Development of a predictive platform for freeze-drying LNP-based formulations

Doctoral project Aranit Harizaj

Doctoral project Rein Verbeke

Doctoral project Silke Roovers

Exploring co-encapsulation of small molecules and immune checkpoint siRNAs in lipid nanoparticles for anti-cancer immunotherapy

Exploring novel drug delivery strategies in rheumatoid arthritis: Nanomedicines and ultrasound triggered drug delivery.

High-Intensity Focused ultrasound to induce and boost anti-tumor immunity.

Nanoparticle design for the targeted delivery of adjuvants to the lymph nodes

Sequencing-based approach for optimal design of mRNA-LNPs for in situ CRISPR-mediated silencing of SIRPα in triple-negative breast cancer microenvironment

The impact of mRNA galsome formulation on immunogenicity and reactogenicity

Towards the clinical evaluation of Galsome-NEO, a glycolipid-adjuvanted mRNA cancer vaccine.

Development and clinical validation of a personalized mRNA-based cancer vaccine for patients with advanced hepatocellular carcinoma

Doxorubicin-loaded microbubbles for ultrasound controlled destruction of tumor cells

Evaluation of mRNA loaded microbubbles for untrasound guided cancer vaccination

Exploration of an mRNA based nanovaccine platform and immunopeptidomics for the development of more effective tuberculosis vaccines.

Exploring and advancing mRNA lipid nanoparticles for the in situ generation of CAR-Ms

Exploring co-encapsulation of antihistamines and immune checkpoint siRNAs in lipid nanoparticles for cancer immunotherapy.

Light for life: high contrast multimodal medical imaging using inorganic fluorophores

Nanoparticle formulations of toll-like receptor agonists and oxaliplatin for local intraperitoneal delivery to treat colorectal peritoneal metastasis

Seeing is believing: Unraveling inflammation processes in auto-immune diabetes with non-invasive imaging.

Sequencing-based approach for optimal design of mRNA-LNPs for in situ CRISPR-mediated silencing of SIRPα in triple-negative breast cancer microenvironment.

Understanding and modulating the pro-inflammatory activity of lipid nanoparticles (LNP) in the COVID-19 mRNA vaccines: towards the development of more effective LNP formulations.

Design and evaluation of mRNA loaded microbubbles for ultrasound triggered cancer vaccination.

Design and evaluation of rtPA loaded microbubbles for sonothrombolysis.

A platform for the fast development of thermostable lyophilized mRNA lipid nanoparticle (LNP) vaccines