Project

Identification of perturbed miRNAs during neuroblasoma development using neuroblasts as normal counterparts

Duration
01 January 2011 → 31 December 2011
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
Keywords
microRNA neuroblast neuroblastoma
 
Project description

Neuroblastoma (NB) tumors arise from neuronal precursor cells of the sympathetic nervous system. We profiled 430 miRNAs of 100 well-characterized NB tumors and compared these to the miRNA profile of the cells-of-origin, the neuroblasts. This resulted in a set of 60 differentially expressed miRNAs. In this project, the role of several miRNAs will be further investigated in a series of in vitro and in vivo experiments.