An integrated translational platform to improve the management and outcome of rare heritable connective tissue disease

Cofunding core facility - Core Zebrafish Facility Ghent (Core ZFG)

Doctoral project Sandra De Ganck

Genetics modifiers in Marfan syndrome

Unraveling phenotypic variability and disease manifestations in brittle bone disorders

Zebrafish in bone research: A deep dive into fragile bone disorders

Doctoral project Freya Swinnen

Doctoral project Helena Soenen

Expanded genetic carrier screening for prosective parents: public relevance, clinical implementation, and the role of non-genetic healthcare providers

Use of Nuclear Transfer technology to overcome mitochondrial diseases and female-related infertility

Discovery of genetic modifiers of the phenotypical cardiovascular variability in Marfan syndrome to pave the road to individualized treatment protocols.

Genetic analysis in consanguineous families from Palestine : a focus on Cystic Fibrosis and Osteogenesis Imperfecta

Genome-wide Epistasis for cardiovascular severity in Marfan Study

Identification of modifier genes responsible for the phenotypic variability in Osteogenesis Imperfecta (OI)- patients using zebrafish models

Identification of modifier genes underlying the phenotypic variability in the ‘Brittle Bone Disease’, using zebrafish models and patient-derived induced pluripotent stem cells

Identification of molecular mechanisms involved in Osteogenesis Imperfecta

Investigating the genetic variability for Osteogenesis Imperfecta and Marfan syndrome and exploring the feasability of the implementation of preconceptional expanded carrier screening in the general population.

Study of the role of GLUT10 in cellular metabolism and growth factor signaling underlying developmental defects.

Unraveling the molecular basis of congenital heart defects

Zebrafish platform for testing pathogenicity of human disease-associated variants

Audiological en genetic determination of hearing loss in patients with Osteogenesis Imperfecta

Comparison of editing, complementing or replacement of defective RNA molecules as a novel treatment method to overcome early embryonic developmental arrest

Localization, identification and functional characterization of disease genes for retinal dystrophies.

Nuclear Transfer for female-related infertility and mitochondrial diseases

Personalized functional genomics in Mendelian diseases: from DNA variants to clinical and bioethical implications

Research equipment for behavior analysis in zebrafish disease models.

Study on the envolvement of LEMD3 and neighbouring genes on 12q14 in the pathogenesis of conditions with elevated bone density and growth disordes

Super-zoom 4D-confocal microscope for in vivo imaging

Unravelling the mitochondrial DNA reversion phenomenon