Research Explorer

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Researcher

Geert Berx

Publications & Research Data

Awards & Distinctions

182 Results

2026

Caspase-3/7 deficiency results in enhanced intestinal inflammation and reduced tumorigenesis

Wei XieLaura WyckaertMike VadiBruno VerstraetenTatyana DivertJef HaerinckRiet De RyckeFemke BaekeMohamed LamkanfiGeert Berx et al.

U Journal Article in SCIENCE ADVANCES

2025

Development and validation of a high-throughput screening pipeline of compound libraries to target EMT

Sven JonckheereJoachim TaminauJamie AdamsJef HaerinckJordy De ConinckJeroen VerstappeKato De ClercqEvelien PeetersAlexander GheldofEva De Smedt et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

EMT and cancer : what clinicians should know

Erik W. ThompsonAndrew D. RedfernSimone BrabletzGeert BerxVeenoo AgarwalKaruna GaneshRuby Y. HuangDana Ishay-RonenPierre SavagnerGuojun Sheng et al.

A1 Journal Article in NATURE REVIEWS CLINICAL ONCOLOGY

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Nele VandenbusscheRenske ImschootBéatrice LintermansLode DenolfJoachim TaminauCharlotte FieuwsGeert BerxKris GevaertKathleen Claes

A1 Journal Article in MOLECULAR ONCOLOGY

The peritoneal microenvironment in the pathogenesis of peritoneal carcinomatosis

Jesse DemuytereWim CeelenGeert BerxAnne Hoorens

2024

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia

Lisa DemoenFilip MatthijssensLindy ReunesBruno PalhaisBéatrice LintermansSara T'SasIgor FijalkowskiJoachim TaminauMuluembet Z. AkeleSiska Van Belle et al.

A1 Journal Article in SCIENCE ADVANCES

Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

Maude JansMagdalena KolataGillian BlanckeAline D'HondtClaudia GrafMaarten CiersMozes SzeAlexandra ThiranIoanna PettaVanessa Andries et al.

A1 Journal Article in NATURE

Identification and validation of extracellular vesicle reference genes for the normalization of RT‐qPCR data

Cláudio PinheiroNiké GuilbertLien LippensQuentin RouxRobin BoiySuzanne FischerSofie Van DorpeBram De CraeneGeert BerxTom Boterberg et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Laser-induced vapor nanobubbles for B16-F10 melanoma cell killing and intracellular delivery of chemotherapeutics

Jana RamonYanou EngelenHerlinde De KeersmaeckerIlia GoemaereDeep PunjJulián Mejía MoralesCédric BonteGeert BerxEsther HosteStephan Stremersch et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

ZEB2 drives intra-tumor heterogeneity and skin squamous cell carcinoma formation with distinct EMP transition states

Jeroen VerstappeNicolas SkrypekJordy De ConinckBieke SoenJoachim TaminauMarianthi TatariKenneth BruneelNele LoretKato De ClercqCaroline Van den Broecke et al.

A1 Journal Article in ISCIENCE

2023

A role for partial epithelial-to-mesenchymal transition in enabling stemness in homeostasis and cancer

Jeroen VerstappeGeert Berx

A1 Journal Article in SEMINARS IN CANCER BIOLOGY

Impact of EMT on regulated cell death and immune activation in colorectal cancer

Hanne VerschuerePeter VandenabeeleGeert Berx

The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation

Jef HaerinckSteven GoossensGeert Berx

A1 Journal Article in NATURE REVIEWS GENETICS

2022

Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1

Yingying HanAlvaro Villarreal-PonceGuadalupe GutierrezQuy NguyenPeng SunTing WuBenjamin SuiGeert BerxThomas BrabletzKai Kessenbrock et al.

A1 Journal Article in CELL REPORTS

Distinct transcriptional programs in ascitic and solid cancer cells induce different responses to chemotherapy in high-grade serous ovarian cancer

Nele LoretNiels VandammeJordy De ConinckJoachim TaminauKato De ClercqGillian BlanckeSven JonckheereSteven GoossensKelly LemeireSofie De Prijck et al.

A1 Journal Article in MOLECULAR CANCER RESEARCH

Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis

Willeke de HaanWouter DheedeneKaterina ApeltSofiane Decombas-DeschampsStefan VinckierStefaan VerhulstAndrea ConidiThomas DeffieuxMichael W. StaringPetra Vandervoort et al.

A1 Journal Article in CARDIOVASCULAR RESEARCH

Epithelial-mesenchymal transition (EMT) as a therapeutic target

Sven JonckheereJamie AdamsDominic De GrooteKyra CampbellGeert BerxSteven Goossens

A1 Journal Article in CELLS TISSUES ORGANS

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state

Farzaneh GhazaviJelle HuysentruytJordy De ConinckStephanie KourulaSofie MartensBehrouz HassanniaTim WartewigTatyana DivertRia RoelandtBastian Popper et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL deficiency in BrafV600EPten-/- melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice

Sofie MartensNozomi TakahashiGillian BlanckeNiels VandammeHanne VerschuereTatyana DivertMarnik VuylstekeGeert BerxPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Myb drives B-cell neoplasms and myeloid malignancies in vivo

Tim PietersAndré Pedro Pinto De AlmeidaSara T'SasKelly LemeireTino HochepiedGeert BerxAlex KentsisSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

Therapeutic targeting of ZEB1-mediated EMT in metastatic colorectal cancer

Sven JonckheereGeert BerxSteven Goossens

2021

Cellular plasticity and heterogeneity in ovarian cancer progression and therapy resistance

Nele LoretGeert BerxPhilippe TummersBart Lambrecht

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud Marchand et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

Marion PicardSatoru YonekuraKarolina SlowickaIoanna PettaConrad RauberBertrand RoutyCorentin RichardValerio IebbaMaryam Tidjani AlouSonia Becharef et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity

Jueqiong WangCarlos FarkasAissa BenyoucefCatherine CarmichaelKatharina HaighNick WongDanny HuylebroeckMarc P. StemmlerSimone BrabletzThomas Brabletz et al.

A1 Journal Article in PLOS BIOLOGY

Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells

Maria Lasierra LosadaMelissa PaulerNiels VandammeSteven GoossensGeert BerxMoritz LeppkesHarald SchuhwerkSimone BrabletzThomas BrabletzMarc P. Stemmler

A1 Journal Article in CELL DEATH DISCOVERY

Partial EMT takes the lead in cancer metastasis

Jef HaerinckGeert Berx

Editorial material

The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma

Manuel RuhMarc P. StemmlerIsabell FrischKathrin FuchsRuthger RoeyJulia KleemannMaike RoasHarald SchuhwerkRebecca L. EcclesAbbas Agaimy et al.

A1 Journal Article in JOURNAL OF PATHOLOGY

The ZEB2-dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer

Rahul SreekumarHajir Al-SaihatiMuhammad EmaduddinKarwan MoutasimMassimiliano MelloneAshish PatelSeval KilicMetin CetinSule ErdemirMarta Salgado Navio et al.

A1 Journal Article in MOLECULAR ONCOLOGY

XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells

Adam WahidaMadeleine MuellerAndreas HiergeistBastian PopperKatja SteigerCaterina BrancaMarkus TschurtschenthalerThomas EngleitnerSainitin DonakondaJordy De Coninck et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

2020

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma

Elien De ThayeKoen Van de VijverJoni Van der MeulenJoachim TaminauGlenn WagemansHannelore DenysJo Van DorpeGeert BerxWim CeelenJan Van Bocxlaer et al.

A1 Journal Article in SCIENTIFIC REPORTS

Guidelines and definitions for research on epithelial–mesenchymal transition

Jing YangParker AntinGeert BerxCédric BlanpainThomas BrabletzMarianne BronnerKyra CampbellAmparo CanoJordi CasanovaGerhard Christofori et al.

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immunodominant AH1 antigen-deficient necroptotic, but not apoptotic, murine cancer cells induce antitumor protection

Tania Love AaesHanne VerschuereAgnieszka KaczmarekLiesbeth HeyndrickxBartosz WiernickiIris DelrueBram De CraeneJoachim TaminauTinneke DelvaeyeMathieu Bertrand et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Intrinsic balance between ZEB family members is important for melanocyte homeostasis and melanoma progression

Kenneth BruneelJeroen VerstappeNiels VandammeGeert Berx

A1 Journal Article in CANCERS

Publisher correction : Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Catherine L. CarmichaelJueqiong WangThao NguyenOluseyi KolawoleAissa BenyoucefCharlotte De MazièreAnna MilneSona SamuelKevin Robert GillinderSoroor Hediyeh-zadeh et al.

A1 Journal Article in BLOOD

The EMT transcription factor ZEB2 promotes proliferation of primary and metastatic melanoma while suppressing an invasive, mesenchymal-like phenotype

Niels VandammeGeertrui DeneckerKenneth BruneelGillian BlanckeOzden AkayJoachim TaminauJordy De ConinckEva De SmedtNicolas SkrypekWouter Van Loocke et al.

A1 Journal Article in CANCER RESEARCH

Tumor engineered model for low-grade serous ovarian carcinoma (LGSOC) : mimicking the tumor environment on a cellular and biophysical level

Elly De VlieghereEva BlondeelWim CeelenBruno De GeestGeert BerxSandra Van VlierbergheOlivier De Wever

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

A1 Journal Article in NATURE CANCER

2019

A new mouse model to study the role of ectopic Nanos3 expression in cancer

Vanessa AndriesEvi De KeuckelaereKatrien StaesTino HochepiedJoachim TaminauKelly LemeirePhilippe BirembautGeert BerxFrans Van Roy

A1 Journal Article in BMC CANCER

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Hannah Van HoveLiesbet MartensIsabelle ScheyltjensKaren De VlaminckAna Rita Pombo AntunesSofie De PrijckNiels VandammeSebastiaan De SchepperGert Van IsterdaelCharlotte Scott et al.

A1 Journal Article in NATURE NEUROSCIENCE

An Ovol2‐Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation

Daniel HaenselPeng SunAdam L MacLeanXianghui MaYuan ZhouMarc P StemmlerSimone BrabletzGeert BerxMaksim V PlikusQing Nie et al.

A1 Journal Article in EMBO REPORTS

From neural crest cells to melanocytes : cellular plasticity during development and beyond

Niels VandammeGeert Berx

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

Gloria MilaniFilip MatthijssensWouter Van LoockeKaat DurinckJuliette RoelsSofie PeirsMorgan ThénozTim PietersLindy ReunesBéatrice Lintermans et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Human decellularized dermal matrix seeded with adipose-derived stem cells enhances wound healing in a murine model : experimental study

Maarten DoornaertBernard DepypereDavid CreytensHeidi DeclercqJoachim TaminauKelly LemeireStan MonstreyGeert BerxPhillip Blondeel

A2 Journal Article in ANNALS OF MEDICINE AND SURGERY

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino Hochepied et al.

A1 Journal Article in SCIENTIFIC REPORTS

The role of epithelial-to-mesenchymal plasticity in ovarian cancer progression and therapy resistance

Nele LoretHannelore DenysPhilippe TummersGeert Berx

A1 Journal Article in CANCERS

Tumor engineering a clinical relevant model that recapitulates the tumor environment of peritoneal metastases in vitro and in vivo

Elly De VlieghereEmiel De JaeghereGlenn WagemansThibaut Van AckerChristian VanhoveSarah NeytsGeert BerxFrank VanhaeckeWim CeelenBruno De Geest et al.

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T-cell leukemia

Qi JinCarlos A MartinezKelly M ArcipowskiYixing ZhuBlanca T Gutierrez-DiazKenneth K WangMegan R JohnsonAndrew G VolkFeng WangJian Wu et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Xenogen-free isolation and culture of human adipose mesenchymal stem cells

Maarten DoornaertElisabeth De MaereJulien ColleHeidi DeclercqJoachim TaminauKelly LemeireGeert BerxPhillip Blondeel

A1 Journal Article in STEM CELL RESEARCH

ZEB1 as 'jack-of-all-trades' in breast cancer progression

Eva De SmedtGeert Berx

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

Steven GoossensJueqiong WangCedric TremblayJelle De MedtsSara T'SasThao NguyenJesslyn SawKatharina HaighDavid J CurtisPieter Van Vlierberghe et al.

A1 Journal Article in HAEMATOLOGICA

ZEB2 in T-cells and T-ALL

Stien De ConinckGeert BerxTom TaghonPieter Van VlierbergheSteven Goossens

A2 Journal Article in ADVANCES IN BIOLOGICAL REGULATION

2018

Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice

Marjolijn RenardSuzanne VanhauwaertMarine VanhomwegenAli RihaniNiels VandammeSteven GoossensGeert BerxPieter Van VlierbergheJody J HaighBieke Decaesteker et al.

A1 Journal Article in SCIENTIFIC REPORTS

Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo

Emiel De JaeghereElly De VlieghereJasper Van HoorickSandra Van VlierbergheGlenn WagemansLeen PietersElodie MelsensMarleen PraetJo Van DorpeMatthieu Boone et al.

A1 Journal Article in BIOMATERIALS

Nanos genes and their role in development and beyond

Evi De KeuckelaerePaco HulpiauYvan SaeysGeert BerxFrans Van Roy

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The role of Nanos3 in tumor progression

Evi De KeuckelaereFrans Van RoyGeert Berx

The TLX1 oncogene modules the enhancer RNA landscape in T-ALL

Karen VerboomWouter Van LoockeJo VandesompeleNiels VandammeGeert BerxYvan SaeysLiesbet MartensPieter Van VlierbergheFranki SpelemanKaat Durinck

The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages

Charlotte ScottWouter T'JonckLiesbet MartensHelena TodorovDorine SichienBieke SoenJohnny BonnardelSofie De PrijckNiels VandammeRobrecht Cannoodt et al.

A1 Journal Article in IMMUNITY

TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia

Karen VerboomWouter Van LoockeJo VandesompeleNiels VandammeGeert BerxLiesbet MartensYvan SaeysPieter Van VlierbergheFranki SpelemanKaat Durinck

ZEB proteins in leukemia : friends, foes, or friendly foes?

Bieke SoenNiels VandammeGeert BerxJürg SchwallerPieter Van VlierbergheSteven Goossens

A2 Journal Article in HEMASPHERE

Zeb1 and Zeb2 : master regulators of mononuclear phagocyte development and homeostasis

Bieke SoenGeert BerxCharlotte Scott

ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition

Nicolas SkrypekKenneth BruneelCindy VandewalleEva De SmedtBieke SoenNele LoretJoachim TaminauSteven GoossensNiels VandammeGeert Berx

A1 Journal Article in EPIGENETICS & CHROMATIN

2017

Confounding factors of ultrafiltration and protein analysis in extracellular vesicle research

Glenn VergauwenBert DhondtJan Van DeunEva De SmedtGeert BerxEvy TimmermanKris GevaertIlkka MiinalainenVeronique CocquytGeert Braems et al.

A1 Journal Article in SCIENTIFIC REPORTS

Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation

Michael DevosBarbara GilbertGeertrui DeneckerKirsten LeursConor Mc GuireKelly LemeireTino HochepiedMarnik VuylstekeJo LambertCaroline Van den Broecke et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

EMT transcription factors in cancer development re-evaluated : beyond EMT and MET

Steven GoossensNiels VandammePieter Van VlierbergheGeert Berx

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Epithelial-to-mesenchymal transition : epigenetic reprogramming driving cellular plasticity

Nicolas SkrypekSteven GoossensEva De SmedtNiels VandammeGeert Berx

A1 Journal Article in TRENDS IN GENETICS

EV-TRACK : transparent reporting and centralizing knowledge in extracellular vesicle research

Jan Van DeunPieter MestdaghPatrizia AgostinisÖzden AkaySushma AnandJasper AnckaertZoraida Andreu MartinezTine BaetensEls BegheinLaurence Bertier et al.

A1 Journal Article in NATURE METHODS

Heterocellular 3D scaffolds as biomimetic of peritoneal metastasis in vitro and in vivo

Emiel De JaeghereElly De VlieghereJasper Van HoorickGlenn WagemansLeen PietersElodie MelsensSara NeytRouba GhobeiraRino MorentJo Van Dorpe et al.

In vivo visualisation of vessel formation in peritoneal tumour scaffolds with μCT

Emiel De JaeghereElly De VlieghereSara NeytBert VandeghinsteJasper Van HoorickGlenn WagemansLeen PietersElodie MelsensGeert BerxSandra Van Vlierberghe et al.

Mouse cutaneous melanoma induced by mutant BRaf arises from expansion and dedifferentiation of mature pigmented melanocytes

Corinna KohlerDavid NittnerFlorian RambowEnrico RadaelliFabio StanchiNiels VandammeArianna BaggioliniLukas SommerGeert BerxJoost J van den Oord et al.

A1 Journal Article in CELL STEM CELL

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Steven GoossensSofie PeirsWouter Van LoockeJueqiong WangMina TakawyFilip MatthijssensStefan E SondereggerKatharina HaighThao NguyenNiels Vandamme et al.

A1 Journal Article in BLOOD

Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange

Tim PietersLieven HaenebalckeKenneth BruneelNiels VandammeTino HochepiedJolanda van HengelDagmar WirthGeert BerxJody J HaighFrans Van Roy et al.

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsV FrismantasFilip MatthijssensW Van LoockeTim PietersNiels VandammeBéatrice LintermansMP DobayGeert BerxBruce Poppe et al.

A1 Journal Article in LEUKEMIA

ZEB1 and ZEB2 dictate melanocyte differentiation and melanoma phenotype switching

Niels VandammeGeert Berx

Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells

Agata StryjewskaRuben DriesTim PietersGriet VerstappenAndrea ConidiKathleen CoddensAnnick FrancisLieve UmansWilfred FJ van IJckenGeert Berx et al.

A1 Journal Article in STEM CELLS

2016

BRD4 inhibition improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

BRD4 inhibition improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

Cyclin D2 overexpression recapitulates mantle cell lymphoma in mice

Tim PietersSteven GoossensSara T'SasGeert BerxJody J HaighPieter Van Vlierberghe

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensJ HaighGeert Berx et al.

Genetic characterization and therapeutic targeting of MYC translocated pediatric T-cell acute lymphoblastic leukemia

Gloria MilaniKaat DurinckFilip MatthijssensSofie PeirsTim PietersLindy ReunesBéatrice LintermansNiels VandammeTim LammensYunlei Li et al.

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19

Hetty HelsmoortelBarbara De MoerlooseTim PietersFarzaneh GhazaviSilvia BresolinHelene CaveAndrica de VriesValerie de HaasChristian FlothoVeerle Labarque et al.

A1 Journal Article in HAEMATOLOGICA

Oncogenic ZEB2 activation drives sensitivity towards LSD1 inhibition in T-Cell acute lymphoblastic leukemia

Steven GoossensSofie PeirsGeert BerxPieter Van VlierbergheJody J Haigh

p120 Catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Tim PietersSteven GoossensLieven HaenebalckeVanessa AndriesAgata StryjewskaRiet De RyckeKelly LemeireTino HochepiedDanny HuylebroeckGeert Berx et al.

A1 Journal Article in PLOS GENETICS

Targeting BET family proteins improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

Targeting BET family proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsViktoras FrismantasFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeWouter Van LoockeGeert BerxBruce PoppeJean-Pierre Bourquin et al.

The combination of ABT-199 and JQ1 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeBéatrice LintermansLindy ReunesGeert BerxBruce PoppePieter Van Vlierberghe

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

Charlotte ScottBieke SoenLiesbet MartensNicolas SkrypekWouter SaelensJoachim TaminauGillian BlanckeGert Van IsterdaelDanny HuylebroeckJody Haigh et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Tissue factor induced by epithelial-mesenchymal transition triggers a procoagulant state that drives metastasis of circulating tumor cells

Morgane BourcyMeggy Suarez-CarmonaJustine LambertMarie-Emilie FrancartHélène SchroederCéline DelierneuxNicolas SkrypekErik W ThompsonGuy JérusalemGeert Berx et al.

A1 Journal Article in CANCER RESEARCH

Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity

Tania Love AaesAgnieszka KaczmarekTinneke DelvaeyeBram De CraeneStefaan De KokerLiesbeth HeyndrickxIris DelrueJoachim TaminauBartosz WiernickiPhilippe De Groote et al.

A1 Journal Article in CELL REPORTS

2015

A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes

Philippe De GrooteHong Tran ThiMathias FransenGiel TangheCorinne UrwylerBram De CraeneKirsten LeursBarbara GilbertGriet Van ImschootRiet De Rycke et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Development and characterization of a new human hepatic cell line

Eva RamboerBram De CraeneJoey De KockGeert BerxVera RogiersTamara VanhaeckeMathieu Vinken

A1 Journal Article in EXCLI JOURNAL

NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest

Vanessa AndriesKarl VandepoeleKatrien StaesGeert BerxPieter BogaertGert Van IsterdaelDaisy GinnebergeEef ParthoensJonathan VandenbusscheKris Gevaert et al.

A1 Journal Article in BMC CANCER

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

Katja HorvayThierry JardéFranca CasagrandaVictoria M PerreauKatharina HaighChristian M NefzgerReyhan AkhtarThomas GridleyGeert BerxJody Haigh et al.

A1 Journal Article in EMBO JOURNAL

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

Mary van HeldenSteven GoossensCécile DaussyAnne-Laure MathieuFabrice FaureAntoine MarçaisNiels VandammeNatalie FarlaKatia MayolSébastien Viel et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells

Elly De VlieghereFélix GremonprezLaurine VersetLore MariënChristopher JonesBram De CraeneGeert BerxBenedicte DescampsChristian VanhoveJean Paul Remon et al.

A1 Journal Article in BIOMATERIALS

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensEnrico RadaelliOdile BlanchetKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonCedric S TremblayMagdaline CostaMorvarid Farhang Ghahremani et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability

Mauricio Quimbaya GomezEric RaspéGeertrui DeneckerBram De CraeneRia RoelandtWim DeclercqXavier SagaertLieven De VeylderGeert Berx

A1 Journal Article in NEOPLASIA

Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential

Bram De CraeneGeertrui DeneckerPetra VermassenJoachim TaminauC MauchAnnie DeroreJ JonkersE FuchsGeert Berx

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

Geertrui DeneckerNiels VandammeOzden AkayD KoludrovicJoachim TaminauKelly LemeireAlexander GheldofBram De CraeneMireille Van GeleLieve Brochez et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Melanoma cells revive an embryonic transcriptional network to dictate phenotypic heterogeneity

Niels VandammeGeert Berx

A2 Journal Article in FRONTIERS IN ONCOLOGY

Strategies for immortalization of primary hepatocytes

Eva RamboerBram De CraeneJoery De KockTamara VanhaeckeGeert BerxVera RogiersMathieu Vinken

A1 Journal Article in JOURNAL OF HEPATOLOGY

ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins

Marianthi TatariBram De CraeneBieke SoenJoachim TaminauPetra VermassenSteven GoossensKatharina HaighSilvia CazzolaJo LambertDanny Huylebroeck et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2013

Cadherins and epithelial-to-mesenchymal transition

Alexander GheldofGeert Berx

A1 Journal Article in Progress in Molecular Biology and Translational Science

Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1

Veronique van den BergheElke StappersBram VandesandeJordane DimidschsteinRoel KroesAnnick FrancisAndrea ConidiFlore LesageRuben DriesSilvia Cazzola et al.

A1 Journal Article in NEURON

Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression

Benjamin KoopmanschGeert BerxJean-Michel FoidartChristine GillesRosita Winkler

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulatory networks defining EMT during cancer initiation and progression

Bram De CraeneGeert Berx

A1 Journal Article in NATURE REVIEWS CANCER

2012

Concepts of metastasis in flux: the stromal progression model

Jonathan P SleemanGerhard ChristoforiRiccardo FoddeJohn G CollardGeert BerxCharles DecraeneCurzio Rüegg

A1 Journal Article in SEMINARS IN CANCER BIOLOGY

Evolutionary functional analysis and molecular regulation of the ZEB transcription factors

Alexander GheldofPaco HulpiauFrans Van RoyBram De CraeneGeert Berx

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Gene expression profiling to dissect the complexity of cancer biology: pitfalls and promise

Eric RaspéCharles DecraeneGeert Berx

A1 Journal Article in SEMINARS IN CANCER BIOLOGY

Identification of putative cancer genes through data integration and comparative genomics between plants and humans

Mauricio Quimbaya GomezKlaas VandepoeleEric RaspéMichiel MatthijsStijn DhondtGerrit BeemsterGeert BerxLieven De Veylder

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2011

Functional analysis of the EMT inducing transcription factor ZEB1 during malignant carcinoma progression

Alexander GheldofGeert Berx

Identification of novel conserved cell cycle genes through data integration and comparative genomics between plants and humans

Mauricio Quimbaya GomezLieven De VeylderGeert Berx

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization

Steven GoossensViktor JanzenSona BartunkovaTomomasa YokomizoBenjamin DrogatMihaela CrisanKatharina HaighEve SeuntjensLieve UmansTamara Riedt et al.

A1 Journal Article in BLOOD

2010

Key signalling nodes in mammary gland development and cancer: the snail1-twist1 conspiracy in malignant breast cancer progression

Ellen FoubertBram De CraeneGeert Berx

A1 Journal Article in BREAST CANCER RESEARCH

Module network inference from a cancer gene expression data set identifies microRNA regulated modules

Eric BonnetMarianthi TatariAnagha Madhusudan JoshiTom MichoelKathleen MarchalGeert BerxYves Van de Peer

A1 Journal Article in PLOS ONE

Regulation of p63 isoforms by snail and slug transcription factors in human squamous cell carcinoma

Michael HerfsPascale HubertMeggy Suarez-CarmonaAnca ReschnerSven SaussezGeert BerxPierre SavagnerJacques BoniverPhilippe Delvenne

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

The MCM-Binding Protein ETG1 Aids Sister Chromatid Cohesion Required for Postreplicative Homologous Recombination Repair

Naoki TakahashiMauricio Quimbaya GomezVeit SchubertTim LammensKlaas VandepoeleIngo SchubertMinami MatsuiDirk InzéGeert BerxLieven De Veylder

A1 Journal Article in PLOS GENETICS

2009

Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes

J Van den BosschePieter BogaertJolanda van HengelChris GuerinGeert BerxK MovahediR Van den BerghA Pereira-FernandesJMC GeunsH Pircher et al.

A1 Journal Article in BLOOD

Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells

Omar NyabiMichaël NaessensKatharina HaighAgnieszka GembarskaSteven GoossensMarion MaetensSarah De ClercqBenjamin DrogatLieven HaenebalckeSona Bartunkova et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Involvement of members of the Cadherin superfamily in cancer

Geert BerxFrans Van Roy

A1 Journal Article in COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

The role of the ZEB family of transcription factors in development and disease

Cindy VandewalleFrans Van RoyGeert Berx

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair

Jean-Christophe MarineGeert Berx

A1 Journal Article in BREAST CANCER RESEARCH

2008

A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genes

Karl VandepoeleVanessa AndriesNadine Van RoyKatrien StaesJo VandesompeleGenevieve LaureysEls De SmetGeert BerxFranki SpelemanFrans Van Roy

A1 Journal Article in PLOS ONE

A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the the human NBPF1 and ACCN1 genes

Frans Van RoyKlaas VandepoeleNadine Van RoyVanessa AndriesKatrien StaesJo VandesompeleGenevieve LaureysEls De SmetGeert BerxFranki Speleman

Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front

Olivier De WeverPatrick PauwelsBram De CraeneM SABBAHS EMAMIG REDEUILHC GESPACHmarc brackeGeert Berx

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

Snail promotes Wnt target gene expression and interacts with beta-catenin

V STEMMERBram De CraeneGeert BerxJ BEHRENS

A1 Journal Article in ONCOGENE

The cell-cell adhesion molecule E-cadherin

Frans Van RoyGeert Berx

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression

A BONNOMETM POLETTEKristin StrumaneC GILLESV DALSTEINC KILEZTKYGeert BerxFrans Van RoyP BIREMBAUTB NAWROCKI-RABY

A1 Journal Article in ONCOGENE

Transforming growth factor-beta 1-mediated slug and snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expression

M HERFSP HUBERTN KHOLODJH CABERGC GILLESGeert BerxP SAVAGNERJ BONIVERP DELVENNE

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

2007

Direct repression of cyclin d1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition

J MEJLVANGM KRIAJEVSKACindy VandewalleT CHERNOVAAE SAYANGeert BerxJK MELLONE TULCHINSKY

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL

Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer

Geert BerxEric RaspéG CHRISTOFORIJP THIERYJP SLEEMAN

A1 Journal Article in CLINICAL & EXPERIMENTAL METASTASIS

VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail

AJ EVANSRC RUSSELLO ROCHETN BURRYJE FISHVWK CHOWWY KIMA SARAVANANMA MAYNARDML GERVAIS et al.

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

2006

A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer

S SPADERNAO SCHMALHOFERF HLUBEKGeert BerxA EGERS MERKELA JUNGT KIRCHNERT BRABLETZ

A1 Journal Article in GASTROENTEROLOGY

E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion

Kristin StrumaneArnaud BonnometChristophe StoveRoosmarijn VandenbrouckeBeatrice Nawrocki-RabyErik BruyneelMarcus MareelPhilippe BirembautGeert BerxFrans Van Roy

A1 Journal Article in CANCER RESEARCH

Modulation of iron transport proteins in human colorectal carcinogenesis

MJ BROOKESS HUGHESFE TURNERG REYNOLDSN SHARMAT ISMAILGeert BerxAT MCKIEN HOTCHINGJ ANDERSON et al.

A1 Journal Article in GUT

Regulation of vimentin by SIP1 in human epithelial breast tumor cells

S BINDELSM MESTDAGTCindy VandewalleN JACOBSL VOLDERSA NOELFrans Van RoyGeert BerxJM FOIDARTC GILLES

A1 Journal Article in ONCOGENE

Snail in the frame of malignant tumor recurrence

Bram De CraeneGeert Berx

A1 Journal Article in BREAST CANCER RESEARCH

2005

DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells

A EGERK AIGNERS SONDEREGGERB DAMPIERS OEHLERM SCHREIBERGeert BerxA CANOH BEUGR FOISNER

A1 Journal Article in ONCOGENE

SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions

Cindy VandewalleJoke ComijnBram De CraenePetra VermassenErik BruyneelH AndersenE TulchinskyFrans Van RoyGeert Berx

A1 Journal Article in NUCLEIC ACIDS RESEARCH

The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program

Bram De CraeneBarbara GilbertChristophe StoveErik BruyneelFrans Van RoyGeert Berx

A1 Journal Article in CANCER RESEARCH

Unraveling signalling cascades for the Snail family of transcription factors

Bram De CraeneFrans Van RoyGeert Berx

A1 Journal Article in CELLULAR SIGNALLING

2004

Cadherins in cancer

Kristin StrumaneGeert BerxFrans Van Roy

Bookchapter in Handbook of Experimental Pharmacology

Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons

Katleen De PreterFilip PattynGeert BerxKristin StrumaneBjörn MentenFrans Van RoyAnne De PaepeFranki SpelemanJo Vandesompele

A1 Journal Article in BMC GENOMICS

Epithelial cell plasticity by dynamic transcriptional regulation of E-cadherin

Geert BerxFrans Van Roy

Bookchapter in Rise and fall of epithelial phenotype

GATA-4 and MEF2C transcription factors control the tissue-specific expression of the αT-catenin gene CTNNA3

Griet VanpouckeSteven GoossensBram De CraeneBarbara GilbertFrans Van RoyGeert Berx

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2003

Functional and molecular characterization of the epithelioid to round transition in human colorectal cancer LoVo cells

PHILIP DEBRUYNEStefan VermeulenGeert BerxM POCARDASC DA ROCHAXD LIL CIRNESMF POUPONFrans Van RoyMarcus Mareel

A1 Journal Article in ONCOGENE

Identification of excretory-secretory products of larval and adult Ostertagia ostertagi by immunoscreening of cDNA libraries

Isabel VercauterenPeter GeldhofIris PeelaersEdwin ClaereboutGeert BerxJozef Vercruysse

A1 Journal Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Identification of potential protective antigens of Ostertagia ostertagi with local antibody probes

Veerle De MaereIsabel VercauterenHeidi SaverwynsEdwin ClaereboutGeert BerxJozef Vercruysse

Protein disulphide isomerase of Ostertagia ostertagi: an excretory-secretory product of L4 and adult worms?

Peter GeldhofIsabel VercauterenD KNOXV DEMAEREAnnelies Van ZeverenGeert BerxJozef VercruysseEdwin Claerebout

A1 Journal Article in INTERNATIONAL JOURNAL FOR PARASITOLOGY

The role of E-cadherin in epithelial differentiation and cancer progression

Kristin StrumaneFrans Van RoyGeert Berx

Bookchapter in Recent Research Development in Cellular Biochemistry

2002

Identification of potential protective antigens of Ostertagia ostertagi with local antibody probes

Veerle De MaereIsabel VercauterenHeidi SaverwynsEdwin ClaereboutGeert BerxJozef Vercruysse

A1 Journal Article in PARASITOLOGY

Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type I patients.

Nadine Van RoyJo VandesompeleGeert BerxK STAESMireille Van GeleEls De SmetAnne De PaepeGenevieve LaureysP VAN DER DRIFTR VERSTEEG et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.

N MULLERA REINACHER-SCHICKS BALDUSJolanda van HengelGeert BerxA BAARFrans Van RoyW SCHMIEGELI SCHWARTE-WALDHOFF

A1 Journal Article in ONCOGENE

2001

E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma.

JC MACHADOC OLIVEIRAR CARVALHOP SOARESGeert BerxC CALDASR SERUCAF CARNEIROM SOBRINHO-SIMOES

A1 Journal Article in ONCOGENE

Expression of the E-cadherin-catenin complex in lung neuroendocrine tumours.

CE CLAVELFriedel NolletGeert BerxS TEJPARB NAWORCKI-RABYHH KAPLANFrans Van RoyPL BIREMBAUT

A1 Journal Article in JOURNAL OF PATHOLOGY

The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression

Geert BerxFrans Van Roy

A1 Journal Article in BREAST CANCER RESEARCH

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.

Joke ComijnGeert BerxP VERMASSENK VERSCHUERENL VAN GRUNSVENErik BruyneelMarcus MareelD HUYLEBROECKFrans Van Roy

A1 Journal Article in MOLECULAR CELL

1999

Distinct deleted regions on chromosome segment 16q23-24 associated with metastases in prostate cancer.

CD LIGeert BerxC LARSSONG AUERU ASPENBLADY PANB SUNDELINP EKMANM NORDENSKJOLDFrans Van Roy et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas.

JC MACHADOP SOARESF CARNEIROA ROCHAS BECKN BLINGeert BerxM SOBRINHO-SIMOES

A1 Journal Article in LABORATORY INVESTIGATION

Identification of eleven novel tumor-associated E-cadherin mutations

Karl-Friedrich BeckerUlrike ReichChristina SchottIngrid BeckerGeert BerxFrans Van RoyHeinz Höfler

A2 Journal Article in HUMAN MUTATION

Neuroblastoma: from molecular cytogenetics to gene expression profiling

Jo VandesompeleNadine Van RoyGeert BerxD PLANTAZAnne De PaepeGenevieve LaureysFrans Van RoyFranki Speleman

Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis.

Marc Van De CraenGeert BerxI VAN DEN BRANDEWalter FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

The role of the E-cadherin/catenin adhesion complex in the development and progression of cancer.

Friedel NolletGeert BerxFrans Van Roy

A2 Journal Article in Molecular Cell Biol. Res. Commun.

1998

Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.

Geert BerxFriedel NolletFrans Van Roy

A1 Journal Article in CELL ADHESION AND COMMUNICATION

Mutations of the human E-cadherin (CDH1) gene.

Geert BerxKF BECKERH HOFLERFrans Van Roy

A1 Journal Article in HUMAN MUTATION

1997

Allelic imbalance at the beta-catenin gene (CTNNB1 at 3p22-21.3) in various human tumor types.

Friedel NolletA VANDENBERGAM KERSEMAEKERSAM CLETONJANSENGeert BerxAY VANDERVEENC EICHPERGERI WIELANDJ DEGREVEGJ LIEFERS et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

An efficient and reliable multiplex PCR-SSCP mutation analysis test applied to the human E-cadherin gene.

Geert BerxFriedel NolletKristin StrumaneFrans Van Roy

A1 Journal Article in HUMAN MUTATION

E-cadherin gene alterations are rare events in thyroid tumors.

P SOARESGeert BerxFrans Van RoyM SOBRINHO-SIMOES

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis.

CBJ VOSAM CLETONJANSENGeert BerxWJF DELEEUWNT TERHAARFrans Van RoyCJ CORNELISSEJL PETERSEMJ VANDEVIJVER

A1 Journal Article in BRITISH JOURNAL OF CANCER

Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ.

WJF DELEEUWGeert BerxCBJ VOSJL PETERSEMJ VANDEVIJVERS LITVINOVFrans Van RoyCJ CORNELISSEAM CLETONJANSEN

A1 Journal Article in JOURNAL OF PATHOLOGY

1996

Cadherin/catenin complex: A target for antiinvasive therapy?

Marcus MareelGeert BerxFrans Van Roymarc bracke

A1 Journal Article in JOURNAL OF CELLULAR BIOCHEMISTRY

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

Geert BerxAM CLETONJANSENKristin StrumaneWJF DELEEUWFriedel NolletFrans Van RoyC CORNELISSE

A1 Journal Article in ONCOGENE

Genomic organization of the human beta-catenin gene (CTNNB1).

Friedel NolletGeert BerxF MOLEMANSFrans Van Roy

A1 Journal Article in GENOMICS

Het menselijke E-cadherine gen : moleculaire karakterisering en analyse van genetische defecten in menselijke tumoren

Geert BerxWalter FiersF. Van Roy

The cadherin/catenin complex: a target for antiinvasive therapy ?

Marcus MareelGeert BerxFrans Van RoyMarc Bracke

A2 Journal Article in Journal Cellular Biochem., 61

1995

Assignment of the human beta-catenin gene (CTNNB1) to 3p22->p21.3 by fluorescence in situ hybridization.

J VANHENGELF NOLLETGeert BerxNadine Van RoyFranki SpelemanFrans Van Roy

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

CLONING AND CHARACTERIZATION OF THE HUMAN INVASION SUPPRESSOR GENE E-CADHERIN (CDH1).

Geert BerxK STAESJ VANHENGELF MOLEMANSMJG BUSSEMAKERSA VANBOKHOVENFrans Van Roy

A1 Journal Article in GENOMICS

E-cadherin is a tumour invasion suppressor gene mutated in human lobular breast cancers.

Geert BerxAM CLETONJANSENF NOLLETWJF DELEEUWMJ VANDEVIJVERC CORNELISSEFrans Van Roy

A1 Journal Article in EMBO JOURNAL

ISOLATION AND CHARACTERIZATION OF A HUMAN PSEUDOGENE (CTNNAP1) FOR ALPHA-E-CATENIN (CTNNA1) - ASSIGNMENT OF THE PSEUDOGENE TO 5Q22 AND THE ALPHA-E-CATENIN GENE TO 5Q31.

F NOLLETJ VANHENGELGeert BerxF MOLEMANSFrans Van Roy

A1 Journal Article in GENOMICS

Transition from the noninvasive to the invasive phenotype and loss of α-catenin in human colon cancer cells

Stefan VermeulenErik Bruyneelmarc brackeGeorges De BruyneKrist'l M VennekensKris VleminckxGeert BerxFrans Van RoyMarcus Mareel

A1 Journal Article in CANCER RESEARCH

1992

The invasion suppressor role of E-cadherin

Frans Van RoyK VleminckxLuc VakaetGeert BerxWalter FiersMarcus Mareel

Bookchapter in Metastasis : basic research and its clinical applications