Doctoral project Laura Icardi

Doctoral project Dries De Clercq

Doctoral project Eleonora Billi

Doctoral project Ioanna Petta

Doctoral project Jolien Janssens

Doctoral project Sofie Desmet

Doctoral project Surya Gupta

Doctoral project Tim Van Acker

ACT: AcTakine-based Cancer Therapy

AcTakines: old monkeys new tricks

Analysis and mining of signaling complexes using contemporary interactomics

Detailed analysis of mechanisms of leptin receptor activation and the development of leptin receptor antagonists.

Development and evaluation of leptin receptor antagonist as a therapeutisch strategy for multiple sclerosis

Development of a generic platform for antigen and immune potentiator delivery via spray drying

ERC Professorship: CYRE

Generation of a human interactome network using MAPPIT

Investigation into mediators of central leptin sensitization upon acute exercise

Investigation into the efficacy of IL-1b AcTaleukins as adjuvant for cancer immunotherapy.

Investigation of the molecular action mechanism of RNF41

MAPPIT

MAPPIT-based receptor interactome analysis

Molecular Mechanisms of nuclear receptors

Protein-protein interactions: from bench to bedside

search for new and analysis of known HIV restriction factors

Search for new and analysis of known HIV restriction factors

Study of crosstalk between beta2-adrenergic signals and the NF-κB cascade. Relevance for neuroinflammation/ neurodegeneration.

Study of nuclear receptor-based cross-talk mechanisms in the combat against inflammation

Study of protein-protein interaction networks in intact cells and application on the leptin receptor

Study of the advantages of the combined activation of GRalpha & PPARalpha for combating inflammatory disorders

The impact of glucocorticoid receptor-mediated signaling on the functioning of metabolically stressed mature human adipocytes

Towards a better understanding of HIV-1 restriction factors

Unraveling IRE1 endonuclease activity and its role in regulating cell fate: an interactomics approach.

Validate protein interaction networks, and study cytokine receptor signalization using the MAPPIT technology

‘VIROTRAP’: A new strategy for the detection of protein-protein interactions

ArrayMAPPIT: scaling up a high-throughput MAPPIT screening format

Circumventing the Biological Obstacles of anti-inflammatory Glucocorticoid Therapy

Development of methotrexate conjugates for the identification of new intracellular targets via the Maspit technology

Faster mapping of cancer driver mutations in new protein-protein interaction interfaces

Investigation into the efficacy of IL-1b AcTaleukins as adjuvant for cancer immunotherapy.

Study of the molecular mechanism of corticosteroids and non-steroidal anti-inflammatory drugs.

Study of the transcriptional cross-talk between PPARα and ERRα

ERC Professorship: CYRE

Study of the interactions between the hepatitis E virus and its host