Combining transcriptomics, epigenetics and in vivo CRISPR screens to unravel the cell-cell communication within the steady-state liver module (deLiver-CRISPR)

Immunological memory of the macrophage niche (MacNicheMemo)

Remodelling of lobular microvasculature to prevent liver failure after extended hepatectomy (LSEC-Regen)

SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomics

Automated analysis of spatial biology data

Doctoral project Birthe Haest

Notch-Induced LXRα Expression is Essential for the Maintenance of Kupffer Cell Identity

Modeling intercellular communication from transcriptomics data by linking ligands to target genes.

BOF-TT-professorship in immunology

ChromaConnect: multiscale integrated modeling and validation of cell-cell communication, gene regulation and cellular processes to understand in vivo differentiation.

Combining in silico and in vivo approaches to unravel the accessory function of liver-resident macrophages

Determinating the master transcription factors driving Kupffer cell differentiation,

Disentangling the different macrophage subsets in the peripheral nerve

Dissecting the regulatory dynamics that govern Kupffer cell differentiation

Elucidating the role of macrophages in liver regeneration and tissue unit formation

Heterogeneity and function in tumor-infiltrating macrophages and dendritic cells during hepatocellular carcinoma development and progression.

Role of resident macrophages in peripheral nerve regeneration after mechanical injury

Role of specific macrophage and dendritic cell subsets in pulmonary and hepatic immune responses

Single-cell SPACE, the next frontier

Study of cell-cell interactions in the liver

Study of the role of Kupffer cells in the pathogenesis of non-alcoholic steatohepatitis.

Unraveling the cell-cell interactions driving liver regeneration

Unravelling cellular heterogeneity and dynamics in normal and malignant hematopoiesis using singlecell bioinformatics

Unravelling the cell-cell circuits underlying the functional reprogramming of Kupffer cells and recruited tumor-associated macrophages during liver metastasis

Unravelling the cell-cell circuits underlying the tissue memory of non-alcoholic fatty liver disease

Unravelling the crosstalk between Stellate cells and Kupffer cells and its role in maintaining Stellate cell quiescence

Unravelling the role of IRF4 and IRF8 in the differentiation and function of the different dendritic cell subsets.

Dissecting the regulatory dynamics that govern Kupffer cell differentiation

Elucidating the role of liver resident Kupffer cells in the regulation of the immune responses to intestinal antigens

FullPicture: Combining Spectral Flow Cytometry with High-Speed Cell Imaging to enable comprehensive profiling of plant and animal cells and their components in real time.

Modelling intercellular signaling events during cellular differentiation from single-cell transcriptomics data

Role of alveolar macrophages in controlling risk or protection from asthma.

Study of the functional role of the distinct lung nd liver antigen-presenting cells subsets in vivo.

The BD FACS Symphony FACS cell sorter: the most advanced multiparameter fluorescence activated cell sorter that allows the identification and purification of rare cells for further functional characterization

BOF-TT-professorship in immunology

Study of the functional role of the distinct lund und liver antigen-presenting cells subsets in vivo

Covid-Track: applying quantitative virology and single-cell genomics to unravel the virus-host interactions leading to severe immunopathologies in COVID-19 patients