Doctoral project Hannah Stocks

Investigating the role of gastrointestinal inflammasome responses during infection and autoinflammation

Cell type-specific functional analysis of inflammasome signalling in intestinal inflammation

Combined chemotherapy and inflammasome neutralization for the treatment of non-small cell lung carcinoma

Discovery and validation of metabolite biomarkers associated with increased susceptibility to intestinal inflammation

Elucidating the cell type specific molecular mechanisms of NLRC4 inflammasome activation

ERANETIL-18 and MRP neutralization for the treatment of anti-IL-1-refractory autoinflammatory diseases

Evaluating the function and the therapeutic potential of IFN-λ in intestinal carcinogenesis

Going viral – how does murine norovirus alter intestinal immunity in the host and across generations?

Inhibition of TNFR1 for the treatment of TNF mediated diseases

Investigating the effects of regulatory phosphorylation and linear ubiquitination on Pyrin-mediated auto-inflammatory disorders.

Investigating the role of intestinal epithelial TRAF6 signalling in intestinal and extra-intestinal Th17-driven immune responses

Revisiting the function and the mechanisms of action of TNF during DSS colitis in conditions of littermate-controlled normalized gut microbiota composition

Signalling mechanisms of the NLRP1b inflammasome in innate immunity

Studying human inflammasome signaling in an in vivo context using humanized mice

Study on the impact of Nlrp3 inflammasome activation in intra-epithelial lymphocytes on intestinal inflammation

The IL-18/IFN signaling axis in NLRC4-dependent inflammatory disease

Functional analysis of inflammasome and immune signaling in conditionally targeted NLRP2-deficient mice

Integrated proteome-centric analysis of immune regulation

Cell type specific functional analysis of inflammasome signalling in the colon, and its role in IBD