Code
01D31818
Duration
01 October 2018 → 30 September 2022
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Gastro-enterology
- Inflammation
- Infectious diseases
- Cell death
- Cell signalling
Keywords
Inflammatory bowel disease
colitis
Tumor Necrosis Factor
Project description
Several mouse studies suggested that TNF protects against DSS-induced colitis. While these studies did not use littermates, a preliminary littermate-controlled experiment showed that in fact TNF has a detrimental role in DSS colitis. This project will aim to re-evaluate the function of TNF in DSS colitis in order to better understand the mechanisms by which TNF affects colitis development.