Research Explorer

Project

Cell-cell communication in the neurogliovascular unit at the level of the blood-brain barrier: focus on endothelial-glial interactions, inflammation and the role of Ca2+ and connexins
Code
3G032015
Duration
01 January 2015 → 31 December 2020
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Cardiac and vascular medicine
    • Neurosciences
    • Cardiac and vascular medicine
    • Neurosciences
    • Cardiac and vascular medicine
    • Neurosciences
Keywords
blood-CSF barrier connexins blood-brain barrier calcium
 
Project description
 

The research proposal focuses on the fundamental understanding of connexin-based intercellular Ca2+ signaling in the neurogliovascular unit, where brain endothelial cells that form the blood-brain barrier interact with glial cells and neurons, and in choroid plexus epithelium that forms the blood-CSF barrier. We study these connexin-dependent intercellular signaling processes in an inflammatory context that is associated with many CNS diseases.