understanding the effect of cortactin, a pleiotropic regulator of cancer cell invasion, using inhibitory nanobodies perturb its functional domains

01 October 2012 → 30 September 2013
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Natural sciences
    • Other biological sciences
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
Project description

We will use nanobody technology to study formation and maturation of invadopodia. We aim to study and counteract invadopodium formation by blocking specific functions of cortactin. Identification of anatagonistic cortactin nanobodies may serve a double purpose: reduce tumor cell motility as well as invadopodium formation. We will use a novel interactomics strategy to understand how nanobodies trigger changes in cancer cell migration and invadopodium formation at the molecular level. Our study will help pin down neww targets for future drug development wit applications in the treatment of cancer.