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Project
EpiSwitch: Characterization and engineering of the specificity determinants of carbohydrate epimerases to achieve a specificity switch.
Information
Project Team
Outputs and Outcomes
Publications
GDP-mannose 3,5-epimerase : a view on structure, mechanism, and industrial potential
Koen Beerens
Ophelia Gevaert
Tom Desmet
A1
Journal Article
in
FRONTIERS IN MOLECULAR BIOSCIENCES
2022
Expanding the enzyme repertoire for sugar nucleotide epimerization : the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus for glucose/mannose interconversion
Christian Rapp
Stevie Van Overtveldt
Koen Beerens
Hansjörg Weber
Tom Desmet
Bernd Nidetzky
A1
Journal Article
in
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
2021
Structure-function relationships in NDP-sugar active SDR enzymes : fingerprints for functional annotation and enzyme engineering
Matthieu Da Costa
Ophelia Gevaert
Stevie Van Overtveldt
Joanna Lange
Henk-Jan Joosten
Tom Desmet
Koen Beerens
A1
Journal Article
in
BIOTECHNOLOGY ADVANCES
2021
Stereo-electronic control of reaction selectivity in short-chain dehydrogenases : decarboxylation, epimerization, and dehydration
Annika J.E. Borg
Koen Beerens
Martin Pfeiffer
Tom Desmet
Bernd Nidetzky
A1
Journal Article
in
CURRENT OPINION IN CHEMICAL BIOLOGY
2021
Determinants of the nucleotide specificity in the carbohydrate epimerase family 1
Stevie Van Overtveldt
Matthieu Da Costa
Ophelia Gevaert
Henk-Jan Joosten
Koen Beerens
Tom Desmet
A1
Journal Article
in
BIOTECHNOLOGY JOURNAL
2020
GDP-altrose as novel product of GDP-mannose 3,5-epimerase : revisiting its reaction mechanism
Ophelia Gevaert
Stevie Van Overtveldt
Matthieu Da Costa
Koen Beerens
Tom Desmet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2020
Novel insights into the existence of the putative UDP-glucuronate 5-epimerase specificity
Ophelia Gevaert
Stevie Van Overtveldt
Matthieu Da Costa
Koen Beerens
Tom Desmet
A1
Journal Article
in
CATALYSTS
2020
Characterization of the first bacterial and thermostable GDP-mannose 3,5-epimerase
Ophelia Gevaert
Stevie Van Overtveldt
Koen Beerens
Tom Desmet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2019