Research Explorer

Project

High resolution mapping and inhibition of invadosomes by means of single-chain antibodies against fascin.
Code
3F024812
Duration
01 October 2012 → 22 July 2016
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Medical biotechnology
    • Other (bio)medical engineering
Keywords
podosomes invadopodia single-chain antibody nanobody
 
Project description

Invadosomes are specialized protrusions present in cancer cells (called invadopodia) and normal hematopoietic cells like macrophages and dendritic cells (called podosomes). In this project, nanobodies will be generated against structural components of invadosomes enabling us to study the role of those components in structure, maturation and stability of invadosomes. Furthermore, nanobodies will be used to inhibit formation of invadosomes.