Dissecting stromal-cancer cell interactions at the perivascular niche to detect and intercept the early metastatic process.

Cellular plasticity and heterogeneity in ovarian cancer progression and therapy resistance

Doctoral project Bieke Soen

Doctoral project Eva De Smedt

Doctoral project Jan Van Landeghem

Doctoral project Jeroen Verstappe

Doctoral project Kenneth Bruneel

Doctoral project Niels Vandamme

Doctoral project Ozden Akay

The cooperation between ZEB1 and epigenetic modulators during claudin-low breast cancer initiation and progression.

The role of EMP in Ovarian Carcinosarcoma progression, immune microenviroment and therapy resistance

Unraveling the molecular regulation of ZEB driven melanoma plasticity as a basis for anti-melanoma therapy

Unravelling the crosstalk between the immune microenvironment and epithelial mesenchymal plasticity (EMP) in colorectal peritoneal metastases.

Asparagine deprivation using a novel safer L-asparaginase to treat ovarian cancer

Doctoral project Evelien Peeters

Heterogeneity of cancer-associated fibroblast organization in the tumour environment: therapeutic applications and consequences of ex vivo adaptations

Impact of epithelial-to-mesenchymal transition on regulated cell death and immune activation in colorectal carcinoma

Targeting transcription factors addiction in acute leukemia

The peritoneal microenvironment in the pathogenesis of peritoneal carcinomatosis

Defining the role of ZEB1 in tumour initiation and progression of basal-like breast cancer

EMT inducers of the Snail transcriptionfactor family driving malignant skin cancer progression.

EMT, stem cells and inflammation: a malignant cocktail for cancer

EMT the ultimate inhibiting mechanism of cell death during cancer development

Epithelial breast cancer: from molecular signaling pathways to clinical application

Functional characterization of the EMT inducer, ZEB2/SIP1 during definitive hematopoiesis

Identification and characterization of residual melanoma cells to MAPL-targeted therapy: a search for biomarkers and novel therapeutic opportunities

Investigate the regulation of ZEB1/2 protein stability using an siRNA library screening 

Investigation of the in vivo role of the EMT-inducing transcription factors and ZEB2 ZEB1 in the development and progression of melanoma and non-melanoma skin cancers

In vivo analysis of the role of a newly identified screenings hit in breast epithelial homeostasis and basal breast cancer progression

In vivo analysis of the role of EMT in triple-negative breast cancer initiation and immune modulation.

Microenvironmental regulation of cancer progression

Research on regulation of Snail and delta EF1 transcriptionfactors during EMT

Role of Nanos-3 in cancer progression

Role of Nanos-3 in cancer progression

Role of the EMT transcription factor ZEB2 in the immune response associated with skin pathologies

Role of the Zeb family of transcription factors in T-cell Acute Lymphoblastic Leukemia (T-ALL)

Role of ZEB2 in T-cell acute lymphoblastic leukemia (T-ALL) initiation and Progression

Study of Cellular Plasticity during Malignant Cancer Progression

Study of the in vivo role of Snail in melanocyte stem cell homeostasis and melanoma during initiation and progression

Targeting pathways involved in ZEB1-driven EMT in an aggressive subtype of colorectal cancer

Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases

The metastic niche: preparation, function and translational evidence of a permissieve micro environment for cancer dissemination

The metazoan cadherin superfamily: evolution, structures and functions

The nuclear balance of ZEB transcription factors – a driver of cellular plasticity for initiation and progression of melanoma.

The role of ZEB1 in basal breast cancer

The role of ZEB transcription factors in epigenetic chromatin remodeling and gene expression regulation during EMT

The role of ZEB transcription factors in malignant progression and therapy resistance in high grade serous ovarian cancer

Towards improved genetic diagnosis for hereditary breast and ovarian cancer: evolution and challenges

Unbiased exploration of epithelial-mesenchymal plasticity in colorectal cancer reveals role for non-canonical STAT1 signalling

Unraveling the molecular regulation of ZEB driven melanoma plasticity as a basis for anti-melanoma therapy

Unravelling EMT-controlled aetiology and chemotherapy resistance of ovarian carcinosarcoma

ZEB1 drives melanoma development by bypassing oncogene-induced senescence in melanocytic nevi

A computational approach to monitor epithelial-to-mesenchymal plasticity in breast cancer patients through epigenetic analysis of cfDNA.

Alpha catenins: protein replacement in the fight against cancer invasion and metastasis

An alternative more tolerable L-asparaginase variant for the treatment of metastatic breast cancer

A patient derived xenograft (PDX) platform for in vivo evaluation of novel anticancer therapies

FullPicture: Combining Spectral Flow Cytometry with High-Speed Cell Imaging to enable comprehensive profiling of plant and animal cells and their components in real time.

Functional role of the Snail family of transcription factors in cancer progression in vivo

In silico identification of functional transcription factor binding sites in higher eukaryotes

Relation between energy and redox metabolism and regulated necrosis during EMT: an opportunity for experimental cancer therapy.

Role of cell adhesion-mediated signaling in craniofacial malformations: an integrated molecular and morphological study

Role of ZEB2 in T-cell acute lymphoblastic leukemia (T-ALL) initiation and Progression

Roles of Nanos family members in cancer progression

SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomics

Structural and functional characterization of class-II classic cadherins end delta-protocadherins

The peritoneal microenvironment in the pathogenesis of colorectal peritoneal carcinomatosis: the role of MMT and cancer-associated fibroblasts

The role of E-cadherin in epithelial differentiation and growth control: mechanisms of transcriptional regulation and abnormal gene expression in human tumors

The use of a less toxic alternative asparaginase variant to treat metastatic breast cancer