Doctoral project Adriaan Verhelle

Doctoral project Isabel Van Audenhove

Doctoral project Jonas Bethuyne

Doctoral project Laurence Bertier

Doctoral project Sarah De Clercq

Doctoral project Wouter Van Overbeke

Perturbation of apolipoprotein E4 (apoE4) activity in AD pathology using single domain antibodies and targeting them to the brain

Perturbing tumor-associated macrophage (TAM) equilibrium using GPNMB/CD206 nanobodies and nanoparticles in breast cancer.

Photoporation of fluorescent nanobodies for super resolution imaging and structure-function analysis of immune and cancer cell invadosomes.

Reshaping the Tumor Microenvironment by Engineered Stem Cells: Immunotherapeutic Approaches for Solid Tumor Treatment

Unraveling monocyte/macrophage heterogeneity in the disturbed gut-liver axis in primary sclerosing cholangitis and ulcerative colitis

Design of smart lactoferrin by nanobody mediated targeting of lactoferrin to intestinal Chlamydia suis and its virulence factors

Design of smart ovotransferrins and a mRNA combination vaccine for controlling avian pathogenic Escherichia coli (APEC) and Chlamydia psittaci in chicken broilers

Developing Furan and Triazolinedione Chemistries for Site-Selective Protein Modification

Doctoral project Edith De Bruycker

Doctoral project Jolien Vanhooren

Exploiting the covalent triazolinedione and furan chemistry toolbox for labelling, crosslinking and degradation of proteins

Nanobody as innovative tool for the control of Maize Lethal Necrosis Virus

Nanobody-mediated targetting of the host defence protein lactoferrin to Chlamydia suis

Camelid nanobodies targeting cellular motility factors as a tool to counteract tumor cell migration, invasion and metastasis

Characterization and intracellular delivery of p53 nanobodies with a therapeutic action

Curtailing gelsolin amyloid formation in a transgene mouse model by means of chaperone nanobodies

Development of a nanobody platform with applications in medicine.

Epitope mapping using VHH antibodies (nanobodies) as a tool to understand the moceluar basis of gelsolin activity in cancer cell invasion

Exosome biogenesis and the actin cytoskeleton: an exploratory study using bona fide Camelidae nanobodies

Exploring the therapeutic effect of Akt2/PKB- Beta –neutralising nanobodies in cancer cells

Gelsolin single domain antibodies (nanobodies) as a therapeutic and research tool in monogenic disorder FAF (familial Amyloidosis of the Finnish type).

High resolution mapping and inhibition of invadosomes by means of single-chain antibodies against fascin.

High resolution mapping of invadopodia by means of single-chain antobodies

Molecular analysis of the intracellular transport of actin binding proteins, and their role in the nucleus

Molecular anatomy of the invadosome: visualisation by super resolution microscopy and furan-modified fluorescent nanobodies

Molecular and cell biological analysis of the role of the PDZ proteins in in tumorgeassocierde processes.

Nanobody-assisted manipulation of the tumor suppressor p53.

Nanobody-assisted precision delivery of the moonlighting host defense protein lactoferrin to combat infections with pathogenic bacteria.

Nanobody footprinting as a tool for high-resolution decomposition of cortactin features that contribute to cancer cell invasion and metastasis, with the prospect of further therapeutic development

New applications of Camelid single domain antibodies (nanobodies) as research tool and potential therapeutic.

Offsetting gelsolin degradation in a transgene mouse model by means of chaperone nanobodies

Perturbation of apolipoprotein E4 (apoE4) activity in AD pathology using single domain antibodies and targeting them to the brain

Perturbation of extracellular matrix (ECM)-degrading cellulair devices by means of photoporation-directed nanobody delivery in immune cells and cancer cells.

Perturbing tumor-associated macrophage (TAM) equilibrium using GPNMB/CD206 nanobodies and nanoparticles in breast cancer.

Photoporation of fluorescent nanobodies for super resolution imaging and structure-function analysis of immune and cancer cell invadosomes.

Probing the ultrastructure of invadosomes by super resolution microscopy and neutralizing nanobodies that target different stages of invadosome formation. 

Prospecting to the use of gelsolin nanobodies as a diagnostic and therapeutic tool in the monogenic disorder familial amyloidosis of the Finnish type (FAF).

Specific nanobodies as a tool to study the role of gelsolin in tumor cell invasion, and to perturb its activity

Study of the physiological role of the binding of phospoinositides to the Zonula Occludens proteins

The metastic niche: preparation, function and translational evidence of a permissieve micro environment for cancer dissemination

understanding the effect of cortactin, a pleiotropic regulator of cancer cell invasion, using inhibitory nanobodies perturb its functional domains

Furan-modified peptide and protein ligands for covalent trapping onto cell-surface receptors

Intelligent edge clouds for resource-intensive, media-rich mobile applications

Longitudinal imaging of cellular dynamics with a biostation IM-Q (microscope with sensitive CCD camera and integrated incubator)

Stimulated emission depletion microscopy (STED): Nanoscopy for innovative research in the life sciences