Project

The metazoan cadherin superfamily: evolution, structures and functions

Code
3G032011
Duration
01 January 2011 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Natural sciences
    • Animal biology
    • Biochemistry and metabolism
    • Evolutionary biology
    • General biology
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Social medical sciences
    • Medical biochemistry and metabolism
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
molecular evolution model organisms cell-cell adhesion
 
Project description

Proposed research aims comprise: 1. analysis of newly sequenced metazoan genomes for novel and conserved cadherin superfamily genes; 2. improved phylogenetic analysis of cadherins across the animal kingdom; 3. structural modeling for selected members; 4. functional assessment by expression analysis for selected interesting cadherin genes; 5. functional assessment of carefully selected cadherin superfamily members by overexpression versus knock down experiments.