Investigating the role and mechanism of EZH2 in immune checkpoint resistance in tumors with Wnt/ß-catenin pathway activation

Decoding the non-coding regulatory genome – Modelling of eye enhanceropathies in Xenopus tropicalis

Doctoral project Jian Song

Doctoral project Mathias Fransen

Doctoral project Rivka Noelanders

Doctoral project Sylvie Janssens

Identification of therapeutic vulnerabilities for rare human cancers using CRISPR dependency mapping in Xenopus tropicalis

Interspecies exploration of the (post)transcriptional and epigenomic signatures associated with Wilms' tumor formation

Onderzoek naar de immuunomgeving van desmoide tumoren

Uncovering novel cancer driver genes using CRISPR/Cas9 multiplexing in <i>Xenopus tropicalis</i>

Unraveling the molecular mechanisms driving the formation of Wilms tumor through novel genetic models and cross-species multi-omics analyses

A novel genetically tractable model for Familial Adenomatous Polyposis in Xenopus

A novel role for Wnt/β-catenin signaling in primordial germ cells during Xenopus development

Characterization of novel target genes of the Wnt signaling pathway relevant to intestinal cancers.

Exploring the regulation of spatiotemporal restricted expression of Wnt-responsive genes in the embryo

Functional assessment of cis-regulatory elements of inherited retinal diseases (IRDs) in Xenopus tropicalis

Identification and characterization of dependency genes in a model for desmoid tumors in Xenopus tropicalis

Identification and characterization of new organ-specific target genes of the canonical Wnt pathway.

Identification and functional analysis of novel organ-specific target genes of the canonical Wnt pathway, using transgenic fluorescent techniques in Xenopus

Identification and functional characterization of novel cadherin-binding proteins via purification of tagged cadherins in transgenic Xenopus embryos

Identification of primary target genes of the canonical Wnt pathway and assessment of their clinical relevance to cancer

Identification of primary target genes of the canonical Wnt pathway and assessment of their clinical relevance to cancer

Identification of therapeutically relevant organ-specific target genes of the Wnt pathway

Identifiying targets for therapy in a novel genetic Xenopus model for desmoid tumor formation.

Identifying targets for therapy in a novel genetic Xenopus model for Familal Adenomatous Polyposis

Interspecies exploration of the (post)transcriptional and epigenomic signatures associated with Wilms' tumor formation

Investigating the function of Wnt/β-catenin signaling in the rhombomeric boundaries

Investigating the immune landscape in desmoid tumors and liposarcomas

Morphological, molecular and functional insights into the cardiovascular complications of autosomal dominant polycystic kidney disease

Morphological, molecular and functional insights into the cardiovascular complications of autosomal dominant polycystic kidney disease

Precision medicine in inherited blindness using integrated omics in human and animal models

Screening for drivers and dependency factors in a novel genetic model for T-ALL in Xenopus tropicalis

Unraveling the molecular mechanisms driving the formation of Wilms tumor through novel genetic models and cross-species multi-omics analyses

A novel CRISPR/Cas9-based workflow in Xenopus tropicalis to test the pathogenicity of human missense variants implicated in inherited blindness

Deciphering the role of human-Xenopus ultraconserved and highly conserved non-coding elements in developmental gene regulation and disease

DEVREPAIR: Paracrine and transcriptional control of cell differentiation in organ development and repair

Elucidating the role of cis-regulation and of ultraconserved non-coding elements associated with the choroideremia gene CHM

In vivo study of the function of RCBTB1, a novel disease gene for inherited retinal dystrophy

Pathomechanistic study of RCBTB1-associated inherited retinal disease using Xenopus tropicalis and patient-derived induced pluripotent stem cells

Personalized functional genomics in Mendelian diseases: from DNA variants to clinical and bioethical implications

SPINDISK: upgrade of in use spinning disk microscope

Super-zoom 4D-confocal microscope for in vivo imaging