Project

Identification of perturbed miRNAs during neuroblasoma development using neuroblasts as normal counterparts

Code

365N4510

Looptijd

01-01-2011 → 31-12-2011

Financiering

Funding by bilateral agreement (private and foundations)

Promotor

Franki Speleman

Onderzoeksdisciplines

Natural sciences
- Genetics
- Systems biology
Medical and health sciences
- Molecular and cell biology
- Morphological sciences
- Oncology
- Morphological sciences
- Oncology
- Molecular and cell biology
- Morphological sciences
- Oncology

Trefwoorden

neuroblast microRNA neuroblastoom

Projectomschrijving

Neuroblastoma (NB) tumors arise from neuronal precursor cells of the sympathetic nervous system. We profiled 430 miRNAs of 100 well-characterized NB tumors and compared these to the miRNA profile of the cells-of-origin, the neuroblasts. This resulted in a set of 60 differentially expressed miRNAs. In this project, the role of several miRNAs will be further investigated in a series of in vitro and in vivo experiments.