Research Explorer

Project

Development of advanded fluorescence microscopy methods for studying the structure, the transport and stability of nanomedicines for gene therapy of the retinal pigment epithelium.
Code
3G019711
Duration
01 January 2011 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Biophysics
    • Biophysics
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Biophysics
  • Engineering and technology
    • Multimedia processing
    • Biological system engineering
    • Signal processing
Keywords
fluorescence microscopy nanomedicines biophotonics
 
Project description
 

Several types of nanomecicines are evaluated for deliviry nucleic acids to retinal pigment epithilium (RPE) cells. However, more information is nedded on their stability and transport in biological media like the vitreous gel, retina and inside the RPE dells. In this project we will develop and apply several advanced fluorescence microscopy methods to increase our understanding of their physico chemical properties.