Project

Role of Nanos-3 in cancer progression

Code

01F06913

Duration

01 October 2013 → 30 September 2015

Funding

Regional and community funding: Special Research Fund

Promotor

Geert Berx

Research disciplines

Natural sciences
- Genetics
- Systems biology
Medical and health sciences
- Laboratory medicine
- Molecular and cell biology
- Morphological sciences
- Oncology
- Laboratory medicine
- Morphological sciences
- Oncology
- Laboratory medicine
- Molecular and cell biology
- Morphological sciences
- Oncology

Project description

Metastasis is the major cause of cancer deaths. We found evidence that a newly identified protein, hNanos-3, might play an important role in tumor dissemination. Three different approaches are followed to investigate whether hNanos-3 expression increases the malignant potential of lung and prostate cancer cells: genetically modified mice, identification of molecular interaction partners, characterization of target transcripts encoding key proteins.