Research Explorer

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Project

Perturbing tumor-associated macrophage (TAM) equilibrium using GPNMB/CD206 nanobodies and nanoparticles in breast cancer.

Outputs and Outcomes

Code

01SC1923

Duration

01 October 2023 → 30 September 2027

Funding

Regional and community funding: Special Research Fund

Promotor

Jan Gettemans

Research disciplines

Engineering and technology
- Nanobiotechnology
- Human health engineering

Keywords

TAM Nanodody Nanoparticle Breast Cancer

Project description

Nanobodies are highly attractive to promote better active nanocarrier targeting, while M2-TAMs (tumor-associated macrophages) dominate the tumor microenvironment (TME) resulting in a worse treatment of breast cancer. Hence, there is a clear need to develop novel strategies to perturb TAM equilibrium. This project will use GPNMB/CD206-targeted nanobodies and nanoparticles to reveal the specific pathways for M2-TAMs re-education.

English

Dutch

English

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