Research Explorer

Project

Study of an innovative strategy to deliver drugs into the brain based on naturally occurring extracellular vesicles.
Code
01N02917
Duration
01 January 2017 → 31 October 2021
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Neurosciences
    • Neurosciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Neurosciences
Keywords
drug delivery blood-brain barrier extracellular vesicles
 
Project description
 

Drug delivery to the brain is still problematic due to the presence of brain barriers such as the blood-cerebrospinal fluid barrier, formed by the choroid plexus epithelial cells. We found that extracellular vesicles, produced by these cells, penetrate the brain. Here, we aim to unravel the mechanism and study whether these extracellular vesicles have potential as therapeutic delivery system.