Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE)

Synergistic drug interactions with CDK12-controlled DNA damage response signaling as potential therapy for high-risk neuroblastoma

Development of patient avatars to scrutinize for customized tyrosine kinase selection and facilitate entry points for combination therapy to combat pediatric sarcoma

Doctoral project Elien Hilgert

Doctoral project Muhammad Rishfi

Functional evaluation of novel therapeutic targets in neuroblastoma using in vivo zebrafish modelling

Preclinical evaluation of combined RRM2/DNA damage response signaling as therapy for high-risk neuroblastoma and potential entry point for sensitization to immune checkpoint inhibition.

Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma

Scrutinizing AURKA degradation as a novel entry point for drug synergism in rhabdomyosarcoma

Doctoral project Lasse Vleminckx

Doctoral project Muhammad Rishfi

Beurs Emmanuel van der Schueren (EvdS) Carolien Van Damme: "Scrutinizing the role of GJC1 as replicative stress resistor in MYCN driven neuroblastoma"

BOF-TT-professorship in pediatric precision oncology

Building a next-generation precision oncology platform for childhood cancer

Development of patient avatars in zebrafish for personalized selection of tyrosine kinase inhibitor-based combination therapy to combat relapsed pediatric sarcoma

Functional assessment of TAS1553 as entry point for synergistic drug interactions with the CDC7-ATR-CHK1 axis in vitro and in vivo

Preclinical evaluation of synergistic drug interactions with CDK12-controlled DNA damage response signaling as potential therapy for high-risk neuroblastoma

Single-cell and spatial multi-omics exploration of tumor intrinsic and microenvironment responses to ALK-ATR-CHK1-RRM2 axis drugging in neuroblastoma

The chromatin remodeling protein PHF6 at the crossroad between the nuclear pore complex and replicative stress responses in the childhood cancer neuroblastoma

The role of the SOX11 lineage-dependency factor as epigenetic master regulator in neuroblastoma

Validation of Actionable Genomic ABerrations in a paediatric Oncology Network for Doctorate students

The dual role PSIP1 in T-cell acute lymphoblastic leukemia (T-ALL)

The PHF6 - TLX1 cooperativity and the IL7R-JAK3 signaling axis as drug target in PHF6 deficient TALL.

ThirdGenT: linking third-generation sequencing of (epi)genomes, (epi)transcriptomes and translatomes to life sciences revolutionizes oncology, rare diseases, microbiology, cell and gene technology, developmental and computational biology

BOF-TT-professorship in pediatric precision oncology

Identification of novel therapeutic targets through multi-level (epi) genomic landscaping of replicative stress resistant neuroblastoma 

The chromatin modifier BRD3 as a key novel player in DNA repair and vulnerable therapeutic target in neuroblastoma

The PHF6 - TLX1 cooperativity and the IL7R-JAK3 signaling axis as drug target in PHF6 deficient T-ALL

The role of BRCA1 as oncogenic replicative stress resistor in MYCN driven neuroblastoma

Unraveling the role of PHF6 in normal T cell development and T-cell acute lymphoblastic leukemia