Research Explorer

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Researcher

Jan Gettemans

Awards & Distinctions

114 Results

2023

Alzheimer’s disease : a systems view provides a unifying explanation of its development

Corlia GroblerMarvi van TongerenJan GettemansDouglas B. KellEtheresia Pretorius

A1 Journal Article in JOURNAL OF ALZHEIMERS DISEASE

Single domain antibodies to study orphan receptors and tackle their mutant counterpart with dominant-negative effect

Edith De BruyckerOlivier ZwaenepoelFrauke CoppietersElfride De BaereJan Gettemans

2022

Nanobodies for accurate recognition of iso-tenuazonic acid and development of sensitive immunoassay for contaminant detection in foods

Feng WangYuan-Yuan YangDe-Bin WanJia-Dong LiYi-Fan LiangZhen-Feng LiYu-Dong ShenZhen-Lin XuJin-Yi YangHong Wang et al.

A1 Journal Article in FOOD CONTROL

Nuclear fascin regulates cancer cell survival

Campbell D LawsonSamantha PeelAsier JayoAdam CorriganPreeti IyerMabel Baxter DalrympleRichard J MarshSusan CoxIsabel Van AudenhoveJan Gettemans et al.

A1 Journal Article in ELIFE

Site-specific fluorescent labeling, single-step immunocytochemistry, and delivery of nanobodies into living cells

Bookchapter in Single-domain antibodies : methods and protocols

Triazolinedione protein modification : from an overlooked off-target effect to a tryptophan-based bioconjugation strategy

Klaas DecoeneKamil ÜnalAn StaesOlivier ZwaenepoelJan GettemansKris GevaertJohan WinneAnnemieke Madder

A1 Journal Article in CHEMICAL SCIENCE

2021

An AKT2-specific nanobody that targets the hydrophobic motif induces cell cycle arrest, autophagy and loss of focal adhesions in MDA-MB-231 cells

Tijs MerckaertOlivier ZwaenepoelKris GevaertJan Gettemans

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

Developing furan and triazolinedione chemistries for site-selective protein modification

Klaas DecoeneAnnemieke MadderJan Gettemans

Enhanced non-toxic immunodetection of Alternaria mycotoxin tenuazonic acid based on ferritin-displayed anti-idiotypic nanobody-nanoluciferase multimers

Feng WangZhen-Feng LiDe-Bin WanNatalia VasylievaYu-Dong ShenZhen-Lin XuJin-Yi YangJan GettemansHong WangBruce D. Hammock et al.

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Transforming nanobodies into high precision tools for protein function analysis

Jan GettemansBrian De Dobbelaer

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Unravelling AKT2 signalling in cancer through nanobody technology

Tijs MerckaertJan GettemansKris Gevaert

2020

Development and characterization of protein kinase B/AKT isoform-specific nanobodies

Tijs MerckaertOlivier ZwaenepoelKris GevaertJan Gettemans

A1 Journal Article in PLOS ONE

Long-term live-cell microscopy with labeled nanobodies delivered by laser-induced photoporation

Jing LiuTim HebbrechtToon BransEef ParthoensSaskia LippensChengnan LiHerlinde De KeersmaeckerWinnok H. De VosStefaan De SmedtRabah Boukherroub et al.

A1 Journal Article in NANO RESEARCH

Nanobody click chemistry for convenient site-specific fluorescent labelling, single step immunocytochemistry and delivery into living cells by photoporation and live cell imaging

Tim HebbrechtJing LiuOlivier ZwaenepoelGaelle BoddinChloé Van LeeneKlaas DecoeneAnnemieke MadderKevin BraeckmansJan Gettemans

A1 Journal Article in NEW BIOTECHNOLOGY

Nanobody derivatization for molecular study and perturbation of cancer cell invadopodia

Tim HebbrechtJan Gettemans

α-Actinin-4 promotes the progression of prostate cancer through the Akt/GSK-3β/β-catenin signaling pathway

Sungyeon ParkMinsoo KangSuhyun KimHyoung-Tae AnJan GettemansJesang Ko

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

2019

Exosomal release of L-plastin by breast cancer cells facilitates metastatic bone osteolysis

Kerstin TiedemannGulzhakhan SadvakassovaNicholas MikolajewiczMichal JuhasZarina SabirovaSébastien TabarièsJan GettemansPeter M SiegelSvetlana V Komarova

A1 Journal Article in TRANSLATIONAL ONCOLOGY

Nanobodies as novel tools to manipulate the activity and location of p53, the guardian of the genome

Anneleen SteelsJan Gettemans

Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant

Toni GiorginoDavide MattioniAmal HassanMario MilaniEloise MastrangeloAlberto BarbiroliAdriaan VerhelleJan GettemansMaria Monica BarzagoLuisa Diomede et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nb-induced stabilisation of p53 in HPV-infected cells

Anneleen SteelsLaura VannevelOlivier ZwaenepoelJan Gettemans

A1 Journal Article in SCIENTIFIC REPORTS

PET imaging of distinct brain uptake of a nanobody and similarly-sized PAMAM dendrimers after intra-arterial administration

Wojciech G. LesniakChengyan ChuAnna JablonskaBabak Behnam AzadOlivier ZwaenepoelMichal ZawadzkiAla LisokMartin G. PomperPiotr WalczakJan Gettemans et al.

A1 Journal Article in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The role of gelsolin domain 3 in familial amyloidosis (Finnish type)

Habiba ZorgatiMårten LarssonWeitong RenAdelene Y. L. SimJan GettemansJonathan M. GrimesWenfei LiRobert C. Robinson

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2018

Cortactin and fascin-1 regulate extracellular vesicle release by controlling endosomal trafficking or invadopodia formation and function

Els BegheinDelphine DevrieseEvy Van HoeyJan Gettemans

A1 Journal Article in SCIENTIFIC REPORTS

High resolution nanobody footprinting of cortactin in cancer cell invasion

Laurence BertierJan Gettemans

Intracellular displacement of p53 using transactivation domain (p53 TAD) specific nanobodies

Anneleen SteelsAdriaan VerhelleOlivier ZwaenepoelJan Gettemans

A1 Journal Article in MABS

Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells

Laurence BertierTim HebbrechtElien MettepenningenNatasja De WitOlivier ZwaenepoelAdriaan VerhelleJan Gettemans

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

Nanobody technology : expanding the toolbox for fundamental research

Els BegheinJan Gettemans

Reviving old protecting group chemistry for site-selective peptide-protein conjugation

Smita GunnooAbhishek IyerWillem VanneckeKlaas DecoeneTim HebbrechtJan GettemansMathias LagaStefan LoverixIgnace LastersAnnemieke Madder

A1 Journal Article in CHEMICAL COMMUNICATIONS

Use, applications and mechanisms of intracellular actions of camelid VHHs

Anneleen SteelsLaurence BertierJan Gettemans

Bookchapter in Antibody engineering

2017

AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model

Adriaan VerhelleNair NishaInge EveraertWouter Van OverbekeLynn SupplyOlivier ZwaenepoelCindy PelemanJo Van DorpeTony LahoutteNick Devoogdt et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

EV-TRACK : transparent reporting and centralizing knowledge in extracellular vesicle research

Jan Van DeunPieter MestdaghPatrizia AgostinisÖzden AkaySushma AnandJasper AnckaertZoraida Andreu MartinezTine BaetensEls BegheinLaurence Bertier et al.

A1 Journal Article in NATURE METHODS

Gelsolin amyloidosis : a diagnostic and therapeutic nanobody approach

Adriaan VerhelleJan Gettemans

Inhibitory cortactin nanobodies delineate the role of NTA- and SH3-domain-specific functions during invadopodium formation and cancer cell invasion

Laurence BertierCiska BoucherieOlivier ZwaenepoelBerlinda VanlooMarleen Van TroysIsabel Van AudenhoveJan Gettemans

A1 Journal Article in FASEB JOURNAL

Nanobody technology : a versatile toolkit for microscopic imaging, protein-protein interaction analysis, and protein function exploration

Els BegheinJan Gettemans

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

VCA nanobodies target N-WASp to reduce invadopodium formation and functioning

Tim HebbrechtIsabel Van AudenhoveOlivier ZwaenepoelAdriaan VerhelleJan Gettemans

A1 Journal Article in PLOS ONE

2016

A nanobody‐based approach to amyloid diseases, the gelsolin case study

Adriaan VerhelleJan Gettemans

Bookchapter in Exploring new findings on amyloidosis

A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles

Els BegheinIsabel Van AudenhoveOlivier ZwaenepoelAdriaan VerhelleAriane De GanckJan Gettemans

A1 Journal Article in SCIENTIFIC REPORTS

Fascin rigidity and L-plastin flexibility cooperate in cancer cell invadopodia and filopodia

Isabel Van AudenhoveMajken DenertCiska BoucherieLeen PietersMaria CornelissenJan Gettemans

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Nanobodies as versatile tools to understand, diagnose, visualize and treat cancer

Isabel Van AudenhoveJan Gettemans

A1 Journal Article in EBIOMEDICINE

Nanobody-based high resolution mapping of actin regulators in cancer and immune cell invadosomes

Isabel Van AudenhoveJan Gettemans

Non-invasive imaging of amyloid deposits in a mouse model of AGel using 99mTc-modified nanobodies and SPECT/CT

Adriaan VerhelleWouter Van OverbekeCindy PelemanRebecca De SmetOlivier ZwaenepoelTony LahoutteJo Van DorpeNick DevoogdtJan Gettemans

A1 Journal Article in MOLECULAR IMAGING AND BIOLOGY

The tax-inducible actin-bundling protein fascin is crucial for release and cell-to-cell transmission of human T-cell leukemia virus type 1 (HTLV-1)

Christine GrossVeit WiesmannSebastian MillenMartina KalmerThomas WittenbergJan GettemansAndrea K Thoma-Kress

A1 Journal Article in PLOS PATHOGENS

Use of nanobodies to localize endogenous cytoskeletal proteins and to determine their contribution to cancer cell invasion by using an ECM degradation assay

Isabel Van AudenhoveJan Gettemans

Bookchapter in Cytoskeleton : methods and protocols

2015

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Wouter Van OverbekeJantana WongsantichonInge EveraertAdriaan VerhelleOlivier ZwaenepoelAnantasak LoonchantaLeslie D BurtnickAriane De GanckTino HochepiedJody Haigh et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Fascin actin bundling controls podosome turnover and disassembly while cortactin is involved in podosome assembly by its SH3 domain in THP-1 macrophages and dendritic cells

Isabel Van AudenhoveNincy DebeufCiska BoucherieJan Gettemans

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Keeping mutant plasma gelsolin safe from harm: gelsolin nanobodies act as a chaperone against pathological proteolysis

Wouter Van OverbekeJan Gettemans

New tools in cancer research : nanobodies are more than just a one-trick pony

Jonas BethuyneJan Gettemans

2014

A nanobody modulates the p53 transcriptional program without perturbing its functional architecture

Jonas BethuyneSteven De GieterOlivier ZwaenepoelAbel Garcia-PinoKaat DurinckAdriaan VerhelleGholamreza Hassanzadeh-GhassabehFranki SpelemanRemy LorisJan Gettemans

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Chaperone nanobodies protect gelsolin against MT1-MMP degradation and alleviate amyloid burden in the gelsolin amyloidosis mouse model

Wouter Van OverbekeAdriaan VerhelleInge EveraertOlivier ZwaenepoelJoël VandekerckhoveClaude CuvelierWim DeraveJan Gettemans

A1 Journal Article in MOLECULAR THERAPY

Stratifying fascin and cortactin function in invadopodium formation using inhibitory nanobodies and targeted subcellular delocalization

Isabel Van AudenhoveCiska BoucherieLeen PietersOlivier ZwaenepoelBerlinda VanlooEvelien MartensCharlotte VerbruggeGholamreza Hassanzadeh-GhassabehJoël VandekerckhoveMaria Cornelissen et al.

A1 Journal Article in FASEB JOURNAL

2013

A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis

Katrien Van ImpeJonas BethuyneSteven CoolFrancis ImpensDavid Ruano-GallegoOlivier De WeverBerlinda VanlooMarleen Van TroysKathleen LambeinCiska Boucherie et al.

A1 Journal Article in BREAST CANCER RESEARCH

L-Plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages

Sarah De ClercqCiska BoucherieJoël VandekerckhoveJan GettemansAude Guillabert

A1 Journal Article in PLOS ONE

Mapping cytoskeletal protein function in cells by means of nanobodies

Isabel Van AudenhoveKatrien Van ImpeDavid Ruano-GallegoSarah De ClercqKevin De MuynckBerlinda VanlooHanne VerstraeteLuis Á FernándezJan Gettemans

A1 Journal Article in CYTOSKELETON

Modulating L‐plastin function in immune cells by nanobodies : how small bodies can have large consequences

Sarah De ClercqJan Gettemans

Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation

Sarah De ClercqOlivier ZwaenepoelEvelien MartensJoël VandekerckhoveAude GuillabertJan Gettemans

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2012

Mutant HSPB8 causes protein aggregates and a reduced mitochondrial membrane potential in dermal fibroblasts from distal hereditary motor neuropathy patients

Joy IrobiAnne HolmgrenVicky De WinterBob AsselberghJan GettemansDirk AdriaensenChantal Ceuterick-de GrooteRudy Van CosterPeter De JongheVincent Timmerman

A1 Journal Article in NEUROMUSCULAR DISORDERS

2011

Actin and arp2/3 localize at the centrosome of interphase cells

Thomas HubertJoël VandekerckhoveJan Gettemans

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cdk1 and BRCA1 target gamma-tubulin to microtubule domains

Thomas HubertJoël VandekerckhoveJan Gettemans

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gamma-Tubulin localizes at actin-based membrane protrusions and inhibits formation of stress-fibers

Thomas HubertSofie PerduJoël VandekerckhoveJan Gettemans

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Unconventional actin conformations localize on intermediate filaments in mitosis

Thomas HubertJoël VandekerckhoveJan Gettemans

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2010

A llama-derived gelsolin single-domain antibody blocks gelsolin-G-actin interaction

Anske Van Den AbbeeleSarah De ClercqAriane De GanckVEERLE DE CORTEBerlinda Van LooSameh Hamdy SororVasundara SrinivasanJan SteyaertJoël VandekerckhoveJan Gettemans

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

An alpaca single-domain antibody blocks filopodia formation by obstructing L-plastin-mediated F-actin bundling

Veerle DelanoteBerlinda VanlooMarie CatillonEvelyne FriederichJoël VandekerckhoveJan Gettemans

A1 Journal Article in FASEB JOURNAL

Camelid single-domain antibodies as a therapeutic approach for familial amyloidosis of the Finnish type (FAF)

Wouter Van OverbekeM GuaraldoJoël VandekerckhoveAriane De GanckJan Gettemans

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

Tsutomu OkaEline RemueKris MeerschaertBerlinda VanlooCiska BoucherieDavid GfellerGary D BaderSachdev S SidhuJoël VandekerckhoveJan Gettemans et al.

A1 Journal Article in BIOCHEMICAL JOURNAL

Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-tooth neuropathy

Leonardo Almeida-SouzaSofie GoethalsVicky de WinterInes DierickRodrigo GallardoJoost Van DurmeJoy IrobiJan GettemansFrederic RousseauJoost Schymkowitz et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleoporin Nup62 in nucleo-cytoplasmic transport and cell migration

Thomas HubertJan GettemansJoël Vandekerckhove

TAZ interacts with zonula occludens-1 and-2 proteins in a PDZ-1 dependent manner

Eline RemueKris MeerschaertTsutomu OkaCiska BoucherieJoël VandekerckhoveMarius SudolJan Gettemans

A1 Journal Article in FEBS LETTERS

2009

Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells

Ariane De GanckVEERLE DE CORTEErik BruyneelMarc BrackeJoël VandekerckhoveJan Gettemans

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

Exo70-Mediated Recruitment of Nucleoporin Nup62 at the Leading Edge of Migrating Cells is Required for Cell Migration

Thomas HubertJoël VandekerckhoveJan Gettemans

A1 Journal Article in TRAFFIC

The PDZ2 domain of zonula occludens-1 and-2 is a phosphoinositide binding domain

Kris MeerschaertMoe Phyu TunEline RemueAriane De GanckCiska BoucherieBerlinda VanlooGisele DegeestJoël VandekerckhovePascale ZimmermannNitin Bhardwaj et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle

Thomas HubertKatrien Van ImpeJoël VandekerckhoveJan Gettemans

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2008

A new role for nuclear transport factor 2 and Ran: Nuclear import of CapG

Katrien Van ImpeThomas HubertVeerle De CorteBerlinda VanlooCiska BoucherieJoël VandekerckhoveJan Gettemans

A1 Journal Article in TRAFFIC

IMMUNOMODULATION OF CANCER CELL MIGRATION AND INVASION USING RECOMBINANT CAMELID NANOBODIES AGAINST CYTOSKELETAL PROTEINS

Veerle DelanoteAnske Van Den AbbeeleSarah De ClercqAriane De GanckKatrien Van ImpeVeerle De CorteBerlinda VanlooCiska BoucherieJoël VandekerckhoveJan Gettemans

Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells

Ariane De GanckVeerle De CorteAn StaesKris GevaertJoël VandekerckhoveJan Gettemans

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The F-actin filament capping protein CapG is a bona fide nucleolar protein

Thomas HubertKatrien Van ImpeJoël VandekerckhoveJan Gettemans

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Tandem PDZ Protein Syntenin Interacts with the Aminoacyl tRNA Synthetase Complex in a Lysyl-tRNA Synthetase-Dependent Manner

Kris MeerschaertEline RemueAriane De GanckAn StaesCiska BoucherieKris GevaertJoël VandekerckhoveLawrence KleimanJan Gettemans

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

2007

Downregulation of gelsolin family proteins counteracts cancer cell invasion in vitro

A VAN DEN ABBEELEVeerle De CorteKatrien Van ImpeErik BruyneelC BOTTCHERIEMarc BrackeJoël VandekerckhoveJan Gettemans

A1 Journal Article in CANCER LETTERS

The tandem PDZ domains of syntenin promote cell invasion

Kris Meerschaert.krErik BruyneelOlivier De WeverBerlinda VanlooCiska BoucherieMarc BrackeJoël VandekerckhoveJan Gettemans

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

2006

Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy

A JORDANOVAJ IROBIFP THOMASP VAN DIJCKKris Meerschaert.krM DEWILI DIERICKA JACOBSE DE VRIENDTV GUERGUELTCHEVA et al.

A1 Journal Article in NATURE GENETICS

Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells

B JANJIA GIGANTIVeerle De CorteM CATILLONErik BruyneelD LENTZJ PLASTINOJan GettemansE FRIEDERICH

A1 Journal Article in JOURNAL OF CELL SCIENCE

2005

A monopartite nuclear localization sequence regulates nuclear targeting of the actin binding protein myopodin

Ariane De GanckThomas HubertKatrien Van ImpeDanny GeelenJoël VandekerckhoveVEERLE DE CORTEJan Gettemans

A1 Journal Article in FEBS LETTERS

Lysophosphatidic acid affinity chromatography reveals pyruvate kinase as a specific LPA-binding protein

S DESMARETL QIANBerlinda VanlooKris Meerschaert.krJozef Van DammeJohan GrootenJoël VandekerckhoveGD PRESTWICHJan Gettemans

A1 Journal Article in BIOLOGICAL CHEMISTRY

Molecular basis for dissimilar nuclear trafficking of the actin-bundling protein isoforms T- and L-plastin

Veerle DelanoteKatrien Van ImpeVeerle De CorteErik BruyneelG VETTERCiska BoucherieMarcus MareelJoël VandekerckhoveE FRIEDERICHJan Gettemans

A1 Journal Article in TRAFFIC

Nuclear actin-binding proteins as modulators of gene transcription

Jan GettemansKatrien Van ImpeVeerle DelanoteT HUBERTJoël VandekerckhoveVeerle De Corte

A1 Journal Article in TRAFFIC

Plastins: versatile modulators of actin organization in (patho)physiological cellular processes

Veerle DelanoteJoël VandekerckhoveJan Gettemans

A1 Journal Article in ACTA PHARMACOLOGICA SINICA

2004

Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy

J IROBIKatrien Van ImpeP SEEMANA JORDANOVAI DIERICKN VERPOORTENA MICHALIKE DE VRIENDTA JACOBSV VAN GERWEN et al.

A1 Journal Article in NATURE GENETICS

Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion

Veerle De CorteKatrien Van ImpeErik BruyneelCiska BoucherieMarcus MareelJoël VandekerckhoveJan Gettemans

A1 Journal Article in JOURNAL OF CELL SCIENCE

Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy

OV EVGRAFOVI MERSIYANOVAJ IROBIL VAN DEN BOSCHI DIERICKCL LEUNGO SCHAGINAN VERPOORTENKatrien Van ImpeV FEDOTOV et al.

A1 Journal Article in NATURE GENETICS

YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3 zeta

C PREISINGERB SHORTVeerle De CorteErik BruyneelA HAASR KOPAJTICHJan GettemansFA BARR

A1 Journal Article in JOURNAL OF CELL BIOLOGY

2003

A kelch beta-propeller featuring as a G beta structural mimic: Reinventing the wheel?

Jan GettemansKris Meerschaert.krJoël VandekerckhoveVeerle De Corte

A2 Journal Article in Science's STKE (signal transduction knowledge environment)

The nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins

Katrien Van ImpeVeerle De CorteL EICHINGERErik BruyneelMarcus MareelJoël VandekerckhoveJan Gettemans

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2002

Fragmin60 encodes an actin-binding protein with a C2 domain and controls actin Thr-203 phosphorylation in Physarum plasmodia and sclerotia.

Tatyana SklyarovaVeerle De CorteKris Meerschaert.krLiesbeth DevriendtBerlinda VanlooJ BAILEYLJ COOKM GOETHALSJozef Van DammeMagda Puype et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Gelsolin-induced epithelial cell invasion is dependent on Ras-Rac signaling.

Veerle De CorteErik BruyneelCiska BoucherieMarcus MareelJoël VandekerckhoveJan Gettemans

A1 Journal Article in EMBO JOURNAL

PIP2-PDZ domain binding controls the association of syntenin with the plasma membrane.

P ZIMMERMANNKris Meerschaert.krG REEKMANSI LEENAERTSJV SMALLJoël VandekerckhoveG DAVIDJan Gettemans

A1 Journal Article in MOLECULAR CELL

Selected BTB/POZ-kelch proteins bind ATP.

Davy T'jampensLiesbeth DevriendtVeerle De CorteJoël VandekerckhoveJan Gettemans

A1 Journal Article in FEBS LETTERS

2000

A novel endogenous PP2C-like phosphatase dephosphorylates casein kinase II-phosphorylated Physarum fragmin.

E WAELKENSVeerle De CorteW MERLEVEDEJoël VandekerckhoveJan Gettemans

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

1999

Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: A mass spectrometric approach.

Veerle De CorteHans DemolM GOETHALSJozef Van DammeJan GettemansJoël Vandekerckhove

A1 Journal Article in PROTEIN SCIENCE

Introduction to the histology and cell biology of the actin cytoskeleton.

Editorial material

Physarum amoebae express a distinct fragmin-like actin-binding protein that controls in vitro phosphorylation of actin by the actin-fragmin kinase.

Davy T'jampensJ BAILEYLJ COOKB CONSTANTINJoël VandekerckhoveJan Gettemans

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain.

S STEINBACHERP HOFL EICHINGERM SCHLEICHERJan GettemansJoël VandekerckhoveR HUBERJ BENZ

A1 Journal Article in EMBO JOURNAL

1998

Disruption of the actin cytoskeleton of mammalian cells by the capping complex actin-fragmin is inhibited by actin phosphorylation and regulated by Ca2+ ions.

B CONSTANTINK MEERSCHAERTJoël VandekerckhoveJan Gettemans

A1 Journal Article in JOURNAL OF CELL SCIENCE

Gelsolin and functionally similar actin-binding proteins are regulated by lysophosphatidic acid.

K MEERSCHAERTV DE CORTEY DE VILLEJoël VandekerckhoveJan Gettemans

A1 Journal Article in EMBO JOURNAL

1997

Molecular cloning, over-expression, developmental regulation and immunolocalization of fragminP, a gelsolin-related actin-binding protein from Physarum polycephalum plasmodia.

D TJAMPENSKris Meerschaert.krB CONSTANTINJ BAILEYLJ COOKV DECORTEHans DemolM GOETHALSJ VANDAMMEJoël Vandekerckhove et al.

A1 Journal Article in JOURNAL OF CELL SCIENCE

Phosphatidylinositol 4,5-bisphosphate specifically stimulates PP60(c-src) catalyzed phosphorylation of gelsolin and related actin-binding proteins.

V DECORTEJan GettemansJoël Vandekerckhove

A1 Journal Article in FEBS LETTERS

1996

A novel type of protein kinase phosphorylates actin in the actin-fragmin complex.

L EICHINGERL BOMBLIESJoël VandekerckhoveM SCHLEICHERJan Gettemans

A1 Journal Article in EMBO JOURNAL

Fragmin, a microfilament regulatory protein from Physarum polycephalum, is phosphorylated by casein kinase II-type enzymes.

VEERLE DE CORTEJan GettemansY DEVILLEE WAELKENSJoël Vandekerckhove

A1 Journal Article in BIOCHEMISTRY

Identification of two Physarum casein kinase II enzymes that phosphorylate fragmin, an endogenous actin-binding protein.

V DECORTEJan GettemansY DEVILLEE WAELKENSP AGOSTINISJoël Vandekerckhove

A1 Journal Article in ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

In vivo phosphorylation of actin in Physarum polycephalum - Study of the substrate specificity of the actin-fragmin kinase.

V DECORTEJan GettemansE WAELKENSJoël Vandekerckhove

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Molecular cloning and expression of the Physarum actin-fragmin kinase (AFK) reveals a novel type of protein kinase.

L EICHINGERM SCHLEICHERJoël VandekerckhoveJan Gettemans

A1 Journal Article in ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

1995

Microfilament Dynamics - Regulation of Actin Polymerization by Actin-Fragmin Kinase and Phosphatases.

E WAELKENSJan GettemansV DECORTEY DEVILLEJ GORISJoël VandekerckhoveW MERLEVEDE

A1 Journal Article in ADVANCES IN ENZYME REGULATION, VOL 35

THE ACTIN-BINDING PROPERTIES OF THE PHYSARUM ACTIN-FRAGMIN COMPLEX - REGULATION OF CALCIUM, PHOSPHOLIPIDS, AND PHOSPHORYLATION.

Jan GettemansY DEVILLEE WAELKENSJoël Vandekerckhove

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1994

Regulation of microfilament dynamics through phosphorylation-dephosphorylation of actin in Physarum polycephalum

Jan GettemansJ. VandekerckhoveE. Waelkens

1993

Purification and partial amino-acid-sequence of the actin-fragmin kinase from Physarum-polycephalum.

Jan GettemansY DEVILLEJoël VandekerckhoveE WAELKENS

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1992

Physarum aclin is phosphorylated as the actin-fragmin complex at residues Thr203 and Thr202 by a specific 80kDa kinase.

Jan GettemansY DEVILLEJoël VandekerckhoveE WAELKENS

A1 Journal Article in EMBO JOURNAL