Project

Epitope mapping using VHH antibodies (nanobodies) as a tool to understand the moceluar basis of gelsolin activity in cancer cell invasion

Code

365H5608

Duration

01 October 2008 → 31 March 2010

Funding

Funding by bilateral agreement (private and foundations)

Promotor

Jan Gettemans

Research disciplines

Natural sciences
- Biochemistry and metabolism
- Systems biology
Medical and health sciences
- Medical biochemistry and metabolism
- Morphological sciences
- Oncology
- Medical biochemistry and metabolism
- Morphological sciences
- Oncology
- Medical biochemistry and metabolism
- Morphological sciences
- Oncology
Engineering and technology
- Catalysis and reacting systems engineering
- Chemical product design and formulation
- General chemical and biochemical engineering
- Process engineering
- Separation and membrane technologies
- Transport phenomena
- Other (bio)chemical engineering

Keywords

nanobody gelsolin VHH

Project description

Lama single domain antibodies raised against gelsolin will be used to neutralize the activity of this protein, primarily in cancer cells. By investigating where in gelsolin these nanobodies bind we can better understand how this protein contributes to malignant cell behavior.