Research Explorer

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Project

Chronic pain in Ehlers-Danlos syndrome: clinical and molecular characterization in human patients and a murine model

Outputs & Impact

Publications & research data ( 20 )

Pathogenic mechanisms in genetically defined Ehlers-Danlos syndromes

Delfien SyxFransiska Malfait

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Classic Ehlers-Danlos syndrome

Fransiska MalfaitSofie SymoensDelfien Syx

Bookchapter in GeneReviews®

Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression

Robin VromanShingo IshiharaSpencer FullamMatthew J WoodNatalie S AdamczykNolan LomeliFransiska MalfaitAnne-Marie MalfaitRachel E MillerAdrienn Markovics

A1 Journal Article in MOLECULAR PAIN

Sensory profiling in classical Ehlers-Danlos syndrome : a case-control study revealing pain characteristics, somatosensory changes, and impaired pain modulation

Marlies ColmanDelfien SyxInge De WandeleLies RombautDeborah WilleZoë MalfaitMira MeeusAnne-Marie MalfaitJessica Van OosterwijckFransiska Malfait

A1 Journal Article in JOURNAL OF PAIN

NRF2 shortage in human skin fibroblasts dysregulates matrisome gene expression and affects collagen fibrillogenesis

Mélanie SalamitoBenjamin GilletDelfien SyxElisabeth VaganayMarilyne MalbouyresCatherine CeruttiNicolas TissotChloé Exbrayat-HéritierPhilippe PerezChristophe Jones et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Unexplored clinical and molecular consequences of the Ehlers-Danlos syndromes

Marlies ColmanFransiska MalfaitDelfien SyxJessica Van Oosterwijck

Analysis of matrisome expression patterns in murine and human dorsal root ganglia

Robin VromanRahel S. HunterMatthew J. WoodOlivia C. DavisZoë MalfaitDale S. GeorgeDongjun RenDiana Tavares-FerreiraTheodore J. PriceRichard J. Miller et al.

A1 Journal Article in FRONTIERS IN MOLECULAR NEUROSCIENCE

Sensory profiling in classical Ehlers-Danlos syndrome : a case-control study revealing pain characteristics, somatosensory changes, and impaired pain modulation

Marlies ColmanDelfien SyxInge De WandeleLies RombautDeborah WilleZoë MalfaitMira MeeusAnne-Marie MalfaitJessica Van OosterwijckFransiska Malfait

Kyphoscoliotic Ehlers‐Danlos syndrome caused by pathogenic variants in FKBP14 : further insights into the phenotypic spectrum and pathogenic mechanisms

Marlies ColmanRobin VromanTibbe DhoogeZoë MalfaitSofie SymoensBiruté BurnytéSheela NampoothiriAriana KariminejadFransiska MalfaitDelfien Syx

A1 Journal Article in HUMAN MUTATION

Atypical variants in COL1A1 and COL3A1 associated with classical and vascular Ehlers-Danlos syndrome overlap phenotypes : expanding the clinical phenotype based on additional case reports

Marlies ColmanMarco CastoriLucia MicaleMarco RitelliMarina ColombiNeeti GhaliFleur Van DijkLuisa MarsiliAdrienne WeeksAnthony Vandersteen et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Editorial : molecular mechanisms of heritable connective tissue disorders

Fransiska MalfaitAntonella ForlinoGerhard SengleTom Van Agtmael

Editorial material

Exploring pain mechanisms in hypermobile Ehlers-Danlos syndrome : a case-control study

Inge De WandeleMarlies ColmanLinda HermansJessica Van OosterwijckMira MeeusLies RombautGRIET BRUSSELMANSDelfien SyxPatrick CaldersFransiska Malfait

A1 Journal Article in EUROPEAN JOURNAL OF PAIN

The Ehlers–Danlos syndromes against the backdrop of inborn errors of metabolism

Tim Van DammeMarlies ColmanDelfien SyxFransiska Malfait

A1 Journal Article in GENES

Four decades in the making : collagen III and mechanisms of vascular Ehlers Danlos Syndrome

Ramla OmarFransiska MalfaitTom Van Agtmael

A2 Journal Article in MATRIX BIOLOGY PLUS

Pain in the Ehlers–Danlos syndromes : mechanisms, models, and challenges

Fransiska MalfaitMarlies ColmanRobin VromanInge De WandeleLies RombautRachel E. MillerAnne-Marie MalfaitDelfien Syx

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Collagens in the physiopathology of the Ehlers–Danlos Syndromes

Fransiska MalfaitRobin VromanMarlies ColmanDelfien Syx

Bookchapter in The collagen superfamily and collagenopathies

Animal models of Ehlers–Danlos syndromes : phenotype, pathogenesis, and translational potential

Robin VromanAnne-Marie MalfaitRachel MillerFransiska MalfaitDelfien Syx

A1 Journal Article in FRONTIERS IN GENETICS

Clinical and molecular characteristics of 168 probands and 65 relatives with a clinical presentation of classical Ehlers-Danlos syndrome

Marlies ColmanDelfien SyxInge De WandeleTibbe DhoogeSofie SymoensFransiska Malfait

A1 Journal Article in HUMAN MUTATION

Pain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers-Danlos syndrome

Delfien SyxRachel E. MillerAlia M. ObeidatPhuong B. TranRobin VromanZoë MalfaitRichard J. MillerFransiska MalfaitAnne-Marie Malfait

A1 Journal Article in PAIN

The Ehlers-Danlos syndromes

Fransiska MalfaitMarco CastoriClair A. FrancomanoCecilia GiuntaTomoki KoshoPeter H. Byers

A1 Journal Article in NATURE REVIEWS DISEASE PRIMERS

Activities ( 0 )

Results

Impact narratives ( 1 )

Area(s): Economic, Health, Social

Patents ( 0 )