A blueprint for combinatorial and adaptive evolution of proteins: phage endolysins as a prominent case study

De novo designed phage lysins to innovate antibiotic development

Doctoral project Gilles Vandermarliere

Engineering phage lysins as novel antimicrobials using underexplored design and expression approaches

Unravelling and customizing phage lysin specificity under therapeutic conditions

Development of phage-inspired coupled diagnostics and targeted antibacterials against streptococci

De novo designed phage lysins to innovate antibiotic development

A paradigm shift in our understanding of the modular complexity of phage lysins for improved antibacterials

Understanding the evolutionary dynamics of phage lysin configurations as a driver for new enzyme-based antibiotics