Research Explorer

Project

Revisiting the function and the mechanisms of action of TNF during DSS colitis in conditions of littermate-controlled normalized gut microbiota composition
Code
01D31818
Duration
01 October 2018 → 30 September 2022
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Gastro-enterology
    • Inflammation
    • Infectious diseases
    • Cell death
    • Cell signalling
Keywords
Inflammatory bowel disease colitis Tumor Necrosis Factor
 
Project description

Several mouse studies suggested that TNF protects against DSS-induced colitis. While these studies did not use littermates, a preliminary littermate-controlled experiment showed that in fact TNF has a detrimental role in DSS colitis. This project will aim to re-evaluate the function of TNF in DSS colitis in order to better understand the mechanisms by which TNF affects colitis development.