Research Explorer

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Researcher

Kris Vleminckx

Publications & Research Data

Awards & Distinctions

118 Results

2025

Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder

Maria del Rocio Pérez BacaMaría Palomares-BraloMichiel VanhooydonckLisa HamerlinckEva D'haeneSebastian LeimbacherEva JacobsLaurenz De CockErika D'haenensAnnelies Dheedene et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Precise, predictable genome integrations by deep-learning-assisted design of microhomology-based templates

Thomas NaertTaiyo YamamotoShuting HanRuth RöckMelanie HornPhilipp BethgeNikita VladimirovFabian F. VoigtJoana Figueiro-SilvaRuxandra Bachmann-Gagescu et al.

A1 Journal Article in NATURE BIOTECHNOLOGY

Regulation of non-canonical expression of ABCA4 in the retinal pigment epithelium by RPE-specific cis-regulation

Miriam BauwensVictor Lopez SorianoAlfredo Dueñas ReyGiulia AscariMunever Burcu CicekdalQuinten MahieuAndy WillaertEva D'haeneKris VleminckxElfride De Baere

2024

CRISPR/Cas9 mediated disruption of an evolutionary conserved putative enhancer in the mab21l2 locus induces developmental eye anomalies in Xenopus tropicalis

Münevver Burcu CicekdalFabiola CeroniRichard HoltThomas NaertSoeren S. LienkampElena SorokinElena SeminaNicolas ChassaingNicola RaggeElfride De Baere et al.

Decoding the non-coding regulatory genome : modelling of eye enhancerophathies in Xenopus tropicalis

Münevver Burcu CicekdalKris VleminckxElfride De BaereThomas Naert

Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development

Fabiola CeroniMünevver Burcu CicekdalRichard HoltElena SorokinaNicolas ChassaingSamuel ClokieThomas NaertLidiya V. TalbotSanaa MuheisenDorine A. Bax et al.

A1 Journal Article in NATURE COMMUNICATIONS

Evolutionary origin of Hoxc13-dependent skin appendages in amphibians

Marjolein CarronAttila Placido SachslehnerMünevver Burcu CicekdalInge BruggemanSuzan DemuynckBahar GolabiElfride De BaereWim DeclercqErwin TschachlerKris Vleminckx et al.

A1 Journal Article in NATURE COMMUNICATIONS

Regulation of non-canonical expression of ABCA4 by an RPE-specific enhancer with implications in ABCA4-associated disease

Victor Lopez SorianoAlfredo Dueñas ReyGiulia AscariMünevver Burcu CicekdalEva D'haeneQuinten MahieuHanna De SaffelAndy WillaertKris VleminckxJuan Jesus Tena-Aguilar et al.

2023

Dual molecular effects of constitutional SF3B2 variants cause a novel dominant spliceosomopathy displaying retinitis pigmentosa or developmental skeletal anomalies

Stijn Van de SompeleCaroline Van CauwenberghMarjolein CarronAlfredo Dueñas ReyFrauke CoppietersToon RosseelHong TranRobrecht CannoodtThalia Van LaethemBrecht Guillemyn et al.

Modelling of rare diseases and developmental processes in Xenopus tropicalis : from retinal degeneration to epidermal structures

Marjolein CarronElfride De BaereKris VleminckxKristof Van Schil

Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis

Dieter TulkensMarthe BoelensThomas NaertMarjolein CarronSuzan DemuynckSylviane DewaeleGert Van IsterdaelDavid CreytensTim PietersSteven Goossens et al.

A1 Journal Article in LEUKEMIA

2022

Engraftment of allotransplanted tumor cells in adult rag2 mutant Xenopus tropicalis

Dieter TulkensDionysia DimitrakopoulouMarthe BoelensTom Van NieuwenhuysenSuzan DemuynckWendy ToussaintDavid CreytensPieter Van VlierbergheKris Vleminckx

A1 Journal Article in CANCERS

Expanding the coding and non-coding genomic landscape of genetic eye diseases

Stijn Van de SompeleElfride De BaereFrauke CoppietersKris Vleminckx

Identifying and characterizing EZH2 as a druggable dependency factor for desmoid tumors in a genetic Xenopus tropicalis model for Gardner's Syndrome

Thomas NaertDieter TulkensTom Van NieuwenhuysenJoanna PrzybylSuzan DemuynckMushriq Al-JazraweMatt van de RijnBenjamin AlmanKim De LeenheerPaul Coucke et al.

Multi-omics approach dissects cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy

Stijn Van de SompeleKent W. SmallMünevver Burcu CicekdalVictor Lopez SorianoEva D'haeneFadi S. ShayaSteven AgemyThijs Van der SnicktAlfredo Dueñas ReyToon Rosseel et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Multi-omics profiling, in vitro and in vivo enhancer assays dissect the cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy

Stijn Van de SompeleKent W. SmallMünevver Burcu CicekdalVictor Lopez SorianoEva D'haeneFadi S. ShayaSteven AgemyThijs Van der SnicktAlfredo Dueñas ReyToon Rosseel et al.

Uncovering novel cancer driver genes using CRISPR/Cas9 multiplexing in Xenopus tropicalis

Dieter TulkensKris VleminckxPieter Van Vlierberghe

2021

CRISPR-SID : identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping

Thomas NaertDieter TulkensTom Van NieuwenhuysenJoanna PrzybylSuzan DemuynckMatt van de RijnMushriq Al-JazraweBenjamin A. AlmanPaul CouckeKim De Leeneer et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2020

CIL-EYE : functional characterization of potential ciliary genes involved in syndromic inherited retinal diseases

Giulia AscariElfride De BaereFrauke CoppietersKris Vleminckx

CRISPR/Cas9 mediated modeling of TP53 and PTEN related malignancies in Xenopus tropicalis

Dionysia DimitrakopoulouKris VleminckxAndy Willaert

Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos

Thomas NaertDieter TulkensNicole A. EdwardsMarjolein CarronNikko-Ideen ShaidaniMarcin WlizlaAnnekatrien BoelSuzan DemuynckMarko E. HorbPaul Coucke et al.

A1 Journal Article in SCIENTIFIC REPORTS

RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis

Thomas NaertDionysia DimitrakopoulouDieter TulkensSuzan DemuynckMarjolein CarronRivka NoelandersLiza EeckhoutGert Van IsterdaelDieter DeforceChristian Vanhove et al.

A1 Journal Article in ONCOGENE

2019

A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus

Jiejing LiMark PerfettoChristopher MaternaRebecca LiHong Tran ThiKris VleminckxMelinda K. DuncanShuo Wei

A1 Journal Article in SCIENTIFIC REPORTS

CRISPR/Cas9-mediated cancer modeling and identification of cancer cell vulnerabilities in Xenopus tropicalis

Thomas NaertKris Vleminckx

Homozygous null TBX4 mutations lead to posterior amelia with pelvic and pulmonary hypoplasia

Ariana KariminejadEmmanuelle Szenker-RaviCaroline LekszasHoma TajsharghiAli-Reza MoslemiThomas NaertHong Tran ThiFatemeh AhangariMinoo RajaeiMojila Nasseri et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Modeling human hereditary cancer syndromes using CRISPR/Cas9 mediated genome editing in Xenopus tropicalis

D. DimitrakopoulouT. NaertD. TulkensR. NoelandersT. Van NieuwenhuysePieter Van VlierbergheKris Vleminckx

Modeling human hereditary cancer syndromes using CRISPR/Cas9 mediated genome editing in Xenopus tropicalis

D. DimitrakopoulouT. NaertD. TulkensR. NoelandersT. Van NieuwenhuysePieter Van VlierbergheKris Vleminckx

Xenopus tropicalis : joining the armada in the fight against blood cancer

Dionysia DimitrakopoulouDieter TulkensPieter Van VlierbergheKris Vleminckx

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

ΔN-Tp63 mediates Wnt/β-catenin-induced inhibition of differentiation in basal stem cells of mucociliary epithelia

Maximilian HaasJose Luis Gomez VazquezDingyuan Iris SunHong Tran ThiMagdalena BrislingerAlexia TascaOrr ShomroniKris VleminckxPeter Walentek

A1 Journal Article in CELL REPORTS

2018

An atlas of Wnt activity during embryogenesis in Xenopus tropicalis

Caroline BordayKarine ParainHong Tran ThiKris VleminckxMuriel PerronAnne H Monsoro-Burq

A1 Journal Article in PLOS ONE

BATCH-GE : analysis of NGS data for genome editing assessment

Wouter SteyaertAnnekatrien BoelPaul CouckeAndy Willaert

Bookchapter in Xenopus : methods and protocols

Cadherin repertoires in lower metazoans : Trichoplax adhaerens and Nematostella vectensis

Srividhya Sundararaman IyerFrans Van RoyKris Vleminckx

Cancer models in Xenopus tropicalis by CRISPR/Cas9 mediated knockout of tumor suppressors

Thomas NaertKris Vleminckx

Bookchapter in Xenopus : methods and protocols

Cell cycle analysis of the embryonic brain of fluorescent reporter Xenopus tropicalis by flow cytometry

Rivka NoelandersKris Vleminckx

Bookchapter in Xenopus : methods and protocols

CRISPR/Cas9 disease models in zebrafish and Xenopus : the genetic renaissance of fish and frogs

Thomas NaertKris Vleminckx

A2 Journal Article in DRUG DISCOVERY TODAY. TECHNOLOGIES

CRISPR/Cas9 mediated knockout of rcbtb1 in Xenopus tropicalis to model RCBTB1-associated retinal disease

Giulia AscariThomas NaertTom Van NieuwenhuysenMarjolein CarronSuzan DemuynckChris GuerinFrauke CoppietersKris VleminckxElfride De Baere

CRISPR/Cas9 mediated knockout of rcbtb1 in Xenopus tropicalis to model RCBTB1-associated retinal disease

Giulia AscariThomas NaertTom Van NieuwenhuysenSuzan DemuynckChris GuerinFrauke CoppietersKris VleminckxElfride De Baere

CRISPR/Cas9-mediated knockout of Rb1 in Xenopus tropicalis

Thomas NaertKris Vleminckx

Bookchapter in The retinoblastoma protein

Genotyping of CRISPR/Cas9 genome edited Xenopus tropicalis

Thomas NaertKris Vleminckx

Bookchapter in Xenopus : methods and protocols

Methods for CRISPR/Cas9 Xenopus tropicalis tissue-specific multiplex genome engineering

Thomas NaertKris Vleminckx

Bookchapter in Xenopus : methods and protocols

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

Emmanuelle Szenker-RaviUmut AltunogluMarc LeushackeCelia Boss-LefevreMuznah KhatooHong Tran ThiThomas NaertRivka NoelandersAmin HajamohideenClaire Beneteau et al.

A1 Journal Article in NATURE

Targeted genome engineering in Xenopus using the transcription activator-like effector nuclease (TALEN) technology

Tom Van NieuwenhuysenKris Vleminckx

Bookchapter in Xenopus : methods and protocols

Wnt/β-catenin signaling in the Xenopus hindbrain : development and cancer

Rivka NoelandersKris Vleminckx

2017

Caspase-9 has a nonapoptotic function in Xenopus embryonic primitive blood formation

Hong Tran ThiMathias FransenDionysia DimitrakopoulouGriet Van ImschootNicolas WillemarckKris Vleminckx

A1 Journal Article in JOURNAL OF CELL SCIENCE

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis

Thomas NaertRobin ColpaertTom Van NieuwenhuysenDionysia DimitrakopoulouDavid CreytensKris Vleminckx

How Wnt signaling builds the brain : bridging development and disease

Rivka NoelandersKris Vleminckx

A1 Journal Article in NEUROSCIENTIST

Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4

Jian SongXueming LiuJiada LiHuadie LiuZhen PengYalan LiuLingyun MeiChufeng HeXinzhang CaiHongsheng Chen et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE

Modeling human disease in Xenopus tropicalis using programmable nucleases

Tom Van NieuwenhuysenKris Vleminckx

TALENs and CRISPR/Cas9 fuel genetically engineered clinically relevant Xenopus tropicalis tumor models

Thomas NaertTom Van NieuwenhuysenKris Vleminckx

A1 Journal Article in GENESIS

2016

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis

Thomas NaertRobin ColpaertTom Van NieuwenhuysenDionysia DimitrakopoulouJ LJurgen HaustraeteAnnekatrien BoelWouter SteyaertTrees LepezDieter Deforce et al.

A1 Journal Article in SCIENTIFIC REPORTS

Hearing loss in Waardenburg syndrome: a systematic review

J SongY FengFrederic AckePaul CouckeKris VleminckxIngeborg Dhooge

A1 Journal Article in CLINICAL GENETICS

Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants

Jeroen VierstraeteAndy WillaertKris VleminckxPetra VermassenLeen PietersPaul CouckeAnne VralKathleen Claes

2015

A molecular atlas of Xenopus respiratory system development

Scott A RankinHong Tran ThiMarcin WlizlaPamela ManciniEmily T ShifleySean D BloorLu HanKris VleminckxSusan E WertAaron M Zorn

A1 Journal Article in DEVELOPMENTAL DYNAMICS

A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes

Philippe De GrooteHong Tran ThiMathias FransenGiel TangheCorinne UrwylerBram De CraeneKirsten LeursBarbara GilbertGriet Van ImschootRiet De Rycke et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Genetic defects in TAPT1 disrupt ciliogenesis and cause a complex lethal osteochondrodysplasia

Sofie SymoensAileen M BarnesCharlotte GistelinckFransiska MalfaitBrecht GuillemynWouter SteyaertDelfien SyxSanne D'hondtMartine BiervlietJulie De Backer et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

SF3B2, a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein

Caroline Van CauwenberghKris VleminckxFrauke CoppietersMarcus KarlstetterThomas LangmannGael ManesChristian P HamelBart LeroyElfride De Baere

SF3B2, a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein

Caroline Van CauwenberghMarcus KarlstetterKris VleminckxGael ManesThomas LangmannChristian HamelBart LeroyFrauke CoppietersElfride De Baere

SF3B2, a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein

Caroline Van CauwenberghKris VleminckxFrauke CoppietersMarcus KarlstetterThomas LangmannGael ManesChristian P HamelBart LeroyElfride De Baere

SF3B2, a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein

Caroline Van CauwenberghKris VleminckxFrauke CoppietersMarcus KarlstetterThomas LangmannGael ManesChristian P HamelBart LeroyElfride De Baere

TALEN mediated mutation of apc and β-catenin in Xenopus tropicalis as powerful models for Wnt driven cancer and Familial Adenomatous Polyposis (FAP)

Tom Van NieuwenhuysenThomas NaertDavid CreytensFrans Van RoyKris Vleminckx

TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis

Tom Van NieuwenhuysenThomas NaertHong Tran ThiGriet Van ImschootSarah GeursEllen SandersDavid CreytensFrans Van RoyKris Vleminckx

A2 Journal Article in ONCOSCIENCE

2014

Defects in TAPT1, involved in axial skeletal patterning, cause a complex lethal recessive disorder of skeletal development

Sofie SymoensAileen BarnesCharlotte GistelinckFransiska MalfaitKris VleminckxBrecht GuillemynDelfien SyxWouter SteyaertEef ParthoensMartine Biervliet et al.

Design and use of transgenic reporter strains for detecting activity of signaling pathways in Xenopus

Hong Tran ThiKris Vleminckx

A1 Journal Article in METHODS

Fezf2 promotes neuronal differentiation through localised activation of Wnt/β-catenin signalling during forebrain development

Siwei ZhangJingling LiRobert LeaKris VleminckxEnrique Amaya

A1 Journal Article in DEVELOPMENT

2013

The Wnt signaling mediator tcf1 is required for expression of foxd3 during Xenopus gastrulation

Sylvie JanssensOlaf van den BroekIan R DavenportRobbert C AkkersFei LiuGert Jan C VeenstraStefan HopplerKris VleminckxOlivier Destrée

A1 Journal Article in INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

2012

Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation

Caroline BordayPauline CabochetteKarine ParainNicolas MazurierSylvie JanssensHong Tran ThiBelaïd SekkaliOdile BronchainKris VleminckxMorgane Locker et al.

A1 Journal Article in DEVELOPMENT

Hes4 controls proliferative properties of neural stem cells during retinal ontogenesis

Warif El YakoubiCaroline BordayJohanna HamdacheKarine ParainHong Tran ThiKris VleminckxMuriel PerronMorgane Locker

A1 Journal Article in STEM CELLS

Identification of novel target genes of the Wnt/β-catenin pathway during Xenopus development and analysis of their epigenetic regulation

Sylvie JanssensKris Vleminckx

Plakophilin-3 is required for late embryonic amphibian development, exhibiting roles in ectodermal and neural tissues

William A MunozMalgorzata KlocKyucheol ChoMoonsup LeeIlse HofmannAmy SaterKris VleminckxPierre D McCrea

A1 Journal Article in PLOS ONE

2011

ARVCF Depletion cooperates with Tbx1 deficiency in the development of 22q11.2DS-like phenotypes in Xenopus

Hong Tran ThiMieke DelvaeyeVeerle VerschuereEmilie DescampsEllen CrabbeLuc Van HoorebekePierre McCreaDominique AdriaensFrans Van RoyKris Vleminckx

A1 Journal Article in DEVELOPMENTAL DYNAMICS

Exploring the role of caspases and RIPK4 during Xenopus development

Mathias FransenKris Vleminckx

The role of Wnt in cell signaling and cell adhesion during early vertebrate development

Sylvie JanssensEllen CrabbeKris Vleminckx

A1 Journal Article in FRONTIERS IN BIOSCIENCE-LANDMARK

Transcription factor Zic2 inhibits Wnt/β-catenin protein signaling

Rasoul PourebrahimRob HoutmeyersStephen GhogomuSylvie JanssensAurore ThelieHong Tran ThiTobias LangenbergKris VleminckxEric BellefroidJean-Jacques Cassiman et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

You'd better catch that Wnt-primitive hematopoiesis requires canonical Wnt signaling

Hong Tran ThiKris Vleminckx

Editorial material

2010

Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development

Nicolas WillemarckEvelien RysmanKoen BrusselmansGriet Van ImschootFrank VanderhoydoncKatrien MoerlooseEvelyne LerutGuido VerhoevenFrans Van RoyKris Vleminckx et al.

A1 Journal Article in CANCER RESEARCH

Direct control of Hoxd1 and Irx3 expression by Wnt/β-catenin signaling during anteroposterior patterning of the neural axis in Xenopus

Sylvie JanssensTinneke DenaeyerTom DerooFrans Van RoyKris Vleminckx

A1 Journal Article in INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The chronic toxicity of molybdate to freshwater organisms, I: generating reliable effects data

Karel De SchamphelaereW StubblefieldP RodriguezKris VleminckxColin Janssen

A1 Journal Article in SCIENCE OF THE TOTAL ENVIRONMENT

Wnt/β-catenin signaling is involved in the induction and maintenance of primitive hematopoiesis in the vertebrate embryo

Hong Tran ThiBelaid SekkaliGriet Van ImschootSylvie JanssensKris Vleminckx

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2009

Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling

Bert De RybelDominique AudenaertGrégory VertWilfried RozhonJuliane MayerhoferFrank PeelmanSilvie CoutuerTinneke DenayerLeentje JansenLong Nguyen et al.

A1 Journal Article in CHEMISTRY & BIOLOGY

Inhibition of the canonical Wnt signaling pathway during craniofacial development: impact on the craniofacial phenotype of Xenopus tadpoles

Emilie DescampsKris VleminckxDominique Adriaens

Requirement of Wnt/beta-catenin signaling in pronephric kidney development

Jon P LyonsRachel K MillerXiaolan ZhouGilbert WeidingerTom DerooTinneke DenayerJae-Il ParkHong JiJi Yeon HongAnnette Li et al.

A1 Journal Article in MECHANISMS OF DEVELOPMENT

2008

Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes

Tinneke DenayerM LOCKERC BORDAYTom DerooSylvie JanssensA HECHTFrans Van RoyM PERRONKris Vleminckx

A1 Journal Article in STEM CELLS

Cell migration during development

Ellen CrabbeKris Vleminckx

Bookchapter in Encyclopedia of life sciences

Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos

Belaïd SekkaliHong Tran ThiEllen CrabbeChristophe De BeuleFrans Van RoyKris Vleminckx

A1 Journal Article in FASEB JOURNAL

Transgenic reporter tools tracing endogenous canonical wnt signaling in Xenopus

Tinneke DenayerHong Tran ThiKris Vleminckx

Bookchapter in Wnt Signaling, Volume II: Pathway Models

2007

Mycobacterium liflandii infection in European colony of Silurana tropicalis

P SUYKERBUYKKris VleminckxFrank PasmansPieter StragierA ABLORDEYHong Tran ThiKatleen HermansM FLEETWOODWM MEYERSF PORTAELS

A1 Journal Article in EMERGING INFECTIOUS DISEASES

2006

A new generation of JASPAR, the open-access repository for transcription factor binding site profiles

Dominique VliegheA SANDELINPieter De BleserKris VleminckxWW WASSERMANFrans Van RoyB LENHARD

A1 Journal Article in NUCLEIC ACIDS RESEARCH

In vivo tracing of canonical Wnt signaling in Xenopus tadpoles by means of an inducible transgenic reporter tool

Tinneke DenayerFrans Van RoyKris Vleminckx

A1 Journal Article in FEBS LETTERS

2005

A genetic Xenopus laevis tadpole model to study lymphangiogenesis

A NYM KOCHM SCHNEIDERE NEVENRT TONGS MAITYC FISCHERS PLAISANCED LAMBRECHTSC HELIGON et al.

A1 Journal Article in NATURE MEDICINE

Canonical Wnt signaling is required for pronephric kidney tubule development.

JP LYONST DEROOH JIEA JONESKris VleminckxPD MCCREA

Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets

JI PARKSW KIMJP LYONSH JITT NGUYENKC CHOMC BARTONTom DerooKris VleminckxPD MCCREA

A1 Journal Article in DEVELOPMENTAL CELL

Kaiso/p120-catenin and TCF/Beta-Catenin complexes coordinately regulate canonical wnt gene targets.

JI PARKJP LYONSH JIT NGUYENMC BARTONT DEROOKris VleminckxPD MCCREA

2004

Evolution of neural precursor selection: functional divergence of proneural proteins

XJ QUANTinneke DenayerJ YANH JAFAR-NEJADA PHILIPPIO LICHTARGEKris VleminckxBA HASSAN

A1 Journal Article in DEVELOPMENT

Global inhibition of Lef1/Tcf-dependent Wnt signaling at its nuclear end point abrogates development in transgenic Xenopus embryos

Tom DerooTinneke DenayerFrans Van RoyKris Vleminckx

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

P120 catenin is required for morphogenetic movements involved in the formation of the eyes and the cranlofacial skeleton in Xenopus

Malgorzata CiesiolkaMieke DelvaeyeGriet Van ImschootVeerle VerschuereP MCCREAFrans Van RoyKris Vleminckx

A1 Journal Article in JOURNAL OF CELL SCIENCE

2003

The p120 catenin regulates morphogenetic movements in early xenopus embryos by modifying the activity of the rho-family small Gtpases.

M CIESIOLKAM DELVAEYEGriet Van ImschootFrans Van RoyKris Vleminckx

2001

Adhesive specificity and the evolution of multicellularity

Bookchapter in Encyclopedia of life sciences

Cell adhesion molecules

Bookchapter in Encyclopedic reference of cancer

2000

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates.

Andreas HechtKris VleminckxMarc P. StemmlerFrans Van RoyRolf Kemler

A1 Journal Article in EMBO JOURNAL

1999

Cadherins and tissue formation: integrating adhesion and signaling.

Kris VleminckxRolf Kemler

A1 Journal Article in BIOESSAYS

The C-terminal transactivation domain of β-catenin is necessary and sufficient for signaling by the LEF-1/β-catenin complex in Xenopus laevis

Kris VleminckxRolf KemlerAndreas Hecht

A1 Journal Article in MECHANISMS OF DEVELOPMENT

1997

Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis

Kris VleminckxEllen WongKathy GugerBonnee RubinfeldPaul PolakisBarry M Gumbiner

A1 Journal Article in JOURNAL OF CELL BIOLOGY

1996

Morphotypic plasticity in vitro and in nude mice of epithelial mouse mammary cells (NMuMG) displaying an epithelioid (e) or a fibroblastic (f) morphotype in culture.

C VANDENBROECKEKris VleminckxG DEBRUYNEL VANHOORDELuc VakaetFrans Van RoyMarcus Mareel

A1 Journal Article in CLINICAL & EXPERIMENTAL METASTASIS

Syndecan-1 expression in mammary epithelial tumor cells is E-cadherin-dependent.

S LEPPAKris VleminckxFrans Van RoyM JALKANEN

A1 Journal Article in JOURNAL OF CELL SCIENCE

1995

Transition from the noninvasive to the invasive phenotype and loss of α-catenin in human colon cancer cells

Stefan VermeulenErik Bruyneelmarc brackeGeorges De BruyneKrist'l M VennekensKris VleminckxGeert BerxFrans Van RoyMarcus Mareel

A1 Journal Article in CANCER RESEARCH

1994

Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer

Marcus MareelKris VleminckxStefan VermeulenY GAOMarc BrackeFrans Van Roy

Bookchapter in Proceedings of the 24th International Symposium of the Princess Takamatsu Cancer Research Fund

Enlarged cell-associated proteoglycans abolish E-cadherin functionality in invasive tumor cells

Kris VleminckxJoris DemanErik BruyneelGeert VandenbosscheAnnick KeirsebilckMarcus MareelFrans Van Roy

A1 Journal Article in CANCER RESEARCH

MICRO-ENCAPSULATION OF MDCK-RAS-E CELLS PREVENTS LOSS OF E-CADHERIN INVASION-SUPPRESSOR FUNCTION IN-VIVO

GMR VANDENBOSSCHEGK DEBRUYNEErik BruyneelG CLEMMINCKKris VleminckxFrans Van RoyMarcus Mareel

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

1993

Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro.

marc brackeBM VYNCKEErik BruyneelStefan VermeulenGK DEBRUYNENA VANLAREBEKEKris VleminckxFrans Van RoyMarcus Mareel

A1 Journal Article in BRITISH JOURNAL OF CANCER

Karakterisering van de cel-cel adhesiemolecule E-cadherine als invasie-suppressor eiwit in epitheliale tumorcellen

NEOPLASTIC PROGRESSION OF HUMAN AND RAT INTESTINAL-CELL LINES AFTER TRANSFER OF THE RAS AND POLYOMA MIDDLE T-ONCOGENES

E CHASTRES EMPEREURY DIGIOIAN ELMAHDANIMarcus MareelKris VleminckxFrans Van RoyV BEXS EMAMIDA SPANDIDOS et al.

A1 Journal Article in GASTROENTEROLOGY

1992

E-Cadherin expression: a counterbalance for cancer cell invasion.

Marcus MareelKris VleminckxStefan Vermeulenmarc brackeFrans Van Roy

A1 Journal Article in BULLETIN DU CANCER

Homotypic cell-cell adhesion molecules and tumor invasion

Marcus MareelKris VleminckxStefan VermeulenY GaoLuc VakaetMarc BrackeFrans Van Roy

A1 Journal Article in PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

1991

DOWN-REGULATION OF E-CADHERIN EXPRESSION IN MADIN DARBY CANINE KIDNEY (MDCK) CELLS INSIDE TUMORS OF NUDE-MICE.

Marcus MareelJ BEHRENSW BIRCHMEIERGK DEBRUYNEKris VleminckxA HOOGEWIJSWC FIERSFrans Van Roy

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

GENETIC MANIPULATION OF E-CADHERIN EXPRESSION BY EPITHELIAL TUMOR-CELLS REVEALS AN INVASION SUPPRESSOR ROLE.

Kris VleminckxLuc VakaetMarcus MareelWalter FiersFrans Van Roy

A1 Journal Article in CELL

Numerical evaluation of the invasion of closely related cell lines into collagen type I gels

Luc VakaetKris VleminckxFrans Van RoyMarcus Mareel

A1 Journal Article in INVASION & METASTASIS

1990

HORMONE SENSITIVITY INVITRO AND INVIVO OF V-RAS-TRANSFECTED MCF-7 CELL DERIVATIVES.

Frans Van RoyMarcus MareelKris VleminckxRudi BeyaertWalter FiersN DEVLEESCHOUWERC MUQUARDTN LEGROSmarc brackeG LECLERCQ

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

1989

EFFECT OF ONCOGENE TRANSFECTION OR PASSAGE INVIVO ON MALIGNANT PHENOTYPES OF RAT2-CELLS.

Frans Van RoyP COOPMANPhilip SuffysG LIEBAUTKris VleminckxJ GAOCH DRAGONETTIWalter FiersMarcus Mareel

A1 Journal Article in ANTICANCER RESEARCH