Project

Revisiting the function and the mechanisms of action of TNF during DSS colitis in conditions of littermate-controlled normalized gut microbiota composition

Code

01D31818

Looptijd

01-10-2018 → 30-09-2022

Financiering

Regional and community funding: Special Research Fund

Promotor

Andy Wullaert

Fellow

Elien Eeckhout

Onderzoeksdisciplines

Medical and health sciences
- Gastro-enterology
- Inflammation
- Infectious diseases
- Cell death
- Cell signalling

Trefwoorden

Inflammatoir darmlijden Tumor Necrosis Factor colitis

Projectomschrijving

Several mouse studies suggested that TNF protects against DSS-induced colitis. While these studies did not use littermates, a preliminary littermate-controlled experiment showed that in fact TNF has a detrimental role in DSS colitis. This project will aim to re-evaluate the function of TNF in DSS colitis in order to better understand the mechanisms by which TNF affects colitis development.