Research Explorer

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Researcher

Martin Guilliams

Awards & Distinctions

89 Results

2024

Time and place: mapping human prenatal macrophages across tissues

Camille WagnerMartin Guilliams

Editorial material

Tissue niche occupancy determines the contribution of fetal- versus bone-marrow-derived macrophages to IgG effector functions

Miriam WoehnerSarah BrechtelsbauerNiklas FriedrichChristof VorsatzJohanna BulangChunguang LiangLena SchorrAlain BeschinMartin GuilliamsJeffrey Ravetch et al.

U Journal Article in CELL REPORTS

2023

A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCédric BosteelsStijn Verwaerde et al.

A complement atlas identifies interleukin-6-dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCédric BosteelsStijn Verwaerde et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

Kupffer cells contested as early drivers in the pathogenesis of primary sclerosing cholangitis

Kevin De MuynckBart VanderborghtFederico Francesco De PontiEva GijbelsSophie Van WeldenMartin GuilliamsCharlotte ScottAlain BeschinMathieu VinkenSander Lefere et al.

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes

Anastasiia GainullinaDenis A. MogilenkoLi-Hao HuangHelena TodorovVipin NarangKi-Wook KimLim Sheau YngAndrew KentBaosen JiaKumba Seddu et al.

A1 Journal Article in CELL REPORTS

The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function

Chrysante S. IliakisJustina KulikauskaiteHelena Catharine AegerterFengqi LiFederica PiattiniClaudia V. JakubzickMartin GuilliamsManfred KopfAndreas Wack

Editorial material

Transient Kupffer cell depletion and subsequent replacement by infiltrating monocyte-derived cells does not alter the induction or progression of hepatocellular carcinoma

Bart VanderborghtKevin De MuynckEva GijbelsSander LefereCharlotte ScottMartin GuilliamsAlain BeschinMathieu VinkenXavier VerhelstAnja Geerts et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

2022

Expanding dendritic cell nomenclature in the single-cell era

Florent GinhouxMartin GuilliamsMiriam Merad

Editorial material

Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria

Haoran AnChenyun QianYija HuangJing LiXianbin TianJiaying FengJiao HuYujie FangFangfang JiaoYuna Zeng et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Liver macrophages in health and disease

Martin GuilliamsCharlotte Scott

A1 Journal Article in IMMUNITY

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

Cédric BosteelsKarel Van DammeElisabeth De LeeuwJozefien DeclercqBastiaan MaesVictor BosteelsLevi HosteLeslie NaesensNincy DebeufJulie Deckers et al.

A1 Journal Article in CELL REPORTS MEDICINE

Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues

Isabelle ScheyltjensHannah Van HoveKaren De VlaminckDaliya KanchevaJonathan BastosMonica Vara-PerezAna Rita Pombo AntunesLiesbet MartensCharlotte ScottJo Van Ginderachter et al.

A1 Journal Article in NATURE PROTOCOLS

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Martin GuilliamsJohnny BonnardelBirthe HaestBart VanderborghtCamille WagnerAnneleen RemmerieAnna BujkoLiesbet MartensTinne ThonéRobin Browaeys et al.

A1 Journal Article in CELL

Understanding hepatic macrophage phenotypes and functions in metabolic-associated fatty liver disease

Anneleen RemmerieCharlotte ScottMartin Guilliams

2021

A workflow for 3D-CLEM investigating liver tissue

Anna KremerEvelien Van HammeJohnny BonnardelPeter BorghgraefChris GuerinMartin GuilliamsSaskia Lippens

A1 Journal Article in JOURNAL OF MICROSCOPY

COMMD10 is critical for Kupffer cell survival and controls Ly6C(hi) monocyte differentiation and inflammation in the injured liver

Keren CohenOdelia MouhadebShani Ben ShlomoMarva LangerAnat NeumannNoam ErezItay MoshkovitsRotem PeletDaniel J. KedarEli Brazowski et al.

A1 Journal Article in CELL REPORTS

Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis

Xiao HuangStephen T. FerrisSunkyung KimMayank N.K. ChoudharyJulia A. BelkChangxu FanYanyan QiRaki SudanYu XiaPritesh Desai et al.

A1 Journal Article in IMMUNITY

Does tissue imprinting restrict macrophage plasticity?

Martin GuilliamsFreya Svedberg

A1 Journal Article in NATURE IMMUNOLOGY

Notch-induced LXRα expression is essential for the maintenance of Kupffer cell identity

Wouter T'JonckMartin GuilliamsCharlotte Scott

Single cell biology : a Keystone Symposia report

Jennifer CableMichael B. ElowitzAna I. DomingosNaomi HabibShalev ItzkovitzHomaira HamidzadaMichael S. BalzerItai YanaiPrisca LiberaliJessica Whited et al.

A1 Journal Article in ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Ana Rita Pombo AntunesIsabelle ScheyltjensFrancesca LodiJulie MessiaenAsier AntoranzJohnny DuerinckDaliya KanchevaLiesbet MartensKaren De VlaminckHannah Van Hove et al.

A1 Journal Article in NATURE NEUROSCIENCE

The conventional dendritic cell lineage is born

Martin GuilliamsCharlotte Scott

Editorial material

2020

Establishment and maintenance of the macrophage niche

Martin GuilliamsGuilhem R. ThierryJohnny BonnardelMarc Bajenoff

A1 Journal Article in IMMUNITY

Hepatocarcinoma induces a tumor necrosis factor-dependent Kupffer cell death pathway that favors its proliferation upon partial hepatectomy

Jean-François HastirSandrine DelbauveLionel LarbanoixDesislava GermanovaCleo GoyvaertsJustine AllardSophie LaurentKarine BreckpotAlain BeschinMartin Guilliams et al.

A1 Journal Article in FRONTIERS IN ONCOLOGY

Stephanie Vargas AguilarOscar AguilarRhys AllanEl Ad David AmirVeronique AngeliMaxim N. ArtyomovNatasha AsinovskiJilian AstaritaK. Frank AustenGeetika Bajpai et al.

A1 Journal Article in NATURE IMMUNOLOGY

Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection

Cédric BosteelsKatrijn NeytManon VanheerswynghelsMary van HeldenDorine SichienNincy DebeufSofie De PrijckVictor BosteelsNiels VandammeLiesbet Martens et al.

A1 Journal Article in IMMUNITY

Integrated scRNA-seq identifies human postnatal thymus seeding progenitors and regulatory dynamics of differentiating immature thymocytes

Marieke LavaertKai Ling LiangNiels VandammeJong-Eun ParkJuliette RoelsMonica S. KowalczykBo LiOrr AshenbergMarcin TabakaDanielle Dionne et al.

A1 Journal Article in IMMUNITY

Myeloid cells TREM down anti-tumor responses

Aimée Bugler-LambMartin Guilliams

Editorial material

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

Elke YdensLukas AmannBob AsselberghCharlotte ScottLiesbet MartensDorine SichienOmar MossadThomas BlankSofie De PrijckDonovan Low et al.

A1 Journal Article in NATURE NEUROSCIENCE

2019

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Hannah Van HoveLiesbet MartensIsabelle ScheyltjensKaren De VlaminckAna Rita Pombo AntunesSofie De PrijckNiels VandammeSebastiaan De SchepperGert Van IsterdaelCharlotte Scott et al.

A1 Journal Article in NATURE NEUROSCIENCE

A subset of type I conventional dendritic cells controls cutaneous bacterial infections through VEGFα-mediated recruitment of neutrophils

Baptiste JanelaAmit A PatelMai Chan LauChi Ching GohRasha MsallamWan Ting KongMichael FehlingsSandra HubertJosephine LumYannick Simoni et al.

A1 Journal Article in IMMUNITY

Decrypting DC development

Martin GuilliamsTomohiko Tamura

Editorial material

Priority lane to cDC1 open for IRF8⁺ progenitors

Martin GuilliamsCharlotte Scott

Editorial material

Rethinking communication in the immune system : the quorum sensing concept

Luca AntonioliCorrado BlandizziPal PacherMartin GuilliamsGyorgy Hasko

A1 Journal Article in TRENDS IN IMMUNOLOGY

Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche

Johnny BonnardelWouter T'JonckDjoere GaublommeRobin BrowaeysCharlotte ScottLiesbet MartensBavo VannesteSofie De PrijckSergei A NedospasovAnna Kremer et al.

A1 Journal Article in IMMUNITY

2018

'NOTCHing up' the in vitro production of dendritic cells

Martin GuilliamsCharlotte Scott

Editorial material

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa Jordao et al.

A1 Journal Article in NATURE COMMUNICATIONS

Cellular origin of human cardiac macrophage populations

Freya SvedbergMartin Guilliams

Editorial material

Dendritic cells in inflammatory disease

Bart LambrechtMartin GuilliamsHamida Hammad

Bookchapter in Inflammation : from molecular and cellular mechanisms to the clinic

Developmental and functional heterogeneity of monocytes

Martin GuilliamsAlexander MildnerSimon Yona

A1 Journal Article in IMMUNITY

Developmental control of macrophage function

Johnny BonnardelMartin Guilliams

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

Editorial for Cellular Immunology special issue on 'Tissue macrophages'

Florent GinhouxMartin Guilliams

Editorial material

Niche signals and transcription factors involved in tissue-resident macrophage development

Wouter T'JonckMartin GuilliamsJohnny Bonnardel

A1 Journal Article in CELLULAR IMMUNOLOGY

Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens

Sylvain NormandNadine WaldschmittAndreas NeerincxRuben Julio Martinez-TorresCamille ChauvinAurelie Couturier-MaillardOlivier BoulardLaetitia CobretFawaz AwadLudovic Huot et al.

A1 Journal Article in NATURE COMMUNICATIONS

Quorum sensing in the immune system

Luca AntonioliCorrado BlandizziPál PacherMartin GuilliamsGyorgy Hasko

Editorial material

Self-maintaining gut macrophages are essential for intestinal homeostasis

Sebastiaan De SchepperSimon VerheijdenJavier Aguilera-LizarragaMaria Francesca ViolaWerend BoesmansNathalie StakenborgIryna VoytyukInga SmidtBram BoeckxIsabelle Dierckx de Casterle et al.

A1 Journal Article in CELL

The role of Kupffer cells in hepatic iron and lipid metabolism

Charlotte ScottMartin Guilliams

Editorial material

The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages

Charlotte ScottWouter T'JonckLiesbet MartensHelena TodorovDorine SichienBieke SoenJohnny BonnardelSofie De PrijckNiels VandammeRobrecht Cannoodt et al.

A1 Journal Article in IMMUNITY

Tissue unit-ed : lung cells team up to drive alveolar macrophage development

Charlotte ScottMartin Guilliams

Editorial material

Von Hippel-Lindau protein is required for optimal alveolar macrophage terminal differentiation, self-renewal, and function

Helena M IzquierdoPaola BrandiManuel-Jose GomezRuth Conde-GarrosaElena PriegoMichel EnamoradoSarai Martinez-CanoIris SanchezLaura ConejeroDaniel Jimenez-Carretero et al.

A1 Journal Article in CELL REPORTS

2017

A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes

Bénédicte MachielsMickael DourcyXue XiaoJustine JavauxClaire MesnilCatherine SabatelDaniel DesmechtFrançois LallemandPhilippe MartiniveHamida Hammad et al.

A1 Journal Article in NATURE IMMUNOLOGY

Development of conventional dendritic cells : from common bone marrow progenitors to multiple subsets in peripheral tissues

Dorine SichienBart LambrechtMartin GuilliamsCharlotte Scott

A1 Journal Article in MUCOSAL IMMUNOLOGY

Differential requirement for IRF8 in the development and function of monocytes and dendritic cells

Dorine SichienBart LambrechtMartin Guilliams

Does niche competition determine the origin of tissue-resident macrophages?

Martin GuilliamsCharlotte Scott

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells

Julie DeckersDorine SichienMaud PlantingaJustine Van MoorleghemManon VanheerswynghelsEsther HosteBernard MalissenDavid DombrowiczMartin GuilliamsKarolien De Bosscher et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Kupffer cell pool is maintained by local proliferation and the differentiation of bone marrow monocytes into short-lived monocyte-derived Kupffer cells during non-alcoholic steatohepatitis and recovery

Lindsey DevisscherCharlotte ScottSander LefereSarah RaevensEliene BogaertsAnnelies ParidaensXavier VerhelstAnja GeertsMartin GuilliamsHans Van Vlierberghe

Macrophage, a long-distance middleman

Martin Guilliams

Myocardial infarction primes autoreactive T cells through activation of dendritic cells

Katrien Van Der BorghtCharlotte ScottVeronika NindlAnn BouchéLiesbet MartensDorine SichienJustine Van MoorleghemManon VanheerswynghelsSofie De PrijckYvan Saeys et al.

A1 Journal Article in CELL REPORTS

Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool

Lindsey DevisscherCharlotte ScottSander LefereSarah RaevensEliene BogaertsAnnelies ParidaensXavier VerhelstAnja GeertsMartin GuilliamsHans Van Vlierberghe

A1 Journal Article in CELLULAR IMMUNOLOGY

2016

A matter of perspective: moving from a pre-omic to a systems-biology vantage of monocyte-derived cell function and nomenclature

Martin GuilliamsBernard Malissen

A1 Journal Article in IMMUNITY

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Charlotte ScottFang ZhengPatrick De BaetselierLiesbet MartensYvan SaeysSofie De PrijckSaskia LippensChloé AbelsSteve SchoonoogheGeert Raes et al.

A1 Journal Article in NATURE COMMUNICATIONS

Editorial: Dendritic cell and macrophage nomenclature and classification

Florent GinhouxMartin GuilliamsShalin H Naik

Editorial material

IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively

Dorine SichienCharlotte ScottLiesbet MartensMatthias VanderkerkenSofie Van GassenMaud PlantingaThorsten JoerisSofie De PrijckLeen VanhoutteManon Vanheerswynghels et al.

A1 Journal Article in IMMUNITY

Isolation of conventional dendritic cells from mouse lungs

Lianne van de LaarMartin GuilliamsSimon Tavernier

Bookchapter in Dendritic cell protocols

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

Calum C BainCatherine A HawleyHannah GarnerCharlotte ScottAnika SchriddeNicholas J SteersMatthias MackAnagha JoshiMartin GuilliamsAllan Mc I Mowat et al.

A1 Journal Article in NATURE COMMUNICATIONS

Macrophage precursors PLASTed INto alveolar space

Martin GuilliamsBart Lambrecht

Editorial material

Pulmonary immune responses against influenza A virus infection

Katrijn NeytBart LambrechtMartin GuilliamsCorine Geurts van Kessel

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

Charlotte ScottBieke SoenLiesbet MartensNicolas SkrypekWouter SaelensJoachim TaminauGillian BlanckeGert Van IsterdaelDanny HuylebroeckJody Haigh et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

Damya LaouiJiri KeirsseYannick MoriasEva Van OvermeireXenia GeeraertsYvon ElkrimMate KissEvangelia BolliQods LahmarDorine Sichien et al.

A1 Journal Article in NATURE COMMUNICATIONS

Tissue-resident macrophage ontogeny and homeostasis

Florent GinhouxMartin Guilliams

A1 Journal Article in IMMUNITY

Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species

Martin GuilliamsCharles-Antoine DutertreCharlotte ScottNaomi McGovernDorine SichienSvetoslav ChakarovSofie Van GassenJinmiao ChenMichael PoidingerSofie De Prijck et al.

A1 Journal Article in IMMUNITY

Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages

Lianne van de LaarWouter SaelensSofie De PrijckLiesbet MartensCharlotte ScottGert Van IsterdaelEik HoffmannRudi BeyaertYvan SaeysBart Lambrecht et al.

A1 Journal Article in IMMUNITY

2015

A death notice for in-vitro-generated GM-CSF dendritic cells?

Martin GuilliamsBernard Malissen

Editorial material

A hitchhiker's guide to myeloid cell subsets: practical implementation of a novel mononuclear phagocyte classification system

Martin GuilliamsLianne van de Laar

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

CCR2⁺CD103⁻ intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells

Charlotte ScottCC BainPB WrightDorine SichienK KotarskyEmma PerssonK LudaMartin GuilliamsBart LambrechtWW Agace et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Ly6C⁻ monocytes regulate parasite-induced liver inflammation by inducing the differentiation of pathogenic Ly6C⁺ monocytes into macrophages

Yannick MoriasChloé AbelsDamya LaouiEva Van OvermeireMartin GuilliamsElio SchouppeFrank TackeCarlie J DevriesPatrick De BaetselierAlain Beschin

A1 Journal Article in PLOS PATHOGENS

2014

Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

Martin GuilliamsFlorent GinhouxClaudia JakubzickShalin H NaikNobuyuki OnaiBarbara U SchramlElodie SeguraRoxane TussiwandSimon Yona

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

Monocytes find a new place to dwell in the niche of heartbreak hotel

Bart LambrechtMartin Guilliams

Editorial material

Mononuclear phagocytes of the intestine, the skin, and the lung

Charlotte ScottSandrine HenriMartin Guilliams

A1 Journal Article in IMMUNOLOGICAL REVIEWS

The function of Fcγ receptors in dendritic cells and macrophages

Martin GuilliamsPierre BruhnsYvan SaeysHamida HammadBart Lambrecht

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

2013

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

Martin GuilliamsIsmé De KleerSandrine HenriSijranke PostLeen VanhoutteSofie De PrijckKim DeswarteBernard MalissenHamida HammadBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Conventional and monocyte-derived CD11b⁺ dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen

Maud PlantingaMartin GuilliamsManon VanheerswynghelsKim DeswarteFilipe Branco MadeiraWendy ToussaintLeen VanhoutteKatrijn NeytNigel KilleenBernard Malissen et al.

A1 Journal Article in IMMUNITY

Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections

Martin GuilliamsBart LambrechtHamida Hammad

A1 Journal Article in MUCOSAL IMMUNOLOGY

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis

Simon YonaKi-Wook KimYochai WolfAlexander MildnerDiana VarolMichal BrekerDalit Strauss-AyaliSergey ViukovMartin GuilliamsAlexander Misharin et al.

A1 Journal Article in IMMUNITY

Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin

Samira TamoutounourMartin GuilliamsFrédéric Montanana SanchisHong LiuDorothea TerhorstCamille MalosseEmeline PolletLaurence ArdouinHervé LucheCindy Sanchez et al.

A1 Journal Article in IMMUNITY

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6C(hi) monocyte precursors

C. C. BainCharlotte ScottH. Uronen-HanssonS. GudjonssonO. JanssonO. GripMartin GuilliamsB. MalissenW. W. AgaceA. Mc I. Mowat

A1 Journal Article in MUCOSAL IMMUNOLOGY

The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β

Anouk K GloudemansMaud PlantingaMartin GuilliamsMonique WillartArifa Ozir-FazalalikhanAlwin van der HamLouis BoonNicola L HarrisHamida HammadHenk C Hoogsteden et al.

A1 Journal Article in PLOS ONE

2012

CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis

Samira TamoutounourSandrine HenriHugues LelouardBéatrice de BovisColin de HaarC Janneke van der WoudeAndrea M WoltmanYasmin ReyalDominique BonnetDorine Sichien et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY