Instellingen beheren
MENU
Over deze site
In English
Home
Onderzoekers
Projecten
Organisaties
Publicaties
Infrastructuur
Contact
Research Explorer
Uw browser ondersteunt geen JavaScript of JavaScript is niet ingeschakeld. Zonder JavaScript kan sommige functionaliteit van deze webapplicatie uitgeschakeld zijn of foutmeldingen veroorzaken. Raadpleeg om JavaScript in te schakelen de handleiding van uw browser of contacteer uw systeembeheerder.
Onderzoeker
Katleen De Preter
Profiel
Projecten
Publicaties
Activiteiten
Prijzen & Erkenningen
330
Resultaten
2024
A fast, affordable and minimally-invasive diagnostic test for Cancer of Unknown Primary (CUP) using DNA methylation profiling
Jilke De Wilde
Ruben Van Paemel
Andries De Koker
Sofie Roelandt
Sofie Van de Velde
Nico Callewaert
Jo Van Dorpe
David Creytens
Bram De Wilde
Katleen De Preter
A1
Artikel in een tijdschrift
in
LABORATORY INVESTIGATION
2024
Computational deconvolution of DNA methylation data from mixed DNA samples
Maísa Renata Ferro Dos Santos
Edoardo Giuili
Andries De Koker
Celine Everaert
Katleen De Preter
A1
Artikel in een tijdschrift
in
BRIEFINGS IN INFORMATICS
2024
Diagnosis of pediatric central nervous system tumors using methylation profiling of cfDNA from cerebrospinal fluid
Lotte Cornelli
Ruben Van Paemel
Maísa Renata Ferro Dos Santos
Sofie Roelandt
Leen Willems
Jelle Vandersteene
Edward Baert
Liselot Mus
Nadine Van Roy
Bram De Wilde
et al.
A1
Artikel in een tijdschrift
in
CLINICAL EPIGENETICS
2024
Evaluation of single-sample network inference methods for precision oncology
Joke Deschildre
Boris Vandemoortele
Jens Uwe Loers
Katleen De Preter
Vanessa Vermeirssen
A1
Artikel in een tijdschrift
in
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
2024
From mutations to splice variants : identifying liquid biopsy derived biomarkers in metastatic prostate cancer
Jan Vanwelkenhuyzen
Piet Ost
Bram De Laere
Katleen De Preter
Proefschrift
2024
Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma
Stéphane Van Haver
Yujie Fan
Sarah-Lee Bekaert
Celine Everaert
Wouter Van Loocke
Vittorio Zanzani
Joke Deschildre
Ines Fernandez Maestre
Adrianna Amaro
Vanessa Vermeirssen
et al.
A1
Artikel in een tijdschrift
in
ISCIENCE
2024
Human pluripotent stem cell modeling, from normal development to neuroblastoma
Stéphane Van Haver
Franki Speleman
Katleen De Preter
Proefschrift
2024
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
Alice Salib
Nisitha Jayatilleke
Janith A. Seneviratne
Chelsea Mayoh
Katleen De Preter
Franki Speleman
Belamy B. Cheung
Daniel R. Carter
Glenn M. Marshall
A1
Artikel in een tijdschrift
in
ONCOGENE
2024
NBAtlas: A harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors.
Noah Bonine
Vittorio Zanzani
Annelies Van Hemelryk
Bavo Vanneste
Christian Zwicker
Tinne Thoné
Sofie Roelandt
Sarah-Lee Bekaert
Jan Koster
Isabelle Janoueix-Lerosey
et al.
U
Artikel in een tijdschrift
in
Cell reports
2024
2023
A harmonized single-cell transcriptomic atlas of human neuroblastoma
Noah Bonine
Vittorio Zanzani
Liselot Mus
Bavo Vanneste
Christian Zwicker
Tinne Thoné
Sofie Roelandt
Cécile Thirant
Amira Kramdi
Isabelle Janoueix-Lerosey
et al.
C3
Conferentie
2023
Case series on clinical applications of liquid biopsy in pediatric solid tumors : towards improved diagnostics and disease monitoring
Nina U. Gelineau
Astrid van Barneveld
Atia Samim
Lieke Van Zogchel
Nathalie Lak
Michelle L. Tas
Yvette Matser
Annelies M. C. Mavinkurve-Groothuis
Martine van Grotel
Jószef Zsiros
et al.
A1
Artikel in een tijdschrift
in
FRONTIERS IN ONCOLOGY
2023
Cell-free DNA as a diagnostic and prognostic biomarker in pediatric rhabdomyosarcoma
Nathalie S.M. Lak
Lieke M.J. van Zogchel
Lily Zappeij-Kannegieter
Ahmad Javadi
Ruben Van Paemel
Charlotte Vandeputte
Katleen De Preter
Bram De Wilde
Mathieu Chicard
Yasmine Iddir
et al.
A1
Artikel in een tijdschrift
in
JCO PRECISION ONCOLOGY
2023
Circulating immune cell dynamics as outcome predictors for immunotherapy in non-small cell lung cancer
Alvaro Marcos Rubio
Celine Everaert
Eufra Van Damme
Katleen De Preter
Karim Vermaelen
A1
Artikel in een tijdschrift
in
JOURNAL FOR IMMUNOTHERAPY OF CANCER
2023
Dramatic impact of blood collection tube and RNA purification method on extracellular RNA transcriptomes
Jasper Anckaert
Francisco Avila Cobos
Anneleen Decock
Philippe Decruyenaere
Jill Deleu
Katleen De Preter
Olivier De Wever
Jilke De Wilde
Bert Dhondt
Thibaut D'huyvetter
et al.
C3
Conferentie
2023
Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma
Jordan F. Hastings
Sharissa L. Latham
Alvin Kamili
Madeleine S. Wheatley
Jeremy Z. R. Han
Marie Wong-Erasmus
Monica Phimmachanh
Max Nobis
Chiara Pantarelli
Antonia L. Cadell
et al.
A1
Artikel in een tijdschrift
in
SCIENCE ADVANCES
2023
Mitotic dysregulation at tumor initiation creates a therapeutic vulnerability to combination anti-mitotic and pro-apoptotic agents for MYCN-driven neuroblastoma
Lei Zhai
Anushree Balachandran
Rebecca Larkin
Janith A. Seneviratne
Sylvia A. Chung
Amit Lalwani
Shoma Tsubota
Dominik Beck
Kenji Kadomatsu
Anneleen Beckers
et al.
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2023
Molecular characterization of SOX11 as multifaceted epigenetic regulator in neuroblastoma
Amber Louwagie
Franki Speleman
Katleen De Preter
Jan Willem Bek
Proefschrift
2023
Novel tissue- and blood-based biomarkers in Barrett’s Esophagus and esophageal adenocarcinoma
Annouck Philippron
Katleen De Preter
Piet Pattyn
Philippe Nafteux
Proefschrift
2023
Nucleic acid biomarkers in blood from patients with esophageal adenocarcinoma : finding the needle in the haystack
Kathleen Schoofs
Katleen De Preter
Jo Vandesompele
Piet Pattyn
Proefschrift
2023
Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study
Anneleen Decock
Olivier De Wever
Celine Everaert
Hetty Helsmoortel
An Hendrix
Pieter Mestdagh
Annelien Morlion
Jo Vandesompele
Ruben Van Paemel
Francisco Avila Cobos
et al.
C3
Conferentie
2023
Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study
Anneleen Decock
Olivier De Wever
Celine Everaert
Hetty Helsmoortel
An Hendrix
Pieter Mestdagh
Annelien Morlion
Jo Vandesompele
Ruben Van Paemel
Francisco Avila Cobos
et al.
C3
Conferentie
2023
SOX11 is a mediator of core regulatory circuit robustness : upregulation of SWI/SNF components and recruitment of transcriptional enhancer NONO
Amber Louwagie
Bieke Decaesteker
Sarah-Lee Bekaert
Fanny De Vloed
Ellen Sanders
Stéphane Van Haver
Tim Pieters
Pieter Van Vlierberghe
S Roberts
S Ek
et al.
C3
Conferentie
2023
SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry
Bieke Decaesteker
Amber Louwagie
Siebe Loontiens
Fanny De Vloed
Sarah-Lee Bekaert
Juliette Roels
Suzanne Vanhauwaert
Sara De Brouwer
Ellen Sanders
A Berezovskaya
et al.
A1
Artikel in een tijdschrift
in
NATURE COMMUNICATIONS
2023
2022
Complementarity of single-nucleus and single-cell RNA sequencing to study the transcriptional heterogeneity of neuroblastoma tumors
Noah Bonine
Tinne Thoné
Bavo Vanneste
Liselot Mus
Celine Everaert
Bram De Wilde
Franki Speleman
Charlotte Scott
Katleen De Preter
C3
Conferentie
2022
Complementarity of single-nucleus and single-cell RNA sequencing to study the transcriptional heterogeneity of neuroblastoma tumors
Noah Bonine
Tinne Thoné
Bavo Vanneste
Liselot Mus
Celine Everaert
Bram De Wilde
Franki Speleman
Charlotte Scott
Katleen De Preter
C3
Conferentie
2022
Comprehensive RNA dataset of tissue and plasma from patients with esophageal cancer or precursor lesions
Kathleen Schoofs
Annouck Philippron
Francisco Avila Cobos
Jan Koster
Steve Lefever
Jasper Anckaert
Danny De Looze
Jo Vandesompele
Piet Pattyn
Katleen De Preter
A1
Artikel in een tijdschrift
in
SCIENTIFIC DATA
2022
Digital PCR-based evaluation of nucleic acid extraction kit performance for the co-purification of cell-free DNA and RNA
Jill Deleu
Kathleen Schoofs
Anneleen Decock
Kimberly Verniers
Sofie Roelandt
Angie Denolf
Joke Verreth
Bram De Wilde
Tom Van Maerken
Katleen De Preter
et al.
A1
Artikel in een tijdschrift
in
HUMAN GENOMICS
2022
MiR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma
Holly Holliday
Jessica Yang
Eoin Dodson
Iva Nikolic
Alvin Kamili
Madeleine Wheatley
Niantao Deng
Sarah Alexandrou
Thomas P. Davis
Maria Kavallaris
et al.
A1
Artikel in een tijdschrift
in
MOLECULAR THERAPY
2022
Opportunities and challenges in interpretable deep learning for drug sensitivity prediction of cancer cells
Bikash Ranjan Samal
Jens Uwe Loers
Vanessa Vermeirssen
Katleen De Preter
A2
Artikel in een tijdschrift
in
FRONTIERS IN BIOINFORMATICS
2022
Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study
Jasper Anckaert
Francisco Avila Cobos
Anneleen Decock
Philippe Decruyenaere
Jill Deleu
Katleen De Preter
Olivier De Wever
Jilke De Wilde
Bert Dhondt
Thibaut D'huyvetter
et al.
Preprint
2022
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
Carolina de Carvalho Nunes
Lisa Depestel
Liselot Mus
Kaylee M. Keller
Louis Delhaye
Amber Louwagie
Muhammad Rishfi
Alex Whale
Neesha Kara
Simon R. Andrews
et al.
A1
Artikel in een tijdschrift
in
SCIENCE ADVANCES
2022
The feasibility of using liquid biopsies as a complementary assay for copy number aberration profiling in routinely collected paediatric cancer patient samples
Ruben Van Paemel
Charlotte Vandeputte
Lennart Raman
Jolien Van Thorre
Leen Willems
Jo Van Dorpe
Malaïka Van der Linden
Jilke De Wilde
Andries De Koker
Björn Menten
et al.
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF CANCER
2022
Toward methodology for comprehensive androgen receptor splice variant profiling in cell-free RNA from patients with metastatic prostate cancer
Jan Vanwelkenhuyzen
Pieter-Jan van Dam
Katleen De Preter
Johan Lindberg
Piet Ost
Bram De Laere
C3
Conferentie
2022
Towards the discovery of prognostic and predictive biomarkers in CHEERS, a radioimmunotherapy phase II trial
Jan Vanwelkenhuyzen
Mathieu Spaas
Kim Van der Eecken
Vibeke Kruse
Sylvie Rottey
Lieve Brochez
Johan Lindberg
Katleen De Preter
Bram De Laere
Piet Ost
C3
Conferentie
2022
When DNA gets in the way in RNA-seq experiments, a sequel
Jasper Verwilt
Maria D. Giraldez
Wim Trypsteen
Ruben Van Paemel
Katleen De Preter
Pieter Mestdagh
Jo Vandesompele
Preprint
2022
2021
Evaluation of a marker independent isolation method for circulating tumor cells in esophageal adenocarcinoma
Annouck Philippron
Lieven Depypere
Steffi Oeyen
Bram De Laere
Charlotte Vandeputte
Philippe Nafteux
Katleen De Preter
Piet Pattyn
A1
Artikel in een tijdschrift
in
PLOS ONE
2021
Expanding the diagnostic toolbox in pediatric oncology : exploration of the value of the cell-free DNA methylome
Ruben Van Paemel
Bram De Wilde
Katleen De Preter
Proefschrift
2021
Frequency and prognostic impact of ALK amplifications and mutations in the European Neuroblastoma Study Group (SIOPEN) high-risk neuroblastoma trial (HR-NBL1)
Angela Bellini
Ulrike Pötschger
Virginie Bernard
Eve Lapouble
Sylvain Baulande
Peter F. Ambros
Nathalie Auger
Klaus Beiske
Marie Bernkopf
David R. Betts
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL ONCOLOGY
2021
From DNA copy number gains and tumor dependencies to novel therapeutic targets for high-risk neuroblastoma
Bieke Decaesteker
Kaat Durinck
Nadine Van Roy
Bram De Wilde
Christophe Van Neste
Stéphane Van Haver
Stephen Roberts
Katleen De Preter
Vanessa Vermeirssen
Franki Speleman
A1
Artikel in een tijdschrift
in
JOURNAL OF PERSONALIZED MEDICINE
2021
Genome-wide study of the effect of blood collection tubes on the cell-free DNA methylome
Ruben Van Paemel
Andries De Koker
Christa Caggiano
Annelien Morlion
Pieter Mestdagh
Bram De Wilde
Jo Vandesompele
Katleen De Preter
A1
Artikel in een tijdschrift
in
EPIGENETICS
2021
MEIS2 is an adrenergic core regulatory transcription factor involved in early initiation of TH-MYCN-driven neuroblastoma formation
Jolien De Wyn
Mark W. Zimmerman
Nina Weichert-Leahey
Carolina de Carvalho Nunes
Belamy B. Cheung
Brian J. Abraham
Anneleen Beckers
Pieter-Jan Volders
Bieke Decaesteker
Daniel R. Carter
et al.
A1
Artikel in een tijdschrift
in
CANCERS
2021
Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study
Ruben Van Paemel
Andries De Koker
Charlotte Vandeputte
Lieke van Zogchel
Tim Lammens
Genevieve Laureys
Jo Vandesompele
Gudrun Schleiermacher
Mathieu Chicard
Nadine Van Roy
et al.
A1
Artikel in een tijdschrift
in
EPIGENETICS
2021
Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions
Liselot Mus
Stéphane Van Haver
Mina Popovic
Wim Trypsteen
Steve Lefever
Nadja Zeltner
Yudelca Ogando
Eva Jacobs
Geertrui Denecker
Ellen Sanders
et al.
A1
Artikel in een tijdschrift
in
GENES CHROMOSOMES & CANCER
2021
SOX11 as guardian of epigenetic plasticity in neuroblastoma
Bieke Decaesteker
Amber Louwagie
Siebe Loontiens
Sara De Brouwer
Carolina de Carvalho Nunes
Geertrui Denecker
Fanny De Vloed
Lisa Depestel
Juliette Roels
Karen Verboom
et al.
C3
Conferentie
2021
The RNA Atlas expands the catalog of human non-coding RNAs
Lucia Lorenzi
Hua-Sheng Chiu
Francisco Avila Cobos
Stephen Gross
Pieter-Jan Volders
Robrecht Cannoodt
Justine Nuytens
Katrien Vanderheyden
Jasper Anckaert
Steve Lefever
et al.
A1
Artikel in een tijdschrift
in
NATURE BIOTECHNOLOGY
2021
The RNA Atlas expands the catalog of human non-coding RNAs (June, 10.1038/s41587-021-00936-1, 2021)
Lucia Lorenzi
Hua-Sheng Chiu
Francisco Avila Cobos
Stephen Gross
Pieter-Jan Volders
Robrecht Cannoodt
Justine Nuytens
Katrien Vanderheyden
Jasper Anckaert
Steve Lefever
et al.
Correctie
2021
The functional annotation and exploration the SOX11 enhanceosome
Amber Louwagie
Bieke Decaesteker
Louis Delhaye
Eva D'haene
Eric de Bony de Lavergne
Volodimir Olexiouk
Sarah Vergult
Rogier Versteeg
Jan Koster
Johan van Nes
et al.
C3
Conferentie
2021
2020
Addressing challenges in transcriptome annotation and cell-type heterogeneity through integration of omics datasets and computational deconvolution
Francisco Avila Cobos
Katleen De Preter
Pieter Mestdagh
Proefschrift
2020
Benchmarking of cell type deconvolution pipelines for transcriptomics data
Francisco Avila Cobos
José Alquicira-Hernandez
Joseph E. Powell
Pieter Mestdagh
Katleen De Preter
A1
Artikel in een tijdschrift
in
NATURE COMMUNICATIONS
2020
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development
Anne-Catherine Dolens
Kaat Durinck
Marieke Lavaert
Joni Van der Meulen
Imke Velghe
Jelle De Medts
Karin Weening
Juliette Roels
Katrien De Mulder
Pieter-Jan Volders
et al.
A1
Artikel in een tijdschrift
in
EMBO REPORTS
2020
Inferring the genomic landscape of lymph-node positive high-risk prostate cancer
Jan Vanwelkenhuyzen
Kim Van der Eecken
Bram De Laere
Simon Sundling
Rebecka Bergström
Johan Lindberg
Katleen De Preter
Henrik Grönberg
Piet Ost
C3
Conferentie
2020
Long noncoding RNA SILC1 is an upstream regulator of SOX11 in neuroblastoma
Amber Louwagie
Bieke Decaesteker
Eva D'haene
Louis Delhaye
Eric de Bony de Lavergne
Christophe Van Neste
Rogier Versteeg
Sara Ek
Björn Menten
Jan Koster
et al.
C3
Conferentie
2020
Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA
Ruben Van Paemel
Andries De Koker
Charlotte Vandeputte
Lieke Van Zogchel
Tim Lammens
Genevieve Laureys
Jo Vandesompele
Gudrun Schleiermacher
Matthieu Chicard
Nadine Van Roy
et al.
C3
Conferentie
2020
SOX11 as guardian of epigenetic plasticity in neuroblastoma
Bieke Decaesteker
Amber Louwagie
Siebe Loontiens
Carolina de Carvalho Nunes
Karen Verboom
Juliette Roels
Eva D'haene
Rogier Versteeg
Kaat Durinck
Anton Henssen
et al.
C3
Conferentie
2020
The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness
Liselot Mus
Irina Lambertz
Shana Claeys
Candy Kumps
Wouter Van Loocke
Christophe Van Neste
Ganesh Umapathy
Marica Vaapil
Christoph Bartenhagen
Genevieve Laureys
et al.
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2020
The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review
Ruben Van Paemel
ROSALIE VLUG
Katleen De Preter
Nadine Van Roy
Franki Speleman
Leen Willems
Tim Lammens
Genevieve Laureys
Gudrun Schleiermacher
Godelieve AM Tytgat
et al.
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF PEDIATRICS
2020
The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : as review (vol 179, pg 191, 2020)
Ruben Van Paemel
Roos Vlug
Katleen De Preter
Nadine Van Roy
Franki Speleman
Leen Willems
Tim Lammens
Genevieve Laureys
Gudrun Schleiermacher
Godelieve A. M. Tytgat
et al.
Correctie
2020
When DNA gets in the way : a cautionary note for DNA contamination in extracellular RNA-seq studies
Jasper Verwilt
Wim Trypsteen
Ruben Van Paemel
Katleen De Preter
MD Giraldez
Pieter Mestdagh
Jo Vandesompele
A1
Artikel in een tijdschrift
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2020
2019
17q gain provides proliferative advantage to human embryonic stem cells under conditions of replicative stress
Liselot Mus
Geertrui Denecker
Stéphane Van Haver
Nadja Zeltner
Yudelca Ogando
Ellen Sanders
Eva Jacobs
Mina Popovic
Christophe Van Neste
Suzanne Vanhauwaert
et al.
C3
Conferentie
2019
17q gain provides proliferative advantage to human embryonic stem cells under replicative stress
Liselot Mus
Stéphane Van Haver
Geertrui Denecker
Nadja Zeltner
Yudelca Ogando
Ellen Sanders
Eva Jacobs
Mina Popovic
Christophe Van Neste
Suzanne Vanhauwaert
et al.
C3
Conferentie
2019
A fast, affordable and minimally-invasive diagnostic test for Cancer of Unknown Primary (CUP) using DNA methylation profiling
Jilke De Wilde
Ruben Van Paemel
Charlotte Vandeputte
Andries De Koker
Joni Van der Meulen
Malaïka Van der Linden
Nico Callewaert
Jo Van Dorpe
David Creytens
Bram De Wilde
et al.
C3
Conferentie
2019
A versatile method for circulating cell-free DNA methylome profiling by reduced representation bisulfite sequencing
Andries De Koker
Ruben Van Paemel
Bram De Wilde
Katleen De Preter
Nico Callewaert
Preprint
2019
ALK positively regulates MYCN activity through repression of HBP1 expression
Shana Claeys
Geertrui Denecker
Kaat Durinck
Bieke Decaesteker
Liselot Mus
Siebe Loontiens
Suzanne Vanhauwaert
Kristina Althoff
Caroline Wigerup
Daniel Bexell
et al.
A1
Artikel in een tijdschrift
in
ONCOGENE
2019
Benchmarking the impact of data transformation, pre-processing and choice of method in the computational deconvolution of transcriptomics data
Francisco Avila Cobos
José Alquicira-Hernandez
Jo Vandesompele
Joseph Powell
Pieter Mestdagh
Katleen De Preter
C3
Conferentie
2019
Core regulatory circuitries and epigenetic plasticity in neuroblastoma
Bieke Decaesteker
Katleen De Preter
Franki Speleman
Proefschrift
2019
DREAM target reactivation by core transcriptional regulators supports neuroblastoma growth
Bieke Decaesteker
Katleen De Preter
Franki Speleman
A2
Artikel in een tijdschrift
in
MOLECULAR & CELLULAR ONCOLOGY
2019
Exploring the contribution of gene dosage effects of 17q gain genes on hESC and neuroblastoma proliferation
Liselot Mus
Geertrui Denecker
Stéphane Van Haver
Nadja Zeltner
Yudelca Ogando
Ellen Sanders
Eva Jacobs
Mina Popovic
Christophe Van Neste
Suzanne Vanhauwaert
et al.
C3
Conferentie
2019
Faster, cheaper and more accurate diagnosis of cancer of unknown primary (CUP) by using methylation profiling.
Jilke De Wilde
Ruben Van Paemel
Charlotte Vandeputte
Andries De Koker
Joni Van der Meulen
Malaïka Van der Linden
Nico Callewaert
Jo Van Dorpe
David Creytens
Bram De Wilde
et al.
C3
Conferentie
2019
Genetic alterations of ALK in high-risk neuroblastoma patients : a SIOPEN study
A. Bellini
V. Bernard
P. Ambros
Katleen De Preter
V. Combaret
K. Beiske
A. Vicha
R. Ladenstein
D. Valteau-Couanet
M. Rossing
et al.
C3
Conferentie
2019
Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes
Dries Rombaut
Hua-Sheng Chiu
Bieke Decaesteker
Celine Everaert
Nurten Yigit
Agathe Pelthier
Isabelle Janoueix
Christophe Bartenhagen
Matthias Fischer
Stephen Roberts
et al.
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2019
Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study
Ruben Van Paemel
Andries De Koker
Charlotte Vandeputte
Lieke van Zogchel
Tim Lammens
Genevieve Laureys
Jo Vandesompele
Gudrun Schleiermacher
Mathieu Chicard
Nadine Van Roy
et al.
Preprint
2019
Modelling single-cell dynamics with trajectories and gene regulatory networks
Robrecht Cannoodt
Yvan Saeys
Katleen De Preter
Proefschrift
2019
Non-invasive classification of pediatric tumor types using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study
Ruben Van Paemel
A. De Koker
Charlotte Vandeputte
L. M. J. van Zogchel
M. Chicard
Tim Lammens
Jo Vandesompele
Nadine Van Roy
G. Schleiermacher
G. A. M. Tytgat
et al.
C3
Conferentie
2019
RNA-based liquid biopsies for better clinical management of Barrett’s esophagus and esophageal adenocarcinoma
Kathleen Schoofs
Annouck Philippron
Philippe Nafteux
Lieven Depypere
Piet Pattyn
Jo Vandesompele
Katleen De Preter
C3
Conferentie
2019
SOX11 as mediator of the adrenergic cell state in NB
Bieke Decaesteker
Amber Louwagie
Sara De Brouwer
Volodimir Olexiouk
Geertrui Denecker
Carolina de Carvalho Nunes
Karen Verboom
Moritz Gartlgruber
Wouter Van Loocke
Elena Afanasyeva
et al.
C3
Conferentie
2019
SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma
Amber Louwagie
Bieke Decaesteker
Sara De Brouwer
Geertrui Denecker
Carolina de Carvalho Nunes
Volodimir Olexiouk
Karen Verboom
Moritz Gartlgruber
Wouter Van Loocke
Elena Afanasyeva
et al.
C3
Conferentie
2019
SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma
Amber Louwagie
Bieke Decaesteker
Carolina de Carvalho Nunes
Geertrui Denecker
Volodimir Olexiouk
Karen Verboom
Moritz Gartlgruber
Wouter Van Loocke
Elena Afanasyeva
Pauline Depuydt
et al.
C3
Conferentie
2019
Searching for liquid RNA biomarkers for esophageal adenocarcinoma
Kathleen Schoofs
Annouck Philippron
Philippe Nafteux
Lieven Depypere
Piet Pattyn
Jo Vandesompele
Katleen De Preter
C3
Conferentie
2019
Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients
Charlotte Vandeputte
Jolien Van Thorre
Ruben Van Paemel
Andries De Koker
Leen Willems
Jo Van Dorpe
Malaïka Van der Linden
Jilke De Wilde
Björn Menten
L. van Zogchel
et al.
C3
Conferentie
2019
Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients
Charlotte Vandeputte
Jolien Van Thorre
Ruben Van Paemel
Andries De Koker
Leen Willems
Jo Van Dorpe
Malaïka Van der Linden
Jilke De Wilde
Björn Menten
Lieke van Zogchel
et al.
C3
Conferentie
2019
Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients
Charlotte Vandeputte
Jolien Van Thorre
Ruben Van Paemel
Andries De Koker
Leen Willems
Jo Van Dorpe
Malaïka Van der Linden
Jilke De Wilde
Björn Menten
Lieke van Zogchel
et al.
C3
Conferentie
2019
Successful copy number alteration profiling using circulating cell-free tumor DNA as a non-invasive alternative for tissue biopsies in pediatric cancer patients
Charlotte Vandeputte
Jolien Van Thorre
Ruben Van Paemel
Andries De Koker
Leen Willems
Jo Van Dorpe
Malaïka Van der Linden
Jilke De Wilde
Björn Menten
Lieke van Zogchel
et al.
C3
Conferentie
2019
The RNA Atlas, a single nucleotide resolution map of the human transcriptome
Lucia Lorenzi
Hua-Sheng Chiu
Francisco Avila Cobos
Stephen Gross
Pieter-Jan Volders
Robrecht Cannoodt
Justine Nuytens
Katrien Vanderheyden
Jasper Anckaert
Steve Lefever
et al.
Preprint
2019
2018
Assessing the biological signal of different RNA fractions for computational deconvolution of healthy tissues
Francisco Avila Cobos
Lucia Lorenzi
Jo Vandesompele
Gary Schroth
Katleen De Preter
Pieter Mestdagh
C3
Conferentie
2018
Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development
Dorien Baetens
Tülay Güran
Berenice B Mendonca
Nathalia L Gomes
Lode De Cauwer
Frank Peelman
Hannah Verdin
Marnik Vuylsteke
Malaïka Van der Linden
Hans Stoop
et al.
A1
Artikel in een tijdschrift
in
GENETICS IN MEDICINE
2018
Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients
Fjoralba Zeka
Anneleen Decock
Alan Van Goethem
Katrien Vanderheyden
Fleur Demuynck
Tim Lammens
Hetty Helsmoortel
Joëlle Vermeulen
Rosa Noguera
Ana P. Berbegall
et al.
A1
Artikel in een tijdschrift
in
JCI INSIGHT
2018
Circulating microRNA biomarkers for metastatic neuroblastoma
Fjoralba Zeka
Alan Van Goethem
Tim Lammens
Anneleen Decock
Hetty Helsmoortel
Genevieve Laureys
Michael Hogarty
Eveline Barbieri
Jason Shohet
Frank Berthold
et al.
C3
Conferentie
2018
Computational deconvolution of transcriptomics data from mixed cell populations
Francisco Avila Cobos
Jo Vandesompele
Pieter Mestdagh
Katleen De Preter
A1
Artikel in een tijdschrift
in
BIOINFORMATICS
2018
Cross-cohort analysis identifies a TEAD4-MYCN positive-feedback loop as the core regulatory element of high-risk neuroblastoma
Presha Rajbhandari
Gonzalo Lopez
Claudia Capdevila
Beatrice Salvatori
Jiyang Yu
Ruth Rodriguez-Barrueco
Daniel Martinez
Mark Yarmarkovich
Nina Weichert-Leahey
Brian J Abraham
et al.
A1
Artikel in een tijdschrift
in
CANCER DISCOVERY
2018
DNA copy number imbalances with clinical relevance in cancer : rare events in big data
Pauline Depuydt
Katleen De Preter
Franki Speleman
Proefschrift
2018
Data Descriptor: Meta-mining of copy number profiles of high-risk neuroblastoma tumors
Pauline Depuydt
J Koster
V Boeva
TD Hocking
Franki Speleman
G Schleiermacher
Katleen De Preter
A1
Artikel in een tijdschrift
in
SCIENTIFIC DATA
2018
Exploring the contribution of gene dosage effects of 17Q gain on ESC and neuroblastoma proliferation
Liselot Mus
Geertrui Denecker
Nadja Zeltner
Yudelca Ogando
Stéphane Van Haver
Ellen Sanders
Eva Jacobs
Mina Popovic
Christophe Van Neste
Suzanne Vanhauwaert
et al.
C3
Conferentie
2018
Exploring the contribution of gene dosage effects of 17q gain genes on hESC and neuroblastoma proliferation
Liselot Mus
Geertrui Denecker
Stéphane Van Haver
Nadja Zeltner
Yudelca Ogando
Ellen Sanders
Eva Jacobs
Mina Popovic
Christophe Van Neste
Suzanne Vanhauwaert
et al.
C3
Conferentie
2018
Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation
Liselot Mus
Geertrui Denecker
Nadja Zeltner
Yudelca Ogando
Stéphane Van Haver
Ellen Sanders
Eva Jacobs
Mina Popovic
Christophe Van Neste
Suzanne Vanhauwaert
et al.
C3
Conferentie
2018
Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation
Liselot Mus
Geertrui Denecker
Nadja Zeltner
Yudelca Ogando
Stéphane Van Haver
Ellen Sanders
Eva Jacobs
Mina Popovic
Christophe Van Neste
Suzanne Vanhauwaert
et al.
C3
Conferentie
2018
Genomic amplifications and distal 6q loss : novel markers for poor survival in high-risk neuroblastoma patients
Pauline Depuydt
Valentina Boeva
Toby D Hocking
Robrecht Cannoodt
Inge M Ambros
Peter F Ambros
Shahab Asgharzadeh
Edward F Attiyeh
Valérie Combaret
Raffaella Defferrari
et al.
A1
Artikel in een tijdschrift
in
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
2018
Identification of novel drug targets downstream of activated ALK in neuroblastoma
Shana Claeys
Franki Speleman
Katleen De Preter
Proefschrift
2018
In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors
Suzanne Vanhauwaert
Bieke Decaesteker
Sara De Brouwer
Carina Leonelli
Kaat Durinck
Pieter Mestdagh
Jo Vandesompele
Karen Sermon
Geertrui Denecker
Christophe Van Neste
et al.
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2018
IncGraph : incremental graphlet counting for topology optimisation
Robrecht Cannoodt
Joeri Ruyssinck
Jana Ramon
Katleen De Preter
Yvan Saeys
A1
Artikel in een tijdschrift
in
PLOS ONE
2018
Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma
Kristina B Emdal
Anna-Kathrine Pedersen
Dorte B Bekker-Jensen
Alicia Lundby
Shana Claeys
Katleen De Preter
Franki Speleman
Chiara Francavilla
Jesper V Olsen
A1
Artikel in een tijdschrift
in
SCIENCE SIGNALING
2018
LDHA in neuroblastoma is associated with poor outcome and its depletion decreases neuroblastoma growth independent of aerobic glycolysis
Carmen Dorneburg
Matthias Fischer
Thomas FE Barth
Wolfgang Mueller-Klieser
Barbara Hero
Judith Gecht
Daniel R Carter
Katleen De Preter
Benjamin Mayer
Lisa Christner
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2018
LDHA predicts poor survival in neuroblastoma and its depletion causes aerobic glycolysis-independent inhibition of neuroblastoma cells
C Dorneburg
M Fischer
TFE Barth
W Mueller-Klieser
B Hero
J Gecht
DR Carter
Katleen De Preter
Franki Speleman
GM Marshall
et al.
C3
Conferentie
2018
Mapping the genomic landscape of inherited retinal disease genes prioritizes genes prone to coding and noncoding copy-number variations
Kristof Van Schil
Sarah Naessens
Stijn Van de Sompele
Marjolein Carron
Alexander Aslanidis
Caroline Van Cauwenbergh
Anja Kathrin Mayer
Mattias Van Heetvelde
Miriam Bauwens
Hannah Verdin
et al.
A1
Artikel in een tijdschrift
in
GENETICS IN MEDICINE
2018
Network modeling of microRNA-mRNA interactions in neuroblastoma tumorigenesis identifies miR-204 as a direct inhibitor of MYCN
Chi Yan Ooi
Daniel R Carter
Bing Liu
Chelsea Mayoh
Anneleen Beckers
Amit Lalwani
Zsuzsanna Nagy
Sara De Brouwer
Bieke Decaesteker
Tzong-Tyng Hung
et al.
A1
Artikel in een tijdschrift
in
CANCER RESEARCH
2018
Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA
Ruben Van Paemel
Anneleen Decock
Charlotte Vandeputte
Tim Lammens
Genevieve Laureys
Franki Speleman
Wim Van Criekinge
Nadine Van Roy
Jo Vandesompele
Katleen De Preter
et al.
C3
Conferentie
2018
Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA
Ruben Van Paemel
Anneleen Decock
Charlotte Vandeputte
Tim Lammens
Genevieve Laureys
Franki Speleman
Wim Van Criekinge
Nadine Van Roy
Jo Vandesompele
Katleen De Preter
et al.
C3
Conferentie
2018
Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA
Ruben Van Paemel
Anneleen Decock
Charlotte Vandeputte
Tim Lammens
Genevieve Laureys
Franki Speleman
Wim Van Criekinge
Nadine Van Roy
Jo Vandesompele
Katleen De Preter
et al.
C3
Conferentie
2018
Promoter-associated proteins of EPAS1 identified by enChIP-MS : a putative role of HDX as a negative regulator
Arash Hamidian
Marica Vaapil
Kristoffer von Stedingk
Toshitsugu Fujita
Camilla U Persson
Pontus Eriksson
Srinivas Veerla
Katleen De Preter
Franki Speleman
Hodaka Fujii
et al.
A1
Artikel in een tijdschrift
in
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2018
SOX11 is a transcriptional circuit dosage sensitive transcription factor controlling SWI/SNF components
Bieke Decaesteker
Sara De Brouwer
Geertrui Denecker
Fanny De Vloed
Wouter Van Loocke
Suzanne Vanhauwaert
Pauline Depuydt
Moritz Gartlgruber
Jolien De Wyn
Genevieve Laureys
et al.
C3
Conferentie
2018
Shallow whole genome sequencing allows successful copy number profiling in formalin-fixed paraffin-embedded material in neuroblastoma patients
Charlotte Vandeputte
Ruben Van Paemel
Bram De Wilde
Malaïka Van der Linden
Jo Van Dorpe
Björn Menten
Franki Speleman
Nadine Van Roy
Katleen De Preter
C3
Conferentie
2018
TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
Bieke Decaesteker
Geertrui Denecker
Christophe Van Neste
Emmy M Dolman
Wouter Van Loocke
Moritz Gartlgruber
Carolina de Carvalho Nunes
Fanny De Vloed
Pauline Depuydt
Karen Verboom
et al.
A1
Artikel in een tijdschrift
in
NATURE COMMUNICATIONS
2018
TBX2 is implicated in cell cycle control and proliferation in neuroblastoma
Bieke Decaesteker
Geertrui Denecker
Christophe Van Neste
Fanny De Vloed
Moritz Gartlgruber
Pauline Depuydt
Wouter Van Loocke
Shana Claeys
Dries Rombaut
Siebe Loontiens
et al.
C3
Conferentie
2018
The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma
Bieke Decaesteker
Geertrui Denecker
Wouter Van Loocke
Moritz Gartlgruber
Pauline Depuydt
Fanny De Vloed
Shana Claeys
Dries Rombaut
Siebe Loontiens
Anton Henssen
et al.
C3
Conferentie
2018
The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma
Bieke Decaesteker
Geertrui Denecker
Christophe Van Neste
Fanny De Vloed
Moritz Gartlgruber
Pauline Depuydt
Wouter Van Loocke
Shana Claeys
Dries Rombaut
Siebe Loontiens
et al.
C3
Conferentie
2018
The extracellular RNA quality control (exRNAQC) study : controlling pre-analytical variables of RNA sequencing in blood-based precision medicine
Francisco Avila Cobos
Anneleen Decock
Katleen De Preter
Bert Dhondt
Olivier De Wever
Bram De Wilde
Celine Everaert
Carolina Fierro
Hetty Helsmoortel
An Hendrix
et al.
C3
Conferentie
2018
The extracellular RNA quality control (exRNAQC) study : controlling pre-analytical variables of RNA sequencing in blood-based precision medicine
Francisco Avila Cobos
Anneleen Decock
Katleen De Preter
Olivier De Wever
Bram De Wilde
Bert Dhondt
Celine Everaert
Carolina Fierro
Hetty Helsmoortel
An Hendrix
et al.
C3
Conferentie
2018
The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease
Bram De Wilde
Anneleen Beckers
Sven Lindner
Kristina Althoff
Katleen De Preter
Pauline Depuydt
Pieter Mestdagh
Tom Sante
Steve Lefever
Falk Hertwig
et al.
A2
Artikel in een tijdschrift
in
ONCOTARGET
2018
The potential of methylome sequencing in the diagnostic work : up of pediatric solid tumors
Ruben Van Paemel
Charlotte Vandeputte
Bram De Wilde
Katleen De Preter
Nadine Van Roy
Jo Vandesompele
Tim Lammens
Wim Van Criekinge
P. Ultz
Nico Callewaert
et al.
C3
Conferentie
2018
Zipper plot : visualizing transcriptional activity of genomic regions
Francisco Avila Cobos
Jasper Anckaert
Pieter-Jan Volders
Celine Everaert
Dries Rombaut
Jo Vandesompele
Katleen De Preter
Pieter Mestdagh
C3
Conferentie
2018
2017
Accelerating drug development for neuroblastoma - New drug development strategy : an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project
Lucas Moreno
Hubert Caron
Birgit Geoerger
Angelika Eggert
Gudrun Schleiermacher
Penelope Brock
Dominique Valteau-Couanet
Louis Chesler
Johannes Schulte
Katleen De Preter
et al.
A1
Artikel in een tijdschrift
in
EXPERT OPINION ON DRUG DISCOVERY
2017
BRD3 as a specific vulnerable therapeutic target in neuroblastoma
Jolien De Wyn
Kaat Durinck
Anneleen Beckers
Siebe Loontiens
Suzanne Vanhauwaert
Daniel Carter
Belamy Chueng
Glenn Marshall
Katleen De Preter
Frank Westermann
et al.
C3
Conferentie
2017
Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome
Shana Claeys
Geertrui Denecker
Robrecht Cannoodt
Candy Kumps
Kaat Durinck
Franki Speleman
Katleen De Preter
A1
Artikel in een tijdschrift
in
ONCOTARGET
2017
Genomic amplifications and distal 6q loss are novel markers for poor survival in high-risk neuroblastoma patients
Pauline Depuydt
Valentina Boeva
Toby D Hocking
Robrecht Cannoodt
Inge M Ambros
Peter F Ambros
Shahab Asgharzadeh
Edward F Attiyeh
Valérie Combaret
Raffaella Defferrari
et al.
C3
Conferentie
2017
HBP1 is a negative epigenetic regulator of MYCN-driven neuroblastoma through interaction with the PRC2 complex
Shana Claeys
Geertrui Denecker
Irina Lambertz
Els Janssens
Suzanne Vanhauwaert
Bieke Decaesteker
Tom Van Maerken
Bram De Wilde
Genevieve Laureys
Kristina Althoff
et al.
C3
Conferentie
2017
Identification of novel, rare markers for poor survival in high-risk neuroblastoma patients by merging and reanalysing existing datasets
Pauline Depuydt
Valentina Boeva
Toby Hocking
Robrecht Cannoodt
Inge Ambros
Peter Ambros
Shahab Asgharzadeh
Edward Attiyeh
Valérie Combaret
Raffaella Defferrari
et al.
C3
Conferentie
2017
Mapping the genomic landscape of inherited retinal disease genes prioritizes genes prone to coding and noncoding copy-number variations
Kristof Van Schil
Sarah Naessens
Stijn Van de Sompele
Marjolein Carron
Alexander Aslanidis
Caroline Van Cauwenbergh
Anja Kathrin Mayer
Mattias Van Heetvelde
Miriam Bauwens
Hannah Verdin
et al.
C3
Conferentie
2017
Mapping the genomic landscape of inherited retinal disease genes prioritizes genes prone to coding and noncoding copy-number variations
Kristof Van Schil
Sarah Naessens
Stijn Van de Sompele
Marjolein Carron
Alexander Aslanidis
Caroline Van Cauwenbergh
Anne Kathrin Mayer
Mattias Van Heetvelde
Miriam Bauwens
Hannah Verdin
et al.
C3
Conferentie
2017
Optimizing a workflow for transcriptome analysis of CTCs isolated from venous blood
Annouck Philippron
Charlotte Vandeputte
Nadine Van Roy
Piet Pattyn
Katleen De Preter
C3
Conferentie
2017
Optimizing a workflow for transcriptome analysis of CTCs isolated from venous blood
Charlotte Vandeputte
Annouck Philippron
Nadine Van Roy
Piet Pattyn
Katleen De Preter
C3
Conferentie
2017
RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma
Carolina de Carvalho Nunes
Siebe Loontiens
Pauline Depuydt
Suzanne Vanhauwaert
Bieke Decaesteker
Bram De Wilde
Katleen De Preter
Geertrui Denecker
Christophe Van Neste
Kaat Durinck
et al.
C3
Conferentie
2017
RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma
Carolina de Carvalho Nunes
Siebe Loontiens
Pauline Depuydt
Suzanne Vanhauwaert
Bieke Decaesteker
Bram De Wilde
Katleen De Preter
Geertrui Denecker
Christophe Van Neste
Kaat Durinck
et al.
C3
Conferentie
2017
SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma
Bieke Decaesteker
Sara De Brouwer
Fanny De Vloed
Geertrui Denecker
Suzanne Vanhauwaert
Jolien De Wyn
Genevieve Laureys
Björn Menten
Pauline Depuydt
Patrick Reynolds
et al.
C3
Conferentie
2017
SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma
Bieke Decaesteker
Sara De Brouwer
Fanny De Vloed
Geertrui Denecker
Suzanne Vanhauwaert
Jolien De Wyn
Genevieve Laureys
Björn Menten
Pauline Depuydt
Jo Vandorpe
et al.
C3
Conferentie
2017
Shallow whole genome sequencing on circulating cell-free DNA allows reliable non-invasive copy number profiling in neuroblastoma patients
Nadine Van Roy
Malaïka Van der Linden
Pauline Depuydt
Björn Menten
Annelies Dheedene
Charlotte Vandeputte
Jo Van Dorpe
Genevieve Laureys
Marjolijn Renard
Tom Sante
et al.
C3
Conferentie
2017
Shallow whole genome sequencing on circulating cell-free DNA allows reliable noninvasive copy-number profiling in neuroblastoma patients
Nadine Van Roy
Malaïka Van der Linden
Björn Menten
Annelies Dheedene
Charlotte Vandeputte
Jo Van Dorpe
Genevieve Laureys
Marleen Renard
Tom Sante
Tim Lammens
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2017
Targeting tachykinin receptors in neuroblastoma
Anton G Henssen
Andrea Odersky
Annabell Szymansky
Marleen Seiler
Kristina Althoff
Anneleen Beckers
Franki Speleman
Simon Schäfers
Katleen De Preter
Kathy Astrahanseff
et al.
A1
Artikel in een tijdschrift
in
ONCOTARGET
2017
The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma
Liselot Mus
Irina Lambertz
Candy Kumps
Shana Claeys
Geertrui Denecker
Wouter Van Loocke
Christophe Van Neste
Jan Koster
Rogier Versteeg
Nadine Van Roy
et al.
C3
Conferentie
2017
The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma
Liselot Mus
Irina Lambertz
Candy Kumps
Shana Claeys
Geertrui Denecker
Wouter Van Loocke
Christophe Van Neste
Jan Koster
Rogier Versteeg
Nadine Van Roy
et al.
C3
Conferentie
2017
The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma
Liselot Mus
Irina Lambertz
Candy Kumps
Shana Claeys
Geertrui Denecker
Wouter Van Loocke
Christophe Van Neste
Jan Koster
Rogier Versteeg
Nadine Van Roy
et al.
C3
Conferentie
2017
The FOXM1/BRIP1 axis in replicative stress induced DNA damage response in neuroblastoma : functional exploration and zebrafish modeling
Suzanne Vanhauwaert
Franki Speleman
Katleen De Preter
Proefschrift
2017
The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex
Geertrui Denecker
Shana Claeys
Irina Lambertz
Els Janssens
Suzanne Vanhauwaert
Bieke Decaesteker
Tom Van Maerken
Bram De Wilde
Genevieve Laureys
Kristina Althoff
et al.
C3
Conferentie
2017
The HBP1 tumour suppressor is a negative epigenetic regulator of MYCN-driven neuroblastoma through interaction with the PRC2 complex
Shana Claeys
Geertrui Denecker
Bieke Decaesteker
Els Janssens
Candy Kumps
Sara De Brouwer
Irina Lambertz
Annelies Fieuw
Suzanne Vanhauwaert
Kristina Althoff
et al.
C3
Conferentie
2017
The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma
Bieke Decaesteker
Geertrui Denecker
Wouter Van Loocke
Moritz Gartlgruber
Pauline Depuydt
Fanny De Vloed
Shana Claeys
Dries Rombaut
Siebe Loontiens
Anton Henssen
et al.
C3
Conferentie
2017
The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives
Delfien Bogaert
Marieke De Bruyne
Veronique Debacker
Pauline Depuydt
Katleen De Preter
Carolien Bonroy
Jan Philippé
Maria Bordon Cueto De Braem
Bart Lambrecht
Tessa Kerre
et al.
A1
Artikel in een tijdschrift
in
HAEMATOLOGICA
2017
The immunophenotypical fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives
Delfien Bogaert
Marieke De Bruyne
Veronique Debacker
Pauline Depuydt
Katleen De Preter
Carolien Bonroy
Jan Philippé
Maria Bordon Cueto De Braem
Bart Lambrecht
Tessa Kerre
et al.
C3
Conferentie
2017
Zipper plot : visualizing transcriptional activity of genomic regions
Francisco Avila Cobos
Jasper Anckaert
Pieter-Jan Volders
Celine Everaert
Dries Rombaut
Jo Vandesompele
Katleen De Preter
Pieter Mestdagh
A1
Artikel in een tijdschrift
in
BMC BIOINFORMATICS
2017
2016
An embryonic stem cell activated FOXM1 transcriptional program marks ultra-high-risk primary neuroblastoma patients for FDI-6 small molecule inhibition
Suzanne Vanhauwaert
Carina Leonelli
Sara De Brouwer
Jolien De Wyn
Anneleen Beckers
Karen Sermon
Jo Vandesompele
Franki Speleman
Katleen De Preter
C3
Conferentie
2016
Asthma inflammatory phenotypes show differential microRNA expression in sputum
Tania Maes
Francisco Avila Cobos
Florence Schleich
Valentina Sorbello
Monique Henket
Katleen De Preter
Ken Bracke
Griet Conickx
Claire Mesnil
Jo Vandesompele
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2016
Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells
Kathrin Fielitz
Kristina Althoff
Katleen De Preter
Julie Nonnekens
Jasmin Ohli
Sandra Elges
Wolfgang Hartmann
Günter Klöppel
Thomas Knösel
Marc Schulte
et al.
A1
Artikel in een tijdschrift
in
ONCOTARGET
2016
Detection of copy number aberrations in cell free DNA from plasma of neuroblastoma patients using shallow massive parallel sequencing
Katleen De Preter
Nadine Van Roy
Björn Menten
Annelies Dheedene
Genevieve Laureys
Bram De Wilde
Franki Speleman
C3
Conferentie
2016
Dual targeting of ALK and RET: establishing a novel basis for the treatment of neuroblastoma
Liselot Mus
Shana Claeys
Bram De Wilde
Genevieve Laureys
Alan Van Goethem
Johannes Schulte
Katleen De Preter
Irina Lambertz
Franki Speleman
C3
Conferentie
2016
Dual targeting of ALK and RET: establishing a novel basis for the treatment of neuroblastoma
Liselot Mus
Shana Claeys
Bram De Wilde
Genevieve Laureys
Alan Van Goethem
Johannes Schulte
Katleen De Preter
Irina Lambertz
Franki Speleman
C3
Conferentie
2016
ETV5 functionally connect ALK and CXCR4 signaling in neuroblastoma
Irina Lambertz
Shana Claeys
Candy Kumps
Liselot Mus
Els Janssens
Nadine Van Roy
Bram De Wilde
Genevieve Laureys
Jan Cools
Olivier De Wever
et al.
C3
Conferentie
2016
ETV5 functionally connects ALK and CXCR4 signaling in neuroblastoma
Irina Lambertz
Liselot Mus
Candy Kumps
Shana Claeys
Nadine Van Roy
Bram De Wilde
Genevieve Laureys
Johannes Shulte
Olivier De Wever
Katleen De Preter
et al.
C3
Conferentie
2016
Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis
Daniel R Carter
Selina K Sutton
Marina Pajic
Jayne Murray
Eric O Sekyere
Jamie Fletcher
Anneleen Beckers
Katleen De Preter
Franki Speleman
Rani E George
et al.
A1
Artikel in een tijdschrift
in
MOLECULAR ONCOLOGY
2016
Improving marker gene discovery from high-dimensional single-cell snapshot data
Robrecht Cannoodt
Wouter Saelens
Katleen De Preter
Yvan Saeys
C3
Conferentie
2016
LncRNAs in the context of Chronic Obstructive Pulmonary Disease (COPD) are associated to immune response and metabolism of xenobiotics
Francisco Avila Cobos
Ken Bracke
Jo Vandesompele
Kimberly Verniers
Guy Joos
Katleen De Preter
Guy Brusselle
Pieter Mestdagh
C3
Conferentie
2016
MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma
Johannes Fabian
Desirée Opitz
Kristina Althoff
Marco Lodrini
Barbara Hero
Ruth Volland
Anneleen Beckers
Katleen De Preter
Anneleen Decock
Nitin Patil
et al.
A1
Artikel in een tijdschrift
in
ONCOTARGET
2016
Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma
Anneleen Decock
Maté Ongenaert
Robrecht Cannoodt
Kimberly Verniers
Bram De Wilde
Genevieve Laureys
Nadine Van Roy
Ana Pilar Berbegall
Julie Bienertova-Vasku
Nick Bown
et al.
A1
Artikel in een tijdschrift
in
ONCOTARGET
2016
Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma
Anneleen Decock
Maté Ongenaert
Robrecht Cannoodt
Kimberly Verniers
Bram De Wilde
Genevieve Laureys
Nadine Van Roy
Ana Pilar Berbegall
Julie Bienertova-Vasku
Nick Bown
et al.
C3
Conferentie
2016
Optimization of a lentiviral inducible CRISPR/Cas9 system to modulate genes essential for sustained growth of cells
Bieke Decaesteker
Suzanne Vanhauwaert
Carina Leonelli
Fanny De Vloed
Givani Dewyn
Katleen De Preter
Franki Speleman
C3
Conferentie
2016
Rol van microRNA in neutrofiel astma
Tania Maes
Francisco Avila Cobos
Florence Schleich
Valentina Sorbello
Monique Henket
Katleen De Preter
Ken Bracke
Griet Conickx
Claire Mesnil
Jo Vandesompele
et al.
A4
Artikel in een tijdschrift
in
BLOEDVATEN HART LONGEN
2016
SOX11 acts as part of the MYCN regulatory protein complex implicated in neuroblastoma
Bieke Decaesteker
Sara De Brouwer
Suzanne Vanhauwaert
Fanny De Vloed
Anneleen Beckers
Genevieve Laureys
Stein Aerts
Sara Ek
Franki Speleman
Katleen De Preter
C3
Conferentie
2016
Sensing mutant ALK: Capicua and ETV5 as executors of aberrant ALK-driven MAPK signaling
Irina Lambertz
Liselot Mus
Candy Kumps
Shana Claeys
Wouter Van Loocke
Christophe Van Neste
Jan Koster
Rogier Versteeg
Nadine Van Roy
Bram De Wilde
et al.
C3
Conferentie
2016
Targeting MYCN-driven transcription by BET-bromodomain inhibition
Anton G Henssen
Kristina Althoff
Andrea Odersky
Anneleen Beckers
Richard Koche
Franki Speleman
Simon Schaefer
Emma Bell
Maike Nortmeyer
Frank Westermann
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2016
The BRIP1/FANCJ DNA helicase is a druggable 17q driver oncogene involved in G-quadruplex induced replicative stress resistance in neuroblastoma
Suzanne Vanhauwaert
Annelies Fieuw
Carina Leonelli
Bieke Decaesteker
Jolien De Wyn
Pauline Depuydt
Sara De Brouwer
Nadine Van Roy
Shuning He
Thomas Look
et al.
C3
Conferentie
2016
The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex
Shana Claeys
Irina Lambertz
Els Janssens
Suzanne Vanhauwaert
Bieke Decaesteker
Candy Kumps
Sara De Brouwer
Annelies Fieuw
Tom Van Maerken
Bram De Wilde
et al.
C3
Conferentie
2016
The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex
Shana Claeys
Irina Lambertz
Els Janssens
Suzanne Vanhauwaert
Bieke Decaesteker
Candy Kumps
Sara De Brouwer
Annelies Fieuw
Tom Van Maerken
Bram De Wilde
et al.
C3
Conferentie
2016
The TBX2 super-enhancer marked transcription factor on 17q is overexpressed in neuroblastoma and infers poor prognosis
Bieke Decaesteker
Fanny De Vloed
Siebe Loontiens
Geertrui Denecker
Wouter Van Loocke
Moritz Gartlgruber
Dries Rombaut
Anneleen Beckers
Shana Claeys
Anton Henssen
et al.
C3
Conferentie
2016
The TBX2 super-enhancer marked transcription factor on 17q is overexpressed in neuroblastoma and infers poor prognosis
Bieke Decaesteker
Anton Henssen
Wouter Van Loocke
Anneleen Beckers
Siebe Loontiens
Johannes Schulte
Katleen De Preter
Franki Speleman
C3
Conferentie
2016
The chromosome 17q super-enhancer landscape in neuroblastoma
Bieke Decaesteker
Anton Henssen
Wouter Van Loocke
Francisco Avila Cobos
Anneleen Beckers
Stein Aerts
Johannes Schulte
Katleen De Preter
Franki Speleman
C3
Conferentie
2016
The genomic region encompassing the overlapping SOX11 and Lnc-SOX11-1:1 loci exhibits a complex DNA copy number and mRNA expression pattern
Bieke Decaesteker
Sara De Brouwer
Robrecht Cannoodt
Dries Rombaut
Wouter Van Loocke
Annelies Fieuw
Fanny De Vloed
Pieter-Jan Volders
Björn Menten
Rogier Versteeg
et al.
C3
Conferentie
2016
The immunophenotypical landscape of patients with primary antibody deficiencies and their asymptomatic first-degree relatives : arguments for a multifactorial aetiology
Delfien Bogaert
Pauline Depuydt
Katleen De Preter
Carolien Bonroy
Jan Philippé
Maria Bordon Cueto De Braem
Tessa Kerre
Bart Lambrecht
Andrea Cerutti
Karim Vermaelen
et al.
C3
Conferentie
2016
Unbiased modelling of dynamic processes with single-cell RNA-sequencing
Robrecht Cannoodt
Wouter Saelens
Katleen De Preter
Yvan Saeys
C3
Conferentie
2016
Unbiased modelling of dynamic processes with single-cell RNA-sequencing
Robrecht Cannoodt
Wouter Saelens
Katleen De Preter
Yvan Saeys
C3
Conferentie
2016
Unbiased modelling of dynamic processes with single-cell RNA-sequencing
Robrecht Cannoodt
Wouter Saelens
Katleen De Preter
Yvan Saeys
C3
Conferentie
2016
2015
A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies
Kristina Althoff
Anneleen Beckers
Emma Bell
Maike Nortmeyer
Theresa Thor
Annika Sprüssel
Sven Lindner
Katleen De Preter
Alexandra Florin
Lukas C Heukamp
et al.
A1
Artikel in een tijdschrift
in
ONCOGENE
2015
An embryonic stem cell activated FOXM1 transcriptional program marks ultra-high-risk primary neuroblastoma patients for FDI-6 small molecule inhibition
Suzanne Vanhauwaert
Carina Leonelli
Sara De Brouwer
Jolien De Wyn
Anneleen Beckers
Neuroblastoma Research consortium
Jo Vandesompele
Karen Sermon
Franki Speleman
Katleen De Preter
C3
Conferentie
2015
Differential module analysis in neuroblastoma regulatory networks
Robrecht Cannoodt
Anneleen Beckers
Caroline Van Cauwenbergh
Franki Speleman
Katleen De Preter
Yvan Saeys
C3
Conferentie
2015
ETV5 functionally connect ALK and RET signaling in neuroblastoma
Irina Lambertz
Shana Claeys
Candy Kumps
Liselot Mus
Anneleen Beckers
Els Janssens
Nadine Van Roy
Genevieve Laureys
Johannes Schulte
Olivier De Wever
et al.
C3
Conferentie
2015
Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma
Ali Rihani
Alan Van Goethem
Maté Ongenaert
Sara De Brouwer
Pieter-Jan Volders
Saurabh Agarwal
Katleen De Preter
Pieter Mestdagh
Jason Shohet
Franki Speleman
et al.
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2015
HBP1 downregulation through mutant ALK represents a novel mechanism for cooperative MYCN activation in neuroblastoma
Shana Claeys
Irina Lambertz
Alan Van Goethem
Candy Kumps
Sara De Brouwer
Annelies Fieuw
Tom Van Maerken
Kristina Althoff
Johannes Schulte
Jean-Baptiste Demoulin
et al.
C3
Conferentie
2015
Identification of differentially expressed microRNAs in neutrophilic asthma
Tania Maes
Katleen De Preter
FN Schleich
M Henket
Ken Bracke
Lies Lahousse
Pieter Mestdagh
Guy Joos
Guy Brusselle
R Louis
C3
Conferentie
2015
Individual patient risk stratification of high-risk neuroblastomas using a two-gene score suited for clinical use
Kristoffer von Stedingk
Katleen De Preter
Jo Vandesompele
Rosa Noguera
Ingrid Øra
Jan Koster
Rogier Versteeg
Sven Påhlman
David Lindgren
Håkan Axelson
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF CANCER
2015
Inferring developmental chronologies from single cell RNA
Robrecht Cannoodt
Wouter Saelens
Katleen De Preter
Yvan Saeys
C3
Conferentie
2015
Integrated and cross-species omics analyses identify the DNA damage response pathway as an important vulnerable pathway in aggressive neuroblastoma tumors
Katleen De Preter
Anneleen Beckers
Suzanne Vanhauwaert
Annelies Fieuw
Sara De Brouwer
Pieter Mestdagh
Jo Vandesompele
Franki Speleman
C3
Conferentie
2015
Integrated genomic analysis identifies specific alterations and activation of YAP in relapsed neuroblastoma
A Eggert
A Schramm
J Koester
Y Assenov
A Kristina
A Engesser
Y Kahlert
J Theissen
B Hero
F Roels
et al.
C3
Conferentie
2015
MYCN transcriptionally represses CD9 to trigger an invasion-metastasis cascade in neuroblastoma
H Deubzer
J Fabian
D Opitz
K Althoff
M Lodrini
K Astrahantseff
B Hero
R Volland
Anneleen Beckers
Katleen De Preter
et al.
C3
Conferentie
2015
MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma
Anneleen Beckers
Gert Van Peer
Daniel R Carter
Moritz Gartlgruber
Carl Herrmann
Saurabh Agarwal
Hetty Helsmoortel
Kristina Althoff
Jan J Molenaar
Belamy B Cheung
et al.
A1
Artikel in een tijdschrift
in
CANCER LETTERS
2015
MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formation
Anneleen Beckers
Gert Van Peer
Daniel R Carter
Kristina Althoff
Belamy B Cheung
Johannes H Schulte
Pieter Mestdagh
Jo Vandesompele
Glenn M Marshall
Katleen De Preter
et al.
A1
Artikel in een tijdschrift
in
ONCOTARGET
2015
Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma
Anneleen Decock
Maté Ongenaert
Robrecht Cannoodt
Kimberly Verniers
Bram De Wilde
Genevieve Laureys
Nadine Van Roy
Ana Pilar Berbegall
Julie Bienertova-Vasku
Nick Bown
et al.
C3
Conferentie
2015
Mutational dynamics between primary and relapse neuroblastomas
Alexander Schramm
Johannes Köster
Yassen Assenov
Krstina Althoff
Martin Peifer
Ellen Mahlow
Andrea Odersky
Daniela Beisser
Corinna Ernst
Anton G Henssen
et al.
A1
Artikel in een tijdschrift
in
NATURE GENETICS
2015
Synergistic combined molecular treatment targeting the HBP1 tumor suppressor gene in neuroblastoma
Shana Claeys
Irina Lambertz
Alan Van Goethem
Anneleen Beckers
Candy Kumps
Tom Van Maerken
Johannes Schulte
Katleen De Preter
Franki Speleman
C3
Conferentie
2015
Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma
Anton Henssen
Kristina Althoff
Richard Koche
Andrea Odersky
Anneleen Beckers
Franki Speleman
Simon Schaefers
Katleen De Preter
Alexandra Florin
Lukas Heukamp
et al.
C3
Conferentie
2015
The HBP1 tumour suppressor at multiple regulatory cross roads in neuroblastoma
Shana Claeys
Irina Lambertz
Alan Van Goethem
Anneleen Beckers
Candy Kumps
Tom Van Maerken
Johannes Schulte
Katleen De Preter
Franki Speleman
C3
Conferentie
2015
The chromosome 17q super-enhancer landscape in neuroblastoma
Bieke Decaesteker
Anton Henssen
Wouter Van Loocke
Anneleen Beckers
Stein Aerts
Johannes Schulte
Katleen De Preter
Franki Speleman
C3
Conferentie
2015
The chromosome 17q super-enhancer landscape in neuroblastoma
Bieke Decaesteker
Anton Henssen
Wouter Van Loocke
Anneleen Beckers
Stein Aerts
Johannes Schulte
Katleen De Preter
Franki Speleman
C3
Conferentie
2015
Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma
Daniel R Carter
Jayne Murray
Belamy B Cheung
Laura Gamble
Jessica Koach
Joanna Tsang
Selina Sutton
Heyam Kalla
Sarah Syed
Andrew J Gifford
et al.
A1
Artikel in een tijdschrift
in
SCIENCE TRANSLATIONAL MEDICINE
2015
Unraveling the MYCN-driven transcriptional landscape of neuroblastoma : a cross-species integrated transcriptome approach
Anneleen Beckers
Franki Speleman
Katleen De Preter
Proefschrift
2015
Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment
Irina Lambertz
Candy Kumps
Shana Claeys
Sven Lindner
Anneleen Beckers
Els Janssens
Daniel Carter
Alex Cazes
Belamy Cheung
Marilena De Mariano
et al.
C3
Conferentie
2015
Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment
Irina Lambertz
Candy Kumps
Shana Claeys
Sven Lindner
Anneleen Beckers
Els Janssens
Daniel R Carter
Alex Cazes
Belamy B Cheung
Marilena De Mariano
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2015
Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment
Irina Lambertz
Candy Kumps
Shana Claeys
Sven Lindner
Anneleen Beckers
Els Janssens
Daniel Carter
Alex Cazes
Belamy Cheung
Marilena De Mariano
et al.
C3
Conferentie
2015
Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment
Irina Lambertz
Candy Kumps
Shana Claeys
Sven Lindner
Anneleen Beckers
Els Janssens
Daniel Carter
Alex Cazes
Belamy Cheung
Marilena De Mariano
et al.
C3
Conferentie
2015
2014
Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma
Alex Cazes
Lucille Lopez-Delisle
Konstantina Tsarovina
Cécile Pierre-Eugène
Katleen De Preter
Michel Peuchmaur
André Nicolas
Claire Provost
Caroline Louis-Brennetot
Romain Daveau
et al.
A1
Artikel in een tijdschrift
in
ONCOTARGET
2014
Characterization of ALK driven molecular networks identifies perturbed RET and cholinergic signaling in neuroblastoma
Irina Lambertz
Candy Kumps
Shana Claeys
Sven Lindler
Anneleen Beckers
Els Janssens
Marilena De Mariano
Sara De Brouwer
Jay Gibbons
Genevieve Laureys
et al.
C3
Conferentie
2014
Differential module analysis in neuroblastoma regulatory networks
Robrecht Cannoodt
Anneleen Beckers
Caroline Van Cauwenbergh
Katleen De Preter
Yvan Saeys
C3
Conferentie
2014
Genetisch geïnspireerde toekomstperspectieven voor de therapie van het neuroblastoom
Bram De Wilde
Tom Van Maerken
Katleen De Preter
Nadine Van Roy
Genevieve Laureys
Jo Vandesompele
Franki Speleman
A2
Artikel in een tijdschrift
in
TIJDSCHRIFT VOOR GENEESKUNDE
2014
Genome-wide methylation analysis unravels differential DNA methylation patterns between (prognostic) neuroblastoma patient subgroups
Anneleen Decock
Maté Ongenaert
Ana Berbegall
Rosa Noguera
Jayne Murray
Michele Haber
Raymond L Stallings
Johannes H Schulte
Valérie Combaret
Gudrun Schleiermacher
et al.
C3
Conferentie
2014
Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma
Eveline Barbieri
Katleen De Preter
Mario Capasso
Zaowen Chen
Danielle M Hsu
Gian Paolo Tonini
Steve Lefever
John Hicks
Rogier Versteeg
Andrea Pession
et al.
A1
Artikel in een tijdschrift
in
CANCER RESEARCH
2014
Identifying novel neuroblastoma oncogenes using semi-supervised learning
Leen De Baets
Robrecht Cannoodt
Joeri Ruyssinck
Katleen De Preter
Tom Dhaene
Yvan Saeys
C3
Conferentie
2014
Integrated genomic analyses for driver gene identification in neuroblastoma
Annelies Fieuw
Franki Speleman
Katleen De Preter
Proefschrift
2014
MYCN safeguards its upregulated expression through negatively controlling its upstream miRNAs
Anneleen Beckers
Gert Van Peer
Daniel Carter
Belamy Cheung
Jo Vandesompele
Glenn Marshall
Katleen De Preter
Franki Speleman
C3
Conferentie
2014
Promoter DNA-methylation in the TH-MYCN neuroblastoma mouse model
Anneleen Beckers
Wouter Van Loocke
Anneleen Decock
Maté Ongenaert
Jo Vandesompele
Franki Speleman
Katleen De Preter
C3
Conferentie
2014
Reduced DICER1 functionality in neuroblastoma through reduced expression levels or somatic mutations
Bram De Wilde
Johannes H Schulte
Anneleen Beckers
Alexander Schramm
Annelies Fieuw
Daniel Carter
Belamy Cheung
Glenn Marshall
Angelika Eggert
Katleen De Preter
et al.
C3
Conferentie
2014
Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling
Sangkyun Lee
Jörg Rahnenführer
Michel Lang
Katleen De Preter
Pieter Mestdagh
Jan Koster
Rogier Versteeg
Raymond L Stallings
Luigi Varesio
Shahab Asgharzadeh
et al.
A1
Artikel in een tijdschrift
in
PLOS ONE
2014
SOX11 is a lineage-survival oncogene in neuroblastoma
Sara De Brouwer
Bieke Decaesteker
Anneleen Beckers
Genevieve Laureys
Monique Morrison
Rodney Stewart
Franki Speleman
Katleen De Preter
C3
Conferentie
2014
SOX11 is a lineage-survival oncogene in neuroblastoma
Bieke Decaesteker
Sara De Brouwer
Geneviève Laureys
Monique Morrison
Rodney Stewart
Franki Speleman
Katleen De Preter
C3
Conferentie
2014
SOX11 is a lineage-survival oncogene in neuroblastoma
Bieke Decaesteker
Sara De Brouwer
Anneleen Beckers
Genevieve Laureys
Monique Morrison
Rodney Stewart
Franki Speleman
Katleen De Preter
C3
Conferentie
2014
SOX11 is a lineage-survival oncogene in neuroblastoma
Bieke Decaesteker
Sara De Brouwer
Anneleen Beckers
Rodney Stewart
Franki Speleman
Katleen De Preter
C3
Conferentie
2014
The HBP1 tumor suppressor is a druggable ALK downregulated gene controlling MYCN activity
Shana Claeys
Candy Kumps
Irina Lambertz
Sara De Brouwer
Sven Lindner
Alan Van Goethem
Tom Van Maerken
Jorge Vialard
Jan Cools
Johannes Schulte
et al.
C3
Conferentie
2014
The HBP1 tumor suppressor is a druggable ALK downregulated gene controlling MYCN activity
Shana Claeys
Candy Kumps
Irina Lambertz
Sara De Brouwer
Sven Lindner
Alan Van Goethem
Tom Van Maerken
Jorge Vialard
Jan Cools
Johannes Schulte
et al.
C3
Conferentie
2014
The MYCN/miR-26a-5p/LIN28B regulatory axis controls MYCN-driven LIN28B upregulation in neuroblastoma
Anneleen Beckers
Andrew Ludwig
Gert Van Peer
Daniel Carter
Belamy Cheung
Sara De Brouwer
Jo Vandesompele
Katleen De Preter
Jason Shohet
Franki Speleman
C3
Conferentie
2014
The MYCN/miR-26a-5p/LIN28B regulatory axis explains MYCN driven LIN28B upregulation during mouse neuroblastoma development
Anneleen Beckers
Daniel Carter
Andrew Ludwig
Gert Van Peer
Belamy Cheung
Jo Vandesompele
Glenn Marshall
Jason Shohet
Katleen De Preter
Franki Speleman
C3
Conferentie
2014
Time-resolved transcriptome analysis of TH-MYCN driven hyperplastic ganglia and tumors marks BRD3 as a novel candidate oncogene
Anneleen Beckers
Daniel Carter
Cheung Belamy
Jo Vandesompele
Glen Marshall
Katleen De Preter
Franki Speleman
C3
Conferentie
2014
ViVar: a comprehensive platform for the analysis and visualization of structural genomic variation
Tom Sante
Sarah Vergult
Pieter-Jan Volders
Wigard P Kloosterman
Geert Trooskens
Katleen De Preter
Annelies Dheedene
Franki Speleman
Tim De Meyer
Björn Menten
A1
Artikel in een tijdschrift
in
PLOS ONE
2014
2013
A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma
Eveline Barbieri
Katleen De Preter
Mario Capasso
Peter Johansson
Tsz-Kwong Man
Zaowen Chen
Paris Stowers
Gian Paolo Tonini
Franki Speleman
Jason M Shohet
A1
Artikel in een tijdschrift
in
PLOS ONE
2013
Different Sarcocystis spp. are present in bovine eosinophilic myositis
Lieve Vangeel
Kurt Houf
Peter Geldhof
Katleen De Preter
Jozef Vercruysse
Richard Ducatelle
Koen Chiers
A1
Artikel in een tijdschrift
in
VETERINARY PARASITOLOGY
2013
Dynamic regulation of miRNAs implicated in the MYCN-EZH2 regulatory axis during neuroblastoma tumor initiation and progression in a MYCN mouse model
Anneleen Beckers
Katleen De Preter
Belamy Cheung
Daniel Carter
Gert Van Peer
Sara De Brouwer
Pieter Mestdagh
Genevieve Laureys
Jo Vandesompele
Glenn Marshall
et al.
C3
Conferentie
2013
ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours
Annica Wilzen
Cecilia Krona
Baldur Sveinbjornsson
Erik Kristiansson
Daniel Dalevi
Ingrid Ora
Katleen De Preter
Raymond L Stallings
John Maris
Rogier Versteeg
et al.
A1
Artikel in een tijdschrift
in
MOLECULAR CANCER
2013
Evaluation of qPCR curve analysis methods for reliable biomarker discovery: bias, resolution, precision, and implications
Jan M Ruijter
Michael W Pfaffl
Sheng Zhao
Andrej N Spiess
Gregory Boggy
Jochen Blom
Robert G Rutledge
Davide Sisti
Antoon Lievens
Katleen De Preter
et al.
A1
Artikel in een tijdschrift
in
METHODS
2013
Focal DNA copy number changes in neuroblastoma target MYCN regulated genes
Candy Kumps
Annelies Fieuw
Pieter Mestdagh
Björn Menten
Steve Lefever
Filip Pattyn
Sara De Brouwer
Tom Sante
Johannes Hubertus Schulte
Alexander Schramm
et al.
A1
Artikel in een tijdschrift
in
PLOS ONE
2013
Genome wide expression, mutation and methylation analysis validates three new mouse models for neuroblastoma targeting MYCN, ALK and LIN28B for pre-clinical studies
Anneleen Beckers
Bram De Wilde
Maté Ongenaert
Candy Kumps
Johannes H Schulte
Jo Vandesompele
Katleen De Preter
Franki Speleman
C3
Conferentie
2013
Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers
Anneleen Decock
Maté Ongenaert
Jasmien Hoebeeck
Katleen De Preter
Gert Van Peer
Wim Van Criekinge
Ruth Ladenstein
Johannes H. Schulte
Rosa Noguera
Raymond L. Stallings
et al.
C3
Conferentie
2013
Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers
Anneleen Decock
Maté Ongenaert
Jasmien Hoebeeck
Katleen De Preter
Gert Van Peer
Wim Van Criekinge
Ruth Ladenstein
Johannes H Schulte
Rosa Noguera
Raymond L Stallings
et al.
C3
Conferentie
2013
Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers
Anneleen Decock
Maté Ongenaert
Jasmien Hoebeeck
Katleen De Preter
Gert Van Peer
Wim Van Criekinge
Ruth Ladenstein
Johannes H Schulte
Rosa Noguera
Raymond L Stallings
et al.
C3
Conferentie
2013
Identification of miRNAs implicated in neuroblastoma tumor initiation and progression through cross-species integrated genomic analysis
Anneleen Beckers
Katleen De Preter
Belamy Cheung
Sara De Brouwer
Gert Van Peer
Pieter Mestdagh
Genevieve Laureys
Jo Vandesompele
Glenn Marshall
Franki Speleman
C3
Conferentie
2013
Identifying and validating DNA methylation biomarkers: the example of neuroblastoma
Anneleen Decock
Maté Ongenaert
Jasmien Hoebeeck
Katleen De Preter
Gert Van Peer
Wim Van Criekinge
Ruth Ladenstein
Johannes H Schulte
Rosa Noguera
Raymond L Stallings
et al.
C3
Conferentie
2013
Improved outcome prediction of children with neuroblastoma using an integrated miRNA and DNA methylation signature
Anneleen Decock
Fjoralba Zeka
Katleen De Preter
Franki Speleman
Jo Vandesompele
C3
Conferentie
2013
MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells
JH Schulte
S Lindner
A Bohrer
J Maurer
Katleen De Preter
Steve Lefever
L Heukamp
S Schulte
J Molenaar
R Versteeg
et al.
A1
Artikel in een tijdschrift
in
ONCOGENE
2013
MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma
Marco Lodrini
Ina Oehme
Christina Schroeder
Till Milde
Marie C Schier
Annette Kopp-Schneider
Johannes H Schulte
Matthias Fischer
Katleen De Preter
Filip Pattyn
et al.
A1
Artikel in een tijdschrift
in
NUCLEIC ACIDS RESEARCH
2013
Network inference by integrating biclustering and feature selection
Robrecht Cannoodt
Joeri Ruyssinck
Katleen De Preter
Tom Dhaene
Yvan Saeys
C3
Conferentie
2013
Perturbed signaling pathways in neuroblastoma : from MYCN to ALK and back
Candy Kumps
Franki Speleman
Katleen De Preter
Proefschrift
2013
The MYCN driven murine and human neuroblastoma methylome and dynamic regulation of chromatin regulators as a guide for epigenetic therapy
Anneleen Beckers
Anneleen Decock
Belamy Cheung
Daniel Carter
Gert Van Peer
Sara De Brouwer
Genevieve Laureys
Jo Vandesompele
Johannes H Schulte
Glenn Marshall
et al.
C3
Conferentie
2013
2012
ALK(F1174L) is a driving oncogene of neuroblastoma in transgenic mice
Johannes Schulte
Lukas Heukamp
Theresa Thor
Candy Kumps
Katleen De Preter
Bram De Wilde
Jo Vandesompele
Franki Speleman
Alexander Schramm
Angelika Eggert
C3
Conferentie
2012
Cancer gene prioritization for targeted resequencing using fitSNP scores
Annelies Fieuw
Bram De Wilde
Franki Speleman
Jo Vandesompele
Katleen De Preter
A1
Artikel in een tijdschrift
in
PLOS ONE
2012
Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis
Jan J Molenaar
Jan Koster
Marli E Ebus
Peter van Sluis
Ellen M Westerhout
Katleen De Preter
David Gisselsson
Iingrid Øra
Franki Speleman
Huib N Caron
et al.
A1
Artikel in een tijdschrift
in
GENES CHROMOSOMES & CANCER
2012
Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma
Sara De Brouwer
Pieter Mestdagh
Irina Lambertz
Filip Pattyn
Anne De Paepe
Frank Westermann
Christina Schroeder
Johannes H Schulte
Alexander Schramm
Katleen De Preter
et al.
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF CANCER
2012
Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome
A Schramm
B Schowe
K Fielitz
M Heilmann
M Martin
T Marschall
J Köster
Jo Vandesompele
Joëlle Vermeulen
Katleen De Preter
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF CANCER
2012
Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers.
Anneleen Decock
Maté Ongenaert
Jasmien Hoebeeck
Katleen De Preter
Gert Van Peer
Wim Van Criekinge
Ruth Ladenstein
Johannes H Schulte
Rosa Noguera
Raymond L Stallings
et al.
A1
Artikel in een tijdschrift
in
GENOME BIOLOGY
2012
Genomic profiling of MYCN and ALKF1174L transgenic neuroblastoma mouse models provides insights into the dynamic process of tumor formation
Katleen De Preter
Anneleen Beckers
Candy Kumps
Pieter Mestdagh
Angelika Eggert
Jo Vandesompele
Franki Speleman
Johannes H Schulte
C3
Conferentie
2012
Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas
Annelies Fieuw
Candy Kumps
Alexander Schramm
Filip Pattyn
Björn Menten
Francesca Antonacci
Peter Sudmant
Johannes H Schulte
Nadine Van Roy
Sarah Vergult
et al.
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF CANCER
2012
Isolation of disseminated neuroblastoma cells from bone marrow aspirates for pretreatment risk assessment by array comparative genomic hybridization
Mado Vandewoestyne
Candy Kumps
Katrien Swerts
Björn Menten
Tim Lammens
Jan Philippé
Katleen De Preter
Genevieve Laureys
Nadine Van Roy
Franki Speleman
et al.
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF CANCER
2012
MiR-137 is epigenetically silenced in MYCN amplified neuroblastoma and targets the polycomb repressive complex 2 (PRC2) component EZH2
Anneleen Beckers
Maté Ongenaert
Anneleen Decock
Candy Kumps
Filip Pattyn
Pieter Mestdagh
Johannes H. Schulte
Franki Speleman
Katleen De Preter
C3
Conferentie
2012
MiR-137 is epigenetically silenced in MYCN amplified neuroblastomas and targets the polycomb repressive complex 2 (PRC2) component EZH2
Anneleen Beckers
Maté Ongenaert
Anneleen Decock
Candy Kumps
Filip Pattyn
the Neuroblastoma Research Consortium (NRC)
Pieter Mestdagh
Johannes H Schulte
Franki Speleman
Katleen De Preter
C3
Conferentie
2012
N-Cadherin in neuroblastoma disease : expression and clinical significance
Tim Lammens
Katrien Swerts
Lara Derycke
ANNEMIE DE CRAEMER
Sara De Brouwer
Katleen De Preter
Nadine Van Roy
Jo Vandesompele
Franki Speleman
Jan Philippé
et al.
A1
Artikel in een tijdschrift
in
PLOS ONE
2012
Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas
Annette Künkele
Katleen De Preter
Lukas Heukamp
Theresa Thor
Kristian W Pajtler
Wolfgang Hartmann
Michel Mittelbronn
Michael A Grotzer
Hedwig E Deubzer
Franki Speleman
et al.
A1
Artikel in een tijdschrift
in
NEURO-ONCOLOGY
2012
Promoter methylation analysis identifies prognostic methylation biomarkers in neuroblastoma
Anneleen Decock
Maté Ongenaert
Jasmien Hoebeeck
Katleen De Preter
Gert Van Peer
Wim Van Criekinge
Ruth Ladenstein
Johannes H Schulte
Rosa Noguera
Raymond L Stallings
et al.
C3
Conferentie
2012
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice
Lukas C Heukamp
Theresa Thor
Alexander Schramm
Katleen De Preter
Candy Kumps
Bram De Wilde
Andrea Odersky
Martin Peifer
Sven Lindner
Annika Spruessel
et al.
A1
Artikel in een tijdschrift
in
SCIENCE TRANSLATIONAL MEDICINE
2012
Transcriptional miRNA/mRNA networks in neuroblastoma: from integrative analysis to molecular therapy
Sara De Brouwer
Franki Speleman
Katleen De Preter
Proefschrift
2012
2011
A 6-gene signature identifies four molecular subgroups of neuroblastoma
Frida Abel
Daniel Dalevi
Maria Nethander
Rebecka Jörnsten
Katleen De Preter
Joëlle Vermeulen
Raymond Stallings
Per Kogner
John Maris
Staffan Nilsson
A1
Artikel in een tijdschrift
in
CANCER CELL INTERNATIONAL
2011
EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells
An De Weer
Joni Van der Meulen
Pieter Rondou
Tom Taghon
Torsten A Konrad
Katleen De Preter
Pieter Mestdagh
Tom Van Maerken
Nadine Van Roy
Marta Jeison
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF HAEMATOLOGY
2011
High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma
Johannes H Schulte
Hagen S Bachmann
Bent Brockmeyer
Katleen De Preter
André Oberthür
Sandra Ackermann
Yvonne Kahlert
Kristian Pajtler
Jessica Theissen
Frank Westermann
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2011
Identification of a new rare recurrent 1q42.2-qter deletion in neuroblastoma
Annelies Fieuw
Candy Kumps
Alexander Schramm
Björn Menten
Johannes Schulte
Nadine Van Roy
Sarah Vergult
Rosa Noguera
Rogier Versteeg
R Stallings
et al.
C3
Conferentie
2011
Identification of tumoral glial precursor cells in neuroblastoma
Sandra Acosta
Gemma Mayol
Eva Rodríguez
Cinzia Lavarino
Katleen De Preter
Candy Kumps
Idoia Garcia
Carmen de Torres
Jaume Mora
A1
Artikel in een tijdschrift
in
CANCER LETTERS
2011
Measurable impact of RNA quality on gene expression results from quantitative PCR
Joëlle Vermeulen
Katleen De Preter
Steve Lefever
Justine Nuytens
Fanny De Vloed
Stefaan Derveaux
Jan Hellemans
Franki Speleman
Jo Vandesompele
A1
Artikel in een tijdschrift
in
NUCLEIC ACIDS RESEARCH
2011
Neuroblastoma genetics and phenotype: a tale of heterogeneity
Franki Speleman
Katleen De Preter
Jo Vandesompele
A1
Artikel in een tijdschrift
in
SEMINARS IN CANCER BIOLOGY
2011
Pharmacological activation of the p53 pathway by nutlin-3 inhibits medulloblastoma cell proliferation in vitro and in vivo
Annette Künkele
Katleen De Preter
Jo Vandesompele
Theresa Thor
Kristian Pajtler
Wolfgang Hartmann
Lukas Heukamp
Alexander Schramm
Angelika Eggert
Johannes H Schulte
C3
Conferentie
2011
miRNA Expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples
Katleen De Preter
Pieter Mestdagh
Joëlle Vermeulen
Fjoralba Zeka
Alene Naranjo
Isabella Bray
Victoria Castel
Caifu Chen
Elzbieta Drozynska
Angelika Eggert
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2011
2010
Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature
Katleen De Preter
Joëlle Vermeulen
B Brors
O Delattre
A Eggert
M Fischer
I Janoueix-Lerosey
C Lavarino
JM Maris
J Mora
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2010
Accurate prediction of neuroblastoma outcome based on miRNA expression profiles
Johannes Schulte
Benjamin Schowe
Pieter Mestdagh
Lars Kaderali
Prabhav Kalaghatgi
Stefanie Schlierf
Joëlle Vermeulen
Bent Brockmeyer
Kristian Pajtler
Theresa Thor
et al.
C3
Conferentie
2010
Accurate prediction of neuroblastoma outcome based on miRNA expression profiles
Johannes H Schulte
Benjamin Schowe
Pieter Mestdagh
Lars Kaderali
Prabhav Kalaghatgi
Stefanie Schlierf
Joëlle Vermeulen
Bent Brockmeyer
Kristian Pajtler
Theresa Thor
et al.
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF CANCER
2010
An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours
Pieter Mestdagh
Erik Fredlund
Filip Pattyn
Ali Rihani
Tom Van Maerken
Joëlle Vermeulen
Candy Kumps
Björn Menten
Katleen De Preter
Alexander Schramm
et al.
C3
Conferentie
2010
An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours
Pieter Mestdagh
E Fredlund
Filip Pattyn
Ali Rihani
Tom Van Maerken
Joëlle Vermeulen
Candy Kumps
Björn Menten
Katleen De Preter
A Schramm
et al.
A1
Artikel in een tijdschrift
in
ONCOGENE
2010
Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastoma
Patrick G Buckley
Leah Alcock
Kenneth Bryan
Isabella Bray
Johannes H Schulte
Alexander Schramm
Angelika Eggert
Pieter Mestdagh
Katleen De Preter
Jo Vandesompele
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2010
High expression of the ALK receptor tyrosine kinase precedes mutation as a determining factor of unfavourable phenotype in primary neuroblastoma
Johannes Schulte
Hagen Bachmann
Bent Brockmeyer
Sandra Nowacki
Yvonne Kahlert
Andre Oberthur
Katleen De Preter
Kristian Pajtler
Jessica Theissen
Frank Westermann
et al.
C3
Conferentie
2010
MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors
Pieter Mestdagh
E Fredlund
Filip Pattyn
JH Schulte
D Muth
Joëlle Vermeulen
Candy Kumps
S Schlierf
Katleen De Preter
Nadine Van Roy
et al.
A1
Artikel in een tijdschrift
in
ONCOGENE
2010
Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification
Sara De Brouwer
Katleen De Preter
Candy Kumps
Piotr Zabrocki
Michael Porcu
Ellen M Westerhout
Arjan Lakeman
Jo Vandesompele
Jasmien Hoebeeck
Tom Van Maerken
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2010
Multiplex Amplicon Quantification (MAQ), a fast and efficient method for the simultaneous detection of copy number alterations in neuroblastoma
Candy Kumps
Nadine Van Roy
L Heyrman
D Goossens
J Del-Favero
R Noguera
Jo Vandesompele
Franki Speleman
Katleen De Preter
A1
Artikel in een tijdschrift
in
BMC GENOMICS
2010
Pharmacologic activation of the P53 pathway by Nutlin-3 inhibits medulloblastoma cell proliferation in vitro
Annette Kuenkele
Katleen De Preter
Jo Vandesompele
Kristian Pajtler
Lukas Heukamp
Michael Grotzer
Alexander Schramm
Angelika Eggert
Johannes Schulte
C3
Conferentie
2010
Predicting outcomes for children with neuroblastoma
Joëlle Vermeulen
Katleen De Preter
Pieter Mestdagh
Genevieve Laureys
Franki Speleman
Jo Vandesompele
A1
Artikel in een tijdschrift
in
DISCOVERY MEDICINE
2010
The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors
Deborah Castelletti
Giulio Fiaschetti
Valeria Di Dato
Urs Ziegler
Candy Kumps
Katleen De Preter
Massimo Zollo
Franki Speleman
Tarek Shalaby
Daniela De Martino
et al.
A1
Artikel in een tijdschrift
in
MOLECULAR CANCER THERAPEUTICS
2010
2009
59-gene prognostic signature sub-stratifies high-risk neuroblastoma patients
Joëlle Vermeulen
Katleen De Preter
Genevieve Laureys
Franki Speleman
Jo Vandesompele
Redactioneel materiaal
2009
Comparison of miRNA profiles of microdissected Hodgkin/Reed-Sternberg cells and Hodgkin cell lines versus CD77+ B-cells reveals a distinct subset of differentially expressed miRNAs
Pieter Van Vlierberghe
An De Weer
Pieter Mestdagh
Tom Feys
Katleen De Preter
Anne De Paepe
Kathleen Lambein
Jo Vandesompele
Nadine Van Roy
Bruno Verhasselt
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF HAEMATOLOGY
2009
Downregulation of miR-449a is essential for the survival of EVI1 positive leukemic cells through modulation of NOTCH1 and BCL2
An De Weer
Pieter Mestdagh
Katleen De Preter
Joni Van der Meulen
Pieter Van Vlierberghe
Tom Van Maerken
Nadine Van Roy
Marta Jeison
Isaac Yaniv
Barbara Cauwelier
et al.
C3
Conferentie
2009
External oligonucleotide standards enable cross laboratory comparison and exchange of real-time quantitative PCR data
Joëlle Vermeulen
Filip Pattyn
Katleen De Preter
Liesbeth Vercruysse
Stefaan Derveaux
Pieter Mestdagh
Steve Lefever
Jan Hellemans
Franki Speleman
Jo Vandesompele
A1
Artikel in een tijdschrift
in
NUCLEIC ACIDS RESEARCH
2009
Gebruik van genexpresieanalyse in de aanpak van neuroblastoom bij kinderen
Joëlle Vermeulen
Katleen De Preter
Pieter Mestdagh
Filip Pattyn
Anne De Paepe
Nadine Van Roy
Genevieve Laureys
Franki Speleman
Jo Vandesompele
A4
Artikel in een tijdschrift
in
ONCO (NEDERLANDSE ED.)
2009
MODULATION OF MIR-449A EXPRESSION DECREASES CELL VIABILITY, INCREASES APOPTOSIS AND INDUCES DIFFERENTIATION IN EVI1 DEREGULATED LEUKEMIA CELLS
An De Weer
Bruce Poppe
Pieter Mestdagh
Katleen De Preter
Pieter Van Vlierberghe
Nadine Van Roy
M Jeison
B Cauwelier
Bruno Verhasselt
Jan Philippé
et al.
C3
Conferentie
2009
Meta-mining of Neuroblastoma and Neuroblast Gene Expression Profiles Reveals Candidate Therapeutic Compounds
Katleen De Preter
Sara De Brouwer
Tom Van Maerken
Filip Pattyn
A Schramm
A Eggert
Jo Vandesompele
Franki Speleman
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2009
Modeling neuroblastomagenesis from neural crest stem cells in vitro and in vivo
J Schulte
A Bohrer
E Mahlow
J Maurer
H Schorle
Katleen De Preter
Jo Vandesompele
Franki Speleman
S Schlierf
K Pajtler
et al.
C3
Conferentie
2009
Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study
Joëlle Vermeulen
Katleen De Preter
Arlene Naranjo
Liesbeth Vercruysse
Nadine Van Roy
Jan Hellemans
Katrien Swerts
Sophie Bravo
Paolo Scaruffi
Gian Paolo Tonini
et al.
A1
Artikel in een tijdschrift
in
LANCET ONCOLOGY
2009
Prognostic role and functional analyses of miRNA expression in neuroblastoma
S Schlierf
Pieter Mestdagh
T Thor
Katleen De Preter
M Baumann
A Eggert
Jo Vandesompele
A Schramm
JH Schulte
C3
Conferentie
2009
RNA pre-amplification enables large-scale RT-qPCR gene-expression studies on limiting sample amounts
Joëlle Vermeulen
Stefaan Derveaux
Steve Lefever
Els De Smet
Katleen De Preter
Nurten Yigit
Anne De Paepe
Filip Pattyn
Franki Speleman
Jo Vandesompele
A2
Artikel in een tijdschrift
in
BMC RESEARCH NOTES
2009
Sarcocystis in bovine eosinophilic myositis: contribution to pathogenesis
Lieve Vangeel
Kurt Houf
Peter Geldhof
Heidi Nollet
Katleen De Preter
Jozef Vercruysse
Richard Ducatelle
Koen Chiers
C3
Conferentie
2009
The emerging molecular pathogenesis of neuroblastoma : implications for improved risk assessment and targeted therapy
Nadine Van Roy
Katleen De Preter
Jasmien Hoebeeck
Tom Van Maerken
Filip Pattyn
Pieter Mestdagh
Joëlle Vermeulen
Jo Vandesompele
Franki Speleman
A1
Artikel in een tijdschrift
in
GENOME MEDICINE
2009
The miR-17-92 gene cluster is amplified and overexpressed in retinoblastoma
E Biewald
Pieter Mestdagh
H Stephan
Katleen De Preter
T Thor
M Baumann
D Lohmann
A Eggert
Franki Speleman
A Schramm
et al.
C3
Conferentie
2009
The miR-17-92 gene cluster is amplified and overexpressed in retinoblastoma
J Schulte
E Biewald
Pieter Mestdagh
H Stephan
Katleen De Preter
D Lohmann
Franki Speleman
A Schramm
Jo Vandesompele
A Eggert
C3
Conferentie
2009
2008
Aberrant splicing of the PTPRD gene mimics microdeletions identified at this locus in neuroblastomas (vol 47, pg 197, 2008)
Prakash Nair
Katleen De Preter
Jo Vandesompele
Franki Speleman
Raymond L Stallings
Correctie
2008
Aberrant splicing of the PTPRD gene mimics microdeletions identified-at locus this in neuroblastomas
Prakash Nair
Katleen De Preter
Jo Vandesompele
Franki Speleman
Raymond L Stallings
A1
Artikel in een tijdschrift
in
GENES CHROMOSOMES & CANCER
2008
CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23
Evi Michels
Jasmien Hoebeeck
Katleen De Preter
Alexander Schramm
Bénédicte Brichard
Anne De Paepe
Angelika Eggert
Genevieve Laureys
Jo Vandesompele
Franki Speleman
A1
Artikel in een tijdschrift
in
BMC CANCER
2008
Copy number alterations and copy number variation in cancer: close encounters of the bad kind
Franki Speleman
Candy Kumps
Karen Buysse
Bruce Poppe
Björn Menten
Katleen De Preter
A1
Artikel in een tijdschrift
in
CYTOGENETIC AND GENOME RESEARCH
2008
Expression profiling of a new class of non-coding RNAs in human neuroblastoma
Pieter Mestdagh
Filip Pattyn
Katleen De Preter
Joëlle Vermeulen
Anne De Paepe
Franki Speleman
Jo Vandesompele
C3
Conferentie
2008
Gene sets enrichment analysis of chromosomal regions
Katleen De Preter
Roland Barriot
Franki Speleman
Jo Vandesompele
Yves Moreau
C3
Conferentie
2008
High throughput stem-loop RT-PCR miRNA expression profiling using minute amounts of input RNA reveals new insights in neuroblastoma pathogenesis
Pieter Mestdagh
Joëlle Vermeulen
Katleen De Preter
Filip Pattyn
Genevieve Laureys
Rosa Noguera
Marta Piqueras
Franki Speleman
Jo Vandesompele
C3
Conferentie
2008
Identification of 2 putative critical segments of 17q gain in neuroblastoma through integrative genomics
Jo Vandesompele
Evi Michels
Katleen De Preter
Björn Menten
Alexander Schramm
Angelika Eggert
Peter F Ambros
Valérie Combaret
Nadine Francotte
Francesca Antonacci
et al.
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF CANCER
2008
Low-cost dedicated mini-arrays for high-throughput analysis of DNA copy-number alterations in neuroblastoma
Katleen De Preter
Björn Menten
Sara De Brouwer
Candy Kumps
Evi Michels
Nadine Van Roy
Jo Vandesompele
Franki Speleman
A1
Artikel in een tijdschrift
in
CANCER LETTERS
2008
Positional gene enrichment analysis of gene sets for high-resolution identification of overrepresented chromosomal regions
Katleen De Preter
Roland Barriot
Franki Speleman
Jo Vandesompele
Yves Moreau
A1
Artikel in een tijdschrift
in
NUCLEIC ACIDS RESEARCH
2008
Unmasking of epigenetically silenced microRNAs in neuroblastoma
Jasmien Hoebeeck
Geert Declerck
Pieter Mestdagh
Filip Pattyn
Katleen De Preter
Joëlle Vermeulen
Nurten Yigit
Anne De Paepe
Franki Speleman
Jo Vandesompele
C3
Conferentie
2008
2007
A detailed inventory of DNA copy number alterations in four commonly used Hodgkin lymphoma cell lines
Tom Feys
Bruce Poppe
Katleen De Preter
Nadine Van Roy
Bruno Verhasselt
Pascale De Paepe
Anne De Paepe
Franki Speleman
C3
Conferentie
2007
A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell lines
Tom Feys
Bruce Poppe
Katleen De Preter
Nadine Van Roy
Bruno Verhasselt
Pascale De Paepe
Anne De Paepe
Franki Speleman
A1
Artikel in een tijdschrift
in
HAEMATOLOGICA
2007
ArrayCGH based classification of neuroblastoma into genomic subgroups
Sara De Brouwer
Evi Michels
Jo Vandesompele
Katleen De Preter
Jasmien Hoebeeck
Joëlle Vermeulen
Alexander Schramm
Jan J Molenaar
Björn Menten
Barbara Marques
et al.
C3
Conferentie
2007
ArrayCGH-based classification of neuroblastoma into genomic subgroups
Evi Michels
Jo Vandesompele
Katleen De Preter
Jasmien Hoebeeck
Joëlle Vermeulen
Alexander Schramm
Jan J Molenaar
Björn Menten
Barbara Marques
Raymond L Stallings
et al.
A1
Artikel in een tijdschrift
in
GENES CHROMOSOMES & CANCER
2007
Detection of DNA copy number alterations in cancer by array comparative genomic hybridization
Evi Michels
Katleen De Preter
Nadine Van Roy
Franki Speleman
A1
Artikel in een tijdschrift
in
GENETICS IN MEDICINE
2007
Genome wide promoter methylation analysis in neuroblastoma with perspectives for integrated molecular profiling
Jasmien Hoebeeck
Maté Ongenaert
Evi Michels
Katleen De Preter
Joëlle Vermeulen
Nurten Yigit
Anne De Paepe
Wim Van Criekinge
Franki Speleman
Jo Vandesompele
C3
Conferentie
2007
High resolution tiling-path BAC array deletion mapping suggests commonly involved 3p21-p22 tumor suppressor genes in neuroblastoma and more frequent tumors
Jasmien Hoebeeck
Evi Michels
Björn Menten
Nadine Van Roy
Angelika Eggert
Alexander Schramm
Katleen De Preter
Nurten Yigit
Els De Smet
Anne De Paepe
et al.
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF CANCER
2007
Integrative genomics in neuroblastoma research
Franki Speleman
Katleen De Preter
Evi Michels
Jasmien Hoebeeck
Filip Pattyn
Joëlle Vermeulen
Nadine Van Roy
Anne De Paepe
Genevieve Laureys
Jo Vandesompele
C3
Conferentie
2007
New insights into the genetic basis of neuroblastoma
Franki Speleman
Katleen De Preter
Jasmien Hoebeeck
Nadine Van Roy
Jo Vandesompele
A4
Artikel in een tijdschrift
in
VERHANDELINGEN VAN DE KONINKLIJKE ACADEMIE VOOR GENEESKUNDE VAN BELGIË
2007
2006
Genome wide measurement of DNA copy number changes in neuroblastoma: dissecting amplicons and mapping losses, gains and breakpoints
Evi Michels
Jo Vandesompele
Jasmien Hoebeeck
Björn Menten
Katleen De Preter
Genevieve Laureys
Nadine Van Roy
Franki Speleman
A1
Artikel in een tijdschrift
in
CYTOGENETIC AND GENOME RESEARCH
2006
Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes
Katleen De Preter
Jo Vandesompele
Pierre Heimann
Nurten Yigit
Siv Beckman
Alexander Schramm
Angelika Eggert
Raymond L Stallings
Yves Benoit
Marleen Renard
et al.
A1
Artikel in een tijdschrift
in
GENOME BIOLOGY
2006
The von Hippel-Lindau tumor suppressor gene expression level has prognostic value in neuroblastoma
Jasmien Hoebeeck
Jo Vandesompele
Helén Nisson
Katleen De Preter
Nadine Van Roy
Els De Smet
Nurten Yigit
Anne De Paepe
Genevieve Laureys
Sven Påhlman
et al.
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF CANCER
2006
2005
No evidence for correlation of DDX1 gene amplification with improved survival probability in patients with MYCN-amplified neuroblastomas
Katleen De Preter
Franki Speleman
Valérie Combaret
John Lunec
Julien Board
Andy Pearson
Anne De Paepe
Nadine Van Roy
Genevieve Laureys
Jo Vandesompele
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL ONCOLOGY
2005
Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11
Katleen De Preter
Jo Vandesompele
Björn Menten
Philippa Carr
Heike Fiegler
Anders Edsjö
Nigel P Carter
Nurten Yigit
Wim Waelput
Nadine Van Roy
et al.
A1
Artikel in een tijdschrift
in
BMC GENOMICS
2005
Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma
Jo Vandesompele
M BAUDIS
Katleen De Preter
Nadine Van Roy
P AMBROS
N BOWN
C BRINKSCHMIDT
H CHRISTIANSEN
V COMBARET
M LASTOWSKA
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL ONCOLOGY
2005
arrayCGHbase: an analysis platform for comparative genomic hybridization microarrays
Björn Menten
Filip Pattyn
Katleen De Preter
Piet Robbrecht
Evi Michels
Karen Buysse
Geert Mortier
Anne De Paepe
Steven van Vooren
Joris Vermeesch
et al.
A1
Artikel in een tijdschrift
in
BMC BIOINFORMATICS
2005
2004
Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons
Katleen De Preter
Filip Pattyn
Geert Berx
Kristin Strumane
Björn Menten
Frans Van Roy
Anne De Paepe
Franki Speleman
Jo Vandesompele
A1
Artikel in een tijdschrift
in
BMC GENOMICS
2004
No evidence for involvement of SDHD in neuroblastoma pathogenesis
Katleen De Preter
Jo Vandesompele
Jasmien Hoebeeck
Caroline Vandenbroecke
Joél Smet
Annick Nuyts
Genevieve Laureys
Valérie Combaret
Nadine Van Roy
Frank Roels
et al.
A1
Artikel in een tijdschrift
in
BMC CANCER
2004
2003
Application of laser capture microdissection in genetic analysis of neuroblastoma and neuroblastoma precursor cells
Katleen De Preter
Jo Vandesompele
Pierre Heimann
Mark M Kockx
Mireille Van Gele
Jasmien Hoebeeck
Els De Smet
Martine Demarche
Genevieve Laureys
Nadine Van Roy
et al.
A1
Artikel in een tijdschrift
in
CANCER LETTERS
2003
ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value
Jo Vandesompele
Anders Edsjö
Katleen De Preter
Håkan Axelson
Franki Speleman
Sven Påhlman
A1
Artikel in een tijdschrift
in
ONCOGENE
2003
Peroxisome mosaics
Frank Roels
Jean-Marie Saudubray
Marisa Giros
Hanna Mandel
François Eyskens
Nieves Saracibar
Begona Atares Pueyo
Jose M Prats
Betty De Prest
Katleen De Preter
et al.
A1
Artikel in een tijdschrift
in
Advances in Experimental Medicine and Biology
2003
2002
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
Jo Vandesompele
Katleen De Preter
Filip Pattyn
Bruce Poppe
Nadine Van Roy
Anne De Paepe
Franki Speleman
A1
Artikel in een tijdschrift
in
GENOME BIOLOGY
2002
Quantification of MYCN, DDX1, and NAG gene copy number in neuroblastoma using a real-time quantitative PCR assay.
Katleen De Preter
Franki Speleman
V COMBARET
J LUNEC
Genevieve Laureys
B EUSSEN
N FRANCOTTE
J BOARD
A PEARSON
Anne De Paepe
et al.
A1
Artikel in een tijdschrift
in
MODERN PATHOLOGY
2002