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

Mice overexpressing β-1,4-galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis

Valerie VanhoorenRoosmarijn VandenbrouckeSylviane DewaeleEvelien Van HammeJody HaighTino HochepiedClaude Libert

A1 Journal Article in PLOS ONE

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

Filip Van HauwermeirenMarietta ArmakaNiki KaragianniKsanthi KranidiotiRoosmarijn VandenbrouckeSonja LogesMaarten Van RoyenJan StaelensLeen PuimègeAjay Palagani et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2012

Intracellular drug delivery in Leishmania-infected macrophages: evaluation of saponin-loaded PLGA nanoparticles

H Van De VenM VermeerschRoosmarijn VandenbrouckeA MatheeussenS ApersW WeyenbergStefaan De SmedtP CosL MaesA Ludwig

A1 Journal Article in JOURNAL OF DRUG TARGETING

Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases

Roosmarijn VandenbrouckeEline DejonckheerePhilippe Van LintDelphine DemeestereElien Van WonterghemIneke VanlaereLeen PuimègeFilip Van HauwermeirenRiet De RyckeConor Mc Guire et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

Modulation of dendritic cells by lipid grafted polyelectrolyte microcapsules

Marie-Luce De TemmermanJoanna RejmanBart LucasRoosmarijn VandenbrouckeClaude LibertJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen

Marie-Luce De TemmermanJoanna RejmanRoosmarijn VandenbrouckeStefaan De KokerClaude LibertJohan GrootenJo DemeesterBruno GanderStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2011

A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?

Roosmarijn VandenbrouckeEline DejonckheereClaude Libert

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression

Eline DejonckheereRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Matrix metalloproteinases as drug targets in ischemia/reperfusion injury

Eline DejonckheereRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in DRUG DISCOVERY TODAY

The first MMP in sepsis

Roosmarijn VandenbrouckeLien DejagerClaude Libert

Editorial material

Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1

Filip Van HauwermeirenRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells

Marie-Luce De TemmermanHeleen DewitteRoosmarijn VandenbrouckeBart LucasClaude LibertJo DemeesterStefaan De SmedtIne LentackerJoanna Rejman

A1 Journal Article in BIOMATERIALS

2010

Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death

Mathieu VinkenElke DecrockElke De VuystMarijke De BockRoosmarijn VandenbrouckeBruno De GeestJo DemeesterNiek SandersTamara VanhaeckeLuc Leybaert et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls

Dries VercauterenRoosmarijn VandenbrouckeArwyn T JonesJoanna RejmanJo DemeesterStefaan De SmedtNiek SandersKevin Braeckmans

A1 Journal Article in MOLECULAR THERAPY

2009

Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery

Koen RaemdonckBroes NaeyeKevin BuyensRoosmarijn VandenbrouckeA HogsetJo DemeesterStefaan De Smedt

A1 Journal Article in Advanced Functional Materials

Monitoring ALS1 and ALS3 Gene Expression During In Vitro Candida albicans Biofilm Formation Under Continuous Flow Conditions

Heleen NailisRoosmarijn VandenbrouckeKelly TillemanDieter DeforceHans NelisTom Coenye

A1 Journal Article in MYCOPATHOLOGIA

Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes

Ine LentackerNan WangRoosmarijn VandenbrouckeJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in MOLECULAR PHARMACEUTICS

2008

Can ultrasound solve the transport barrier of the neural retina?

Liesbeth PeetersIne LentackerRoosmarijn VandenbrouckeBart LucasJo DemeesterNiek SandersStefaan De Smedt

A1 Journal Article in PHARMACEUTICAL RESEARCH

Dextran microgels for time-controlled delivery of siRNA

Koen RaemdonckTinneke Van ThienenRoosmarijn VandenbrouckeNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Evaluation of Digitally Encoded Layer-by-layer Coated Microparticles as Cell Carriers

Farzaneh FayazpourBart LucasRoosmarijn VandenbrouckeStefaan DerveauxJan TavernierSam LievensJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Loading of PEGylated siRNA lipoplexes on microbubbles restores their siRNA delivery capacity in the presence of ultrasound

Roosmarijn VandenbrouckeIne LentackerJo DemeesterStefaan De SmedtNiek Sanders

Maintaining the silence: reflections on long-term RNAi

Koen RaemdonckRoosmarijn VandenbrouckeJo DemeesterNiek SandersStefaan De Smedt

A1 Journal Article in DRUG DISCOVERY TODAY

New strategies for nucleic acid delivery to conquer cellular and nuclear membranes

Ine LentackerRoosmarijn VandenbrouckeBart LucasJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in Journal of Controlled Release

Non-viral delivery strategies to guide therapeutic nucleic acids through cellular barriers

Roosmarijn VandenbrouckeN SandersJ Demeester

Opportunities for digitally encoded microcarriers in pharmacy and cell-based assays

Farzaneh FayazpourBart LucasN HUYGEBAERTKevin BraeckmansStefaan DerveauxRoosmarijn VandenbrouckeJean Paul RemonJo DemeesterChris VervaetStefaan De Smedt

Prolonged gene silencing in hepatoma cells and primary hepatocytes after siRNA delivery with biodegradable poly(beta-amino esters)

Roosmarijn VandenbrouckeBruno De GeestJo DemeesterStefaan De SmedtNiek Sanders

Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters)

Roosmarijn VandenbrouckeBruno De GeestStefan BonnéM VINKENT VAN HAECKEH HEIMBERGE WAGNERV ROGIERSStefaan De SmedtJo Demeester et al.

A1 Journal Article in JOURNAL OF GENE MEDICINE

Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles

Roosmarijn VandenbrouckeIne LentackerJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2007

Cellular entry pathway and gene transfer capacity of TAT-modified lipoplexes

Roosmarijn VandenbrouckeStefaan De SmedtJo DemeesterNiek Sanders

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Line FRAP with the confocal laser scanning microscope for diffusion measurements in small regions of 3-D samples

Kevin BraeckmansKatrien RemautRoosmarijn VandenbrouckeBart LucasStefaan De SmedtJo Demeester

A1 Journal Article in BIOPHYSICAL JOURNAL

Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore

Roosmarijn VandenbrouckeBart LucasJo DemeesterStefaan De SmedtNiek Sanders

Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore

Roosmarijn VandenbrouckeBart LucasJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2006

E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion

Kristin StrumaneArnaud BonnometChristophe StoveRoosmarijn VandenbrouckeBeatrice Nawrocki-RabyErik BruyneelMarcus MareelPhilippe BirembautGeert BerxFrans Van Roy

A1 Journal Article in CANCER RESEARCH

Intracellularly degradable polyelectrolyte microcapsules

Bruno De GeestRoosmarijn VandenbrouckeAM GUENTHERGB SUKHORUKOVWE HENNINKNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED MATERIALS

The internalization route resulting in successful gene expression depends on polyethylenimine both cell line and polyplex type

K VON GERSDORFFNiek SandersRoosmarijn VandenbrouckeStefaan De SmedtE WAGNERM OGRIS

A1 Journal Article in MOLECULAR THERAPY

Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA

Ine LentackerBruno De GeestRoosmarijn VandenbrouckeLiesbeth PeetersJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in LANGMUIR

2004

Enhancement of nuclear uptake of therapeutic genes and macromolecules by using NLS and PTD containing viral peptides

Roosmarijn VandenbrouckeEls VanderleydenStefaan De SmedtNiek SandersJo Demeester