Research Explorer

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Researcher

Ine Lentacker

Publications & Research Data

Awards & Distinctions

111 Results

2026

Lipid-stabilized ICG nanoaggregates for the photodisruption of vitreous opacities

Pouria RamezaniJan FélixYera UssembayevMariana Hugo Borges Barreto SilvaIne LentackerRein VerbekeKevin BraeckmansStefaan De SmedtFélix Sauvage

A1 Journal Article in MATERIALS TODAY BIO

Protocol to annotate dendritic cell maturation types in vivo making use of lipid nanoparticle-based

Karo Van LilJanne SwinnenGreta WebbSofie RennenVictor BosteelsSandra MaréchalClint De NolfJessica VettersJiri BrezinaEvelien Van De Velde et al.

A2 Journal Article in STAR PROTOCOLS

2025

Challenges and opportunities in mRNA vaccine development against bacteria

Ilke AernoutRein VerbekeFabien Henri TheryPatrick WillemsUri EliaStefaan De SmedtRino RappuoliDan PeerFrancis ImpensIne Lentacker

A1 Journal Article in NATURE MICROBIOLOGY

Current state of mRNA vaccine development against Mycobacterium tuberculosis

Ilke AernoutRein VerbekeStefaan De SmedtFrancis ImpensIne Lentacker

Bookchapter in Trends in mRNA vaccine research

High-intensity focused ultrasound to induce and boost antitumor immunity

Yanou EngelenIne LentackerStefaan De Smedt

Immunogenic cell death as interplay between physical anticancer modalities and immunotherapy

Yanou EngelenRobin DemuynckJana RamonK. BreckpotStefaan De SmedtGuillaume LajoinieKevin BraeckmansDmitri KryskoIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy

Arne van der VrekenFabien Henri TheryChenggong TuKevin MwangiSofie MeulewaeterLien De BeckEdith JanssensKim De VeirmanKarin VanderkerkenElke De Bruyne et al.

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Sofie RennenVictor BosteelsClint De NolfGreta WebbKaro Van LilSandra MaréchalJessica VettersEvelien Van De VeldeFarzaneh FayazpourRia Roelandt et al.

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Sofie RennenVictor BosteelsClint De NolfSandra MaréchalJessica VettersKaro Van LilGreta WebbJanne SwinnenEvelien Van De VeldeFarzaneh Fayazpour et al.

A1 Journal Article in CELL REPORTS

Lipid-stabilized ICG nanoaggregates for the photodisruption of vitreous opacities

Pouria RamezaniJan FélixMariana Hugo Borges Barreto SilvaIne LentackerRein VerbekeKevin BraeckmansStefaan De SmedtFélix Sauvage

mRNA galsomes vaccine protects budgerigars against virulent Chlamydia psittaci challenge

Anne De MeystJoeri Van MieghemKoen ChiersKoen RaemdonckRein VerbekeIne LentackerDaisy Vanrompay

A1 Journal Article in VACCINES

Preclinical toxicological assessment of an α-galactosylceramide-adjuvanted mRNA cancer vaccine in Wistar Han rats and domestic pigs

Sofie MeulewaeterMargo De VelderDiethard ReckelbusKevin MwangiThomas EhouarneIlke AernoutYanou EngelenFëllanza HalimiIsis Van herteryckLobke De Bels et al.

A1 Journal Article in MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT

Sequence simplification of antigen coding IVT mRNA allows accelerated synthetic DNA template generation and epitope immunogenicity validation

Arthur EspritDorien AutaersIlke AernoutIne LentackerSteve PascoloKris ThielemansKarine BreckpotLorenzo Franceschini

A1 Journal Article in MOLECULAR THERAPY NUCLEIC ACIDS

2024

Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria

Sofie MeulewaeterIlke AernoutJoke DeprezYanou EngelenMargo De VelderLorenzo FranceschiniKarine BreckpotSerge Van CalenberghCaroline AsselmanKatie Boucher et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Considerations on the design of lipid-based mRNA vaccines against cancer

Sofie MeulewaeterYao ZhangAbishek WadhwaKevin FoxIne LentackerKenneth W. HarderPieter R. CullisStefaan De SmedtMiffy H.Y. ChengRein Verbeke

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Immunopeptidomics mapping of Listeria monocytogenes T cell epitopes in mice

Adillah GulLecia L. PewePatrick WillemsRupert MayerFabien Henri TheryCaroline AsselmanIlke AernoutRein VerbekeDenzel EggermontLaura Van Moortel et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Laser-induced vapor nanobubbles for B16-F10 melanoma cell killing and intracellular delivery of chemotherapeutics

Jana RamonYanou EngelenHerlinde De KeersmaeckerIlia GoemaereDeep PunjJulián Mejía MoralesCédric BonteGeert BerxEsther HosteStephan Stremersch et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Nanomedicine to aid immunogenic cell death (ICD)-based anticancer therapy

Robin DemuynckYanou EngelenAndre SkirtachStefaan De SmedtIne LentackerDmitri Krysko

A1 Journal Article in TRENDS IN CANCER

Optimizing high-intensity focused ultrasound-induced immunogenic cell-death using passive cavitation mapping as a monitoring tool

Yanou EngelenDmitri KryskoIuliia EfimovaKarine BreckpotMichel VersluisStefaan De SmedtGuillaume LajoinieIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Selective replacement of cholesterol with cationic amphiphilic drugs enables the design of lipid nanoparticles with improved RNA delivery

Bram BogaertAliona DebisschopThomas EhouarneHannelore Van EeckhoutteJoyceline De VolderAn JacobsEline PottieRiet De RyckeAurélie CrabbéPieter Mestdagh et al.

A1 Journal Article in NANO LETTERS

The role of mRNA-galsomes and LNPs in enhancing HIV-specific T cell responses across various lymphoid organs

Sigrid D’haeseSabine den RooverRein VerbekeIlke AernoutSofie MeulewaterJoëlle CosynsJessy MeertSarah VanbellingenThessa LaeremansIne Lentacker et al.

A1 Journal Article in MOLECULAR THERAPY NUCLEIC ACIDS

Towards the clinical evaluation of Galsome-NEO, a glycolipid-adjuvanted mRNA cancer vaccine

Sofie MeulewaeterStefaan De SmedtIne Lentacker

2023

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures

Sofie MeulewaeterGust NuyttenMiffy H.Y. ChengStefaan De SmedtPieter R. CullisThomas De BeerIne LentackerRein Verbeke

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Dependence of sonoporation efficiency on microbubble size : an in vitro monodisperse microbubble study

Benjamin van ElburgJoke DeprezMartin van den BroekStefaan De SmedtMichel VersluisGuillaume LajoinieIne LentackerTim Segers

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine

Thomas ErtveldtSofie MeulewaeterYannick De VlaeminckOscar OlarteKatrijn BroosSerge Van CalenberghStephanie BourgeoisJoke DeprezYves HeremansCleo Goyvaerts et al.

A1 Journal Article in THERANOSTICS

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

Joke DeprezRein VerbekeSofie MeulewaeterIlke AernoutHeleen DewitteTine DecruyJulie CoudenysJulie Van DuyseGert Van IsterdaelDan Peer et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

2022

Evaluation of liposome-loaded microbubbles as a theranostic tool in a murine collagen-induced arthritis model

Joke DeprezSilke RooversGuillaume LajoinieHeleen DewitteTine DecruyJulie CoudenysBenedicte DescampsChristian VanhoveMichel VersluisDirk Elewaut et al.

A2 Journal Article in SCIENTIA PHARMACEUTICA

Fluorine MR imaging probes dynamic migratory profiles of perfluorocarbon-loaded dendritic cells after streptozotocin-induced inflammation

Shweta SainiAn-Sofie VanherwegenSayuan LiangRein VerbekeHannelie KorfIne LentackerStefaan De SmedtConny GysemansUwe Himmelreich

A1 Journal Article in MOLECULAR IMAGING AND BIOLOGY

Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes

Rupert MayerRein VerbekeCaroline AsselmanIlke AernoutAdillah GulDenzel EggermontKatie BoucherFabien Henri TheryTeresa MaiaHans Demol et al.

A1 Journal Article in NATURE COMMUNICATIONS

Nanoparticle mediated targeting of toll-like receptors to treat colorectal cancer

Ragna HaegebaertMaxime KempersWim CeelenIne LentackerKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2021

Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells

Aranit HarizajBenedicte DescampsChristophe MangodtStephan StremerschArianna StoppaLieve BalcaenToon BransHilde De RoosterNausikaa DevriendtJuan Fraire et al.

A1 Journal Article in BIOMATERIALS SCIENCE

Exploring novel drug delivery strategies in rheumatoid arthritis : nanomedicines and ultrasound triggered drug delivery

Joke DeprezStefaan De SmedtPeggy JacquesIne Lentacker

mRNA in cancer immunotherapy : beyond a source of antigen

Lien Van HoeckeRein VerbekeHeleen DewitteIne LentackerKarim VermaelenKarine BreckpotSandra Van Lint

A1 Journal Article in MOLECULAR CANCER

Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells dagger

Aranit HarizajFilip Van HauwermeirenStephan StremerschRiet De RyckeHerlinde De KeersmaeckerToon BransJuan FraireKarolien GrauwenStefaan De SmedtIne Lentacker et al.

A1 Journal Article in NANOSCALE

Opening doors with ultrasound and microbubbles : beating biological barriers to promote drug delivery

Joke DeprezG. LajoinieYanou EngelenStefaan De SmedtIne Lentacker

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Photoporation with biodegradable polydopamine nanosensitizers enables safe and efficient delivery of mRNA in human T cells

Aranit HarizajMike WelsLaurens RaesStephan StremerschGlenn GoetgelukToon BransBart VandekerckhoveFélix SauvageStefaan De SmedtIne Lentacker et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Physical transfection technologies for macrophages and dendritic cells in immunotherapy

Aranit HarizajStefaan De SmedtIne LentackerKevin Braeckmans

A1 Journal Article in EXPERT OPINION ON DRUG DELIVERY

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across

An-Katrien MinnaertHelena VanlucheneRein VerbekeIne LentackerStefaan De SmedtKoen RaemdonckNiek SandersKatrien Remaut

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

The dawn of mRNA vaccines : the COVID-19 case

Rein VerbekeIne LentackerStefaan De SmedtHeleen Dewitte

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2020

Light-responsive nanoparticles : from bio-imaging to intracellular delivery

Aranit HarizajKevin BraeckmansIne LentackerDirk Poelman

mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice

Lien Van HoeckeRein VerbekeDorien De VliegerHeleen DewitteKenny RooseSharon Van NevelOlga KryskoClaus BachertBert SchepensIne Lentacker et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Ultrasound-responsive cavitation nuclei for therapy and drug delivery

Klazina KooimanSilke RooversSimone A. G. LangeveldRobert T. KlevenHeleen DewitteMeaghan A. O'ReillyJean-Michel EscoffreAyache BouakazMartin D. VerweijKullervo Hynynen et al.

A1 Journal Article in ULTRASOUND IN MEDICINE AND BIOLOGY

2019

Biocompatible lipid‐coated persistent luminescent nanoparticles for in vivo imaging of dendritic cell migration

Aranit HarizajOlivier De ClercqBenedicte DescampsChristian VanhoveStefaan De SmedtDirk PoelmanIne LentackerKevin Braeckmans

A1 Journal Article in PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Broadening the message : a nanovaccine co-loaded with messenger RNA and α-GalCer induces antitumor immunity through conventional and natural killer T cells

Rein VerbekeIne LentackerKarine BreckpotJonas JanssensSerge Van CalenberghStefaan De SmedtHeleen Dewitte

A1 Journal Article in ACS NANO

Challenges for labeling and longitudinal tracking of adoptively transferred autoreactive T lymphocytes in an experimental type-1 diabetes model

Shweta SainiHannelie KorfSayuan LiangRein VerbekeBella ManshianKoen RaemdonckIne LentackerConny GysemansStefaan De SmedtUwe Himmelreich

A1 Journal Article in MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

Enhancing nucleic acid delivery with ultrasound and microbubbles

Heleen DewitteSilke RooversStefaan De SmedtIne Lentacker

Bookchapter in Nanotechnology for nucleic acid delivery : methods and protocols

Longitudinal in vivo assessment of host-microbe interactions in a murine model of pulmonary aspergillosis

Shweta SainiJennifer PoelmansHannelie KorfJames L. DooleySayuan LiangBella B. ManshianRein VerbekeStefaan J. SoenenGreetje Vande VeldeIne Lentacker et al.

A1 Journal Article in ISCIENCE

Sonoprinting liposomes on tumor spheroids by microbubbles and ultrasound

Silke RooversJoke DeprezD PriwitaningrumG LajoinieN RivronHeidi DeclercqOlivier De WeverE StrideS Le GacM Versluis et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Sonoprinting of nanomedicines : from mechanistic insights to preclinical translation

Silke RooversStefaan De SmedtIne Lentacker

Sonoprinting of nanoparticle-loaded microbubbles : unraveling the multi-timescale mechanism

Silke RooversGuillaume LajoinieIne De CockToon BransHeleen DewitteKevin BraeckmansMichel VersuisStefaan De SmedtIne Lentacker

A1 Journal Article in BIOMATERIALS

The role of ultrasound-driven microbubble dynamics in drug delivery : from microbubble fundamentals to clinical translation

Silke RooversTim SegersGuillaume LajoinieJoke DeprezMichel VersluisStefaan De SmedtIne Lentacker

A1 Journal Article in LANGMUIR

Three decades of messenger RNA vaccine development

Rein VerbekeIne LentackerStefaan De SmedtHeleen Dewitte

A1 Journal Article in NANO TODAY

Trap levels in persistent phosphors for bio-imaging

Dirk PoelmanOlivier De ClercqJiaren DuAranit HarizajIne LentackerKevin Braeckmans

2018

Non-spherical oscillations drive the ultrasound-mediated release from targeted microbubbles

Guillaume LajoinieYing LuanErik GelderblomBenjamin DolletFrits MastikHeleen DewitteIne LentackerNico de JongMichel Versluis

A1 Journal Article in COMMUNICATIONS PHYSICS

Optimized messenger RNA immunolipoplexes for cancer immunotherapy : balancing immunogenicity and adjuvancy

Rein VerbekeIne LentackerKarine BreckpotSerge Van CalenberghStefaan De SmedtHeleen Dewitte

Tri-modal in vivo imaging of pancreatic islets transplanted subcutaneously in mice

Sayuan LiangKarim LouchamiBryan HolvoetRein VerbekeChristophe M DerooseBella ManshianStefaan J SoenenIne LentackerUwe Himmelreich

A1 Journal Article in MOLECULAR IMAGING AND BIOLOGY

2017

Co-delivery of nucleoside-modified mRNA and immunomodulators for cancer immunotherapy: restoring the immunogenicity of immunosilent mRNA

Rein VerbekeIne LentackerLaura WayteckKarine BreckpotBenedicte DescampsChristian VanhoveStefaan De SmedtHeleen Dewitte

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy : restoring the immunogenicity of immunosilent mRNA

Rein VerbekeIne LentackerLaura WayteckKarine BreckpotMieke Van BockstalBenedicte DescampsChristian VanhoveStefaan De SmedtHeleen Dewitte

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Dynamic fluorescence microscopy of cellular uptake of intercalating model drugs by ultrasound-activated microbubbles

BHA LammertinkR DeckersM DerieppeIne De CockIne LentackerG StormCTW MoonenC Bos

A1 Journal Article in MOLECULAR IMAGING AND BIOLOGY

mRNA-based nanoparticles for therapeutic cancer vaccination

Rein VerbekeLaura WayteckKarine BreckpotChristian VanhoveBenedicte DescampsStefaan De SmedtHeleen DewitteIne Lentacker

2016

In vitro methods to study bubble-cell interactions : fundamentals and therapeutic applications

Guillaume LajoinieIne De CockConstantin C CoussiosIne LentackerSéverine Le GacEleanor StrideMichel Versluis

A1 Journal Article in BIOMICROFLUIDICS

Microvascular injury and perfusion changes induced by ultrasound and microbubbles in a machine-perfused pig liver

Christina P. KeravnouIne De CockIne LentackerMaria-Louisa IzamisMichalakis A. Averkiou

A1 Journal Article in ULTRASOUND IN MEDICINE AND BIOLOGY

Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon

Katrijn BroosKevin VanderjeughtJanik PuttemansCleo GoyvaertsCarlo HeirmanHeleen DewitteRein VerbekeIne LentackerKris ThielemansKarine Breckpot

A2 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Sonoprinting and the importance of microbubble loading for the ultrasound mediated cellular delivery of nanoparticles

Ine De CockGuillaume LajoinieMichel VersluisStefaan De SmedtIne Lentacker

A1 Journal Article in BIOMATERIALS

Unraveling microbubble-cell interactions and drug delivery mechanisms in ultrasound-guided therapy

Ine De CockStefaan De SmedtIne Lentacker

2015

Design and evaluation of immunotherapeutic imaging for cancer vaccination

Heleen DewitteStefaan De SmedtKarine BreckpotIne Lentacker

Evaluation of mRNA lipoplexes for single-step antigen loading and maturation of dendritic cells in cancer immunotherapy

Rein VerbekeHeleen DewitteIne LentackerStefaan De Smedt

Immunogenic mRNA nanoparticles for dendritic cell-based cancer vaccination

Rein VerbekeHeleen DewitteIne LentackerStefaan De Smedt

Laser-induced vapor nanobubbles for efficient delivery of macromolecules in live cells

Ranhua XiongKoen RaemdonckKaren PeynshaertIne LentackerIne De CockJo DemeesterStefaan De SmedtAndre SkirtachKevin Braeckmans

Microbubbles as magic bullets in cancer immunotherapy

Heleen DewitteSandra Van LintKatrien VanderperrenHendrik HaersEmmelie StockStefaan De SmedtKarine BreckpotIne Lentacker

The ReNAissanCe of mRNA-based cancer therapy

Sandra Van LintDries RenmansKatrijn BroosHeleen DewitteIne LentackerCarlo HeirmanKarine BreckpotKris Thielemans

A1 Journal Article in EXPERT REVIEW OF VACCINES

Theranostic mRNA-loaded microbubbles in the lymphatics of dogs: implications for drug delivery

Heleen DewitteKatrien VanderperrenHendrik HaersEmmelie StockLuc DuchateauMyriam HestaJimmy SaundersStefaan De SmedtIne Lentacker

A1 Journal Article in THERANOSTICS

Ultrasound and microbubble mediated drug delivery: acoustic pressure as determinant for uptake via membrane pores or endocytosis

Ine De CockElisa ZagatoKevin BraeckmansYing LuanNico de JongStefaan De SmedtIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2014

Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro

Heleen DewitteRein VerbekeKarine BreckpotRoosmarijn VandenbrouckeClaude LibertStefaan De SmedtIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Comparison of gold nanoparticle mediated photoporation: vapor nanobubbles outperform direct heating for delivering macromolecules in live cells

Ranhua XiongKoen RaemdonckKaren PeynshaertIne LentackerIne De CockJo DemeesterStefaan De SmedtAndre SkirtachKevin Braeckmans

A1 Journal Article in ACS NANO

Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment

Heleen DewitteRein VerbekeKarine BreckpotStefaan De SmedtIne Lentacker

A1 Journal Article in NANO TODAY

The bubble breakthrough in cancer immunotherapy

Heleen DewitteSandra Van LintKatrien VanderperrenStefaan De SmedtKarine BreckpotIne Lentacker

The bubble breakthrough in cancer immunotherapy : Mma-sonoporation in dendritic cell-based cancer vaccination

Heleen DewitteSandra Van LintKatrien VanderperrenKris ThielemansStefaan De SmedtKarine BreckpotIne Lentacker

The bubble breakthrough in cancer immunotherapy : Mma-sonoporation in dendritic cell-based cancer vaccination

Heleen DewitteSandra Van LintKatrien VanderperrenKris ThielemansStefaan De SmedtKarine BreckpotIne Lentacker

The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy

Heleen DewitteSandra Van LintCarlo HeirmanKris ThielemansStefaan De SmedtKarine BreckpotIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Ultrasound assisted drug delivery Preface

Chrit MoonenIne Lentacker

Editorial material

Understanding ultrasound induced sonoporation: definitions and underlying mechanisms

Ine LentackerIne De CockR DeckersStefaan De SmedtCTW Moonen

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

2013

Design and evaluation of theranostic perfluorocarbon particles for simultaneous antigen-loading and 19F-MRI tracking of dendritic cells

Heleen DewitteBart GeersSayuan LiangUwe HimmelreichJo DemeesterStefaan De SmedtIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Doxorubicin liposome-loaded microbubbles for contrast imaging and ultrasound-triggered drug delivery

Jean-Michel EscoffreChristophoros MannarisBart GeersAnthony NovellIne LentackerMichalakis AverkiouAyache Bouakaz

A1 Journal Article in IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

Enhancing nucleic acid delivery with ultrasound and microbubbles

Steven CoolBart GeersIne LentackerStefaan De SmedtNiek Sanders

Bookchapter in Nanotechnology for nucleic acid delivery : methods and protocols

Focal delivery of AAV2/1-transgenes into the rat brain by localized ultrasound-induced BBB opening

Angelika AlonsoEileen ReinzBarbara LeuchsJuergen KleinschmidtMarc FatarBart GeersIne LentackerMichael G. HennericiStefaan De SmedtStephen Meairs

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Injectable drug-loaded microbubbles : a magic bullet for image-guided cancer therapy?

Bart GeersStefaan De SmedtJo DemeesterIne Lentacker

Liposome shedding from a vibrating microbubble on nanoseconds timescale

Ying LuanGuillaume LajoinieErik GelderblomIlya SkachkovHeleen DewitteIne LentackerTom van RooijHendrik VosTon van der SteenMichel Versluis et al.

Targeted liposome-loaded microbubbles for cell-specific ultrasound-triggered drug delivery

Bart GeersOlivier De WeverJo DemeesterMarc BrackeStefaan De SmedtIne Lentacker

A1 Journal Article in SMALL

2012

Acoustical properties of individual liposome-loaded microbubbles

Ying LuanTelli FaezErik GelderblomIlya SkachkovBart GeersIne LentackerTon van der SteenMichel VersluisNico de Jong

A1 Journal Article in ULTRASOUND IN MEDICINE AND BIOLOGY

Characterizing ultrasound-controlled drug release by high-speed fluorescence imaging

Ying LuanErik GelderblomGuillaume LajoinieIlya SkachkovHeleen DewitteBart GeersIne LentackerTon van der SteenMichel VersluisNico de Jong

Crucial factors and emerging concepts in ultrasound-triggered drug delivery

Bart GeersHeleen DewitteStefaan De SmedtIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

The mechanisms behind sonoporation through the eyes of an AAV-vector

Bart GeersIne LentackerAngelika AlonsoNiek SandersJo DemeesterStephen MeairsStefaan De Smedt

A2 Journal Article in PUBLICATIONS QUARTERLY / AMERICAN CHEMICAL SOCIETY

2011

Elucidating the mechanisms behind sonoporation with adeno-associated virus-loaded microbubbles

Bart GeersIne LentackerAngelika AlonsoNiek SandersJo DemeesterStephen MeairsStefaan De Smedt

A1 Journal Article in MOLECULAR PHARMACEUTICS

Evaluation of doxorubicin-containing microbubbles for ultrasound-triggered delivery

Jean-Michel EscoffreBart GeersIne LentackerAyache Bouakaz

mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells

Marie-Luce De TemmermanHeleen DewitteRoosmarijn VandenbrouckeBart LucasClaude LibertJo DemeesterStefaan De SmedtIne LentackerJoanna Rejman

A1 Journal Article in BIOMATERIALS

Optical characterization of individual liposome-loaded microbubbles

Ying LuanTelli FaezIlya SkachkovErik GelderblomBart GeersIne LentackerTon van der SteenMichel VersluisNico de Jong

Self-assembled liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug-delivery

Bart GeersIne LentackerNiek SandersJo DemeesterStephen MeairsStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2010

Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved

Ine LentackerBart GeersJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in MOLECULAR THERAPY

2009

Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy

Ine LentackerNiek SandersStefaan De SmedtJo Demeester

Drug loaded microbubble design for ultrasound triggered delivery

Ine LentackerStefaan De SmedtNiek Sanders

A1 Journal Article in SOFT MATTER

Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes

Ine LentackerNan WangRoosmarijn VandenbrouckeJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in MOLECULAR PHARMACEUTICS

2008

Can ultrasound solve the transport barrier of the neural retina?

Liesbeth PeetersIne LentackerRoosmarijn VandenbrouckeBart LucasJo DemeesterNiek SandersStefaan De Smedt

A1 Journal Article in PHARMACEUTICAL RESEARCH

Circumventing the endocytotic uptake of highly PEGylated lipoplexes by using lipoplex loaded microbubbles and ultrasound can drastically increase their transfection efficiency

Ine LentackerStefaan De SmedtNiek Sanders

Loading of PEGylated siRNA lipoplexes on microbubbles restores their siRNA delivery capacity in the presence of ultrasound

Roosmarijn VandenbrouckeIne LentackerJo DemeesterStefaan De SmedtNiek Sanders

New strategies for nucleic acid delivery to conquer cellular and nuclear membranes

Ine LentackerRoosmarijn VandenbrouckeBart LucasJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in Journal of Controlled Release

Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles

Roosmarijn VandenbrouckeIne LentackerJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2007

Lipoplex-loaded microbubbles for gene delivery: A Trojan horse controlled by ultrasound

Ine LentackerStefaan De SmedtJo DemeesterVeerle Van MarckMarc BrackeNiek Sanders

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Wanted and unwanted properties of surface PEGylated nucleic acid nanoparticles in ocular gene transfer

Niek SandersLiesbeth PeetersIne LentackerJo DemeesterStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2006

Microbubbles which bind and protect DNA against nucleases

Ine LentackerStefaan De SmedtJo DemeesterNiek Sanders

Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA

Ine LentackerBruno De GeestRoosmarijn VandenbrouckeLiesbeth PeetersJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in LANGMUIR