Tracking epigenetic plasticity in circulating tumor-derived DNA to monitor drug resistance and guide personalized treatment in cancer patients

Benchmarking and optimization of computational deconvolution tools on the DNA methylation profile of liquid biopsies of cancer patients

Development of a computational pipeline for monitoring epigenetic plasticity in blood plasma of cancer patients

Development of a minimally-invasive test for accurate diagnosis of Cancer of Unknown Primary (CUP) using DNA methylation profiling

Doctoral project Bikash Ranjan Samal

Doctoral project Jilke De Wilde

Doctoral project Lotte Cornelli

Nucleic acid biomarkers in blood from patients with esophageal adenocarcinoma: Finding the needle in the haystack

Prediction of response and toxicity for immunotherapy of melanoma, kidney and lung cancer patients by transcriptome based immuno-profiling

Study of neuroblastoma tumor heterogeneity via single-cell transcriptome analysis

Systemic immune epigenomic predictors of immunotherapy response in NSCLC patients: Potential and pitfalls

Deciphering regulatory heterogeneity in high-risk neuroblastoma

Development of a high sensitivity circulating cell free DNA methylation analysis method and its application in cancer management.

Doctoral project Annelies Fieuw

From mutations to splice variants: identifying liquid biopsy derived biomarkers in metastatic prostate cancer

Human pluripotent stem cell modeling, from normal development to neuroblastoma

Integration of multiple omics levels to unravel epigenetic differences in systemic immune cells of ICI responders and non-responders

Molecular characterization of SOX11 as multifaceted epigenetic regulator in neuroblastoma

Multi-omics characterisation of extracellular vesicles fractions in liquid biopsies for biomarker identification

Validation and application of new methods for microsatellite instability detection and methylation profiling on paraffin-embedded biopsies

A comprehensive atlas and pipeline for integrative multimodal single-cell analysis of PBMCs

A computational approach to monitor epithelial-to-mesenchymal plasticity in breast cancer patients through epigenetic analysis of cfDNA.

A SIOPEN pragmatic clinical trial to MOnitor NeuroblastomA relapse with LIquid biopsy Sensitive Analysis

Bioinformatics for future precision medicine in cancer treatment

BOF-ZAP professorship in Translational genomics and bioinformatics

Characterizing regulatory heterogeneity in high-risk neuroblastoma

Development of a data-mining pipeline for drug target identification from circulating transcriptomes of lung cancer patients

Development of a fast, minimally-invasive and affordable test for accurate diagnosis of Cancer of Unknown Primary (CUP) using DNA methylation profiling.

Development of a minimally-invasive test for accurate diagnosis of Cancer of Unknown Primary (CUP) using DNA methylation profiling

Development of a non-invasive test to predict immunotherapy response in lung cancer patients

Development of a toolbox for temporal monitoring of pediatric cancers using liquid biopsy samples

International Thematic Network - PrIOMIC 2023-2024

NIPITplus, a multi-cancer blood test to predict immune checkpoint inhibitor response and monitor toxicity

Non-invasive drug identification for tumors: a tool for precision oncology

Non invasive drug identification for tumors (NIDIT): a tool for precision oncology

Non-invasive prediction of immune-therapy response in lung cancer patients (NIPIT)

Non-invasive prediction of immunotherapy response for lung cancer patients

Prediction of immunotherapy response and toxicity in melanoma, renal cell and lung cancer using transcriptome based systemic immune phenotyping.

Single cell expression profiling of neuroblastoma in search of novel treatment approaches for chemoresistant clones

SOX11 controlled SWI/SNF combinatorial assembly and neuroblastoma super-enhancer landscaping

The neuroblastoma 17q enigma: exploiting zebrafish modeling to study the cooperative role of 17q genes in MYCN driven tumor formation

The SOX11 transcription factor as “lineage survival” oncogene in neuroblastoma

Translational oncogenomics and bioinformatics in cancer research

Universal, cost-effective and hypersensitive open-source technology platform for liquid biopsy based on methylome profiling of circulating DNA.

Unraveling neuroblastoma subtype 2A using differential network methods.

Development of a high sensitivity circulating cell free DNA methylation analysis method and its application in cancer management

FullPicture: Combining Spectral Flow Cytometry with High-Speed Cell Imaging to enable comprehensive profiling of plant and animal cells and their components in real time.

Functional study of the ALK-F1174 mutation in

Gene-Environment iNteractions in the pathogenesis of Tobacco smoking-induced Lung diseases (GENT-Lung)

Photolithographic DNA printer for massively parallel synthesis of DNA oligonucleotides for spatial - omics and hybrid capture target enrichment applications

Reconstruction of dynamic initiation and progression gene expression regulatory networks in neuroblastoma

SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomics

The DNA methylome in Common Variable Immunodeficiencies (CVID): a comprehensive study characterizing its heterogeneity and its role in disease subclassification

ThirdGenT: linking third-generation sequencing of (epi)genomes, (epi)transcriptomes and translatomes to life sciences revolutionizes oncology, rare diseases, microbiology, cell and gene technology, developmental and computational biology

BOF-ZAP professorship in Translational genomics and bioinformatics

Reconstructing m(i)RNA regulatory networks implicated in invasion and metastasis in neuroblastoma

Study of neuroblastoma oncogenesis through mRNA and miRNA expression profiling of normal neuroblasts and neuroblastoma stem cells

Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE)