Research Explorer

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Researcher

Andy Wullaert

Publications & Research Data

Awards & Distinctions

63 Results

2025

Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice

Hannah StocksJolien Van CleemputLinos VandekerckhoveAndy Wullaert

Editorial material

Harnessing human immune system mouse models to validate NADPH oxidase 1 inhibition as a treatment for hepatocellular carcinoma

Zenzi De VosLander HeyerickHannah StocksAndy WullaertAnne HoorensSander LefereSarah RaevensAnja GeertsXavier VerhelstHans Van Vlierberghe et al.

Investigation of human-specific innate immune signaling

Hannah StocksAndy WullaertLinos Vandekerckhove

Neonatal microbiota colonization primes maturation of goblet cell-mediated protection in the pre-weaning colon

Asa JohanssonMahadevan Venkita SubramaniBahtiyar YilmazElisabeth E. L. NystromElena LayuntaLiisa ArikeFelix SommerPhilip RosenstielLars VereeckeLouise Manneras-Holm et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling

Muralikrishna AkulaElisabeth GilisPieter HertensLieselotte Vande WalleMozes SzeJulie CoudenysYunus IncikOmar KhanMartin O. BergoDirk Elewaut et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2024

Caspase-12 is expressed in Purkinje neurons and prevents psychiatric-like behavior in mice

Lin-Yan HuangYi-Ning LiuJie ChenHai-Xue ZhuLi-Li LiZhi-Yan LiangJin-Xiu SongYu-Jie LiZhao-Li HuDieter Demon et al.

A1 Journal Article in MOLECULAR NEUROBIOLOGY

Development of human innate immune responses in a humanized mouse model expressing four human myelopoiesis transgenes

Hannah StocksElisabeth De LeeuwBart LambrechtLinos VandekerckhoveGeert van LooAndy Wullaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Myeloid A20 is critical for alternative macrophage polarization and type-2 immune-mediated helminth resistance

Ioanna PettaMarie ThorpMaarten CiersGillian BlanckeLouis BoonTim MeeseFilip Van NieuwerburghAndy WullaertRichard GrencisDirk Elewaut et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Recent Insights in Pyrin inflammasome activation : identifying potential novel therapeutic approaches in Pyrin-associated autoinflammatory syndromes

Flore WoutersJeroen BogieAndy WullaertJeroen van der Hilst

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Regulation of inflammasome signaling by the linear deubiquitinase OTULIN

Maria Giulia DoglioAndy WullaertGeert van Loo

2023

Complex regulation of alarmins S100A8/A9 and secretion via gasdermin D pores exacerbates autoinflammation in familial Mediterranean fever

Selina K. JorchAnnika McNallyPhilipp BergerJonas WolfKim KaiserAndrian Chetrusca CovashStefanie RobeckIsabell PastauOlesja FehlerSaskia-L. Jauch-Speer et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection

Elien EeckhoutLisa HamerlinckVeronique JonckheerePetra Van DammeGeert van LooAndy Wullaert

A1 Journal Article in CELL DEATH & DISEASE

Investigating the role of gastrointestinal inflammasome responses during infection and autoinflammation

Elien EeckhoutAndy Wullaert

Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion

Maria Giulia DoglioLien VerboomEmily Ruilova SosorangaUlrika FrisingTomoko AsaokaYannick GansemansFilip Van NieuwerburghGeert van LooAndy Wullaert

A1 Journal Article in SCIENCE IMMUNOLOGY

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Elien EeckhoutTomoko AsaokaHanne Van GorpDieter DemonCharlotte Girard-Guyonvarc'hVanessa AndriesLars VereeckeCem GabayMohamed LamkanfiGeert van Loo et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

Development of in vivo models to study candida infections and innate immune responses

Ona RogiersPatrick Van DijckAndy Wullaert

GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis

Dhruv ChauhanDieter DemonLieselotte Vande WalleOonagh PaerewijckAnnalisa ZecchinLeslie BosselerKarin SantoniRemi PlanesSilvia Ribó GenéAmelie Fossoul et al.

A1 Journal Article in EMBO REPORTS

Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice

Ulrika FrisingSilvia Ribó GenéMaria Giulia DoglioBernard MalissenGeert van LooAndy Wullaert

A1 Journal Article in EMBO REPORTS

2021

IL1 beta promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin D

Mate KissLieselotte Vande WallePedro Henrique Viana SaavedraEls LebeggeHelena Van DammeAleksandar MurgaskiJunbin QianManuel EhlingSamantha PrettoEvangelia Bolli et al.

A1 Journal Article in CANCER IMMUNOLOGY RESEARCH

Punching holes in cellular membranes : biology and evolution of gasdermins

Elke De SchutterRia RoelandtFranck RiquetGuy Van CampAndy WullaertPeter Vandenabeele

A1 Journal Article in TRENDS IN CELL BIOLOGY

2020

Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis

Bartosz WiernickiHanne DuboisYulia Y. TyurinaBehrouz HassanniaHulya BayirValerian E. KaganPeter VandenabeeleAndy WullaertTom Vanden Berghe

A1 Journal Article in CELL DEATH & DISEASE

Publisher correction : Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Arne MartensDario PriemEsther HosteJessica VettersSofie RennenLeen CatrysseSofie VoetLaura DeelenMozes SzeHanna-Kaisa Vikkula et al.

A1 Journal Article in NATURE IMMUNOLOGY

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

A1 Journal Article in NATURE CANCER

2019

Candidalysin crucially contributes to Nlrp3 inflammasome activation by Candida albicans hyphae

Ona RogiersUlrika FrisingSoňa KucharíkováMary Ann Jabra-RizkGeert van LooPatrick Van DijckAndy Wullaert

A1 Journal Article in MBIO

Characterisation of innate immune responses associated with gastrointestinal norovirus infection

Hanne DuboisAndy WullaertMohamed Lamkanfi

El Tor biotype Vibrio cholerae activates the caspase-11-independent canonical Nlrp3 and Pyrin inflammasomes

Michail MamantopoulosUlrika FrisingTomoko AsaokaGeert van LooMohamed LamkanfiAndy Wullaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis

Scott B DrutmanFilomeen HaerynckFranklin L ZhongDavid HumNicholas J HernandezSerkan BelkayaFranck RapaportSarah Jill de JongDavid CreytensSimon Tavernier et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

Hanne DuboisFrederic SorgeloosSoroush T. SarvestaniLiesbet MartensYvan SaeysJason M. MackenzieMohamed LamkanfiGeert van LooIan GoodfellowAndy Wullaert

A1 Journal Article in PLOS PATHOGENS

Nucleic acid induced interferon and inflammasome responses in regulating host defense to gastrointestinal viruses

Hanne DuboisGeert van LooAndy Wullaert

A1 Journal Article in INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

Karolina SlowickaInmaculada Serramito-GómezEmilio Boada-RomeroArne MartensMozes SzeIoanna PettaHanna-Kaisa VikkulaRiet De RyckeEef ParthoensSaskia Lippens et al.

A1 Journal Article in NATURE COMMUNICATIONS

2018

Cell death signaling at the crossroads of inflammasome activation

Nathalia Moraes de VasconcelosAndy WullaertMohamed Lamkanfi

Defining the impact of host genotypes on microbiota composition requires meticulous control of experimental variables

Andy WullaertMohamed LamkanfiKathy D McCoy

A1 Journal Article in IMMUNITY

Extraction of DNA from murine fecal pellets for downstream phylogenetic microbiota analysis by next-generation sequencing

Elien EeckhoutAndy Wullaert

A2 Journal Article in BIO-PROTOCOL

Inflammasomes in intestinal host-microbe interactions

Michail MamantopoulosAndy WullaertMohamed Lamkanfi

Inflammasomes make the case for littermate-controlled experimental design in studying host-microbiota interactions

Michail MamantopoulosFrancesca RonchiKathy D McCoyAndy Wullaert

A1 Journal Article in GUT MICROBES

Mechanism and functions of the cytosolic receptor Pyrin

Pedro Henrique Viana SaavedraAndy WullaertMohamed Lamkanfi

2017

Nlrp6-and ASC-dependent inflammasomes do not shape the commensal gut microbiota composition

Michail MamantopoulosFrancesca RonchiFilip Van HauwermeirenSara Vieira-SilvaBahtiyar YilmazLiesbet MartensYvan SaeysStefan K DrexlerAmir S YazdiJeroen Raes et al.

A1 Journal Article in IMMUNITY

2016

Bifidobacteria prevent tunicamycin-induced endoplasmic reticulum stress and subsequent barrier disruption in human intestinal epithelial Caco-2 monolayers

Takuya AkiyamaKenji OishiAndy Wullaert

A1 Journal Article in PLOS ONE

General strategies in inflammasome biology

Hanne DuboisAndy WullaertMohamed Lamkanfi

A1 Journal Article in Current Topics in Microbiology and Immunology

NEMO prevents RIP kinase 1-mediated epithelial cell death and chronic intestinal inflammation by NF-κB-dependent and -independent functions

Katerina VlantisAndy WullaertApostolos PolykratisVangelis KondylisMarius DannappelRobin SchwarzerPatrick WelzTeresa CoronaHenning WalczakFalk Weih et al.

A1 Journal Article in IMMUNITY

TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice

Katerina VlantisApostolos PolykratisPatrick-Simon WelzGeert van LooManolis PasparakisAndy Wullaert

A1 Journal Article in GUT

2013

Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo

Svetlana BeckerTobias A OelschlaegerAndy WullaertManolis PasparakisJan WehkampEduard F StangeMichael Gersemann

A1 Journal Article in PLOS ONE

2011

Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

Katerina VlantisAndy WullaertYoshiteru SasakiMarc Schmidt-SupprianKlaus RajewskyTania RoskamsManolis Pasparakis

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

Patrick-Simon WelzAndy WullaertKaterina VlantisVangelis KondylisVanesa Fernandez-MajadaMaria ErmolaevaPetra KirschAnja Sterner-KockGeert van LooManolis Pasparakis

A1 Journal Article in NATURE

NF-κB in the regulation of epithelial homeostasis and inflammation

Andy WullaertMarion C BonnetManolis Pasparakis

A1 Journal Article in CELL RESEARCH

2010

Role of NF-κB activation in intestinal immune homeostasis

A1 Journal Article in INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

2009

Generalized immune activation as a direct result of activated CD4+ T cell killing

Rute MarquesAdam WilliamsUrszula EksmondAndy WullaertNigel KileenManolis PasparakisDimitris KioussisGeorge Kassiotis

A2 Journal Article in JOURNAL OF BIOLOGY

2008

ABINs inhibit EGF receptor-mediated NF-kappa B activation and growth of EGF receptor-overexpressing tumour cells

Lieven HuangLynn VerstrepenKaren HeyninckAndy WullaertH REVETSP DE BAETSELIERRudi Beyaert

A1 Journal Article in ONCOGENE

The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1 beta maturation

Marlies GallePeter SchotteMira HaegmanAndy WullaertHJ YANGS JINRudi Beyaert

A1 Journal Article in JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

2007

Epithelial NEMO links innate immunity to chronic intestinal inflammation

Arianna NenciChristoph BeckerAndy WullaertRalph GareusGeert van LooSilvio DaneseMarion HuthAlexei NikolaevClemens NeufertBlair Madison et al.

A1 Journal Article in NATURE

Hepatic tumor necrosis factor signaling and nuclear factor-kappa B: Effects on liver homeostasis and beyond

Andy WullaertGeert van LooKaren HeyninckRudi Beyaert

A1 Journal Article in ENDOCRINE REVIEWS

Inhibition of NF-kappa B activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G(1) cell cycle arrest in primary hepatocytes

P PAPELEUAndy WullaertG ELAUTT HENKENSM VINKENG LAUSD TOURWERudi BeyaertV ROGIERST VANHAECKE

A1 Journal Article in CELL PROLIFERATION

LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappa B activation

Andy WullaertLynn VerstrepenSofie Van HuffelM Adib-ConquySigrid CornelisMarja KreikeMira HaegmanKarim El BakkouriMatthew SandersKelly Verhelst et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2006

Effect of ABINs on intracellular signaling pathways involved in TNF-mediated liver injury

Andy WullaertRudi Beyaert

Mechanisms of crosstalk between TNF-induced NF-kappa B and JNK activation in hepatocytes

Andy WullaertKaren HeyninckRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production

Tina MahieuJM PARKH REVETSB PASCHEA LENGELINGJan StaelensAndy WullaertIneke VanlaereTino HochepiedFrans Van Roy et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin: tool and target for intracellular NF-κB inhibitors

Andy WullaertKaren HeyninckSophie JanssensRudi Beyaert

A1 Journal Article in TRENDS IN IMMUNOLOGY

2005

Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality

Andy WullaertBen WielockxSofie Van HuffelVeerle BogaertB DE GEESTP PAPELEUPeter SchotteKarim El BakkouriKaren HeyninckClaude Libert et al.

A1 Journal Article in HEPATOLOGY

Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model

Karim El BakkouriAndy WullaertMira HaegmanKaren HeyninckRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2003

Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease

Karen HeyninckAndy WullaertRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2002

Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.

Tino HochepiedAndy WullaertFG BERGERH BAUMANNPeter BrouckaertLothar SteidlerClaude Libert

A1 Journal Article in GUT