Microscopy is an essential technique for biomedical research. Taking advantage of the optical transparency of zebrafish embryos and larvae, dynamic in vivo processes can be efficiently imaged. Besides observations of unlabeled specimens using brightfield or phase contrast microscopy, transgenic zebrafish reporter lines can be used with cell type-specific overexpression of different fluorophores. Living cells or organoids expressing fluorescent reporters can be imaged to track dynamic processes. Specific protein expression patterns can be detected in immunofluorescently labeled fixed tissue sections and cell cultures. 

These techniques enable us to study pathophysiological processes in tissue samples from model organisms and biopsies obtained from patients. The requested microscope will benefit research on cancer, connective tissue disease, cardiovascular disease, inherited blindness, neurodevelopmental disorders, kidney disease, inborn errors of immunity, and neuromuscular disease.