Study of crosstalk between beta2-adrenergic signals and the NF-κB cascade. Relevance for neuroinflammation/ neurodegeneration.

01 October 2007 → 30 September 2013
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
NF-κB adrb2 signal transduction (neuro-)inflammation
Project description

Recent studies indicate signals derived from the beta2 adrenergic receptor (adrb2) modulate inflammation. In this study we use different in vitro and in vivo models of neuroinflammation to unravel the molecular basis of this interaction. More specifically, we want to address how beta-adrenergic signals modulate the molecular function of NF-κB, one of the crucial mediators of inflammatory reactions.