Project

The role of the transcription factors Ets-1, E4BP4 and GATA-3 in the development of human natural killer cells.

Duration
01 October 2012 → 01 October 2014
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Hematology
    • Immunology
    • Laboratory medicine
    • Hematology
    • Immunology
    • Laboratory medicine
Keywords
natural killer cells development Transcription factors
 
Project description

This project aims to investigate the role of the transcription factors Ets-1, E4BP4 and GATA-3 in the development of human natural killer cells by overexpression as well as deletion of these transcription factors in human cord blood CD34+ precursors and human embryonic stem cells, respectively. These modified precursors will then be allowed to differentiate into natural killer cells in vitro.