Epithelial ovarian cancer is the most lethal of all gynecologic malignancies. This poor prognosis is mainly due to a delayed diagnosis resulting in advanced stage of disease and frequent therapy-resistant relapses.  We will address the role of the EMT (epithelial mesenchymal transition) inducing transcription factors ZEB1 and ZEB2 in tumor initiation, progression, metastasis and therapy-resistance in high-grade serous ovarian carcinoma.